Blockade of Nav1.8 Currents in Nociceptive Trigeminal Neurons Contributes to Anti-trigeminovascular Nociceptive Effect of Amitriptyline

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Neuromolecular medicine

• Publication date

  2014-06-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1007/s12017-013-8282-6PMID 24292897
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Migraine: the seventh disabler

  2013influential reference
• Rufinamide Attenuates Mechanical Allodynia in a Model of Neuropathic Pain in the Mouse and Stabilizes Voltage-gated Sodium Channel Inactivated State

  2013cited by this paper
• Effect of amitriptyline on tetrodotoxin-resistant Nav1.9 currents in nociceptive trigeminal neurons

  2013cited by this paper
• Headache yesterday in China: A new approach to estimating the burden of headache, applied in a general-population survey in China

  2013cited by this paper
• The Prevalence and Burden of Primary Headaches in China: A Population‐Based Door‐to‐Door Survey

  2012cited by this paper
• Amitriptyline modulates calcium currents and intracellular calcium concentration in mouse trigeminal ganglion neurons.

  2012cited by this paper
• Allodynia and migraine

  2012cited by this paper
• Prostaglandin E2 induces immediate migraine-like attack in migraine patients without aura

  2012cited by this paper
• Antinociceptive activities of lidocaine and the nav1.8 blocker a803467 in diabetic rats.

  2012cited by this paper
• The differential effect of intrathecal Nav1.8 blockers on the induction and maintenance of capsaicin- and peripheral ischemia-induced mechanical allodynia and thermal hyperalgesia.

  2012cited by this paper
• Pretreatment with intrathecal amitriptyline potentiates anti-hyperalgesic effects of post-injury intra-peritoneal amitriptyline following spinal nerve ligation

  2012cited by this paper
• Genetic variations in tumor necrosis factor alpha, interleukin-10 genes, and migraine susceptibility.

  2011cited by this paper
• TNF-α enhances the currents of voltage gated sodium channels in uninjured dorsal root ganglion neurons following motor nerve injury.

  2011cited by this paper
• The effects of OB-induced depression on nociceptive behaviors induced by electrical stimulation of the dura mater surrounding the superior sagittal sinus.

  2011cited by this paper
• New directions in migraine

  2011cited by this paper
• Episodic and chronic migraineurs are hypersensitive to thermal stimuli between migraine attacks

  2011cited by this paper
• Effects of prostaglandin D2 on tetrodotoxin‐resistant Na+ currents in DRG neurons of adult rat

  2011influential reference
• Plasma and saliva levels of nerve growth factor and neuropeptides in chronic migraine patients.

  2011cited by this paper
• The Use of Antidepressants for Headache Prophylaxis

  2011cited by this paper
• Antisense-Mediated Knockdown of NaV1.8, but Not NaV1.9, Generates Inhibitory Effects on Complete Freund's Adjuvant-Induced Inflammatory Pain in Rat

  2011cited by this paper
• Amitriptyline inhibits currents and decreases the mRNA expression of voltage-gated sodium channels in cultured rat cortical neurons.

  2010influential reference
• Substance P Sensitizes P2X3 in Nociceptive Trigeminal Neurons

  2010cited by this paper
• Pain channelopathies

  2010cited by this paper
• Pharmacological prophylaxis of chronic migraine: a review of double-blind placebo-controlled trials

  2010cited by this paper
• Perisurgical amitriptyline produces a preventive effect on afferent hypersensitivity following spared nerve injury

  2009cited by this paper
• PKCε-dependent potentiation of TTX-resistant Nav1.8 current by neurokinin-1 receptor activation in rat dorsal root ganglion neurons

  2009cited by this paper
• Additive antinociceptive effects of the selective Nav1.8 blocker A-803467 and selective TRPV1 antagonists in rat inflammatory and neuropathic pain models.

  2009cited by this paper
• A Peripherally Acting Nav1.7 Sodium Channel Blocker Reverses Hyperalgesia and Allodynia on Rat Models of Inflammatory and Neuropathic Pain

  2009cited by this paper
• Origin of pain in migraine: evidence for peripheral sensitisation.

  2009influential reference
• Effects of carbamazepine and amitriptyline on tetrodotoxin-resistant Na+ channels in immature rat trigeminal ganglion neurons

  2008influential reference
• A Selective Nav1.8 Sodium Channel Blocker, A-803467 [5-(4-Chlorophenyl-N-(3,5-dimethoxyphenyl)furan-2-carboxamide], Attenuates Spinal Neuronal Activity in Neuropathic Rats

  2008cited by this paper
• Inhibition of the Cardiac L-Type Calcium Channel Current by Antidepressant Drugs

  2008cited by this paper
• Sodium channel blockade may contribute to the analgesic efficacy of antidepressants.

  2007cited by this paper
• Blockers of voltage-gated sodium channels for the treatment of central nervous system diseases.

  2007cited by this paper
• Use-Dependent Block by Lidocaine but Not Amitriptyline Is More Pronounced in Tetrodotoxin (TTX)-Resistant Nav1.8 Than in TTX-Sensitive Na+ Channels

  2007influential reference
• Increased plasma substance P and CGRP levels, and high ACE activity in migraineurs during headache‐free periods

  2007cited by this paper
• A-803467, a potent and selective Nav1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat

  2007influential reference
• Sensory neuron sodium channel Nav1.8 is essential for pain at low temperatures

  2007cited by this paper
• Molecular Basis of Cav2.3 Calcium Channels in Rat Nociceptive Neurons*

  2007cited by this paper
• Nav 1.8-null mice show stimulus-dependent deficits in spinal neuronal activity

  2006cited by this paper
• [Mechanisms and genetics of migraine].

  2006cited by this paper
• Cost of disorders of the brain in Europe.

  2006influential reference
• PATHOPHYSIOLOGY OF MIGRAINE

  2006cited by this paper
• Involvement of the TTX‐resistant sodium channel Nav 1.8 in inflammatory and neuropathic, but not post‐operative, pain states

  2006cited by this paper
• [Is migraine a neuronal channelopothy?].

  2005cited by this paper
• Algorithm for neuropathic pain treatment: An evidence based proposal

  2005cited by this paper
• Mutation in the neuronal voltage-gated sodium channel SCN1A in familial hemiplegic migraine.

  2005cited by this paper
• Algorithm for neuropathic pain treatment: An evidence based proposal

  2005cited by this paper
• Contactin regulates the current density and axonal expression of tetrodotoxin‐resistant but not tetrodotoxin‐sensitive sodium channels in DRG neurons

  2005cited by this paper
• Calcitonin gene‐related peptide enhances TTX‐resistant sodium currents in cultured dorsal root ganglion neurons from adult rats

  2005influential reference
• Behavioral changes and trigeminal ganglion sodium channel regulation in an orofacial neuropathic pain model

  2005cited by this paper
• Low Income and Education Levels May Cause Medication Overuse and Chronicity in Migraine Patients

  2005cited by this paper
• Cost of disorders of the brain in Europe

  2005cited by this paper
• The role of Na(V)1.8 sodium channel in the maintenance of chronic inflammatory hypernociception.

  2005cited by this paper
• The neurobiology of antiepileptic drugs for the treatment of nonepileptic conditions

  2004influential reference
• Peripherally administered amitriptyline derivatives have differential anti-allodynic effects in a rat model of neuropathic pain.

  2004cited by this paper
• State‐dependent block of voltage‐gated Na+ channels by amitriptyline via the local anesthetic receptor and its implication for neuropathic pain

  2004cited by this paper
• Tricyclic antidepressants as long‐acting local anesthetics

  2003cited by this paper
• Activation of presynaptic NMDA receptors coupled to NaV1.8-resistant sodium channel C-fibers causes retrograde mechanical nociceptor sensitization

  2003cited by this paper
• Sensory and electrophysiological properties of guinea‐pig sensory neurones expressing Nav 1.7 (PN1) Na+ channel α subunit protein

  2003cited by this paper
• Anti‐allodynic effect of NW‐1029, a novel Na+ channel blocker, in experimental animal models of inflammatory and neuropathic pain

  2003cited by this paper
• Haploinsufficiency of ATP1A2 encoding the Na+/K+ pump α2 subunit associated with familial hemiplegic migraine type 2

  2003cited by this paper
• Amitriptyline Inhibits Voltage-Sensitive Sodium Currents in Rat Gastric Sensory Neurons

  2002cited by this paper
• Sciatic nerve block with bupivacaine-loaded microspheres prevents hyperalgesia in an inflammatory animal model

  2002cited by this paper
• Roles of Tetrodotoxin (TTX)-Sensitive Na+ Current, TTX-Resistant Na+ Current, and Ca2+ Current in the Action Potentials of Nociceptive Sensory Neurons

  2002cited by this paper
• Inhibition of neuropathic pain by decreased expression of the tetrodotoxin‐resistant sodium channel, NaV1.8

  2002cited by this paper
• Deficits in Visceral Pain and Referred Hyperalgesia in Nav1.8 (SNS/PN3)-Null Mice

  2002influential reference
• A role for the TTX-resistant sodium channel Nav 1.8 in NGF-induced hyperalgesia, but not neuropathic pain

  2001cited by this paper
• Amitriptyline versus Bupivacaine in Rat Sciatic Nerve Blockade

  2001cited by this paper
• The Pathophysiology of Migraine

  2001cited by this paper
• Contribution of Na(v)1.8 sodium channels to action potential electrogenesis in DRG neurons.

  2001cited by this paper
• Diversity of expression of the sensory neuron-specific TTX-resistant voltage-gated sodium ion channels SNS and SNS2.

  2000influential reference
• Expression of sodium channel SNS/PN3 and ankyrin(G) mRNAs in the trigeminal ganglion after inferior alveolar nerve injury in the rat.

  2000cited by this paper
• Amitriptyline modulation of Na(+) channels in rat dorsal root ganglion neurons.

  2000influential reference
• Block of human heart hH1 sodium channels by amitriptyline.

  2000cited by this paper
• Changes in Expression of Two Tetrodotoxin-Resistant Sodium Channels and Their Currents in Dorsal Root Ganglion Neurons after Sciatic Nerve Injury But Not Rhizotomy

  2000cited by this paper
• A comparison of the potential role of the tetrodotoxin-insensitive sodium channels, PN3/SNS and NaN/SNS2, in rat models of chronic pain.

  1999influential reference
• The tetrodotoxin-resistant sodium channel SNS has a specialized function in pain pathways

  1999cited by this paper
• Inhibition of neuronal Na+ channels by antidepressant drugs.

  1998cited by this paper
• Modulation of TTX-R INa by PKC and PKA and Their Role in PGE2-Induced Sensitization of Rat Sensory Neurons In Vitro

  1998influential reference
• Familial hemiplegic migraine and episodic ataxia type-2 are caused by mutations in the Ca2+ channel gene CACNL1A4.

  1996cited by this paper
• Familial Hemiplegic Migraine and Episodic Ataxia Type-2 Are Caused by Mutations in the Ca Channel

  1996cited by this paper
• Characterization of TTX‐sensitive and TTX‐resistant sodium currents in small cells from adult rat dorsal root ganglia.

  1993cited by this paper
• Amitriptyline inhibits striatal efflux of neurotransmitters via blockade of voltage-dependent Na+ channels.

  1992cited by this paper
• Blockade of cardiac sodium channels by amitriptyline and diphenylhydantoin. Evidence for two use-dependent binding sites.

  1991cited by this paper
• The visceral organ brain

  1991cited by this paper
• The neurobiology of vascular head pain

  1984cited by this paper
• Local anesthetics: hydrophilic and hydrophobic pathways for the drug- receptor reaction

  1977cited by this paper
• Cardiac effects of amitriptyline in rats.

  1976cited by this paper

• Indeterminate dental pain: clinical characteristics and neurovascular compression; a retrospective case comparative study

  2025cites this paper
• REPRINTED WITH PERMISSION OF IASP – PAIN 164 (2023) 3–13: Ambroxol for neuropathic pain: hiding in plain sight?

  2023cites this paper
• European Headache Federation (EHF) critical re-appraisal and meta-analysis of oral drugs in migraine prevention—part 1: amitriptyline

  2023cites this paper
• Scorpion Neurotoxin Syb-prII-1 Exerts Analgesic Effect through Nav1.8 Channel and MAPKs Pathway

  2022cites this paper
• Ambroxol for neuropathic pain: hiding in plain sight?

  2022cites this paper
• Comparison of lidocaine and ropivacaine stellate ganglion blockade in treating upper limb postherpetic neuralgia

  2022cites this paper
• Inhibitory Actions of Clinical Analgesics, Analgesic Adjuvants, and Plant-Derived Analgesics on Nerve Action Potential Conduction

  2022cites this paper
• Growth Differentiation Factor-15 Produces Analgesia by Inhibiting Tetrodotoxin-Resistant Nav1.8 Sodium Channel Activity in Rat Primary Sensory Neurons

  2021cites this paper
• Scientific evidence for the treatment of children with irritable bowel syndrome.

  2021cites this paper
• Cognitive impairment in a classical rat model of chronic migraine may be due to alterations in hippocampal synaptic plasticity and N-methyl-D-aspartate receptor subunits

  2020cites this paper
• Inhibition of Fast Nerve Conduction Produced by Analgesics and Analgesic Adjuvants—Possible Involvement in Pain Alleviation

  2020cites this paper
• Topical Ambroxol 20% for the Treatment of Classical Trigeminal Neuralgia – A New Option? Initial Clinical Case Observations

  2019cites this paper
• Key Role of the Membrane Trafficking of Nav1.5 Channel Protein in Antidepressant-Induced Brugada Syndrome

  2018cites this paper
• Modulation of tetrodotoxin‐resistant Na+ channels by amitriptyline in dural afferent neurons

  2018cites this paper
• A Feasibility Research on Restoration of Demyelination in Trigeminal Nerve with Transnasal Administration of BDNF/ NGF Loading on PEG-PLA Nanoparticles

  2018cites this paper
• Inhibitory Effect of Amitriptyline on the Impulse Activity of Cold Thermoreceptor Terminals of Intact and Tear-Deficient Guinea Pig Corneas

  2017cites this paper
• Sigma‐1 receptor agonist increases axon outgrowth of hippocampal neurons via voltage‐gated calcium ions channels

  2017cites this paper
• Depression and anxiety behaviour in a rat model of chronic migraine

  2017cites this paper
• Antidepressants inhibit Nav1.3, Nav1.7, and Nav1.8 neuronal voltage-gated sodium channels more potently than Nav1.2 and Nav1.6 channels expressed in Xenopus oocytes

  2017cites this paper
• Sodium Channel Blockers for the Treatment of Pain

  2017cites this paper
• Gastrointestinal Pharmacology.

  2017cites this paper
• Recent Trends in the Discovery of Small Molecule Blockers of Sodium Channels.

  2016cites this paper
• Pain transduction: a pharmacologic perspective

  2016cites this paper
• Amitriptyline Therapy in Chronic Pain

  2015cites this paper
• Are all types of migraine channelopathies

  2015cites this paper
• SDF1–CXCR4 signaling contributes to persistent pain and hypersensitivity via regulating excitability of primary nociceptive neurons: involvement of ERK-dependent Nav1.8 up-regulation

  2015cites this paper
• Anatomy of Headache

  2015cites this paper
• Myelinated Ah-type trigeminal ganglion neurons in female rats: neuroexcitability, chemosensitivity to histamine, and potential clinical impact.

  2014cites this paper
• The Use of Non-Narcotic Pain Medication in Pediatric Gastroenterology

  2014cites this paper
• Update of Chronic Tension-Type Headache

  2014cites this paper
• Research progress of 18 F-FDG PET/CT radiomics in diagnosis, treatment and prognosis of lung cancer

  year unknowncites this paper