Probing for Improved Potency and In Vivo Bioavailability of Excitatory Amino Acid Transporter Subtype 1 Inhibitors UCPH-101 and UCPH-102: Design, Synthesis and Pharmacological Evaluation of Substituted 7-Biphenyl Analogs

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Neurochemical Research

• Publication date

  2014-02-28

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1007/s11064-014-1264-8PMID 24682739
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Mechanisms of glutamate transport.

  2013cited by this paper
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  2012cited by this paper
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  2010cited by this paper
• Metabotropic glutamate receptors: physiology, pharmacology, and disease.

  2010cited by this paper
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• Ionotropic glutamate receptors & CNS disorders.

  2008cited by this paper
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  2008cited by this paper
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• Pharmacological characterization of human excitatory amino acid transporters EAAT1, EAAT2 and EAAT3 in a fluorescence-based membrane potential assay.

  2004cited by this paper
• WAY‐855 (3‐amino‐tricyclo[2.2.1.02.6]heptane‐1,3‐dicarboxylic acid): a novel, EAAT2‐preferring, nonsubstrate inhibitor of high‐affinity glutamate uptake

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• Substrate inhibitors and blockers of excitatory amino acid transporters in the treatment of neurodegeneration: critical considerations.

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• Molecular cloning, gene structure, expression profile and functional characterization of the mouse glutamate transporter (EAAT3) interacting protein GTRAP3-18.

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• The expression of the glutamate re-uptake transporter excitatory amino acid transporter 1 (EAAT1) in the normal human CNS and in motor neurone disease: an immunohistochemical study.

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• Expression of the high-affinity glutamate transporter EAAT4 in mammalian cerebral cortex

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  2016cites this paper
• Identification of a New Class of Selective Excitatory Amino Acid Transporter Subtype 1 (EAAT1) Inhibitors Followed by a Structure-Activity Relationship Study.

  2016cites this paper
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