An Update on the Gut Microbiome and the Use of Probiotics for Disease Prevention in Preterm Infants

Very low birth weight infants (VLBWIs) are at high risk for inflammatory diseases including necrotizing enterocolitis (NEC) or neonatal sepsis, which are primary causes of neonatal mortality. The intestinal microbiota plays an essential role in maintaining local immune homeostasis and enhancing the intestinal barrier in preterm infants; however, appropriate intestinal colonization with normal flora after birth is interrupted by immature gastrointestinal tract, intestinal mucosal damage, insufficient nutrient transport, or formation of abnormal intestinal flora due to the use of antimicrobials in VLBWIs. Large randomized controlled trials and meta-analyses have highlighted the potential benefits of the clinical use of probiotics on NEC or neonatal sepsis for immunologically immature VLBWIs. However, standardized guidelines for the optimum strain, combination of strains, dosage, timing, and duration of probiotics are unknown for the routine application of probiotics in VLBWIs. Here, we review the results of previous studies on the effects of probiotics in preventing morbidity, NEC, or neonatal sepsis in VLBWIs with the administration of single-strain or multi-strain probiotics. Future clinical trials should address the safety of each probiotic strain and the potential efficacy of strain combinations for the routine use of probiotics in preterm infants. The key findings of the manuscript: This study reviewed the focus on the efficacy of probiotics for the prevention of sepsis and necrotizing enterocolitis in preterm infants weighing less than 1,500 g at birth according to single-strain probiotics or multi-strain probiotics.

• Publication year

  2018

• Venue

  Epidemiology

• Publication date

  2018-02-28

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.4172/2161-1165.1000339
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Prevention of necrotizing enterocolitis with probiotics: a systematic review and meta-analysis

  2016cited by this paper
• A randomised controlled trial of the probiotic Bifidobacterium breve BBG-001 in preterm babies to prevent sepsis, necrotising enterocolitis and death: the Probiotics in Preterm infantS (PiPS) trial.

  2016cited by this paper
• Probiotic Supplementation and Late-Onset Sepsis in Preterm Infants: A Meta-analysis

  2016cited by this paper
• Gut microbiota, the immune system, and diet influence the neonatal gut–brain axis

  2015cited by this paper
• Probiotics (Lactobacillus acidophilus and Bifidobacterium bifidum) prevent NEC in VLBW infants fed breast milk but not formula

  2015cited by this paper
• Probiotics for prevention of necrotizing enterocolitis in preterm infants (Review)

  2014cited by this paper
• Saccharomyces boulardii for prevention of necrotizing enterocolitis in preterm infants: a randomized, controlled study

  2013cited by this paper
• Lactobacillus Reuteri for the prevention of necrotising enterocolitis in very low birthweight infants: a randomised controlled trial

  2013cited by this paper
• Intestinal mucosal defense system, Part 1. Consensus recommendations for immunonutrients.

  2013cited by this paper
• Feeding the preterm infant: opportunities and challenges of bringing science to the bedside.

  2013cited by this paper
• Intestinal mucosal defense system, Part 2. Probiotics and prebiotics.

  2013cited by this paper
• Mechanisms of gut barrier failure in the pathogenesis of necrotizing enterocolitis: Toll-like receptors throw the switch.

  2013cited by this paper
• The Altered Gut Microbiome and Necrotizing Enterocolitis

  2013cited by this paper
• Probiotic Effects on Late-onset Sepsis in Very Preterm Infants: A Randomized Controlled Trial

  2013cited by this paper
• Probiotic supplement reduces risk of necrotizing enterocolitis and mortality in preterm very low-birth-weight infants: an updated meta-analysis of 20 randomized, controlled trials.

  2012cited by this paper
• Double-blind, randomised clinical assay to evaluate the efficacy of probiotics in preterm newborns weighing less than 1500 g in the prevention of necrotising enterocolitis

  2012cited by this paper
• Neurodevelopmental outcomes of extremely premature infants conceived after assisted conception: a population based cohort study

  2012cited by this paper
• Human milk oligosaccharide consumption by intestinal microbiota.

  2012cited by this paper
• Facultative to strict anaerobes ratio in the preterm infant microbiota

  2012cited by this paper
• Gut microbiota in preterm infants: assessment and relevance to health and disease

  2012cited by this paper
• Establishment and development of intestinal microbiota in preterm neonates.

  2012cited by this paper
• Critical systematic review of the level of evidence for routine use of probiotics for reduction of mortality and prevention of necrotizing enterocolitis and sepsis in preterm infants.

  2012cited by this paper
• Oral probiotics: Lactobacillus sporogenes for prevention of necrotizing enterocolitis in very low-birth weight infants: a randomized, controlled trial

  2011cited by this paper
• Efficacy of Bifidobacterium breve and Lactobacillus casei oral supplementation on necrotizing enterocolitis in very-low-birth-weight preterm infants: a double-blind, randomized, controlled trial.

  2011influential reference
• Updated Meta-analysis of Probiotics for Preventing Necrotizing Enterocolitis in Preterm Neonates

  2010cited by this paper
• [Effects of probiotics on intestinal bacterial colonization in premature infants].

  2010cited by this paper
• Consumption of human milk oligosaccharides by gut-related microbes.

  2010cited by this paper
• Intestinal Microbial Ecology in Premature Infants Assessed with Non–Culture-Based Techniques

  2010cited by this paper
• Bovine lactoferrin supplementation for prevention of late-onset sepsis in very low-birth-weight neonates: a randomized trial.

  2009cited by this paper
• 16S rRNA gene-based analysis of fecal microbiota from preterm infants with and without necrotizing enterocolitis

  2009cited by this paper
• Oral Probiotics Prevent Necrotizing Enterocolitis in Very Low Birth Weight Preterm Infants: A Multicenter, Randomized, Controlled Trial

  2008cited by this paper
• Bacterial Colonization, Probiotics, and Necrotizing Enterocolitis

  2008cited by this paper
• Adverse neurodevelopment in preterm infants with postnatal sepsis or necrotizing enterocolitis is mediated by white matter abnormalities on magnetic resonance imaging at term.

  2008cited by this paper
• The effect of a bifidobacter supplemented bovine milk on intestinal permeability of preterm infants.

  2007cited by this paper
• Oral probiotics reduce the incidence and severity of necrotizing enterocolitis in very low birth weight infants.

  2005cited by this paper
• Neurodevelopmental and Growth Outcomes of Extremely Low Birth Weight Infants After Necrotizing Enterocolitis

  2005cited by this paper
• Lactobacillus Sepsis Associated With Probiotic Therapy

  2005cited by this paper
• An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune system.

  2005cited by this paper
• The intestine and its microflora are partners for the protection of the host: report on the Danone Symposium "The Intelligent Intestine," held in Paris, June 14, 2002.

  2003cited by this paper
• Identification of Multiple Isolated Lymphoid Follicles on the Antimesenteric Wall of the Mouse Small Intestine1

  2002cited by this paper
• Probiotics Feeding in Prevention of Urinary Tract Infection, Bacterial Sepsis and Necrotizing Enterocolitis in Preterm Infants

  2002cited by this paper
• Update on host defense and immunonutrients.

  2002cited by this paper
• Molecular analysis of commensal host-microbial relationships in the intestine.

  2001cited by this paper
• Hypothesis: inappropriate colonization of the premature intestine can cause neonatal necrotizing enterocolitis

  2001cited by this paper
• Analysis of intestinal flora development in breast-fed and formula-fed infants by using molecular identification and detection methods.

  2000cited by this paper
• Liver abscess due to a Lactobacillus rhamnosus strain indistinguishable from L. rhamnosus strain GG.

  1999cited by this paper
• Intestinal microflora stimulates myoelectric activity of rat small intestine by promoting cyclic initiation and aboral propagation of migrating myoelectric complex

  1994cited by this paper

• No citing papers are available for this paper.