Influence of combined treatment of low dose rapamycin and cyclosporin A on corneal allograft survival

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Graefe's Archive for Clinical and Experimental Ophthalmology

• Publication date

  2010-06-24

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1007/s00417-010-1420-zPMID 20574747
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Levels of Foxp3 in Regulatory T Cells Reflect Their Functional Status in Transplantation1

  2009influential reference
• Graft failure IV. Immunologic mechanisms of corneal transplant rejection

  2008cited by this paper
• [Significance of cyclosporin A absorption for effective immunomodulatory therapy after high-risk keratoplasty].

  2008cited by this paper
• Reduction of Foxp3-expressing regulatory T cell infiltrates during the progression of renal allograft rejection in a mouse model.

  2008cited by this paper
• FOXP3 Expression in Human Kidney Transplant Biopsies Is Associated with Rejection and Time Post Transplant but Not with Favorable Outcomes

  2008cited by this paper
• Bedeutung der Cyclosporin-A-Absorption für eine effektive immunmodulatorische Therapie nach Hochrisikokeratoplastik

  2008cited by this paper
• Current concepts and perspectives of immunosuppression in organ transplantation

  2007cited by this paper
• Rapamycin, not cyclosporine, permits thymic generation and peripheral preservation of CD4+CD25+FoxP3+ T cells

  2007cited by this paper
• Kidney Transplant Rejection in Australia and New Zealand: Relationships Between Rejection and Graft Outcome

  2007cited by this paper
• Immune Mechanisms of Corneal Allograft Rejection

  2007cited by this paper
• CCR7 is required for the in vivo function of CD4+ CD25+ regulatory T cells

  2007cited by this paper
• Expression Patterns of Regulatory T‐Cell Markers in Accepted and Rejected Nonhuman Primate Kidney Allografts

  2007cited by this paper
• The effect of immunosuppressive drug rapamycin on regulatory CD4+CD25+Foxp3+T cells in mice.

  2007cited by this paper
• A Potential Side Effect of Cyclosporin A: Inhibition of CD4+CD25+ Regulatory T Cells in Mice

  2006cited by this paper
• Differential Roles of CD8+ and CD8− T Lymphocytes in Corneal Allograft Rejection in ‘High‐Risk’ Hosts

  2006cited by this paper
• How Effective Is Penetrating Corneal Transplantation? Factors Influencing Long-Term Outcome in Multivariate Analysis

  2006cited by this paper
• An Open Prospective Pilot Study on the Use of Rapamycin after Penetrating High-Risk Keratoplasty

  2006cited by this paper
• CD4+ T-Cell–Independent Rejection of Corneal Allografts

  2006cited by this paper
• Influence of local and systemic CTLA4Ig gene transfer on corneal allograft survival

  2006cited by this paper
• Cutting Edge: Atopy Promotes Th2 Responses to Alloantigens and Increases the Incidence and Tempo of Corneal Allograft Rejection1

  2005cited by this paper
• The impact of corneal allograft rejection on the long-term outcome of corneal transplantation.

  2005cited by this paper
• Immunosuppression with Cyclosporine A and Mycophenolate Mofetil After Penetrating High-Risk Keratoplasty: A Retrospective Study

  2005cited by this paper
• Rapamycin selectively expands CD4+CD25+FoxP3+ regulatory T cells.

  2005cited by this paper
• Inhibitory and Stimulatory Effects of Cyclosporine A on the Development of Regulatory T Cells In Vivo

  2005cited by this paper
• Lymph Node Occupancy Is Required for the Peripheral Development of Alloantigen-Specific Foxp3+ Regulatory T Cells1

  2005cited by this paper
• Cyclosporine and rapamycin act in a synergistic and dose-dependent manner in a model of immunosuppressant-induced kidney damage.

  2004cited by this paper
• Acceleration of apoptosis in CD4+CD8+ thymocytes by rapamycin accompanied by increased CD4+CD25+ T cells in the periphery1

  2004cited by this paper
• Fate of MHC-matched corneal allografts in Th1-deficient hosts.

  2004cited by this paper
• The balance of deletion and regulation in allograft tolerance

  2003cited by this paper
• Sirolimus: its discovery, biological properties, and mechanism of action.

  2003cited by this paper
• Preliminary findings in corneal allograft rejection in patients with keratoconus.

  2003cited by this paper
• THE IMMUNE RESPONSE TO CORNEAL ALLOGRAFT REQUIRES A SITE-SPECIFIC DRAINING LYMPH NODE1

  2002cited by this paper
• Interleukin 2 Signaling Is Required for CD4+ Regulatory T Cell Function

  2002cited by this paper
• Tracking the Immunoregulatory Mechanisms Active During Allograft Tolerance1

  2002cited by this paper
• The conundrum of death, dying and organ donation

  2002cited by this paper
• The critical role of lymph nodes in corneal alloimmunization and graft rejection.

  2001cited by this paper
• The effect of duration and timing of systemic cyclosporine therapy on corneal allograft survival in a rat model

  2001cited by this paper
• RAD, a new immunosuppressive macrolide in murine corneal transplantation

  2001cited by this paper
• Systemic cyclosporin A in high risk penetrating keratoplasties: a case-control study

  2001cited by this paper
• IL-10 Is Required for Regulatory T Cells to Mediate Tolerance to Alloantigens In Vivo1

  2001cited by this paper
• The effect of corticosteroid and cyclosporin A on murine corneal allograft rejection

  2000influential reference
• Survival of corneal allografts following adenovirus-mediated gene transfer of interleukin-4

  2000cited by this paper
• Long-term outcome of systemic cyclosporine treatment following penetrating keratoplasty.

  1999cited by this paper
• The immune privilege of corneal allografts.

  1999cited by this paper
• Combined effect of rapamycin and cyclosporine in the prevention of rat corneal allograft rejection.

  1998cited by this paper
• Synergistic mechanisms by which sirolimus and cyclosporin inhibit rat heart and kidney allograft rejection

  1997cited by this paper
• Orthotopic corneal transplantation in the mouse — a new surgical technique with minimal endothelial cell loss

  1996influential reference
• Anterior chamber-associated immune deviation promotes corneal allograft survival.

  1996cited by this paper
• Immunopharmacology of rapamycin.

  1996cited by this paper
• Ocular immune privilege and the Faustian dilemma. The Proctor lecture.

  1996cited by this paper
• Characterization of cell-mediated immune responses elicited by orthotopic corneal allografts in mice.

  1995cited by this paper
• Systemic cyclosporine in high-risk keratoplasty. Short- versus long-term therapy.

  1994cited by this paper
• Effect of the maintenance immunosuppressive drug regimen on kidney transplant outcome.

  1994cited by this paper
• Factors predictive of corneal graft survival. Report from the Australian Corneal Graft Registry.

  1992cited by this paper
• Synergistic effect of rapamycin and cyclosporine in pancreaticoduodenal transplantation in the rat.

  1992cited by this paper
• Graft survival in four common groups of patients undergoing penetrating keratoplasty.

  1991cited by this paper
• Induction of anterior chamber-associated immune deviation requires an intact, functional spleen

  1981cited by this paper
• Brief Definitive Report Identification of Regulatory T Cells in Tolerated Allografts

  year unknowncited by this paper

• Activation of the mTOR pathway enhances PPARγ/SREBP-mediated lipid synthesis in human meibomian gland epithelial cells

  2024cites this paper
• Rapamycin Antagonizes Angiogenesis and Lymphangiogenesis through Myeloid-Derived Suppressor Cells in Corneal Transplantation.

  2023cites this paper
• The mTOR signalling in corneal diseases: a recent update.

  2023cites this paper
• Characterization and Evaluation of Rapamycin-Loaded Nano-Micelle Ophthalmic Solution

  2023cites this paper
• Rapamycin Eyedrops Increased CD4+Foxp3+ Cells and Prevented Goblet Cell Loss in the Aged Ocular Surface

  2020cites this paper
• Immune privilege in corneal transplantation.

  2019cites this paper
• AICAR prolongs corneal allograft survival via the AMPK-mTOR signaling pathway in mice.

  2019cites this paper
• Inhibition of mTOR by Rapamycin Aggravates Corneal Epithelial Stem Cell Deficiency by Upregulating Inflammatory Response

  2019cites this paper
• Literature review and suggested protocol for prevention and treatment of corneal graft rejection

  2019cites this paper
• Rapamycin Nano-Micelle Ophthalmic Solution Reduces Corneal Allograft Rejection by Potentiating Myeloid-Derived Suppressor Cells' Function

  2018cites this paper
• The Balance of Th1/Th2 and LAP+Tregs/Th17 Cells Is Crucial for Graft Survival in Allogeneic Corneal Transplantation

  2018cites this paper
• A Recombinant G Protein Plus Cyclosporine A–Based Respiratory Syncytial Virus Vaccine Elicits Humoral and Regulatory T Cell Responses against Infection without Vaccine-Enhanced Disease

  2016cites this paper
• Topical application of sphingosine 1-phosphate receptor 1 prolongs corneal graft survival in mice.

  2015cites this paper
• An immunotherapeutic strategy for prolonging graft survival in mice.

  2015cites this paper
• Harnessing Regulatory T Cells for Clinical Use in Transplantation: The End of the Beginning

  2014cites this paper
• Critical appraisal of loteprednol ointment, gel, and suspension in the treatment of postoperative inflammation and pain following ocular and corneal transplant surgery

  2014cites this paper
• Immunsuppressiva zur Verhinderung von Abstoßungsreaktionen nach allogenen Hornhauttransplantationen

  2014cites this paper
• [Immunosuppressives to prevent rejection reactions after allogeneic corneal transplantation].

  2014cites this paper
• Prevention and Treatment of Transplant Rejection in Keratoplasty

  2014cites this paper
• Immunsuppression nach Keratoplastik Present State of the Art in Topical and Systemic Immunosuppression after Keratoplasty

  2013cites this paper
• Aktueller Stand der lokalen und systemischen Immunsuppression nach Keratoplastik

  2013cites this paper
• Evaluation of corneal graft survival in mice model.

  2013cites this paper
• Topical Use of Rapamycin in Herpetic Stromal Keratitis

  2012cites this paper
• Bevacizumab and rapamycin can decrease corneal opacity and apoptotic keratocyte number following photorefractive keratectomy.

  2012cites this paper
• Le rejet d’allogreffe de cornée

  2011cites this paper
• [Rejection of corneal allografts].

  2011cites this paper