Photoaffinity labeling identifies the substrate-binding site of mammalian squalene epoxidase.

No abstract is available for this paper.

• Publication year

  2004

• Venue

  Biochemical and Biophysical Research Communications - BBRC

• Publication date

  2004-02-27

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/J.BBRC.2004.01.012PMID 15013417
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Phosphorylation of Supernatant Protein Factor Enhances Its Ability to Stimulate Microsomal Squalene Monooxygenase*

  2003cited by this paper
• Supernatant protein factor and tocopherol-associated protein: an unexpected link between cholesterol synthesis and vitamin E (review).

  2003cited by this paper
• SREBP-2 and NF-Y are involved in the transcriptional regulation of squalene epoxidase.

  2002cited by this paper
• Crystal structure of the human supernatant protein factor.

  2002cited by this paper
• Inhibition of human squalene monooxygenase by selenium compounds

  2002cited by this paper
• Molecular and functional characterization of an odorant binding protein of the Asian elephant, Elephas maximus: implications for the role of lipocalins in mammalian olfaction.

  2002cited by this paper
• Supernatant protein factor, which stimulates the conversion of squalene to lanosterol, is a cytosolic squalene transfer protein and enhances cholesterol biosynthesis

  2001cited by this paper
• Inhibition of human squalene monooxygenase by tellurium compounds: evidence of interaction with vicinal sulfhydryls.

  2001cited by this paper
• Resveratrol inhibits human squalene monooxygenase

  2001cited by this paper
• Garlic and garlic-derived compounds inhibit human squalene monooxygenase.

  2001cited by this paper
• Ellagitannins and hexahydroxydiphenoyl esters as inhibitors of vertebrate squalene epoxidase.

  2001cited by this paper
• Photoaffinity labeling and site-directed mutagenesis of rat squalene epoxidase.

  2000cited by this paper
• Using photolabile ligands in drug discovery and development.

  2000cited by this paper
• Cloning, heterologous expression, and enzymological characterization of human squalene monooxygenase.

  2000cited by this paper
• Green tea polyphenols: novel and potent inhibitors of squalene epoxidase.

  2000cited by this paper
• Galloyl esters from rhubarb are potent inhibitors of squalene epoxidase, a key enzyme in cholesterol biosynthesis.

  2000cited by this paper
• Inhibition of vertebrate squalene epoxidase by isoprenyl gallates and phenylalkyl gallates.

  2000cited by this paper
• Potent and selective inhibition of squalene epoxidase by synthetic galloyl esters.

  2000cited by this paper
• 2.10 – Squalene Epoxidase and Oxidosqualene : Lanosterol Cyclase—Key Enzymes in Cholesterol Biosynthesis

  1999cited by this paper
• An example of intron junctional sliding in the gene families encoding squalene monooxygenase homologues in Arabidopsis thaliana and Brassica napus*

  1999cited by this paper
• Sulfonamide derivatives of benzylamine block cholesterol biosynthesis in HepG2 cells: a new type of potent squalene epoxidase inhibitors.

  1998cited by this paper
• Interdomain binding of NADPH in p-Hydroxybenzoate Hydroxylase as Suggested by Kinetic, Crystallographic and Modeling Studies of Histidine 162 and Arginine 269 Variants*

  1998cited by this paper
• Localization of the squalene epoxidase gene (SQLE) to human chromosome region 8q24.1.

  1997cited by this paper
• Cloning and expression of squalene epoxidase from the pathogenic yeast Candida albicans.

  1997cited by this paper
• Design and synthesis of new potential photoaffinity labels for mammalian squalene epoxidase

  1997cited by this paper
• Identification of a novel conserved sequence motif in flavoprotein hydroxylases with a putative dual function in FAD/NAD(P)H binding

  1997cited by this paper
• Differential inhibition of fungal amd mammalian squalene epoxidases by the benzylamine SDZ SBA 586 in comparison with the allylamine terbinafine.

  1997cited by this paper
• Section Review: Cardiovascular & Renal: Squalene epoxidase inhibitors

  1996cited by this paper
• Design and synthesis of new hypocholesterolemic organosilanes with antioxidant properties

  1996cited by this paper
• Molecular identification of zeaxanthin epoxidase of Nicotiana plumbaginifolia, a gene involved in abscisic acid biosynthesis and corresponding to the ABA locus of Arabidopsis thaliana.

  1996cited by this paper
• Purification and characterization of recombinant squalene epoxidase.

  1995cited by this paper
• Nucleotide sequence of a cDNA for mouse squalene epoxidase.

  1995cited by this paper
• Retention of the label during the conversion of [3-3H] squalene into (3S)-2,3-oxidosqualene catalyzed by mammalian squalene oxidase.

  1995cited by this paper
• Chemical reagents in photoaffinity labeling

  1995cited by this paper
• Crystal structures of mutant Pseudomonas aeruginosa p-hydroxybenzoate hydroxylases: the Tyr201Phe, Tyr385Phe, and Asn300Asp variants.

  1995cited by this paper
• Molecular Cloning and Expression of Rat Squalene Epoxidase (*)

  1995cited by this paper
• Stereocontrolled synthesis of fluorosqualenes and fluoroepoxy-squalenes as inhibitors of squalene epoxidase and 2,3-oxidosqualene cyclase

  1995cited by this paper
• FAD is a further essential cofactor of the NAD(P)H and O2‐dependent zeaxanthin‐epoxidase

  1995cited by this paper
• (Aryloxy)methylsilane derivatives as new cholesterol biosynthesis inhibitors: synthesis and hypocholesterolemic activity of a new class of squalene epoxidase inhibitors.

  1995cited by this paper
• Purification of pig and rat liver squalene epoxidase by affinity chromatography

  1995cited by this paper
• Stereocontrolled Synthesis of Fluorosqualenes and Fluoroepoxysqualenes as Inhibitors of Squalene Epoxidase and 2,3-Oxidosqualene Cyclase.

  1995cited by this paper
• Larva lights: a decade of photoaffinity labeling with juvenile hormone analogues.

  1994cited by this paper
• Novel non-squalenoid photoaffinity labels for mammalian squalene epoxidase

  1994cited by this paper
• Odorant binding by a pheromone binding protein: active site mapping by photoaffinity labeling.

  1994cited by this paper
• Trisnorsqualene methyl hydroxylamine: a potent dual inhibitor of mammalian squalene epoxidase and oxidosqualene cyclase

  1993cited by this paper
• Inhibition and activation of porcine squalene epoxidase.

  1992cited by this paper
• Purification and properties of the NADH reductase component of alkene monooxygenase from Mycobacterium strain E3

  1992cited by this paper
• Epoxidation of 2,3-oxidosqualene to 2,3;22,23-squalene dioxide by squalene epoxidase.

  1992cited by this paper
• Terminal Difluoro Olefin Analogues of Squalene are Time‐Dependent Inhibitors of Squalene Epoxidase.

  1992cited by this paper
• Terminal difluoro olefin analogs of squalene are time-dependent inhibitors of squalene epoxidase

  1992cited by this paper
• The gene encoding squalene epoxidase from Saccharomyces cerevisiae: cloning and characterization.

  1991cited by this paper
• Squalene epoxidase as a target for the allylamines.

  1991cited by this paper
• 26-Hydroxysqualene and derivatives: substrates and inhibitors for squalene epoxidase

  1991cited by this paper
• Regio- and stereo-controlled synthesis of [24,30-14C]-labeled-2,3-epoxysqualene

  1991cited by this paper
• Evaluation of squalene analogs bearing photoreactive groups as inhibitors of squalene epoxidase and oxidosqualene cyclase

  1991cited by this paper
• Effect of a novel squalene epoxidase inhibitor, NB-598, on the regulation of cholesterol metabolism in Hep G2 cells.

  1991cited by this paper
• Inhibition of vertebrate squalene epoxidase by extended and truncated analogues of trisnorsqualene alcohol.

  1990cited by this paper
• Inhibition of squalene epoxidase and sterol side-chain methylation by allylamines.

  1990cited by this paper
• NB-598: a potent competitive inhibitor of squalene epoxidase.

  1990cited by this paper
• Syntheses of homologous, tritium‐labelled photoaffinity analogs of the natural juvenile hormones JH I, JH II, and JH III

  1990cited by this paper
• Regulation of squalene epoxidase in HepG2 cells.

  1990cited by this paper
• Squalene analogues containing isopropylidene mimics as potential inhibitors of pig liver squalene epoxidase and oxidosqualene cyclase.

  1989cited by this paper
• Drug design based on biosynthetic studies: synthesis, biological activity, and kinetics of new inhibitors of 2,3-oxidosqualene cyclase and squalene epoxidase.

  1989cited by this paper
• Synthesis of allyl vinyl silanes. Preparation of 12-(dimethylsila)squalene

  1989cited by this paper
• Trisnorsqualene cyclopropylamine: a reversible, tight-binding inhibitor of squalene epoxidase

  1989cited by this paper
• Trisnorsqualene alcohol, a potent inhibitor of vertebrate squalene epoxidase

  1989cited by this paper
• Polyacrylamide gel miniaturization improves protein visualization and autoradiographic detection.

  1989cited by this paper
• Chemistry of pheromone and hormone metabolism in insects.

  1987cited by this paper
• Squalene epoxidase from rat liver microsomes.

  1985cited by this paper
• Efficient Synthesis and Intramolecular Cyclopropanation of Unsaturated Diazoacetic Esters

  1984cited by this paper
• Effects of a supernatant protein activator on microsomal squalene-2,3-oxide-lanosterol cyclase.

  1979cited by this paper
• Letter: Enzymic epoxidation of squalene variants.

  1975cited by this paper
• Studies on squalene epoxidase of rat liver.

  1970cited by this paper
• Laboratory techniques in biochemistry and molecular biology

  1969cited by this paper

• Squalene epoxidase promotes hepatocellular carcinoma development by activating STRAP transcription and TGF‐β/SMAD signalling

  2022influential citation
• Limonoid biosynthesis 3: Functional characterization of crucial genes involved in neem limonoid biosynthesis.

  2021cites this paper
• The shape of human squalene epoxidase expands the arsenal against cancer

  2019cites this paper
• Studies of 4-arylthiazolylhydrazones derived from 1-indanones as Trypanosoma cruzi squalene epoxidase inhibitors by molecular simulations.

  2018cites this paper
• Squalene epoxidase as a promising metabolic target in cancer treatment.

  2018cites this paper
• Squalene monooxygenase – a target for hypercholesterolemic therapy

  2011cites this paper
• Sterol and Steroid Biosynthesis and Metabolism in Plants and Microorganisms

  2010cites this paper
• Molecular Biogeochemistry of Modern and Ancient Marine Microbes

  2010cites this paper
• Glyoxylyl Chloride p‐Toluenesulfonylhydrazone

  2009cites this paper
• Structure-Function Correlations of Two Highly Conserved Motifs in Saccharomyces cerevisiae Squalene Epoxidase

  2008cites this paper
• A squalene epoxidase is involved in biosynthesis of both the antitumor compound clavaric acid and sterols in the basidiomycete H. sublateritium.

  2007cites this paper
• Site-directed mutagenesis of conserved aromatic residues in rat squalene epoxidase.

  2007cites this paper
• Photoaffinity labeling and its application in structural biology

  2007cites this paper
• Steroids, triterpenoids and molecular oxygen

  2006cites this paper
• Characterization of Squalene Epoxidase of Saccharomyces cerevisiae by Applying Terbinafine-Sensitive Variants

  2006cites this paper
• Amino Acid Substitution in Trichophyton rubrum Squalene Epoxidase Associated with Resistance to Terbinafine

  2005cites this paper
• Single amino acid exchanges in FAD-binding domains of squalene epoxidase of Saccharomyces cerevisiae lead to either loss of functionality or terbinafine sensitivity.

  2005cites this paper
• Biodegradation of Natural Rubber and Related Compounds: Recent Insights into a Hardly Understood Catabolic Capability of Microorganisms

  2005cites this paper
• Alexander Steinbüchel Microorganisms Hardly Understood Catabolic Capability of aRelated Compounds : Recent Insights into Biodegradation of Natural Rubber and

  2005cites this paper