WWOX protein expression in normal human tissues

No abstract is available for this paper.

• Publication year

  2006

• Venue

  Journal of Molecular Histology

• Publication date

  2006-08-29

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1007/s10735-006-9046-5PMID 16941225PMCID PMC4144810
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Common chromosomal fragile sites and cancer: focus on FRA16D.

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• Characterization of the tumor suppressor gene WWOX in primary human oral squamous cell carcinomas

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• PKA-mediated protein phosphorylation regulates ezrin-WWOX interaction.

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• Roles of FHIT and WWOX fragile genes in cancer.

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• WWOX--the FRA16D cancer gene: expression correlation with breast cancer progression and prognosis.

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• Common fragile sites, extremely large genes, neural development and cancer.

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• WWOX mRNA expression profile in epithelial ovarian cancer supports the role of WWOX variant 1 as a tumour suppressor, although the role of variant 4 remains unclear.

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• Concordant loss of fragile gene expression early in breast cancer development

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• WW domain-containing proteins, WWOX and YAP, compete for interaction with ErbB-4 and modulate its transcriptional function.

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• WWOX protein expression varies among ovarian carcinoma histotypes and correlates with less favorable outcome

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• Fragile genes as biomarkers: epigenetic control of WWOX and FHIT in lung, breast and bladder cancer

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• WWOX binds the specific proline-rich ligand PPXY: identification of candidate interacting proteins

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• Frequent loss of WWOX expression in breast cancer: correlation with estrogen receptor status

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• Frequent downregulation and loss of WWOX gene expression in human hepatocellular carcinoma

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• Expression of FRA16D/WWOX and FRA3B/FHIT genes in hematopoietic malignancies.

  2003cited by this paper
• An opposing view on WWOX protein function as a tumor suppressor.

  2003cited by this paper
• WWOX, the common chromosomal fragile site, FRA16D, cancer gene

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• Short‐chain dehydrogenase/reductase (SDR) relationships: A large family with eight clusters common to human, animal, and plant genomes

  2002cited by this paper
• Genetic alterations of the tumor suppressor gene WWOX in esophageal squamous cell carcinoma.

  2002cited by this paper
• WWOX, the FRA16D gene, behaves as a suppressor of tumor growth.

  2001cited by this paper
• WWOX: A candidate tumor suppressor gene involved in multiple tumor types

  2001cited by this paper
• WWOX, a novel WW domain-containing protein mapping to human chromosome 16q23.3-24.1, a region frequently affected in breast cancer.

  2000influential reference
• A 700-kb physical map of a region of 16q23.2 homozygously deleted in multiple cancers and spanning the common fragile site FRA16D.

  2000cited by this paper
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• The Role of WWOX in Cancer Progression: Mechanisms and Therapeutic Potential

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• Neuroimaging features of WOREE syndrome: a mini-review of the literature

  2023cites this paper
• Neuronal wires and novel epileptic gene studies: Methods and mechanism of brain network and - Recent update

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• Expansion of the clinical and molecular spectrum of WWOX‐related epileptic encephalopathy

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• WWOX and metabolic regulation in normal and pathological conditions

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• TGFα-EGFR pathway in breast carcinogenesis, association with WWOX expression and estrogen activation

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• The effects of protocadherin 8 and WWOX in prostate adenocarcinoma

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• Neurological Disorders Associated with WWOX Germline Mutations—A Comprehensive Overview

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• Interaction of Wwox with Brca1 and associated complex proteins prevents premature resection at double-strand breaks and aberrant homologous recombination.

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• WWOX-Related Neurodevelopmental Disorders: Models and Future Perspectives

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• Preliminary study of genome-wide association identified novel susceptibility genes for thyroid-related hormones in Chinese population

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• Evaluation of reproductive traits and the effect of nutrigenetics on bulls submitted to fetal programming

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• Neuronal deletion of Wwox, associated with WOREE syndrome, causes epilepsy and myelin defects.

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• Cellular Expression and Subcellular Localization of Wwox Protein During Testicular Development and Spermatogenesis in Rats

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• Preliminary study of genome-wide association identified novel susceptibility genes for thyroid-related hormones in Chinese population

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• Wwox deficiency leads to neurodevelopmental and degenerative neuropathies and glycogen synthase kinase 3β-mediated epileptic seizure activity in mice

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• Characterization of WWOX expression and function in canine mast cell tumors and malignant mast cell lines

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• Wwox Deficiency Causes Downregulation of Prosurvival ERK Signaling and Abnormal Homeostatic Responses in Mouse Skin

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• Loss of Wwox Perturbs Neuronal Migration and Impairs Early Cortical Development

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• Downregulation of WW domain-containing oxidoreductase leads to tamoxifen-resistance by the inactivation of Hippo signaling

  2019cites this paper
• The WWOX Gene Influences Cellular Pathways in the Neuronal Differentiation of Human Neural Progenitor Cells

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• Loss of Wwox Causes Defective Development of Cerebral Cortex with Hypomyelination in a Rat Model of Lethal Dwarfism with Epilepsy

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• Wwox deletion leads to reduced GABA-ergic inhibitory interneuron numbers and activation of microglia and astrocytes in mouse hippocampus.

  2019cites this paper
• Oscillatory Activity in the Cortex, Motor Thalamus and Nucleus Reticularis Thalami in Acute TTX and Chronic 6-OHDA Dopamine-Depleted Animals

  2018cites this paper
• Modeling WWOX Loss of Function in vivo: What Have We Learned?

  2018cites this paper
• Delineating WWOX Protein Interactome by Tandem Affinity Purification-Mass Spectrometry: Identification of Top Interactors and Key Metabolic Pathways Involved

  2018cites this paper
• The phenotypic spectrum of WWOX-related disorders: 20 additional cases of WOREE syndrome and review of the literature

  2018cites this paper
• Cancerous Protein Network That Inhibits the Tumor Suppressor Function of WW Domain-Containing Oxidoreductase (WWOX) by Aberrantly Expressed Molecules

  2018cites this paper
• WWOX Tumor Suppressor Gene in Breast Cancer, a Historical Perspective and Future Directions

  2018cites this paper
• Exogenous WWOX enhances apoptosis and weakens metastasis in CNE2 nasopharyngeal carcinoma cells through the intrinsic apoptotic pathway.

  2017cites this paper
• Fhit and Wwox loss-associated genome instability: A genome caretaker one-two punch.

  2017cites this paper
• Sporadic Hirschsprung Disease: Mutational Spectrum and Novel Candidate Genes Revealed by Next-generation Sequencing

  2017cites this paper
• Novel mutations in WWOX, RARS2, and C10orf2 genes in consanguineous Arab families with intellectual disability

  2016cites this paper
• Defining the role(s) of non-classical tumour suppressor Wwox in cellular function using Drosophila melanogaster genetic modelling

  2015cites this paper
• Loss of wwox expression in zebrafish embryos causes edema and alters Ca2+ dynamics

  2015cites this paper
• Role of WW domain proteins WWOX in development, prognosis, and treatment response of glioma

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• Alteration of WWOX in human cancer, a clinical view

  2015cites this paper
• The tumor suppressor WW domain-containing oxidoreductase modulates cell metabolism

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• Pleiotropic Functions of Tumor Suppressor WWOX in Normal and Cancer Cells*

  2015influential citation
• Biological profiles of endocrine breast cancer

  2015cites this paper
• The fragile site WWOX gene and the developing brain

  2015cites this paper
• Roles of the WWOX in pathogenesis and endocrine therapy of breast cancer

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• Immunohistochemical assessment of tumor suppressor gene Wwox in relation to proliferative marker KI67 proteins expression in giant cell lesions of the jaws and giant cell tumor of long bones

  2015cites this paper
• The tumour suppressor gene WWOX is mutated in autosomal recessive cerebellar ataxia with epilepsy and mental retardation.

  2014cites this paper
• WWOX at the crossroads of cancer, metabolic syndrome related traits and CNS pathologies.

  2014cites this paper
• γδ T Cells and Their Potential for Immunotherapy

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• Alternating expression levels of WWOX tumor suppressor and cancer-related genes in patients with bladder cancer

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• Impact of decitabine on immunohistochemistry expression of the putative tumor suppressor genes FHIT, WWOX, FUS1 and PTEN in clinical tumor samples

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  2013cites this paper
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  2011cites this paper
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• Role of the WWOX tumor suppressor gene in bone homeostasis and the pathogenesis of osteosarcoma.

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• Reversing effect of exogenous WWOX gene expression on malignant phenotype of primary cultured lung carcinoma cells.

  2010cites this paper
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  2010cites this paper
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• WWOX gene is associated with HDL cholesterol and triglyceride levels

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• Generation and Characterization of Mice Carrying a Conditional Allele of the Wwox Tumor Suppressor Gene

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• WWOX: Its genomics, partners, and functions

  2009cites this paper
• Targeted ablation of the WW domain-containing oxidoreductase tumor suppressor leads to impaired steroidogenesis.

  2009cites this paper
• The JNK inhibitor SP600129 enhances apoptosis of HCC cells induced by the tumor suppressor WWOX.

  2008cites this paper
• WW-domain-containing oxidoreductase is associated with low plasma HDL-C levels.

  2008cites this paper
• Targeted ablation of the Wwox tumor suppressor leads to impaired steroidogenesis

  2008cites this paper
• WWOX tumor suppressor gene.

  2008cites this paper
• WWOX (WW domain containing oxidoreductase)

  2008cites this paper
• WWOX in biological control and tumorigenesis

  2007cites this paper
• WWOX hypomorphic mice display a higher incidence of B‐cell lymphomas and develop testicular atrophy

  2007cites this paper
• WW domain-containing oxidoreductase: a candidate tumor suppressor.

  2007cites this paper
• Wwox Suppresses Prostate Cancer Cell Growth through Modulation of ErbB2-Mediated Androgen Receptor Signaling

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• Association between Decreased WWOX Protein Expression and Thyroid Cancer Development

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