Demonstration of N- and C-terminal domain intramolecular interactions in rat liver carnitine palmitoyltransferase 1 that determine its degree of malonyl-CoA sensitivity.

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Biochemical Journal

• Publication date

  2005-04-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1042/BJ20041533PMID 15498023PMCID PMC1134933
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Phosphorylation of Rat Liver Mitochondrial Carnitine Palmitoyltransferase-I

  2004cited by this paper
• Crystal structure of carnitine acetyltransferase and implications for the catalytic mechanism and fatty acid transport.

  2003cited by this paper
• Structure of Human Carnitine Acetyltransferase

  2003cited by this paper
• A novel brain-expressed protein related to carnitine palmitoyltransferase I.

  2002cited by this paper
• The Extreme C Terminus of Rat Liver Carnitine Palmitoyltransferase I Is Not Involved in Malonyl-CoA Sensitivity but in Initial Protein Folding*

  2002cited by this paper
• Rat liver mitochondrial contact sites and carnitine palmitoyltransferase-I.

  2001cited by this paper
• The N-terminal Domain of Rat Liver Carnitine Palmitoyltransferase 1 Contains an Internal Mitochondrial Import Signal and Residues Essential for Folding of Its C-terminal Catalytic Domain*

  2001cited by this paper
• Specificity of the interactions between Glu-3, Ser-24, and Gln-30 within the N-terminal segment of rat liver mitochondrial overt carnitine palmitoyltransferase (L-CPT I) in determining the malonyl-CoA sensitivity of the enzyme.

  2001cited by this paper
• Distinct Kinetics of Carnitine Palmitoyltransferase I in Contact Sites and Outer Membranes of Rat Liver Mitochondria*

  2001cited by this paper
• Molecular and enzymatic characterization of a unique carnitine palmitoyltransferase 1A mutation in the Hutterite community.

  2001cited by this paper
• Molecular enzymology of carnitine transfer and transport.

  2001cited by this paper
• Reconstitution of purified, active and malonyl-CoA-sensitive rat liver carnitine palmitoyltransferase I: relationship between membrane environment and malonyl-CoA sensitivity.

  2000cited by this paper
• High throughput protein fold identification by using experimental constraints derived from intramolecular cross-links and mass spectrometry

  2000cited by this paper
• Identification of Positive and Negative Determinants of Malonyl-CoA Sensitivity and Carnitine Affinity within the Amino Termini of Rat Liver- and Muscle-type Carnitine Palmitoyltransferase I*

  2000cited by this paper
• Use of Six Chimeric Proteins to Investigate the Role of Intramolecular Interactions in Determining the Kinetics of Carnitine Palmitoyltransferase I Isoforms*

  2000cited by this paper
• A Single Amino Acid Change (Substitution of Glutamate 3 with Alanine) in the N-terminal Region of Rat Liver Carnitine Palmitoyltransferase I Abolishes Malonyl-CoA Inhibition and High Affinity Binding*

  1999cited by this paper
• The malonyl-CoA-long-chain acyl-CoA axis in the maintenance of mammalian cell function.

  1999cited by this paper
• The N-terminal Domain of Rat Liver Carnitine Palmitoyltransferase 1 Mediates Import into the Outer Mitochondrial Membrane and Is Essential for Activity and Malonyl-CoA Sensitivity*

  1998cited by this paper
• Deletion of the conserved first 18 N-terminal amino acid residues in rat liver carnitine palmitoyltransferase I abolishes malonyl-CoA sensitivity and binding.

  1998cited by this paper
• The Malonyl-CoA-sensitive Form of Carnitine Palmitoyltransferase Is Not Localized Exclusively in the Outer Membrane of Rat Liver Mitochondria*

  1998cited by this paper
• Lipid molecular order in liver mitochondrial outer membranes, and sensitivity of carnitine palmitoyltransferase I to malonyl-CoA

  1998cited by this paper
• Topological and functional analysis of the rat liver carnitine palmitoyltransferase 1 expressed in Saccharomyces cerevisiae

  1998cited by this paper
• Enrichment of carnitine palmitoyltransferases I and II in the contact sites of rat liver mitochondria.

  1998cited by this paper
• Topology of carnitine palmitoyltransferase I in the mitochondrial outer membrane.

  1997cited by this paper
• The mitochondrial carnitine palmitoyltransferase system. From concept to molecular analysis.

  1997cited by this paper
• Are the β-Cell Signaling Molecules Malonyl-CoA and Cystolic Long-Chain Acyl-CoA Implicated in Multiple Tissue Defects of Obesity and NIDDM?

  1996cited by this paper
• Expression of liver carnitine palmitoyltransferase I and II genes during development in the rat.

  1994cited by this paper
• Modulation of the malonyl-CoA sensitivity of hepatic carnitine palmitoyltransferase (CPT) by phospholipids.

  1994cited by this paper
• Expression of a cDNA for rat liver carnitine palmitoyltransferase I in yeast establishes that catalytic activity and malonyl-CoA sensitivity reside in a single polypeptide.

  1994cited by this paper
• Evidence that the sensitivity of carnitine palmitoyltransferase I to inhibition by malonyl-CoA is an important site of regulation of hepatic fatty acid oxidation in the fetal and newborn rabbit. Perinatal development and effects of pancreatic hormones in cultured rabbit hepatocytes.

  1990cited by this paper
• Sensitivity of inhibition of rat liver mitochondrial outer-membrane carnitine palmitoyltransferase by malonyl-CoA to chemical- and temperature-induced changes in membrane fluidity.

  1990cited by this paper
• Role of carnitine palmitoyltransferase I in the regulation of hepatic ketogenesis during the onset and reversal of chronic diabetes.

  1988cited by this paper
• Restoration of the properties of carnitine palmitoyltransferase I in liver mitochondria during re-feeding of starved rats.

  1986cited by this paper
• Altered release of carnitine palmitoyltransferase activity by digitonin from liver mitochondria of rats in different physiological states.

  1985cited by this paper
• The effect of fasting on the activity of liver carnitine palmitoyltransferase and its inhibition by malonyl-CoA.

  1981cited by this paper
• Evaluation of malonyl-CoA in the regulation of long-chain fatty acid oxidation in the liver. Evidence for an unidentified regulatory component of the system.

  1980cited by this paper
• A possible role for malonyl-CoA in the regulation of hepatic fatty acid oxidation and ketogenesis.

  1977cited by this paper
• Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

  1970cited by this paper
• Protein measurement with the Folin phenol reagent.

  1951cited by this paper

• International Union of Basic and Clinical Pharmacology: Fundamental insights and clinical relevance regarding the carnitine palmitoyltransferase family of enzymes.

  2025cites this paper
• Direct expression of CPT1a enables a high throughput platform for the discovery of CPT1a modulators

  2024cites this paper
• Acidosis attenuates CPT-I-supported bioenergetics as a potential mechanism limiting lipid oxidation

  2023cites this paper
• Mitochondrial morphology controls fatty acid utilization by changing CPT1 sensitivity to malonyl‐CoA

  2023cites this paper
• The Physiological and Pathological Role of Acyl-CoA Oxidation

  2023cites this paper
• CPT1A-mediated fat oxidation, mechanisms and therapeutic potential.

  2020cites this paper
• Nutrition Supplements to Stimulate Lipolysis: A Review in Relation to Endurance Exercise Capacity.

  2016cites this paper
• Carnitine palmitoyltransferase 1C: From cognition to cancer.

  2016cites this paper
• Enhancing hepatic mitochondrial fatty acid oxidation stimulates eating in food-deprived mice.

  2015cites this paper
• The role of altered fatty acid metabolism in cardiomyopathy and heart failure : an in vivo magnetic resonance imaging and spectroscopy approach

  2014cites this paper
• AMPK regulation of fatty acid metabolism and mitochondrial biogenesis: implications for obesity.

  2013cites this paper
• Characterization of a malonyl-CoA insensitive carnitine palmitoyltransferase 1b mouse (CPT1bE3A)

  2013cites this paper
• La voie ASP-C5L2 : un pont entre l'homéostasie métabolique et l'inflammation

  2013cites this paper
• Relació estructura-funció de les proteïnes CPT1

  2012cites this paper
• Drug-induced toxicity on mitochondria and lipid metabolism: mechanistic diversity and deleterious consequences for the liver.

  2011cites this paper
• An Environment-dependent Structural Switch Underlies the Regulation of Carnitine Palmitoyltransferase 1A*♦

  2011cites this paper
• Regulation of Carnitine Palmitoyltransferase (CPT) I during Fasting in Rainbow Trout (Oncorhynchus mykiss) Promotes Increased Mitochondrial Fatty Acid Oxidation

  2011cites this paper
• Packing of transmembrane domain 2 of carnitine palmitoyltransferase‐1A affects oligomerization and malonyl‐CoA sensitivity of the mitochondrial outer membrane protein

  2011cites this paper
• Regulation of Ketone Body and Coenzyme A Metabolism in Liver

  2011cites this paper
• METABOLISM IN LIVER

  2011cites this paper
• Fatty acid‐induced oxidation and triglyceride formation is higher in insulin‐producing MIN6 cells exposed to oleate compared to palmitate

  2010cites this paper
• Genome duplication events have led to a diversification in the CPT I gene family in fish.

  2010cites this paper
• Inhibition of hepatic carnitine palmitoyl-transferase I (CPT IA) by valproyl-CoA as a possible mechanism of valproate-induced steatosis.

  2010influential citation
• Transmembrane domain interactions in carnitine palmitoyltransferase I

  2010cites this paper
• A characteristic Glu17 residue of pig carnitine palmitoyltransferase 1 is responsible for the low Km for carnitine and the low sensitivity to malonyl‐CoA inhibition of the enzyme

  2009cites this paper
• The Randle cycle revisited: a new head for an old hat.

  2009cites this paper
• Modulation of the hepatic malonyl-CoA-carnitine palmitoyltransferase 1A partnership creates a metabolic switch allowing oxidation of de novo fatty acids.

  2009cites this paper
• Effects of dietary fatty acid composition on the regulation of carnitine palmitoyltransferase (CPT) I in rainbow trout (Oncorhynchus mykiss).

  2009cites this paper
• Self-association of Transmembrane Domain 2 (TM2), but Not TM1, in Carnitine Palmitoyltransferase 1A

  2009cites this paper
• Structural insight into function and regulation of carnitine palmitoyltransferase

  2009cites this paper
• Rat liver mitochondrial carnitine palmitoyltransferase-I, hepatic carnitine, and malonyl-CoA: Effect of starvation

  2008cites this paper
• Carnitine palmitoyltransferase 1: Central to cell function

  2008cites this paper
• Carnitine palmitoyltransferase I and Acyl-CoA dehydrogenase 9 in retina: insights of retinopathy in mitochondrial trifunctional protein defects.

  2008cites this paper
• Malonyl-CoA, a key signaling molecule in mammalian cells.

  2008cites this paper
• Contribution of FAT/CD36 to the regulation of skeletal muscle fatty acid oxidation: an overview

  2008cites this paper
• The role of protein-mediated transport in regulating mitochondrial long-chain fatty acid oxidation

  2008influential citation
• Proteomics of mitochondrial inner and outer membranes

  2008cites this paper
• Intertissue regulation of carnitine palmitoyltransferase I (CPTI): mitochondrial membrane properties and gene expression in rainbow trout (Oncorhynchus mykiss).

  2008cites this paper
• Definition by Functional and Structural Analysis of Two Malonyl-CoA Sites in Carnitine Palmitoyltransferase 1A*

  2007cites this paper
• Modulation of carnitine palmitoyltransferase-1 for the treatment of obesity.

  2007cites this paper
• Rat Liver Carnitine Palmitoyltransferase 1 Forms an Oligomeric Complex within the Outer Mitochondrial Membrane*

  2007cites this paper
• The Mitochondrial Intermembrane Loop Region of Rat Carnitine Palmitoyltransferase 1A Is a Major Determinant of Its Malonyl-CoA Sensitivity*

  2006cites this paper
• Mitochondrial long chain fatty acid oxidation, fatty acid translocase/CD36 content and carnitine palmitoyltransferase I activity in human skeletal muscle during aerobic exercise

  2006cites this paper