SCIENCE@home

Control of synaptic vesicle endocytosis by an extracellular signalling molecule

K. J. Smillie,J. Pawson,E. Perkins,M. Jackson,M. Cousin

Published 2013 in Nature Communications

ABSTRACT

Signalling cascades control multiple aspects of presynaptic function. Synaptic vesicle endocytosis was assumed to be exempt from modulation, due to its essential role maintaining synaptic vesicle supply and thus neurotransmission. Here we show that brain-derived neurotrophic factor arrests the rephosphorylation of the endocytosis enzyme dynamin I via an inhibition of glycogen synthase kinase 3. This event results in a selective inhibition of activity-dependent bulk endocytosis during high-intensity firing. Furthermore, the continued presence of brain-derived neurotrophic factor alleviates the rundown of neurotransmission during high activity. Thus, synaptic strength can be modulated by extracellular signalling molecules via a direct inhibition of a synaptic vesicle endocytosis mode. Synaptic vesicle endocytosis is required for neurotransmission at nerve terminals. Smillie et al. show that brain-derived neurotrophic factor inhibits a specific type of synaptic vesicle endocytosis, which reverses the depression of neurotransmission observed during high-intensity stimulation.

PUBLICATION RECORD

CITATION MAP

EXTRACTION MAP

CLAIMS

  • No claims are published for this paper.

CONCEPTS

  • No concepts are published for this paper.

REFERENCES

Showing 1-49 of 49 references · Page 1 of 1

CITED BY

Showing 1-44 of 44 citing papers · Page 1 of 1