Magnesium, Iron, and Zinc Supplementation for the Treatment of Attention Deficit Hyperactivity Disorder: A Systematic Review on the Recent Literature

Background: The etiology of attention deficit hyperactivity disorder (ADHD) is not exactly known and its etiology is multifactorial. The usual treatment for these children is based on pharmacotherapy treatment, although the pharmacotherapy has a high effectiveness in ADHD treatment, it often causes different side effects. Existing evidence suggests that children who receive mineral supplement without considering their age and supplement formula may perform better on different behavioral tests compared with those receiving placebo. Methods: In this study, we tried to review the previous evidence regarding the effects of minerals in prevention and management of ADHD. We searched PubMed/Medline, Google Scholar, Ovid, Scopus, and ISI web of science up to June 2013. “iron,” “iron supplementation,” “magnesium,” “magnesium supplementation,” “zinc,” “zinc supplementation,” “attention deficit hyperactivity disorder” were used as the keywords. Totally 11 randomized controlled trials were eligible to be included in the systematic review. Results: Our review showed that we don’t have any predominant evidence about using mineral supplementation on children with ADHD. Conclusions: We need more evidence for indicating the effect of zinc, magnesium, and iron supplementation in the treatment of ADHD among children.

• Publication year

  2015

• Venue

  International Journal of Preventive Medicine

• Publication date

  2015-09-02

• Fields of study

  Medicine

• Identifiers
  DOI 10.4103/2008-7802.164313PMID 26445630PMCID 4587068
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2016cited by this paper
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  2016cited by this paper
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  2014cited by this paper
• Correlations of ADHD symptoms with neurometabolites measured by 1H magnetic resonance spectroscopy.

  2014cited by this paper
• Advances in molecular genetic studies of attention deficit hyperactivity disorder in China

  2014cited by this paper
• Which polyunsaturated fatty acids are active in children with attention-deficit hyperactivity disorder receiving PUFA supplementation? A fatty acid validated meta-regression analysis of randomized controlled trials.

  2014cited by this paper
• Mild Traumatic Brain Injury and ADHD

  2014cited by this paper
• Anxiety as a consequence of modern dietary pattern in adults in Tehran--Iran.

  2013cited by this paper
• Nutrients for prevention and treatment of mental health disorders.

  2013cited by this paper
• The Diet Factor in Attention-Deficit/Hyperactivity Disorder

  2012cited by this paper
• How dietary patterns could have a role in prevention, progression, or management of diabetes mellitus? Review on the current evidence

  2012cited by this paper
• Iron and attention deficit/hyperactivity disorder: what is the empirical evidence so far? A systematic review of the literature

  2012cited by this paper
• Dietary patterns and attention deficit hyperactivity disorder among Iranian children.

  2012influential reference
• [Role of magnesium in nerve tissue].

  2012cited by this paper
• The effects of dietary and nutrient interventions on arterial stiffness: a systematic review.

  2011cited by this paper
• [Zinc in the therapy of the attention-deficit/hyperactivity disorder in children. A preliminar randomized controlled trial].

  2011influential reference
• Zinc for Attention-Deficit/Hyperactivity Disorder: Placebo-Controlled Double-Blind Pilot Trial Alone and Combined with Amphetamine

  2011influential reference
• Zinc en la terapia del síndrome de déficit de atención e hiperactividad en niños: Un estudio controlado aleatorio preliminar

  2011cited by this paper
• A systematic review of insomnia and complementary medicine.

  2011cited by this paper
• Prevalence of Attention-Deficit/Hyperactivity Disorder Symptoms in Preschool-aged Iranian Children

  2011influential reference
• Supplementation of polyunsaturated fatty acids, magnesium and zinc in children seeking medical advice for attention-deficit/hyperactivity problems - an observational cohort study

  2010influential reference
• Adverse Reactions to Methylphenidate Treatment for Attention-Deficit/Hyperactivity Disorder: Structure and Associations with Clinical Characteristics and Symptom Control

  2009cited by this paper
• Altered iron metabolism in lymphocytes from subjects with restless legs syndrome.

  2008cited by this paper
• Nutritional and Environmental Approaches to Preventing and Treating Autism and Attention Deficit Hyperactivity Disorder (ADHD): A Review

  2008cited by this paper
• Effects of iron supplementation on attention deficit hyperactivity disorder in children.

  2008influential reference
• Nutritional and dietary influences on attention deficit hyperactivity disorder.

  2008cited by this paper
• The worldwide prevalence of ADHD: a systematic review and metaregression analysis.

  2007cited by this paper
• Food additives and hyperactive behaviour in 3-year-old and 8/9-year-old children in the community: a randomised, double-blinded, placebo-controlled trial.

  2007cited by this paper
• [Effect of MAGNE-B6 on the clinical and biochemical manifestations of the syndrome of attention deficit and hyperactivity in children].

  2006cited by this paper
• [Effect of MAGNE-B6 on the clinical and biochemical manifestations of the syndrome of attention deficit and hyperactivity in children].

  2006cited by this paper
• Improvement of neurobehavioral disorders in children supplemented with magnesium-vitamin B6. II. Pervasive developmental disorder-autism.

  2006cited by this paper
• Improvement of neurobehavioral disorders in children supplemented with magnesium-vitamin B6. I. Attention deficit hyperactivity disorders.

  2006cited by this paper
• Attention-Deficit/Hyperactivity Disorder: A Selective Overview

  2005cited by this paper
• Iron deficiency: Differential effects on monoamine transporters

  2005cited by this paper
• Magnesium metabolism in mice selected for high and low erythrocyte magnesium levels.

  2004cited by this paper
• BMC Psychiatry BioMed Central

  2004influential reference
• Magnesium VitB6 Intake Reduces Central Nervous System Hyperexcitability in Children

  2004influential reference
• Double-blind, placebo-controlled study of zinc sulfate in the treatment of attention deficit hyperactivity disorder.

  2004influential reference
• Use of complementary and alternative medicine for symptoms of attention-deficit hyperactivity disorder.

  2002cited by this paper
• MRI measurement of brain iron in patients with restless legs syndrome

  2001cited by this paper
• How efficacious and safe is short-acting methylphenidate for the treatment of attention-deficit disorder in children and adolescents? A meta-analysis.

  2001cited by this paper
• Diagnosis and treatment of attention-deficit/hyperactivity disorder in children and adolescents. Council on Scientific Affairs, American Medical Association.

  1998cited by this paper
• Magnesium Deficiency-Dependent Audiogenic Seizures (MDDASs) in Adult Mice: A Nutritional Model for Discriminatory Screening of Anticonvulsant Drugs and Original Assessment of Neuroprotection Properties

  1998cited by this paper
• The effects of magnesium physiological supplementation on hyperactivity in children with attention deficit hyperactivity disorder (ADHD). Positive response to magnesium oral loading test.

  1997cited by this paper
• Iron treatment in children with attention deficit hyperactivity disorder. A preliminary report.

  1997influential reference
• Assessing the quality of reports of randomized clinical trials: is blinding necessary?

  1996cited by this paper
• Zinc deficiency in attention-deficit hyperactivity disorder.

  1996cited by this paper
• Relationships between serum free fatty acids and zinc, and attention deficit hyperactivity disorder: a research note.

  1996cited by this paper
• Activity and attention in zinc-deprived adolescent monkeys.

  1996cited by this paper
• Zinc deficiency in attention-deficit hyperactivity disorder.

  1990cited by this paper
• Release of [3H]norepinephrine from rat hippocampal slices by N-methyl-D-aspartate: comparison of the inhibitory effects of Mg2+ and MK-801.

  1988cited by this paper
• Behavioral characteristics of rats experiencing chronic zinc deficiency.

  1979influential reference

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  2025cites this paper
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  2023cites this paper
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  2022cites this paper
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  2022cites this paper
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  2022cites this paper
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  2021cites this paper
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  2021cites this paper
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  2021cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018influential citation
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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  2017influential citation
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  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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  2016cites this paper
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  2016cites this paper
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  2016cites this paper
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  2016cites this paper
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  2016cites this paper