Optimal cutoff of the triglyceride to high-density lipoprotein cholesterol  ratio to detect cardiovascular risk factors among Han adults in Xinjiang

BackgroundTo determine whether TG/HDL-C ratio, which has been shown to be an indicator of the metabolic syndrome (MetS) and insulin resistance (IR), can predict cardiovascular risk factors in the Chinese Han population in Xinjiang.MethodsThe cardiovascular risk survey (CRS) was conducted from October 2007 to March 2010. A total of 14,618 representative participants were selected using a four-stage stratified sampling method. A total of 5757 Han participants were included in the study. The present statistical analysis was restricted to the 5595 Han subjects who had complete anthropometric data. The sensitivity, specificity, and distance on the receiver operating characteristic (ROC) curve in each TG/HDL level were calculated. The shortest distance in the ROC curves was used to determine the optimal cutoff of the TG/HDL-C ratio for detecting cardiovascular risk factors.ResultsThe prevalence of hypertension, hypercholesterolemia, and hypertriglyceridemia was higher with higher TG/HDL-C ratio for both men and women. The TG/HDL-C ratio was positively associated with systolic blood pressure, diastolic blood pressure, and serum concentrations of total cholesterol. The optimal TG/HDL-C ratio cutoffs for predicting hypertension, dyslipidemia, diabetes, and ≥2 of these risk factors for Han adults in Xinjiang were 1.3, 1.3, 1.4, and 1.4 in men and 0.9, 1.0, 1.0, and 1.1 in women, respectively.ConclusionsThe evaluation of TG/HDL-C ratio should be considered for one of cardiovascular risk factor predictors among Han adults in Xinjiang.

• Publication year

  2016

• Venue

  Journal of Health, Population and Nutrition

• Publication date

  2016-09-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1186/s41043-016-0067-8PMID 27586369PMCID 5025992
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Apolipoprotein C-I Polymorphism and Its Association with Serum Lipid Levels and Longevity in the Bama Population

  2017cited by this paper
• Triglyceride to high density lipoprotein cholesterol ratio and its association with periodontal disease in Korean adults: findings based on the 2012–2014 Korean national health and nutrition examination survey

  2017cited by this paper
• Interethnic Differences in Serum Lipids and Implications for Cardiometabolic Disease Risk in African Ancestry Populations.

  2017cited by this paper
• Association between Lipid Ratios and Insulin Resistance in a Chinese Population

  2015cited by this paper
• Optimal cutoff of the waist-to-hip ratio for detecting cardiovascular risk factors among Han adults in Xinjiang

  2014cited by this paper
• Optimal cutoff of the waist-to-hip ratio for detecting cardiovascular risk factors among Han adults in Xinjiang

  2014cited by this paper
• The genetics of fat distribution

  2014cited by this paper
• Appropriate Body Mass Index and Waist Circumference Cutoffs for Categorization of Overweight and Central Adiposity among Uighur Adults in Xinjiang

  2013cited by this paper
• The Metabolic Syndrome among Postmenopausal Women in Rural Canton: Prevalence, Associated Factors, and the Optimal Obesity and Atherogenic Indices

  2013cited by this paper
• Association of the FTO and ADRB2 genes with body composition and fat distribution in obese women.

  2013cited by this paper
• Association Study Between the Polymorphisms of the Fat Mass- and Obesity-Associated Gene with the Risk of Intervertebral Disc Degeneration in the Han Chinese Population

  2013cited by this paper
• Relation among the plasma triglyceride/high-density lipoprotein cholesterol concentration ratio, insulin resistance, and associated cardio-metabolic risk factors in men and women.

  2012cited by this paper
• Prediction of metabolic syndrome among postmenopausal Ghanaian women using obesity and atherogenic markers

  2012cited by this paper
• Impaired fasting glucose, ancestry and waist‐to‐height ratio: main predictors of incident diagnosed diabetes in the Canary Islands

  2012cited by this paper
• Serum Lipids and Lipoproteins in Chinese Men and Women

  2012influential reference
• Polymorphisms in the SAA1 gene are associated with ankle-to-brachial index in Han Chinese healthy subjects

  2011cited by this paper
• Usefulness of the High Triglyceride-to-HDL Cholesterol Ratio to Identify Cardiometabolic Risk Factors and Preclinical Signs of Organ Damage in Outpatient Children

  2011cited by this paper
• [Epidemiological survey of lipid levels and factors in Kazakan people over 30-year old in Fukang of Xinjiang].

  2011cited by this paper
• The prevalence of hypertension, obesity and dyslipidemia in individuals of over 30 years of age belonging to minorities from the pasture area of Xinjiang

  2010cited by this paper
• Polymorphisms in the SAA1/2 Gene Are Associated with Carotid Intima Media Thickness in Healthy Han Chinese Subjects: The Cardiovascular Risk Survey

  2010cited by this paper
• Insulin resistance and triglyceride/HDLc index are associated with coronary artery disease

  2010cited by this paper
• Contribution of high plasma triglycerides and low high-density lipoprotein cholesterol to residual risk of coronary heart disease after establishment of low-density lipoprotein cholesterol control.

  2010cited by this paper
• Prevalence of Metabolic Syndrome, Insulin Resistance, Impaired Fasting Blood Glucose, and Dyslipidemia in Uygur and Kazak Populations

  2010cited by this paper
• Triglyceride/HDL-cholesterol ratio is an independent predictor for coronary heart disease in a population of Iranian men.

  2009cited by this paper
• The triglyceride/high-density lipoprotein cholesterol ratio predicts all-cause mortality in women with suspected myocardial ischemia: a report from the Women's Ischemia Syndrome Evaluation (WISE).

  2009cited by this paper
• Usefulness of the triglyceride-high-density lipoprotein versus the cholesterol-high-density lipoprotein ratio for predicting insulin resistance and cardiometabolic risk (from the Framingham Offspring Cohort).

  2008cited by this paper
• Emergence of chronic non-communicable diseases in China.

  2008influential reference
• Impact of triglyceride levels beyond low-density lipoprotein cholesterol after acute coronary syndrome in the PROVE IT-TIMI 22 trial.

  2008cited by this paper
• Triglycerides and the Risk of Coronary Heart Disease: 10 158 Incident Cases Among 262 525 Participants in 29 Western Prospective Studies

  2007cited by this paper
• [Chinese guidelines on prevention and treatment of dyslipidemia in adults].

  2007cited by this paper
• How to best define the metabolic syndrome

  2006cited by this paper
• A comparison of lipid variables as predictors of cardiovascular disease in the Asia Pacific region.

  2005cited by this paper
• Major causes of death among men and women in China.

  2005cited by this paper
• Comparison of Serum Lipid Values in Patients With Coronary Artery Disease at 70 Years of Age

  2005cited by this paper
• Comparison of serum lipid values in patients with coronary artery disease at <50, 50 to 59, 60 to 69, and >70 years of age.

  2005cited by this paper
• Nonfasting Apolipoprotein B and Triglyceride Levels as a Useful Predictor of Coronary Heart Disease Risk in Middle-Aged UK Men

  2002cited by this paper
• Global burden of cardiovascular diseases: part I: general considerations, the epidemiologic transition, risk factors, and impact of urbanization.

  2001cited by this paper
• Relationship of baseline serum cholesterol levels in 3 large cohorts of younger men to long-term coronary, cardiovascular, and all-cause mortality and to longevity.

  2000cited by this paper
• Pleiotropic genetic effects on LDL size, plasma triglyceride, and HDL cholesterol in families.

  1999cited by this paper
• Effect of statins on risk of coronary disease: a meta-analysis of randomized controlled trials.

  1999cited by this paper
• Blood pressure, cholesterol, and stroke in eastern Asia. Eastern Stroke and Coronary Heart Disease Collaborative Research Group.

  1998cited by this paper
• Blood pressure, cholesterol, and stroke in eastern Asia

  1998cited by this paper
• Triglyceride concentration and ischemic heart disease: an eight-year follow-up in the Copenhagen Male Study.

  1998cited by this paper
• Fasting triglycerides, high-density lipoprotein, and risk of myocardial infarction.

  1997influential reference
• Recommendations for routine blood pressure measurement by indirect cuff sphygmomanometry. American Society of Hypertension.

  1992cited by this paper
• Serum cholesterol concentration and coronary heart disease in population with low cholesterol concentrations.

  1991cited by this paper
• Increased apo A-I and apo A-II fractional catabolic rate in patients with low high density lipoprotein-cholesterol levels with or without hypertriglyceridemia.

  1991cited by this paper

• Hormone Replacement Therapy and Cardiovascular Outcomes by Race and Ethnicity

  2026cites this paper
• Predictive ability of plasma concentration of triglyceride/high density lipoprotein-cholesterol ratio for cardiometabolic variables in a sub-Sahara black African adolescent population–Nigerians

  2025influential citation
• Triglyceride-to-High-Density Lipoprotein Ratio as a Predictor of 28-Day Mortality Risk in Patients with Sepsis: A Retrospective Cohort Study.

  2025cites this paper
• The nonlineard association between triglyceride to HDL cholesterol ratio and long-term heart disease risk: findings from China Health and Retirement Longitudinal Study (CHARLS)

  2024cites this paper
• Association of triglycerides to high density lipoprotein cholesterol ratio with hypertension in Chinese adults: a cross-sectional study

  2023cites this paper
• Lipid residual cardiovascular risk parameters in patients with familial hypercholesterolemia - importance of triglyceride to high-density lipoprotein ratio

  2023cites this paper
• The Influence of Parents’ Nutritional Education Program on Their Infants’ Metabolic Health

  2022cites this paper
• Associations of total urinary arsenic with total cholesterol and high-density lipoprotein among 12-17-year-old participants from the 2009-2016 NHANES cycles: A cross-sectional study.

  2022cites this paper
• Lipid profile, lipid ratios, apolipoproteins, and risk of cardiometabolic multimorbidity in men: The Kuopio Ischaemic Heart Disease Risk Factor Study

  2022cites this paper
• Insulin Resistance Indexes as Biomarkers of Lifetime Cardiovascular Risk among Adults from Peru

  2021cites this paper
• Periodontitis and its higher levels of severity are associated with the triglyceride/high density lipoprotein cholesterol (TG/HDL-C) ratio.

  2021cites this paper
• Association and diagnostic value of a novel uric acid index to cardiovascular risk

  2021cites this paper
• Association between Periodontal Disease and Levels of Triglyceride and Total Cholesterol among Korean Adults

  2020cites this paper
• Triglyceride to high-density lipoprotein cholesterol and low-density lipoprotein cholestrol to high-density lipoprotein cholesterol ratios are predictors of cardiovascular risk in Iranian adults: Evidence from a population-based cross-sectional study

  2020cites this paper
• Diagnostic Performance of the TG/HDL-C Ratio in the Prediction of Insulin Resistance in Brazzaville, Republic of Congo

  2020cites this paper
• Association of triglycerides to high-density lipoprotein-cholesterol ratio with risk of incident hypertension

  2020cites this paper
• An Age-Period-Cohort Analysis of Biomarkers of Lifestyle-Related Diseases Using the National Health and Nutrition Survey in Japan, 1973–2018

  2020cites this paper
• Association of the TG / HDLC and Monocyte Count / HDLC Ratios with Coronary Artery Disease in Non-ST Segment Elevation Myocardial Infarction

  2019cites this paper
• Comparison of discrimination for cardio-metabolic risk by different cut-off values of the ratio of triglycerides to HDL cholesterol

  2019influential citation
• Impact of nonfasting triglycerides/high-density lipoprotein cholesterol ratio on secondary prevention in patients treated with statins.

  2018cites this paper
• Association of triglyceride to HDL cholesterol ratio with cardiometabolic outcomes

  2018cites this paper
• Triglyceride to high density lipoprotein cholesterol ratio and its association with periodontal disease in Korean adults: findings based on the 2012–2014 Korean national health and nutrition examination survey

  2017cites this paper
• Serum resistin levels inversely associated with cardiovascular risk indices in type 2 diabetics from central Mexico.

  2017cites this paper
• Interethnic Differences in Serum Lipids and Implications for Cardiometabolic Disease Risk in African Ancestry Populations.

  2017cites this paper
• Apolipoprotein C-I Polymorphism and Its Association with Serum Lipid Levels and Longevity in the Bama Population

  2017cites this paper
• Triglyceride-rich lipoproteins induce adipogenic differentiation through an apolipoprotein E/LRP1/caveolae-dependent pathway: A hypothesis for diet-induced obesity.

  2016cites this paper
• Software Agents in Retinal Vessels Classification

  2016cites this paper