Nephroprotective effects of Feijoa Sellowiana leaves extract on renal injury induced by acute dose of ecstasy (MDMA) in mice

Objective(s): Because of the high total phenolic contents of Feijoa sellowiana, its nephroprotective effect was determined in 3,4-methylene dioxymethamphetamine (MDMA) treated mice. Materials and Methods: Animals received 10, 20 and 40 mg/kg doses of aqueous or methanol extract of F. sellowiana leaves, intra-peritoneally. After one hour, an acute administration of MDMA (20 mg/kg, IP) was injected. Nephroprotective effect was assayed by determination of serum creatinine, serum urea and kidney glutathione level. Histopathological study was also used. Results : Both extracts at 40 mg/kg resulted in a significant reversal in the raised serum creatinine levels (P <0.05). Not statistically significant was observed in effect of two extracts (P>0.05). A decrease in urea/ creatinine ratio was observed following aqueous extract treatment. Methanolic extract showed higher activity in increasing kidney glutathione (P<0.001 compared to MDMA group). Methanol extract showed higher protective activity in histopathology study. Conclusion: F. sellowiana extract resulted in a markedly decrease in the nephrotoxicity of MDMA in mice.

• Publication year

  2014

• Venue

  Iranian Journal of Basic Medical Sciences

• Publication date

  2014-01-01

• Fields of study

  Medicine, Environmental Science

• Identifiers
  DOI 10.22038/IJBMS.2014.2159PMID 24592310PMCID 3938889
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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