Engineering a soluble high-affinity receptor domain that neutralizes staphylococcal enterotoxin C in rabbit models of disease.

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Protein engineering, design & selection : PEDS

• Publication date

  2013-02-01

• Fields of study

  Biology, Medicine, Engineering

• Identifiers
  DOI 10.1093/protein/gzs094PMID 23161916PMCID PMC3542526
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2011influential reference
• Staphylococcal Toxic Shock Syndrome 2000–2006: Epidemiology, Clinical Features, and Molecular Characteristics

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  2009influential reference
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  1997influential reference
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  1990cited by this paper
• The staphylococcal enterotoxins and their relatives.

  1990influential reference
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  1987cited by this paper
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  1982cited by this paper

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