Genetic Polymorphism of msp1 and msp2 in Plasmodium falciparum Isolates from Côte d'Ivoire versus Gabon

Introduction. The characterization of genetic profile of Plasmodium isolates from different areas could help in better strategies for malaria elimination. This study aimed to compare P. falciparum diversity in two African countries. Methods. Isolates collected from 100 and 73 falciparum malaria infections in sites of Côte d'Ivoire (West Africa) and Gabon (Central Africa), respectively, were analyzed by a nested PCR amplification of msp1 and msp2 genes. Results. The K1 allelic family was widespread in Côte d'Ivoire (64.6%) and in Gabon (56.6%). For msp2, the 3D7 alleles were more prevalent (>70% in both countries) compared to FC27 alleles. In Côte d'Ivoire, the frequencies of multiple infections with msp1 (45.1%) and msp2 (40.3%) were higher than those found for isolates from Gabon, that is, 30.2% with msp1 and 31.4% with msp2. The overall complexity of infection was 1.66 (SD = 0.79) in Côte d'Ivoire and 1.58 (SD = 0.83) in Gabon. It decreased with age in Côte d'Ivoire in contrast to Gabon. Conclusion. Differences observed in some allelic families and in complexity profile may suggest an impact of epidemiological facies as well as immunological response on genetic variability of P. falciparum.

• Publication year

  2016

• Venue

  Journal of Parasitology Research

• Publication date

  2016-03-24

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1155/2016/3074803PMID 27110390PMCID 4823507
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Multiplicity of Infection and Disease Severity in Plasmodium vivax

  2016cited by this paper
• Allelic Diversity of MSP1 Gene in Plasmodium falciparum from Rural and Urban Areas of Gabon

  2015cited by this paper
• Plasmodium falciparum: genetic diversity and complexity of infections in an isolated village in western Thailand.

  2015cited by this paper
• Efficacy and Safety of Artesunate-Amodiaquine versus Artemether-Lumefantrine in the Treatment of Uncomplicated Plasmodium falciparum Malaria in Sentinel Sites across Côte d'Ivoire

  2015cited by this paper
• Genetic polymorphism of merozoite surface protein-1 in Plasmodium falciparum isolates from patients with mild to severe malaria in Libreville, Gabon

  2015cited by this paper
• Genetic diversity and complexity of Plasmodium falciparum infections in Lagos, Nigeria.

  2014cited by this paper
• Spread of artemisinin resistance in Plasmodium falciparum malaria.

  2014cited by this paper
• Falciparum Malaria as an Emerging Cause of Fever in Adults Living in Gabon, Central Africa

  2014cited by this paper
• Monitoring parasite diversity for malaria elimination in sub-Saharan Africa

  2014cited by this paper
• Increase in malaria prevalence and age of at risk population in different areas of Gabon

  2013cited by this paper
• Genetic polymorphism of merozoite surface protein-1 and merozoite surface protein-2 in Plasmodium falciparum isolates from children in South of Benin

  2013cited by this paper
• Genetic diversity of Plasmodium falciparum among school-aged children from the Man region, western Côte d’Ivoire

  2013cited by this paper
• Malarial parasite diversity in chimpanzees: the value of comparative approaches to ascertain the evolution of Plasmodium falciparum antigens

  2013cited by this paper
• Genetic polymorphism of merozoite surface protein-1 and merozoite surface protein-2 in Plasmodium falciparum isolates from Brazzaville, Republic of Congo

  2011cited by this paper
• Plasmodium falciparum genotypes diversity in symptomatic malaria of children living in an urban and a rural setting in Burkina Faso

  2009influential reference
• The evolution of drug-resistant malaria.

  2009cited by this paper
• The multiplicity of Plasmodium falciparum infections is associated with acquired immunity to asexual blood stage antigens.

  2009cited by this paper
• Plasmodium falciparum: worldwide sequence diversity and evolution of the malaria vaccine candidate merozoite surface protein-2 (MSP-2).

  2007cited by this paper
• Plasmodium falciparum genotype population dynamics in asymptomatic children from Senegal.

  2006cited by this paper
• [Prevalence, genetic diversity and multiplicity of Plasmodium falciparum infection in school children in central Cote d'Ivoire].

  2006cited by this paper
• Genetic diversity in the Block 2 region of the merozoite surface protein 1 (MSP-1) of Plasmodium falciparum: additional complexity and selection and convergence in fragment size polymorphism.

  2006cited by this paper
• Genetic diversity and structure of African Plasmodium falciparum populations in urban and rural areas.

  2006cited by this paper
• Prévalence, diversité antigénique et multiplicité d'infections de plasmodium falciparum en milieu scolaire au centre de la Côte d'Ivoire.

  2006cited by this paper
• Genetic diversity in the merozoite surface protein 1 gene of Plasmodium falciparum in different malaria-endemic localities.

  2004cited by this paper
• Plasmodium falciparum multiple infections in Mozambique, its relation to other malariological indices and to prospective risk of malaria morbidity

  2003cited by this paper
• Polymorphism in two merozoite surface proteins of Plasmodium falciparum isolates from Gabon

  2003cited by this paper
• [Comparative study of four malaria diagnostic techniques used in Ivory Coast].

  2002cited by this paper
• A recombinant blood-stage malaria vaccine reduces Plasmodium falciparum density and exerts selective pressure on parasite populations in a phase 1-2b trial in Papua New Guinea.

  2002cited by this paper
• Plasmodium falciparum merozoite surface protein 1 (MSP1): genotyping and humoral responses to allele-specific variants.

  2002cited by this paper
• Evidence for intragenic recombination in Plasmodium falciparum: identification of a novel allele family in block 2 of merozoite surface protein-1: Asembo Bay Area Cohort Project XIV.

  2002cited by this paper
• Prospective risk of morbidity in relation to multiplicity of infection with Plasmodium falciparum in São Tomé.

  2001cited by this paper
• Genetic diversity of Plasmodium falciparum and its relationship to parasite density in an area with different malaria endemicities in West Uganda

  2001cited by this paper
• [No influence of season of transmission nor age of patients on the complexity and genetic diversity of Plasmodium falciparum infection in Cotonou, Benin].

  2001cited by this paper
• Microsatellite markers reveal a spectrum of population structures in the malaria parasite Plasmodium falciparum.

  2000cited by this paper
• The epidemiology of multiple Plasmodium falciparum infections. 5. Variation of Plasmodium falciparum msp1 block 2 and msp2 allele prevalence and of infection complexity in two neighbouring Senegalese villages with different transmission conditions

  1999cited by this paper
• The epidemiology of multiple Plasmodium falciparum infections. 11. Premunition in Plasmodium falciparum infection : Insights from the epidemiology of multiple infections

  1999cited by this paper
• A primary malarial infection is composed of a very wide range of genetically diverse but related parasites.

  1998cited by this paper
• Unstable malaria in Sudan: the influence of the dry season. Clone multiplicity of Plasmodium falciparum infections in individuals exposed to variable levels of disease transmission.

  1998cited by this paper
• No influence of age on infection complexity and allelic distribution in Plasmodium falciparum infections in Ndiop, a Senegalese village with seasonal, mesoendemic malaria.

  1998cited by this paper
• Transmission intensity and Plasmodium falciparum diversity on the northwestern border of Thailand.

  1998cited by this paper

• Plasmodium falciparum genetic diversity in border areas of Myanmar assessed by genotyping merozoite surface protein genes

  2026cites this paper
• Malaria prevalence, transmission potential and efficacy of artemisinin-based combination therapy in the Kenyan Central highlands: a zone previously characterized as malaria-free

  2025cites this paper
• Genetic diversity and humoral responses to Plasmodium falciparum in a context of stable malaria transmission in Cte dIvoire

  2025cites this paper
• Investigating polymorphism of Plasmodium falciparum msp1 and msp2 vaccine candidates reveals a high proportion of genetically diverse monoclonal infections in Cameroon

  2025cites this paper
• Genetic Diversity of Plasmodium falciparum in Korhogo Health District, Northern Côte d’Ivoire

  2025cites this paper
• Genetic polymorphism of msp2 in Plasmodium falciparum isolates among asymptomatic malaria infections from two ecological settings in Cameroon

  2025cites this paper
• Genetic diversity of Plasmodium falciparum and Plasmodium vivax field isolates from the Nowshera district of Pakistan

  2024cites this paper
• A Comparative Study of Genetic Diversity and Multiplicity of Infection in Uncomplicated Plasmodium falciparum Infections in Selected Regions of Pre-Elimination and High Transmission Settings Using MSP1 and MSP2 Genes

  2024cites this paper
• Genetic polymorphism of merozoite surface protein 1 and antifolate-resistant genes in Plasmodium falciparum from Mali and Niger

  2023cites this paper
• Plasmodium falciparum Genetic Diversity and Resistance Genotype Profile in Infected Placental Samples Collected After Delivery in Ouagadougou

  2023cites this paper
• Plasmodium falciparum population structure inferred by msp1 amplicon sequencing of parasites collected from febrile patients in Kenya

  2023cites this paper
• Plasmodium falciparum msp-1 and msp-2 genetic diversity and multiplicity of infection in isolates from Congolese patients in the Republic of Congo

  2023cites this paper
• The diversity of Plasmodium falciparum isolates from asymptomatic and symptomatic school-age children in Kinshasa Province, Democratic Republic of Congo

  2023cites this paper
• Genetic Diversity of Merozoite Surface Protein-1 and -2 Genes in Plasmodium falciparum Isolates among Asymptomatic Population in Boset and Badewacho Districts, Southern Ethiopia

  2022cites this paper
• Plasmodium falciparum msp1 and msp2 genetic diversity in parasites isolated from symptomatic and asymptomatic malaria subjects in the South of Benin

  2022cites this paper
• P. falciparum msp1 and msp2 genetic diversity in P. falciparum single and mixed infection with P. malariae among the asymptomatic population in Southern Benin.

  2022cites this paper
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• Potential Opportunities and Challenges of Deploying Next Generation Sequencing and CRISPR-Cas Systems to Support Diagnostics and Surveillance Towards Malaria Control and Elimination in Africa

  2022cites this paper
• Detection of high frequency of MAD20 allelic variants of Plasmodium falciparum merozoite surface protein 1 gene from Adama and its surroundings, Oromia, Ethiopia

  2021cites this paper
• Allelic diversity of MSP1 and MSP2 repeat loci correlate with levels of malaria endemicity in Senegal and Nigerian populations

  2021cites this paper
• Genetic diversity of Plasmodium falciparum populations in three malaria transmission settings in Madagascar

  2021cites this paper
• Genomic miscellany and allelic frequencies of Plasmodium falciparum msp-1, msp-2 and glurp in parasite isolates

  2021cites this paper
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  2021cites this paper
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  2021cites this paper
• An Evolution From a Predominant K1 Allelic Variant to MAD20 of msp1 Gene Between 2015 to 2019 in Metehara, Southeast Ethiopia

  2021cites this paper
• Molecular epidemiology of Plasmodium falciparum by multiplexed amplicon deep sequencing in Senegal

  2020cites this paper
• Is genetic diversity of Plasmodium falciparum suggestive of malaria endemic zone in West Africa? An attempt to respond by a cross-sectional comparative study between Senegal and Nigeria

  2020cites this paper
• Genetic Diversity of Merozoite Surface Protein 2 (MSP2) Plasmodium falciparum Clinical Isolate in Wamena General Hospital

  2020cites this paper
• Determinants of Plasmodium falciparum multiplicity of infection and genetic diversity in Burkina Faso

  2020influential citation
• Genetic diversity and genotype multiplicity of Plasmodium falciparum infection in patients with uncomplicated malaria in Chewaka district, Ethiopia

  2020cites this paper
• Genetic diversity of Plasmodium falciparum and genetic profile in children affected by uncomplicated malaria in Cameroon

  2020cites this paper
• Low genetic diversity and complexity of submicroscopic Plasmodium falciparum infections among febrile patients in low transmission areas in Senegal

  2019cites this paper
• Genetic diversity of Plasmodium falciparum infection among children with uncomplicated malaria living in Pointe-Noire, Republic of Congo

  2019cites this paper
• Comparison of msp genotyping and a 24 SNP molecular assay for differentiating Plasmodium falciparum recrudescence from reinfection

  2019cites this paper
• Ex vivo efficacy of selective chalcone derivatives on reference strains and field isolates of Plasmodium falciparum

  2019cites this paper
• Genetic polymorphism of Merozoite Surface Protein 1 (msp1) and 2 (msp2) genes and multiplicity of Plasmodium falciparum infection across various endemic areas in Senegal

  2019cites this paper
• Novel empirical and bioinformatic approaches to characterising Plasmodium falciparum antigens and their application to a merozoite-stage vaccine candidate

  2019cites this paper
• Dynamics of Plasmodium falciparum genetic diversity among asymptomatic and symptomatic children in three epidemiological areas in Cote d’Ivoire

  2019cites this paper
• Plasmodium falciparum msp1 and msp2 genetic diversity and allele frequencies in parasites isolated from symptomatic malaria patients in Bobo-Dioulasso, Burkina Faso

  2018cites this paper
• Spatial and temporal distribution of Pfmsp1 and Pfmsp2 alleles and genetic profile change of Plasmodium falciparum populations in Gabon.

  2018cites this paper
• Genetic diversity of the msp-1, msp-2, and glurp genes of Plasmodium falciparum isolates in Northwest Ethiopia

  2018cites this paper
• Dissecting the mechanism of severe malaria

  2017influential citation
• Genetic diversity and multiplicity of infection of Plasmodium falciparum isolates from Kolkata, West Bengal, India.

  2016cites this paper