Mimicking a p53‐MDM2 interaction based on a stable immunoglobulin‐like domain scaffold

No abstract is available for this paper.

• Publication year

  2018

• Venue

  Proteins: Structure, Function, and Bioinformatics

• Publication date

  2018-07-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1002/prot.25519PMID 29696695
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  1996cited by this paper
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  1994cited by this paper
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