The missense variation landscape of FTO, MC4R and TMEM18 in obese children of African ancestry

Sandra Deliard,Saarene Panossian,F. Mentch,Cecilia Kim,C. Hou,E. Frackelton,J. Bradfield,J. Glessner,Haitao Zhang,Kai Wang,P. Sleiman,R. Chiavacci,R. Berkowitz,H. Hakonarson,Jianhua Zhao,S. Grant

Published 2012 in Obesity

ABSTRACT

Common variation at the loci harboring fat mass and obesity (FTO), melanocortin receptor 4 (MC4R), and transmembrane protein 18 (TMEM18) is consistently reported as being statistically most strongly associated with obesity. Investigations if these loci also harbor rarer missense variants that confer substantially higher risk of common childhood obesity in African American (AA) children were conducted.

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