G-Quadruplex DNA Bound by a Synthetic Ligand is Highly Dynamic

Using single molecule fluorescence resonance energy transfer, we investigated the interaction between a quadruplex-binding ligand and the human telomeric G-quadruplex. The binding of quinolinecarboxamide macrocycle to telomeric DNA was essentially irreversible and selectively induced and favored one quadruplex conformation. The ligand−quadruplex complex displayed intramolecular dynamics including quadruplex folding and unfolding in the absence of ligand association and dissociation. We report that the G-quadruplex can be stabilized without preventing the intrinsic intramolecular dynamics of telomeric DNA.

• Publication year

  2009

• Venue

  Journal of the American Chemical Society

• Publication date

  2009-08-17

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1021/ja903408rPMID 19685880PMCID 2737377
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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