Mechanisms for absorption enhancement of inhaled insulin by sodium taurocholate.

No abstract is available for this paper.

• Publication year

  2002

• Venue

  European Journal of Pharmaceutical Sciences

• Publication date

  2002-10-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1016/S0928-0987(02)00133-1PMID 12356421
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• A comparison of the permeation enhancement potential of simple bile salt and mixed bile salt:fatty acid micellar systems using the CaCo-2 cell culture model.

  2000cited by this paper
• Evaluation of absorption enhancement for a potent cyclopeptidic alpha(nu)beta(3)-antagonist in a human intestinal cell line (Caco-2).

  2000cited by this paper
• Intra-individual variability of the metabolic effect of inhaled insulin together with an absorption enhancer.

  2000cited by this paper
• Evaluation of absorption enhancement for a potent cyclopeptidic ανβ3-antagonist in a human intestinal cell line (Caco-2)

  2000cited by this paper
• Inhaled insulin.

  1999cited by this paper
• Proteolytic enzymes as a limitation for pulmonary absorption of insulin: in vitro and in vivo investigations.

  1999cited by this paper
• Investigation into the Presence of Insulin‐degrading Enzyme in Cultured Type II Alveolar Cells and the Effects of Enzyme Inhibitors on Pulmonary Bioavailability of Insulin in Rats

  1998cited by this paper
• Peptide delivery via the pulmonary route: a valid approach for local and systemic delivery

  1997cited by this paper
• A novel dry powder aerosol delivery system for real time measurement of the inhaled dose to large animals (dogs)

  1997cited by this paper
• Time–action Profile of Inhaled Insulin

  1997cited by this paper
• Dissociation of insulin oligomers and enhancement of percutaneous absorption of insulin.

  1996cited by this paper
• Effects of Permeation Enhancers on the Transport of a Peptidomimetic Thrombin Inhibitor (CRC 220) in a Human Intestinal Cell Line (Caco-2)

  1996cited by this paper
• Human Insulin: Basic Sciences to Therapeutic Uses

  1996cited by this paper
• Pulmonary absorption enhancement of peptides by absorption enhancers and protease inhibitors

  1996cited by this paper
• Mechanisms of macromolecule absorption by the lungs

  1996cited by this paper
• Susceptibility of insulin to proteolysis in rat lung homogenate and its protection from proteolysis by various protease inhibitors.

  1995cited by this paper
• Pulmonary Absorption of Peptides and Proteins

  1995cited by this paper
• Mechanisms of absorption enhancement and tight junction regulation

  1994cited by this paper
• Absorption Enhancement of Intrapulmonary Administered Insulin by Various Absorption Enhancers and Protease Inhibitors in Rats

  1994cited by this paper
• Effects of Various Protease Inhibitors on the Intestinal Absorption and Degradation of Insulin in Rats

  1994cited by this paper
• Pulmonary Delivery of Free and Liposomal Insulin

  1993cited by this paper
• Differential Effects of Anionic, Cationic, Nonionic, and Physiologic Surfactants on the Dissociation, α-Chymotryptic Degradation, and Enteral Absorption of Insulin Hexamers

  1993cited by this paper
• Intratracheal delivery of insulin Absorption from solution and aerosol by rat lung

  1992cited by this paper
• A mechanistic study on enhancement of rectal permeability to insulin in the albino rabbit.

  1992cited by this paper
• Dissociation of Insulin Oligomers by Bile Salt Micelles and Its Effect on α-Chymotrypsin-Mediated Proteolytic Degradation

  1992cited by this paper
• (D) Routes of delivery: Case studies

  1992cited by this paper
• Epithelial transport of drugs in cell culture. VII: Effects of pharmaceutical surfactant excipients and bile acids on transepithelial permeability in monolayers of human intestinal epithelial (Caco-2) cells.

  1992cited by this paper
• Mucosal penetration enhancers for facilitation of peptide and protein drug absorption.

  1991cited by this paper
• Cell cultures as models for drug absorption across the intestinal mucosa.

  1991cited by this paper
• Insulin and proinsulin proteolysis in mucosal homogenates of the albino rabbit: implications in peptide delivery from nonoral routes.

  1990cited by this paper
• Toxicity determined in vitro by morphological alterations and neutral red absorption.

  1985cited by this paper

• Inhaled Biologics: Overcoming Challenges and Recent Advances.

  2026cites this paper
• Systemic delivery of sorafenib tosylate loaded LeciPlex®: A comparative assessment of nano assembly, biocompatibility, and In vivo drug disposition

  2025cites this paper
• Optimization of Carrier-Based Dry Powder Inhaler Performance: A Review

  2025cites this paper
• Recent Advances in Development of Buccal Formulations: From Small to Macromolecules

  2025cites this paper
• Perfluorocarbon-Loaded Poly(lactide-co-glycolide) Nanoparticles from Core to Crust: Multifaceted Impact of Surfactant on Particle Ultrastructure, Stiffness, and Cell Uptake

  2025cites this paper
• Exploring the Potential of Three-Layered Self-assembled Biomaterial-Based Dry Powder Inhaler for Enhanced Structural Integrity and Lung Deposition of Bioactive Lysozyme

  2024cites this paper
• Bile salts: unlocking the potential as bio-surfactant for enhanced drug absorption

  2024cites this paper
• Oral Self-Nanoemulsifying System Containing Ionic Liquid of BX795 Is Effective against Genital HSV-2 Infection in Mice.

  2023cites this paper
• Absorption enhancer approach for protein delivery by various routes of administration: a rapid review

  2023cites this paper
• Challenges and Strategies to Enhance the Systemic Absorption of Inhaled Peptides and Proteins

  2022cites this paper
• Mechanisms and solutions for nasal drug delivery - a narrative review.

  2022cites this paper
• Bile acid‐based advanced drug delivery systems, bilosomes and micelles as novel carriers for therapeutics

  2022cites this paper
• Interaction of Human Intestinal Bile Salt with Bioactive Diet Capsaicin and Indole-3-Carbinol

  2021cites this paper
• Bile acid transporter as a bioinspired method for oral therapeutics delivery system

  2021cites this paper
• Translation of pulmonary protein therapy from bench to bedside: Addressing the bioavailability challenges

  2021cites this paper
• Absorption enhancement of macromolecule-administered intrapulmonary

  2020cites this paper
• Chitosan and Trimethyl Chitosan (TMC) as Drug Absorption Enhancers

  2020cites this paper
• Strategies to Enhance Drug Absorption via Nasal and Pulmonary Routes

  2019cites this paper
• Comparative research of effects of permeability enhancers on the effectiveness of model protein (insulin) administered via the inhalation route

  2019cites this paper
• The influence of surfactant on the properties of albendazole-bile salts particles designed for lung delivery

  2019cites this paper
• Thiolated Polymers: Pharmaceutical Tool in Nasal Drug Delivery of Proteins and Peptides

  2019cites this paper
• Effect of the aggregation state of bile salts on their transdermal absorption enhancing properties

  2019cites this paper
• Drug Bioavailability Enhancing Agents of Natural Origin (Bioenhancers) that Modulate Drug Membrane Permeation and Pre-Systemic Metabolism

  2019influential citation
• Bile Acids and Their Derivatives as Potential Modifiers of Drug Release and Pharmacokinetic Profiles

  2018cites this paper
• Thiolated Polymers: Pharmaceutical Tool in Nasal Drug Delivery of Proteins and Peptides

  2018cites this paper
• Sex-specific modulation of drug bioavailability with pharmaceutical excipients

  2018cites this paper
• Bile salt enhancers for inhalation: Correlation between in vitro and in vivo lung effects

  2018cites this paper
• Reshaping antibiotics through hydrophobic drug-bile acid ionic complexation enhances activity against Staphylococcus aureus biofilms.

  2017cites this paper
• Ameliorating Effects of Sphingomyelin-Based Liposomes on Sarcopenia in Senescence-Accelerated Mice.

  2016cites this paper
• In-vitro investigation regarding the effects of Gelucire® 44/14 and Labrasol® ALF on the secretory intestinal transport of P-gp substrates.

  2016cites this paper
• Inhaled Biologics: From Preclinical to Product Approval.

  2016cites this paper
• Formulation Approaches to Overcome Biopharmaceutical Limitations of Inhaled Peptides/Proteins.

  2015cites this paper
• Biorelevant media resistant co-culture model mimicking permeability of human intestine.

  2015cites this paper
• Polymer‐based Delivery Systems for the Pulmonary Delivery of Biopharmaceuticals

  2015cites this paper
• Combined use of bile acids and aminoacids to improve permeation properties of acyclovir.

  2015cites this paper
• Improvement of pulmonary absorptions of poorly absorbable drugs using Gelucire 44/14 as an absorption enhancer

  2014cites this paper
• Absorption enhancing excipients in systemic nasal drug delivery.

  2014cites this paper
• Design and development of novel mitochondrial targeted nanocarriers, DQAsomes for curcumin inhalation.

  2014cites this paper
• Absorption Enhancing Excipients in Systemic Nasal Drug Delivery

  2014cites this paper
• Inhaled proteins: challenges and perspectives.

  2013cites this paper
• Formulation and transport properties of tenofovir loaded liposomes through Caco-2 cell model

  2013cites this paper
• Peptide and protein delivery using new drug delivery systems.

  2013cites this paper
• Application of bile acids in drug formulation and delivery

  2013cites this paper
• Concanavalin A conjugated biodegradable nanoparticles for oral insulin delivery

  2012cites this paper
• Diabetes Treatment by Inhalation of Insulin – Shine and Decline of a Novel Type of Therapy

  2011cites this paper
• Surfactants: their critical role in enhancing drug delivery to the lungs.

  2011cites this paper
• Preparation and characterization of iron-containing liposomes: their effect on soluble iron uptake by Caco-2 cells

  2011cites this paper
• Pulmonary Delivery of Peptides and Proteins

  2011cites this paper
• Formulation and in vitro evaluation of highly dispersive insulin dry powder formulations for lung administration.

  2010cites this paper
• Investigation on the synergistic effect of a combination of chemical enhancers and modulated iontophoresis for transdermal delivery of insulin

  2010cites this paper
• Formulation strategy and use of excipients in pulmonary drug delivery.

  2010cites this paper
• The effects of excipients on transporter mediated absorption.

  2010cites this paper
• Transport evaluation of alendronate across Caco-2 cell monolayers.

  2009cites this paper
• Physicochemical and biological characterization of monoketocholic acid, a novel permeability enhancer.

  2009cites this paper
• The effects of common solubilizing agents on the intestinal membrane barrier functions and membrane toxicity in rats.

  2009cites this paper
• Solid lipid nanoparticles for pulmonary delivery of insulin.

  2008cites this paper
• RETRACTED ARTICLE: The Influence of Sodium Hyaluronate, l-Leucine and Sodium Taurocholate on the Nebulization of Aqueous Betamethasone-17-Valerate Suspensions

  2008cites this paper
• Retraction Note on: The Influence of Sodium Hyaluronate, l-Leucine and Sodium Taurocholate on the Nebulization of Aqueous Betamethasone-17-Valerate Suspensions

  2008cites this paper
• Anti-inflammatory effects of locally applied enzyme-loaded ultradeformable vesicles on an acute cutaneous model

  2008cites this paper
• Inhaled insulin--does it become reality?

  2008cites this paper
• Enhancement of Insulin Transport Across Primary Rat Alveolar Epithelial Cell Monolayers by Endogenous Cellular Factor(s)

  2007cites this paper
• The Stability of Insulin in Solid Formulations Containing Melezitose and Starch. Effects of Processing and Excipients

  2006cites this paper
• Effects of Sodium Taurocholate on the Absorption of Inhaled 99mTc-DTPA

  2006cites this paper
• Inhaled Insulin is Better Absorbed When Administered as a Dry Powder Compared to Solution in the Presence or Absence of Alkylglycosides

  2006cites this paper
• Inhaled insulin: a novel and non-invasive way for insulin administration?

  2006cites this paper
• 20 Nasal Delivery of Peptide Drugs

  2006cites this paper
• Developments in the rat adjuvant arthritis model and its use in therapeutic evaluation of novel non-invasive treatment by SOD in Transfersomes.

  2005cites this paper
• Population Pharmacokinetic–Pharmacodynamic Modeling of Subcutaneous and Pulmonary Insulin in Rats

  2005cites this paper
• Rectal and vaginal administration of insulin–chitosan formulations: An experimental study in rabbits

  2005influential citation
• Biophysical approaches for studying the integrity and function of tight junctions.

  2005cites this paper
• The use of absorption enhancers to enhance the dispersibility of spray‐dried powders for pulmonary gene therapy

  2005cites this paper
• Correlation between epithelial toxicity and surfactant structure as derived from the effects of polyethyleneoxide surfactants on caco-2 cell monolayers and pig nasal mucosa.

  2005cites this paper
• Absorption enhancers in pulmonary protein delivery.

  2004cites this paper
• The effect of various liposome formulations on insulin penetration across Caco-2 cell monolayer.

  2004cites this paper
• International Journal of Nanomedicine Dovepress Liposomes Containing Glycocholate as Potential Oral Insulin Delivery Systems: Preparation, in Vitro Characterization, and Improved Protection against Enzymatic Degradation

  year unknowncites this paper