The hippocampus in depth: a sublayer-specific perspective of entorhinal-hippocampal function.

Understanding how the brain represents events is a fundamental question in neuroscience. The entorhinal-hippocampal system is central to such representations, which are severely compromised in some neurological diseases. In spite of much progress, a comprehensive, integrated view of spatial, temporal and other aspects of episodic representation remains elusive. Here, we review recent data on the role of cell-type specific entorhinal inputs which excite deep and superficial CA1 pyramidal cells by direct and indirect pathways. We discuss how an entorhinal dialogue with deep-superficial CA1 cells can multiplex neuronal activity along theta phases and how their reactivation may be segregated during sharp-wave ripples. Thus, deep and superficial CA1 sublayers provide substrate for general hippocampal function.

• Publication year

  2018

• Venue

  Current Opinion in Neurobiology

• Publication date

  2018-10-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.conb.2018.04.013PMID 29729527
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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