PTHrP, its receptor, and protein kinase A activation in osteosarcoma

In osteosarcoma, knockdown of the parathyroid hormone-related protein (PTHrP) receptor reduces activation through cyclic AMP-dependent protein kinase A (PKA) and substantially decreases tumor differentiation, invasion, and proliferation in vivo. These findings complement other evidence supporting a central role of the PKA pathway in osteosarcoma biology and pathogenesis.

• Publication year

  2014

• Venue

  Molecular & Cellular Oncology

• Publication date

  2014-12-08

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.4161/23723548.2014.965624PMID 27308361PMCID 4905201
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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