Effects of N-acetyl cysteine on oxidative stress and TNF-α gene expression in diclofenac-induced hepatotoxicity in rats

No abstract is available for this paper.

• Publication year

  2017

• Venue

  Toxicology Mechanisms and Methods

• Publication date

  2017-06-08

• Fields of study

  Medicine, Chemistry, Environmental Science

• Identifiers
  DOI 10.1080/15376516.2017.1334732PMID 28535741
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Nephroprotective and Anti-Inflammatory Effects of Pistacia atlantica Leaf Hydroethanolic Extract Against Gentamicin-Induced Nephrotoxicity in Rats

  2017influential reference
• Anti-inflammatory and ameliorative effects of gallic acid on fluoxetine-induced oxidative stress and liver damage in rats

  2017cited by this paper
• Performance and Side Effects of Supplementation with N-Acetylcysteine: A Systematic Review and Meta-Analysis

  2017cited by this paper
• Suppressive effect of Spirulina fusiformis on diclofenac-induced hepato-renal injury and gastrointestinal ulcer in Wistar albino rats: A biochemical and histological approach.

  2017cited by this paper
• Protective Effects of Hydroalcoholic Extract of Ferulago Angulata Against Gentamicin-induced Nephrotoxicity in Rats.

  2016influential reference
• Adverse drug reactions and organ damage: The liver.

  2016influential reference
• Sinapic acid mitigates gentamicin-induced nephrotoxicity and associated oxidative/nitrosative stress, apoptosis, and inflammation in rats.

  2016cited by this paper
• A minireview on N-acetylcysteine: An old drug with new approaches.

  2016influential reference
• Hepatotoxicity by Drugs: The Most Common Implicated Agents

  2016cited by this paper
• Cytokines TNF-α, IL-6, IL-17F, and IL-4 Differentially Affect Osteogenic Differentiation of Human Adipose Stem Cells

  2016cited by this paper
• Antioxidant Vitamins and Trace Elements in Critical Illness.

  2016cited by this paper
• Biological Activities of Reactive Oxygen and Nitrogen Species: Oxidative Stress versus Signal Transduction

  2015cited by this paper
• Salivary biomarkers of oxidative stress: A critical review.

  2015cited by this paper
• Protective effect of ursodeoxycholic acid, resveratrol, and N-acetylcysteine on nonalcoholic fatty liver disease in rats

  2015cited by this paper
• Hepatoprotective Action of Echinophora platyloba DC Leaves Against Acute Toxicity of Acetaminophen in Rats

  2014cited by this paper
• Pharmacokinetic variations of tetramethylpyrazine phosphate after oral administration in hepatic precancerous mice and its hepatoprotective effects

  2014cited by this paper
• The protective effects of n-acetylcysteine against acute hepatotoxicity

  2013cited by this paper
• Biochemical and molecular mechanisms of N-acetyl cysteine and silymarin-mediated protection against maneb- and paraquat-induced hepatotoxicity in rats.

  2013cited by this paper
• Co-administration of trientine and flaxseed oil on oxidative stress, serum lipids and heart structure in diabetic rats.

  2013cited by this paper
• Protective Effect of Taurine and Bismuth Subnitrate against Cyclosporine and Sodium Diclofenac-Induced Nephrotoxicity in Rats

  2011cited by this paper
• Drug-induced toxicity on mitochondria and lipid metabolism: mechanistic diversity and deleterious consequences for the liver.

  2011influential reference
• Hepatoprotective effect of Woodfordia fruticosa Kurz flowers on diclofenac sodium induced liver toxicity in rats.

  2011influential reference
• Hypolipidemic and hypoglycemic effects of aerial part of Cynara scolymus in streptozotocin-induced diabetic rats

  2011cited by this paper
• EFFECT OF ORAL N-ACETYLCYSTEINE TREATMENT ON PLASMA INFLAMMATORY AND OXIDATIVE STRESS MARKERS IN PERITONEAL DIALYSIS PATIENTS: A PLACEBO-CONTROLLED STUDY

  2010cited by this paper
• Drug-induced liver injury.

  2010cited by this paper
• Species-specific toxicity of diclofenac and troglitazone in primary human and rat hepatocytes.

  2009influential reference
• The Hematoxylins and Eosin

  2008cited by this paper
• Acute effects of diclofenac and DMSO to Daphnia magna: immobilisation and hsp70-induction.

  2008cited by this paper
• PROTECTIVE EFFECT OF N-ACETYL CYSTEINE IN CARBON TETRACHLORIDE-INDUCED HEPATOTOXICITY IN RATS

  2005cited by this paper
• The metabolism of diclofenac--enzymology and toxicology perspectives.

  2003cited by this paper
• Mechanistic studies on the bioactivation of diclofenac: identification of diclofenac-S-acyl-glutathione in vitro in incubations with rat and human hepatocytes.

  2003cited by this paper
• Induction of hepatic heme oxygenase-1 by diclofenac in rodents: role of oxidative stress and cytochrome P-450 activity.

  2003influential reference
• Experimental hyperlipidemia and the effect of NSAIDs.

  2002influential reference
• Rapid, fluorimetric-liquid chromatographic determination of malondialdehyde in biological samples.

  2002cited by this paper
• Inhibition and uncoupling of oxidative phosphorylation by nonsteroidal anti-inflammatory drugs: study in mitochondria, submitochondrial particles, cells, and whole heart.

  1999cited by this paper
• Oxidative damage to proteins: spectrophotometric method for carbonyl assay.

  1994cited by this paper
• Selected methods for the determination of ascorbic acid in animal cells, tissues, and fluids.

  1979cited by this paper
• Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge.

  1972cited by this paper
• Superoxide dismutase: improved assays and an assay applicable to acrylamide gels.

  1971cited by this paper

• Curcumin-selenium nanoparticles: A promising approach in disease prevention and treatment.

  2026cites this paper
• Potential hepatoprotective role of Amphora coffeaeformis algae against diazinon-induced hepatotoxicity in adult Sprague–Dawley rats

  2025cites this paper
• Ameliorating the toxicity induced by L-arginine through iris germanica methanolic extract in an experimental model of acute pancreatitis

  2025cites this paper
• Alogliptin repositioning confers protection against diclofenac-induced liver injury by inhibiting TLR4/NF-κB, ROS/TXNIP, and NLRP3 inflammasome-mediated pyroptosis in rats.

  2025cites this paper
• Protective effects of glycine against diclofenac-induced toxicity in isolated rat hepatocytes.

  2025cites this paper
• Cymbopogon citratus: A Modulator of TNF-α and IL-10 in NSAID-Induced Hepatorenal Toxicity in Adult Wistar Rats

  2024cites this paper
• Drug-Induced Liver Toxicity

  2024cites this paper
• Network Pharmacology Prediction and Experimental Validation of Ferulic Acid’s Protective Effects against Diclofenac‐Induced Liver Injury

  2024cites this paper
• Role of Imaging Modalities and N-Acetylcysteine Treatment in Sepsis-Associated Encephalopathy

  2023cites this paper
• Evaluating the protective effect of metformin against diclofenac-induced oxidative stress and hepatic damage: In vitro and in vivo studies.

  2023cites this paper
• Role of Oxidative Stress on Insulin Resistance in Diet-Induced Obesity Mice

  2023cites this paper
• Diclofenac prodrugs nanoparticles: an alternative and efficient treatment for rheumatoid arthritis?

  2023cites this paper
• Carvacrol Exerts Anti-Inflammatory, Anti-Oxidative Stress and Hepatoprotective Effects Against Diclofenac-Induced Liver Injury in Male Rats

  2023cites this paper
• The effect of subacute co-exposure to carbon tetrachloride and diclofenac on the liver of male wistar rats

  2023cites this paper
• Topical Effects of N-Acetyl Cysteine and Doxycycline on Inflammatory and Angiogenic Factors in the Rat Model of Alkali-Burned Cornea

  2022cites this paper
• Protective effects of N-acetyl cysteine against oxidative stress in ibuprofen-induced hepatotoxicity in rats

  2022cites this paper
• Protective role of ellagic acid and taurine against fluoxetine induced hepatotoxic effects on biochemical and oxidative stress parameters, histopathological changes, and gene expressions of IL-1β, NF-κB, and TNF-α in male Wistar rats.

  2022cites this paper
• α-Lipoic Acid Protects against Cyclosporine A-Induced Hepatic Toxicity in Rats: Effect on Oxidative Stress, Inflammation, and Apoptosis

  2022cites this paper
• Hepatoprotective Effect of Coenzyme Q10 in Rats with Diclofenac Toxicity.

  2022cites this paper
• Hepatorenal protective activity of Artemisia against diclofenac toxicity in male rats

  2022cites this paper
• Evaluation of the Protective Effects of Ellagic Acid and Taurine on Lipid Pro le and Gene Expressions of NF-κB, IL-1β, and TNF-α against Fluoxetine Induced Hepatotoxicity in Male Wistar Rats

  2021cites this paper
• Does Short-Term and Low-Dose N-Acetylcysteine Affect Oxidative Stress and Inflammation in The Liver Tissues of Diabetic Rats?

  2021cites this paper
• The in silico mechanism of hVKOR interaction with acetaminophen and its metabolite, as well as N-acetyl cysteine: caution on application in COVID-19 patients

  2021cites this paper
• The effect of N-acetyl cysteine and doxycycline on TNF-α-Rel-a inflammatory pathway and downstream angiogenesis factors in the cornea of rats injured by 2-chloroethyl-ethyl sulfide

  2021cites this paper
• Amelioration of the hepatotoxic effects of nonsteroidal drugs using vitamin C and determination of their relationship with the lipid profile

  2021cites this paper
• Protective Effect of Ellagic Acid on Induced Liver Injury

  2021cites this paper
• Investigating the Protective Role of N-Acetyl Cysteine and S-Methyl Cysteine in the Activity of Antioxidant Enzymes and the Level of lipid Peroxidation Due to Acetamiprid Administration in Rat Kidney and Serum

  2020cites this paper
• Protective effect of royal jelly against diclofenac-induced hepato-renal damage and gastrointestinal ulcerations in rats

  2020cites this paper
• Selenium attenuates diclofenac‐induced testicular and epididymal toxicity in rats

  2020cites this paper
• Gallic acid mitigates diclofenac-induced liver toxicity by modulating oxidative stress and suppressing IL-1β gene expression in male rats

  2020cites this paper
• Toxins mechanism in instigating hepatotoxicity

  2020cites this paper
• Ameliorative Effects of Cirsium jaonicum, Artemisia annua and Curcuma longa on Non-alcoholic Fatty Liver Disease

  2020cites this paper
• Protective Effect of N-acetyl-cysteine Against Rat Liver Mitochondrial Toxicity Induced by CuSO4

  2020cites this paper
• Diclofenac-Induced Kidney Damage in Wistar Rats: Involvement of Antioxidant Mechanism

  2019cites this paper
• Protective effects of Ajwa date extract against tissue damage induced by acute diclofenac toxicity

  2019cites this paper
• Progesterone exerts antidepressant-like effect in a mouse model of maternal separation stress through mitigation of neuroinflammatory response and oxidative stress

  2019cites this paper
• Curcumin and Selenium Prevent Lipopolysaccharide/Diclofenac-Induced Liver Injury by Suppressing Inflammation and Oxidative Stress

  2019cites this paper
• Modulatory effects of artichoke (Cynara scolymus L.) leaf extract against oxidative stress and hepatic TNF-α gene expression in acute diazinon-induced liver injury in rats

  2019cites this paper
• Quercetin through mitigation of inflammatory response and oxidative stress exerts protective effects in rat model of diclofenac-induced liver toxicity

  2019cites this paper
• Nephroprotective effect of silymarin against diclofenac induced renal damage and oxidative stress in male rats

  2019cites this paper
• Withdrawal effects following repeated ethanol exposure are prevented by N-acetylcysteine in zebrafish.

  2019cites this paper
• Protective and anti-inflammatory effects of hydroalcoholic leaf extract of Origanum vulgare on oxidative stress, TNF-α gene expression and liver histological changes in paraquat-induced hepatotoxicity in rats

  2019influential citation
• Silymarin mitigates diclofenac-induced liver toxicity through inhibition of inflammation and oxidative stress in male rats

  2019cites this paper
• Protective effect of hydro alcoholic extract of Pistacia atlantica against acetaminophen-induced hepatotoxicity and oxidative stress in male rats

  2019cites this paper
• Ameliorative effects of N-acetyl cysteine on diclofenac-induced renal injury in male rats based on serum biochemical parameters, oxidative biomarkers, and histopathological study.

  2019cites this paper
• Hepatoprotective effects of silymarin against diclofenac-induced liver toxicity in male rats based on biochemical parameters and histological study

  2019cites this paper
• Beneficial effects of N-acetylcysteine on hepatic oxidative stress in streptozotocin-induced diabetic rats.

  2018cites this paper
• Application of the comparison approach to open TG-GATEs: A useful toxicogenomics tool for detecting modes of action in chemical risk assessment.

  2018cites this paper
• Evaluation of the effects of the hydroalcoholic extract of Terminalia chebula fruits on diazinon-induced liver toxicity and oxidative stress in rats

  2017cites this paper