Advances in mass spectrometry based strategies to study receptor tyrosine kinases

This review discusses advances in mass spectrometry-based strategies to investigate receptor tyrosine kinase signalling networks and activation dynamics.

• Publication year

  2017

• Venue

  IUCrJ

• Publication date

  2017-02-23

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1107/S2052252516020546PMID 28250950PMCID 5330522
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2019influential reference
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  2017cited by this paper
• Mass-spectrometric exploration of proteome structure and function

  2016cited by this paper
• Resistance to BET Bromodomain Inhibitors Is Mediated by Kinome Reprogramming in Ovarian Cancer.

  2016cited by this paper
• Technical advances in proteomics: new developments in data-independent acquisition

  2016cited by this paper
• Quantitative Phosphoproteomics Analysis of ERBB3/ERBB4 Signaling

  2016cited by this paper
• Multilayered proteomics reveals molecular switches dictating ligand-dependent EGFR trafficking

  2016cited by this paper
• Measurement of Phosphorylated Peptides with Absolute Quantification.

  2016cited by this paper
• Phosphoproteomics in translational research: a sarcoma perspective.

  2016cited by this paper
• Phosphotyrosine signaling analysis in human tumors is confounded by systemic ischemia-driven artifacts and intra-specimen heterogeneity.

  2015cited by this paper
• Targeted phosphoproteomics of insulin signaling using data-independent acquisition mass spectrometry

  2015cited by this paper
• Inhibition of Lapatinib-Induced Kinome Reprogramming in ERBB2-Positive Breast Cancer by Targeting BET Family Bromodomains.

  2015cited by this paper
• Immobilized Metal Affinity Chromatography Coupled to Multiple Reaction Monitoring Enables Reproducible Quantification of Phospho-signaling*

  2015cited by this paper
• Neuroblastoma Tyrosine Kinase Signaling Networks Involve FYN and LYN in Endosomes and Lipid Rafts

  2015cited by this paper
• Evaluation of Kinase Activity Profiling Using Chemical Proteomics.

  2015cited by this paper
• High-throughput phosphoproteomics reveals in vivo insulin signaling dynamics

  2015cited by this paper
• Plos One

  2015cited by this paper
• MARQUIS: A Multiplex Method for Absolute Quantification of Peptides and Post-Translational Modifications

  2014cited by this paper
• Multiplexed ion beam imaging of human breast tumors

  2014cited by this paper
• Discoidin domain receptors: a proteomic portrait

  2014cited by this paper
• STRING v10: protein–protein interaction networks, integrated over the tree of life

  2014cited by this paper
• OpenSWATH enables automated, targeted analysis of data-independent acquisition MS data

  2014cited by this paper
• Discoidin Domain Receptor 2 Signaling Networks and Therapy in Lung Cancer

  2014cited by this paper
• Global Analysis of Muscle-specific Kinase Signaling by Quantitative Phosphoproteomics*

  2014cited by this paper
• Highly multiplexed imaging of tumor tissues with subcellular resolution by mass cytometry

  2014cited by this paper
• Targeted Peptide Measurements in Biology and Medicine: Best Practices for Mass Spectrometry-based Assay Development Using a Fit-for-Purpose Approach

  2014cited by this paper
• Ultradeep human phosphoproteome reveals a distinct regulatory nature of Tyr and Ser/Thr-based signaling.

  2014cited by this paper
• Integrated proteomic analysis of post-translational modifications by serial enrichment

  2013cited by this paper
• Phosphoproteomics of collagen receptor networks reveals SHP-2 phosphorylation downstream of wild-type DDR2 and its lung cancer mutants

  2013cited by this paper
• Linking Proteomic and Transcriptional Data through the Interactome and Epigenome Reveals a Map of Oncogene-induced Signaling

  2013cited by this paper
• Wrangling Phosphoproteomic Data to Elucidate Cancer Signaling Pathways

  2013cited by this paper
• Simultaneous Reconstruction of Multiple Signaling Pathways via the Prize-Collecting Steiner Forest Problem

  2012cited by this paper
• Labeling and Identification of Direct Kinase Substrates

  2012cited by this paper
• Dynamic reprogramming of the kinome in response to targeted MEK inhibition in triple-negative breast cancer.

  2012cited by this paper
• TiSH--a robust and sensitive global phosphoproteomics strategy employing a combination of TiO2, SIMAC, and HILIC.

  2012cited by this paper
• Phosphoproteomic studies of receptor tyrosine kinases: future perspectives.

  2012cited by this paper
• Computational analysis of phosphoproteomics: progresses and perspectives.

  2011cited by this paper
• A large-scale method to measure absolute protein phosphorylation stoichiometries

  2011cited by this paper
• Mosaic amplification of multiple receptor tyrosine kinase genes in glioblastoma.

  2011cited by this paper
• iTRAQ Labeling is Superior to mTRAQ for Quantitative Global Proteomics and Phosphoproteomics*

  2011cited by this paper
• Single-Cell Mass Cytometry of Differential Immune and Drug Responses Across a Human Hematopoietic Continuum

  2011cited by this paper
• Phosphotyrosine signaling analysis of site-specific mutations on EGFRvIII identifies determinants governing glioblastoma cell growth.

  2010cited by this paper
• Kinase mutations in human disease: interpreting genotype–phenotype relationships

  2010cited by this paper
• Differential Effects of EGFR Ligands on Endocytic Sorting of the Receptor

  2009cited by this paper
• An integrated comparative phosphoproteomic and bioinformatic approach reveals a novel class of MPM-2 motifs upregulated in EGFRvIII-expressing glioblastoma cells.

  2008cited by this paper
• Hydrophilic Interaction Chromatography Reduces the Complexity of the Phosphoproteome and Improves Global Phosphopeptide Isolation and Detection*S

  2008influential reference
• Lrp4 is a receptor for Agrin and forms a complex with MuSK.

  2008cited by this paper
• Phosphoproteomics: unraveling the signaling web.

  2008cited by this paper
• Quantitative chemical proteomics reveals mechanisms of action of clinical ABL kinase inhibitors

  2007cited by this paper
• ATM and ATR Substrate Analysis Reveals Extensive Protein Networks Responsive to DNA Damage

  2007cited by this paper
• Multiple reaction monitoring for robust quantitative proteomic analysis of cellular signaling networks

  2007cited by this paper
• Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer.

  2007cited by this paper
• EGF–ERBB signalling: towards the systems level

  2006cited by this paper
• Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

  2006cited by this paper
• Immunoaffinity profiling of tyrosine phosphorylation in cancer cells

  2005cited by this paper
• Time-resolved Mass Spectrometry of Tyrosine Phosphorylation Sites in the Epidermal Growth Factor Receptor Signaling Network Reveals Dynamic Modules*S

  2005cited by this paper
• Large-scale characterization of HeLa cell nuclear phosphoproteins.

  2004cited by this paper
• Specificity in signal transduction: from phosphotyrosine-SH2 domain interactions to complex cellular systems.

  2004cited by this paper
• Titania as a Chemo-affinity Support for the Column-switching HPLC Analysis of Phosphopeptides: Application to the Characterization of Phosphorylation Sites in Proteins by Combination with Protease Digestion and Electrospray Ionization Mass Spectrometry

  2004cited by this paper
• Phosphoproteome analysis by mass spectrometry and its application to Saccharomyces cerevisiae

  2002cited by this paper
• Phosphoprotein Analysis Using Antibodies Broadly Reactive against Phosphorylated Motifs*

  2002cited by this paper
• Cell signaling by receptor tyrosine kinases.

  2000cited by this paper
• The protein tyrosine kinase family of the human genome

  2000cited by this paper
• Epidermal growth factor receptor (EGFR) and EGFR mutations, function and possible role in clinical trials.

  1997cited by this paper
• Transforming gene product of Rous sarcoma virus phosphorylates tyrosine

  1980influential reference
• THE CANCER CELL

  1924cited by this paper
• P O B O X 1 1 7 2 2 1 0 0 L U N D + 4 6 4 6 -2 2 2 0 0 0 0

  year unknowncited by this paper
• Supplementary Information Supplementary Figures

  year unknowncited by this paper

• Omics-Based Investigations of Breast Cancer

  2023cites this paper
• Characterization of the RAS/RAF/ERK Signal Cascade as a Novel Regulating Factor in Alpha-Amanitin-Induced Cytotoxicity in Huh-7 Cells

  2022cites this paper
• A data independent acquisition all ion fragmentation mode tool for the suspect screening of natural toxins in surface water

  2021cites this paper
• A review on recent trends in the phosphoproteomics workflow. From sample preparation to data analysis.

  2021cites this paper
• Global phosphoproteomic study of high/low specific productivity industrially relevant mAb producing recombinant CHO cell lines

  2021cites this paper
• Using Multilayer Heterogeneous Networks to Infer Functions of Phosphorylated Sites

  2020cites this paper
• Integrating phosphoproteomics into kinase-targeted cancer therapies in precision medicine.

  2019cites this paper
• Post-translational regulation of planarian regeneration.

  2019cites this paper
• Kinomics toolbox—A web platform for analysis and viewing of kinomic peptide array data

  2018cites this paper
• The Expression Pattern of the Phosphoproteome Is Significantly Changed During the Growth Phases of Recombinant CHO Cell Culture.

  2018cites this paper
• Quantitative phosphoproteomic analysis of acquired cancer drug resistance to pazopanib and dasatinib

  2018cites this paper
• Progress and impact of clinical phosphoproteomics on precision oncology

  2017cites this paper
• In vitro methods for testing antiviral drugs

  2017cites this paper