Structure and Biophysics of CBFβ/RUNX and Its Translocation Products.

No abstract is available for this paper.

• Publication year

  2017

• Venue

  Advances in Experimental Medicine and Biology

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1007/978-981-10-3233-2_2PMID 28299648
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Structural basis of Ets1 activation by Runx1

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  2011cited by this paper
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  2010cited by this paper
• CBFbeta is critical for AML1-ETO and TEL-AML1 activity.

  2009cited by this paper
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  2009cited by this paper
• Structure of the AML1-ETO eTAFH domain-HEB peptide complex and its contribution to AML1-ETO activity.

  2009cited by this paper
• The affinity of Ets-1 for DNA is modulated by phosphorylation through transient interactions of an unstructured region.

  2008cited by this paper
• Structural basis for recognition of SMRT/N-CoR by the MYND domain and its contribution to AML1/ETO's activity.

  2007cited by this paper
• Genome-wide analyses reveal properties of redundant and specific promoter occupancy within the ETS gene family.

  2007cited by this paper
• Methylation-independent silencing of the tumor suppressor INK4b (p15) by CBFbeta-SMMHC in acute myelogenous leukemia with inv(16).

  2007cited by this paper
• A TAF4-homology domain from the corepressor ETO is a docking platform for positive and negative regulators of transcription

  2007cited by this paper
• Disease mutations in RUNX1 and RUNX2 create nonfunctional, dominant‐negative, or hypomorphic alleles

  2007cited by this paper
• The tetramer structure of the Nervy homology two domain, NHR2, is critical for AML1/ETO's activity.

  2006cited by this paper
• The acute myeloid leukemia fusion protein AML1-ETO targets E proteins via a paired amphipathic helix-like TBP-associated factor homology domain

  2006cited by this paper
• A mutation in the S-switch region of the Runt domain alters the dynamics of an allosteric network responsible for CBFbeta regulation.

  2006cited by this paper
• The runx genes: gain or loss of function in cancer

  2005cited by this paper
• The Structural and Dynamic Basis of Ets-1 DNA Binding Autoinhibition*

  2005cited by this paper
• Variable Control of Ets-1 DNA Binding by Multiple Phosphates in an Unstructured Region

  2005cited by this paper
• E Protein Silencing by the Leukemogenic AML1-ETO Fusion Protein

  2004cited by this paper
• CBFβ allosterically regulates the Runx1 Runt domain via a dynamic conformational equilibrium

  2004cited by this paper
• Cloning, expression, purification and crystallization of NHR3 domain from acute myelogenous leukemia-related protein AML1-ETO.

  2004cited by this paper
• Molecular basis for a dominant inactivation of RUNX1/AML1 by the leukemogenic inversion 16 chimera.

  2004cited by this paper
• ETO interacting proteins

  2004cited by this paper
• Gfi‐1 attaches to the nuclear matrix, associates with ETO (MTG8) and histone deacetylase proteins, and represses transcription using a TSA‐sensitive mechanism

  2003cited by this paper
• Energetic Contribution of Residues in the Runx1 Runt Domain to DNA Binding*

  2003cited by this paper
• The ETO (MTG8) gene family.

  2003cited by this paper
• Multisite phosphorylation provides sophisticated regulation of transcription factors.

  2002cited by this paper
• Mutations in the RUNX2 gene in patients with cleidocranial dysplasia

  2002cited by this paper
• Altered affinity of CBFβ-SMMHC for Runx1 explains its role in leukemogenesis

  2002cited by this paper
• Altered affinity of CBF beta-SMMHC for Runx1 explains its role in leukemogenesis.

  2002cited by this paper
• The RUNX1 Runt domain at 1.25A resolution: a structural switch and specifically bound chloride ions modulate DNA binding.

  2002cited by this paper
• Structural analyses of DNA recognition by the AML1/Runx-1 Runt domain and its allosteric control by CBFbeta.

  2001cited by this paper
• ETO, a Target of t(8;21) in Acute Leukemia, Makes Distinct Contacts with Multiple Histone Deacetylases and Binds mSin3A through Its Oligomerization Domain

  2001cited by this paper
• The leukemia-associated AML1 (Runx1)–CBFβ complex functions as a DNA-induced molecular clamp

  2001cited by this paper
• MTG8 proto-oncoprotein interacts with the regulatory subunit of type II cyclic AMP-dependent protein kinase in lymphocytes

  2001cited by this paper
• Auto-Inhibition and Partner Proteins, Core-Binding Factor β (CBFβ) and Ets-1, Modulate DNA Binding by CBFα2 (AML1)

  2000cited by this paper
• Phosphorylation represses Ets-1 DNA binding by reinforcing autoinhibition.

  2000cited by this paper
• Structural basis for the heterodimeric interaction between the acute leukaemia‐associated transcription factors AML1 and CBFβ

  2000cited by this paper
• Identification of the regions involved in DNA binding by the mouse PEBP2α protein

  2000cited by this paper
• Auto-Inhibition of Ets-1 Is Counteracted by DNA Binding Cooperativity with Core-Binding Factor α2

  2000cited by this paper
• Energetic and Functional Contribution of Residues in the Core Binding Factor β (CBFβ) Subunit to Heterodimerization with CBFα*

  2000cited by this paper
• Immunoglobulin motif DNA recognition and heterodimerization of the PEBP2/CBF Runt domain

  2000cited by this paper
• Biophysical characterization of interactions between the core binding factor α and β subunits and DNA

  2000cited by this paper
• Biophysical characterization of interactions between the core binding factor alpha and beta subunits and DNA.

  2000cited by this paper
• Identification of the regions involved in DNA binding by the mouse PEBP2alpha protein.

  2000cited by this paper
• Solution structure of core binding factor beta and map of the CBF alpha binding site.

  1999cited by this paper
• Molecular insights into PEBP2/CBF beta-SMMHC associated acute leukemia revealed from the structure of PEBP2/CBF beta.

  1999cited by this paper
• Solution structure of core binding factor β and map of the CBFα binding site

  1999cited by this paper
• ETO-2, a new member of the ETO-family of nuclear proteins

  1999cited by this paper
• Molecular insights into PEBP2/CBFβ-SMMHC associated acute leukemia revealed from the structure of PEBP2/CBFβ

  1999cited by this paper
• The Ig fold of the core binding factor alpha Runt domain is a member of a family of structurally and functionally related Ig-fold DNA-binding domains.

  1999cited by this paper
• Mutual activation of Ets‐1 and AML1 DNA binding by direct interaction of their autoinhibitory domains

  1999cited by this paper
• Negative regulation of granulocytic differentiation in the myeloid precursor cell line 32Dcl3 by ear-2, a mammalian homolog of Drosophila seven-up, and a chimeric leukemogenic gene, AML1/ETO.

  1998cited by this paper
• The AML1-MTG8 Leukemic Fusion Protein Forms a Complex with a Novel Member of the MTG8(ETO/CDR) Family, MTGR1

  1998cited by this paper
• ETO, fusion partner in t(8;21) acute myeloid leukemia, represses transcription by interaction with the human N-CoR/mSin3/HDAC1 complex.

  1998cited by this paper
• The MYND Motif Is Required for Repression of Basal Transcription from the Multidrug Resistance 1 Promoter by the t(8;21) Fusion Protein

  1998cited by this paper
• Aberrant Recruitment of the Nuclear Receptor Corepressor-Histone Deacetylase Complex by the Acute Myeloid Leukemia Fusion Partner ETO

  1998cited by this paper
• Molecular basis of leukemogenesis

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• Overexpression, Purification, and Biophysical Characterization of the Heterodimerization Domain of the Core-binding Factor β Subunit*

  1998cited by this paper
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  1998cited by this paper
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  1997cited by this paper
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• The CBFbeta subunit is essential for CBFalpha2 (AML1) function in vivo.

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