Effect of nitric oxide synthase inhibitor on a hyperglycemic rat model of reversible focal ischemia: detection of excitatory amino acids release and hydroxyl radical formation.

No abstract is available for this paper.

• Publication year

  1998

• Venue

  Brain Research

• Publication date

  1998-04-27

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1016/S0006-8993(98)00089-4PMID 9593867
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Focal ischemia of the rat brain, with special reference to the influence of plasma glucose concentration

  2004cited by this paper
• Perfusion Deficit Parallels Exacerbation of Cerebral Ischemia/Reperfusion Injury in Hyperglycemic Rats

  1997cited by this paper
• Hydroxyl radical formation in hyperglycemic rats during middle cerebral artery occlusion/reperfusion.

  1997cited by this paper
• Peroxynitrite Inhibits Glutamate Transporter Subtypes (*)

  1996cited by this paper
• A comparison of the early development of ischemic brain damage in normoglycemic and hyperglycemic rats using magnetic resonance imaging

  1996cited by this paper
• In vivo evidence of hydroxyl radical formation induced by elevation of extracellular glutamate after cerebral ischemia in the cortex of anesthetized rats.

  1996cited by this paper
• Brain Temperature Alters Hydroxyl Radical Production during Cerebral Ischemia/Reperfusion in Rats

  1996cited by this paper
• ARL 17477, a Potent and Selective Neuronal NOS Inhibitor Decreases Infarct Volume after Transient Middle Cerebral Artery Occlusion in Rats

  1996cited by this paper
• Nitric Oxide Synthase Inhibition by L-NAME Prevents Brain Acidosis during Focal Cerebral Ischemia in Rabbits

  1996cited by this paper
• Relationship between Extracellular Glutamate Concentration and Voltage-Sensitive Calcium Channel Function in Focal Cerebral Ischemia in the Rat

  1996cited by this paper
• In vivo Detection of Superoxide Anion Production by the Brain Using a Cytochrome c Electrode

  1995cited by this paper
• Evolution of Regional Changes in Apparent Diffusion Coefficient during Focal Ischemia of Rat Brain: The Relationship of Quantitative Diffusion NMR Imaging to Reduction in Cerebral Blood Flow and Metabolic Disturbances

  1995cited by this paper
• Tirilazad Pretreatment Improves Early Cerebral Metabolic and Blood Flow Recovery from Hyperglycemic Ischemia

  1995cited by this paper
• Nitric oxide synthase inhibitor NG-nitro-L-arginine methyl ester decreases ischemic damage in reversible focal cerebral ischemia in hyperglycemic rats.

  1995cited by this paper
• Nitric Oxide Synthase Inhibition and Cerebrovascular Regulation

  1994cited by this paper
• Stroke in the diabetic patient.

  1994cited by this paper
• The influence of plasma glucose concentrations on ischemic brain damage is a threshold function.

  1994cited by this paper
• Nitric Oxide Synthase Inhibition Reduces Caudate Injury Following Transient Focal Ischemia in Cats

  1994cited by this paper
• Excitotoxicity, free radicals, and cell membrane changes

  1994cited by this paper
• Comparison of diffusion‐weighted MRI with changes in cell volume in a rat model of brain injury

  1994cited by this paper
• Nitric oxide inhibition aggravates ischemic damage of hippocampal but not of NADPH neurons in gerbils.

  1994cited by this paper
• The NOS Inhibitor, 7-Nitroindazole, Decreases Focal Infarct Volume but Not the Response to Topical Acetylcholine in Pial Vessels

  1994cited by this paper
• The Effect of Nitric Oxide Synthase Inhibition on Infarct Volume After Reversible Focal Cerebral Ischemia in Conscious Rats

  1993cited by this paper
• Mechanisms Involved in the Neuroprotective Activity of a Nitric Oxide Synthase Inhibitor During Focal Cerebral Ischemia

  1993cited by this paper
• Nitric Oxide Measured by a Porphyrinic Micro Sensor in Rat Brain after Transient Middle Cerebral Artery Occlusion

  1993cited by this paper
• Acidosis-related brain damage.

  1993cited by this paper
• The evolution of acute stroke recorded by multimodal magnetic resonance imaging.

  1993cited by this paper
• Metabolic changes associated with altering blood glucose levels in short duration forebrain ischemia.

  1993cited by this paper
• Amino acids and serotonin are released into the lumbar spinal cord of the anesthetized cat following intradermal capsaicin injections.

  1993cited by this paper
• N-methyl-D-aspartate-induced nitric oxide release: an in vivo microdialysis study.

  1993cited by this paper
• Low dose L-NAME reduces infarct volume in the rat MCAO/reperfusion model.

  1993cited by this paper
• Two Pathways of Cyclic GMP Production Through Glutamate Receptor‐Mediated Nitric Oxide Synthesis

  1992cited by this paper
• Forebrain Ischemia in Diabetic and Nondiabetic BB Rats Studied With 31P Magnetic Resonance Spectroscopy

  1992cited by this paper
• Regulation of Neuronal Nitric Oxide and Cyclic GMP Formation by Ca2+

  1992cited by this paper
• The neuroprotective effect of a nitric oxide inhibitor in a rat model of focal cerebral ischaemia

  1992cited by this paper
• Focal and Perifocal Changes in Tissue Energy State during Middle Cerebral Artery Occlusion in Normo- and Hyperglycemic Rats

  1992cited by this paper
• Inhibition of Nitric Oxide Synthesis Increases Focal Ischemic Infarction in Rat

  1992cited by this paper
• Effects of Hyperglycemia on the Time Course of Changes in Energy Metabolism and pH during Global Cerebral Ischemia and Reperfusion in Rats: Correlation of 1H and 31P NMR Spectroscopy with Fatty Acid and Excitatory Amino Acid Levels

  1992cited by this paper
• Effects of dimethylthiourea on ischemic brain damage in hyperglycemic rats.

  1992cited by this paper
• Nitric oxide mediates neuronal death after focal cerebral ischemia in the mouse.

  1991cited by this paper
• Glutamate, nitric oxide and cell-cell signalling in the nervous system.

  1991cited by this paper
• Interaction between free radicals and excitatory amino acids in the formation of ischemic brain edema in rats.

  1991cited by this paper
• Effect of plasma glucose on infarct size in focal cerebral ischemia‐reperfusion

  1991cited by this paper
• Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures.

  1991cited by this paper
• Temporal evolution of ischemic damage in rat brain measured by proton nuclear magnetic resonance imaging.

  1991cited by this paper
• Constitutive and inducible nitric oxide synthases incorporate molecular oxygen into both nitric oxide and citrulline.

  1991cited by this paper
• Nitric oxide synthesis in the CNS endothelium and macrophages differs in its sensitivity to inhibition by arginine analogues.

  1991cited by this paper
• Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide.

  1990cited by this paper
• Excitatory amino acid release and free radical formation may cooperate in the genesis of ischemia-induced neuronal damage

  1990cited by this paper
• Early detection of regional cerebral ischemia in cats: Comparison of diffusion‐ and T2‐weighted MRI and spectroscopy

  1990cited by this paper
• Continuous Nimodipine Treatment Attenuates Cortical Infarction in Rats Subjected to 24 Hours of Focal Cerebral Ischemia

  1990cited by this paper
• Enhancement of Iron-Catalyzed Free Radical Formation by Acidosis in Brain Homogenates: Difference in Effect by Lactic Acid and CO2

  1989cited by this paper
• Correlation between cerebral blood flow and histologic changes in a new rat model of middle cerebral artery occlusion.

  1989cited by this paper
• Cerebral blood volume in a rat model of ischemia by MR imaging at 4.7 T.

  1989cited by this paper
• Superoxide, iron, vascular endothelium and reperfusion injury.

  1989cited by this paper
• Invited Commentary:Superoxide, Iron, Vascular Endothelium and Reperfusion Injury

  1989cited by this paper
• Reversible middle cerebral artery occlusion without craniectomy in rats.

  1989cited by this paper
• Excitatory Amino Acid Release from Rat Hippocampal Slices as a Consequence of Free‐Radical Formation

  1988cited by this paper
• Naphthalene-2,3-dicarboxyaldehyde/cyanide ion: a rationally designed fluorogenic reagent for primary amines

  1987cited by this paper
• Ionic dependence of glutamate neurotoxicity

  1987cited by this paper
• Use of salicylate with high pressure liquid chromatography and electrochemical detection (LCED) as a sensitive measure of hydroxyl free radicals in adriamycin treated rats.

  1986cited by this paper
• Evaluation of 2,3,5-triphenyltetrazolium chloride as a stain for detection and quantification of experimental cerebral infarction in rats.

  1986cited by this paper
• Changes in Extra- and Intracellular pH in the Brain during and following Ischemia in Hyperglycemic and in Moderately Hypoglycemic Rats

  1986cited by this paper
• Reaction of superoxide with nitric oxide to form peroxonitrite in alkaline aqueous solution

  1985cited by this paper
• Calcium dependence of toxic cell death: a final common pathway.

  1979cited by this paper
• STUDIES ON FUNCTIONAL AND METABOLIC ROLE OF UREA CYCLE INTERMEDIATES IN BRAIN

  1976cited by this paper
• Journal of Cerebral Blood Flow and Metabolism Acidosis Causes Failure of Astrocyte Glutamate Uptake during Hypoxia

  year unknowncited by this paper
• Journal of Cerebral Blood Flow and Metabolism Simultaneous Measurement of Salicylate Hydroxylation and Glutamate Release in the Penumbral Cortex following Transient Middle Cerebral Artery Occlusion in Rats

  year unknowncited by this paper

• Mechanisms of SIRT1/SIRT3-mediated reduction of mitochondrial regeneration and inflammatory response in diabetic cerebral ischemia-reperfusion injury

  2025cites this paper
• Hyperglycemia in acute ischemic stroke: physiopathological and therapeutic complexity

  2021influential citation
• Peroxynitrite activates NLRP3 inflammasome and contributes to hemorrhagic transformation and poor outcome in ischemic stroke with hyperglycemia.

  2021cites this paper
• Microstructural Integrity of Salvaged Penumbra after Mechanical Thrombectomy

  2019cites this paper
• Commentary: Heat stress-induced neuroinflammation and aberration in monoamine levels in hypothalamus are associated with temperature dysregulation

  2017cites this paper
• Electroacupuncture reduces apoptotic index and inhibits p38 mitogen-activated protein kinase signaling pathway in the hippocampus of rats with cerebral ischemia/reperfusion injury

  2017cites this paper
• Diabetic aggravation of stroke and animal models

  2017cites this paper
• [Tripotolide ameliorates inflammation and apoptosis induced by focal cerebral ischemia/reperfusion in rats].

  2016cites this paper
• Magnetic Resonance Imaging in Experimental Stroke and Comparison With Histology: Systematic Review and Meta-Analysis

  2015cites this paper
• Early Release of HMGB1 may Aggravate Neuronal Damage after Transient Focal Ischemia in Diabetic Rat Brain

  2015cites this paper
• Hyperglycemia in Experimental Cerebral Ischemia

  2015cites this paper
• L-NAME combats excitotoxicity and recuperates neurological deficits in MCAO/R rats.

  2015cites this paper
• Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 1089 Hyperglycemia in Experimental Cerebral Ischemia

  2015cites this paper
• Hyperglycemia / hypoglycemia-induced mitochondrial dysfunction and cerebral ischemic damage in diabetics

  2014cites this paper
• Hyperglycemia as a Risk Factor of Ischemic Stroke

  2013cites this paper
• Drug Metabolism & Toxicology

  2013cites this paper
• Pathophysiology of post-stroke hyperglycaemia and brain arterial patency

  2013cites this paper
• Neuroprotective effect of penehyclidine hydrochloride on focal cerebral ischemia-reperfusion injury

  2013cites this paper
• Attenuating brain inflammation, ischemia, and oxidative damage by hyperbaric oxygen in diabetic rats after heat stroke.

  2013cites this paper
• Considering hyperglycemia and thrombolysis in the Stroke Hyperglycemia Insulin Network Effort (SHINE) trial

  2012cites this paper
• Diabetes-Mediated Exacerbation of Neuronal Damage and Inflammation After Cerebral Ischemia in Rat: Protective Effects of Water-Soluble Extract from Culture Medium of Ganoderma lucidum Mycelia

  2012cites this paper
• 3-Bromo-7-nitroindazole attenuates brain ischemic injury in diabetic stroke via inhibition of endoplasmic reticulum stress pathway involving CHOP.

  2012cites this paper
• The Influence of Stroke Risk Factors and Comorbidities on Assessment of Stroke Therapies in Humans and Animals

  2012cites this paper
• Hyperglycaemia and Infarct Size in Animal Models of Middle Cerebral Artery Occlusion: Systematic Review and Meta-Analysis

  2011cites this paper
• Diffusion tensor MRI for the assessment of cerebral ischemia/reperfusion injury in the penumbra of non-human primate stroke model

  2011cites this paper
• Hyperbaric oxygenation alleviates MCAO-induced brain injury and reduces hydroxyl radical formation and glutamate release

  2010cites this paper
• Protective Effects of Oral Administrated Ascorbic Acid against Oxidative Stress and Neuronal Damage after Cerebral Ischemia/Reperfusion in Diabetic Rats

  2010cites this paper
• UvA-DARE ( Digital Academic Repository ) Nitric oxide in focal cerebral ischemia , an experimental study

  2008cites this paper
• A new technique allowing prolonged temporary cerebral artery occlusion.

  2008cites this paper
• Nitric oxide in focal cerebral ischemia, an experimental study

  2008cites this paper
• Hyperglycemia in Acute Ischemic Stroke: A Vascular Perspective

  2007cites this paper
• Increased oxidative stress during hyperglycemic cerebral ischemia.

  2007cites this paper
• [Influence of diabetes mellitus on cerebral ischemia and reperfusion injury].

  2006cites this paper
• Role of AT1 receptors in permeability of the blood-brain barrier in diabetic hypertensive rats.

  2006cites this paper
• Response to Letter by Tsuda

  2006cites this paper
• Nitric oxide synthase inhibitors in experimental stroke and their effects on infarct size and cerebral blood flow ; a systematic review

  2006cites this paper
• Early treadmill exercise decreases intrastriatal hemorrhage-induced neuronal cell death and increases cell proliferation in the dentate gyrus of streptozotocin-induced hyperglycemic rats.

  2005cites this paper
• Nitric oxide synthase inhibitors in experimental ischemic stroke and their effects on infarct size and cerebral blood flow: a systematic review.

  2005cites this paper
• Chelation of intracellular calcium reduces cell death after hyperglycemic in vitro ischemia in murine hippocampal slice cultures.

  2005cites this paper
• Role of AT 1 receptors and NAD ( P ) H oxidase in diabetes-aggravated ischemic brain injury

  2004cites this paper
• Expression of superoxide dismutase in hyperglycemic focal cerebral ischemia in the rat.

  2004cites this paper
• Plasma Homocysteine and Oxidative Stress in Cardiovascular Disease

  2004cites this paper
• Role of AT1 receptors and NAD(P)H oxidase in diabetes-aggravated ischemic brain injury.

  2004cites this paper
• Activation of cell death pathway after a brief period of global ischemia in diabetic and non-diabetic animals.

  2004cites this paper
• Is neuroprotective efficacy of nNOS inhibitor 7-NI dependent on ischemic intracellular pH?

  2003cites this paper
• Intrastriatal microinjection of sodium nitroprusside induces cell death and reduces binding of dopaminergic receptors

  2003cites this paper
• Effects of 2-Deoxy-D-Glucose on Focal Cerebral Ischemia in Hyperglycemic Rats

  2003cites this paper
• Diabetes activates cell death pathway after transient focal cerebral ischemia.

  2003cites this paper
• Transient forebrain ischemia induced phosphorylation of cAMP-responsive element-binding protein is suppressed by hyperglycemia.

  2003cites this paper
• Pre- and post-treatment with pirlindole and dehydropirlindole protects cultured brain cells against nitric oxide-induced death.

  2003cites this paper
• ラット高血糖負荷時の脳虚血・再灌流における脳内一酸化窒素(NO)産生の検討

  2002cites this paper
• Blocking Nitric Oxide Toxicity

  2002cites this paper
• Effects of propofol on lactate accumulation and oedema formation in focal cerebral ischaemia in hyperglycaemic rats.

  2002cites this paper
• The Impact of Hypercarbia on the Evolution of Brain Injury in a Porcine Model of Traumatic Brain Injury and Systemic Hemorrhage

  2001cites this paper
• Experimental Stroke in the Female Diabetic, db/db, Mouse

  2001cites this paper
• Immunohistochemical detection of inducible nitric oxide synthase, nitrotyrosine and manganese superoxide dismutase following hyperglycemic focal cerebral ischemia.

  2001cites this paper
• Bradykinin elicits "second window" myocardial protection in rat heart through an NO-dependent mechanism.

  2001cites this paper
• Treatment of pediatric traumatic brain injury: a broad path to a narrow gate.

  2001cites this paper
• Hydroxyl Radical Production in the Cortex and Striatum in a Rat Model of Focal Cerebral Ischemia

  2000cites this paper
• Oxidative stress in the context of acute cerebrovascular stroke.

  2000cites this paper
• Nitric Oxide in Brain Ischemia/Reperfusion Injury

  2000cites this paper
• Secondary Neurologic Injury Resulting from Nonhypotensive Hemorrhage Combined with Mild Traumatic Brain Injury

  1999cites this paper