Allelic Variation of HERV-K(HML-2) Endogenous Retroviral Elements in Human Populations

No abstract is available for this paper.

• Publication year

  2004

• Venue

  Journal of Molecular Evolution

• Publication date

  2004-11-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1007/s00239-004-2656-1PMID 15693620
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Complement component C4 gene intron 9 as a phylogenetic marker for primates: long terminal repeats of the endogenous retrovirus ERV-K(C4) are a molecular clock of evolution

  2004influential reference
• Analysis of primate genomic variation reveals a repeat-driven expansion of the human genome.

  2003cited by this paper
• Duplications of the AZFa region of the human Y chromosome are mediated by homologous recombination between HERVs and are compatible with male fertility.

  2003cited by this paper
• SVA elements are nonautonomous retrotransposons that cause disease in humans.

  2003influential reference
• Large-scale variation among human and great ape genomes determined by array comparative genomic hybridization.

  2003cited by this paper
• Genomic DNA insertions and deletions occur frequently between humans and nonhuman primates.

  2003cited by this paper
• Human-specific subfamilies of HERV-K (HML-2) long terminal repeats: three master genes were active simultaneously during branching of hominoid lineages.

  2003influential reference
• A technique for genome-wide identification of differences in the interspersed repeats integrations between closely related genomes and its application to detection of human-specific integrations of HERV-K LTRs.

  2002influential reference
• Modern human origins: progress and prospects.

  2002cited by this paper
• Molecular phylogeny and evolution of the human endogenous retrovirus HERV-W LTR family in hominoid primates.

  2002influential reference
• Non-traditional Alu evolution and primate genomic diversity.

  2002cited by this paper
• Mammalian retroelements.

  2002cited by this paper
• A comprehensive analysis of recently integrated human Ta L1 elements.

  2002cited by this paper
• Genome-wide comparison of differences in the integration sites of interspersed repeats between closely related genomes.

  2002influential reference
• Molecular-evolutionary mechanisms for genomic disorders.

  2002cited by this paper
• Identification of paralogous HERV-K LTRs on human chromosomes 3, 4, 7 and 11 in regions containing clusters of olfactory receptor genes

  2001cited by this paper
• Evidence for genomic rearrangements mediated by human endogenous retroviruses during primate evolution

  2001influential reference
• Initial sequencing and analysis of the human genome

  2001cited by this paper
• Insertional polymorphisms of full-length endogenous retroviruses in humans.

  2001influential reference
• Genomic organization of the human endogenous retrovirus HERV-K(HML-2.HOM) (ERVK6) on chromosome 7.

  2001influential reference
• Evolutionary Dynamics of the Human Endogenous Retrovirus Family HERV-K Inferred from Full-Length Proviral Genomes

  2001influential reference
• HERV-K(OLD): Ancestor Sequences of the Human Endogenous Retrovirus Family HERV-K(HML-2)

  2001influential reference
• Transcriptionally active HERV-K genes: identification, isolation, and chromosomal mapping.

  2001influential reference
• Solitary human endogenous retroviruses-K LTRs retain transcriptional activity in vivo, the mode of which is different in different cell types.

  2001cited by this paper
• Genomic divergences between humans and other hominoids and the effective population size of the common ancestor of humans and chimpanzees.

  2001influential reference
• Full-sized HERV-K (HML-2) human endogenous retroviral LTR sequences on human chromosome 21: map locations and evolutionary history.

  2001influential reference
• Retroviruses and primate evolution.

  2000cited by this paper
• Deletion of azoospermia factor a (AZFa) region of human Y chromosome caused by recombination between HERV15 proviruses.

  2000cited by this paper
• Identification and Characterization of Novel Human Endogenous Retrovirus Families by Phylogenetic Screening of the Human Genome Mapping Project Database

  2000cited by this paper
• Differences in HERV-K LTR insertions in orthologous loci of humans and great apes.

  2000cited by this paper
• Solitary HERV‐K LTRs possess bi‐directional promoter activity and contain a negative regulatory element in the U5 region

  2000cited by this paper
• Practical Quantum Cryptography: A Comprehensive Analysis (Part One)

  2000cited by this paper
• Many human endogenous retrovirus K (HERV-K) proviruses are unique to humans.

  1999cited by this paper
• Structural Constraints on RNA Virus Evolution

  1999cited by this paper
• Constructing primate phylogenies from ancient retrovirus sequences.

  1999cited by this paper
• Genome-Wide Screening, Cloning, Chromosomal Assignment, and Expression of Full-Length Human Endogenous Retrovirus Type K

  1999influential reference
• Biased Nucleotide Composition of the Genome of HERV-K Related Endogenous Retroviruses and Its Evolutionary Implications

  1999cited by this paper
• A human endogenous retrovirus-like (HERV) LTR formed more than 10 million years ago due to an insertion of HERV-H LTR into the 5' LTR of HERV-K is situated on human chromosomes 10, 19 and Y.

  1999cited by this paper
• Proviral Structure, Chromosomal Location, and Expression of HERV-K-T47D, a Novel Human Endogenous Retrovirus Derived from T47D Particles

  1998cited by this paper
• Evolutionary relationships within a subgroup of HERV-K-related human endogenous retroviruses.

  1998cited by this paper
• Subfamilies and nearest-neighbour dendrogram for the LTRs of human endogenous retroviruses HERV-K mapped on human chromosome 19: physical neighbourhood does not correlate with identity level

  1998cited by this paper
• Long terminal repeats of human endogenous retrovirus K family (HERV‐K) specifically bind host cell nuclear proteins

  1998cited by this paper
• Human Endogenous Retrovirus K Homologous Sequences and Their Coding Capacity in Old World Primates

  1998cited by this paper
• Large-scale sequence comparisons reveal unusually high levels of variation in the HLA-DQB1 locus in the class II region of the human MHC.

  1998influential reference
• Human-Specific Integrations of the HERV-K Endogenous Retrovirus Family

  1998influential reference
• Characterization of a Novel Class of Interspersed LTR Elements in Primate Genomes: Structure, Genomic Distribution, and Evolution

  1998cited by this paper
• Functional characterization of the protease of human endogenous retrovirus, K10: can it complement HIV-1 protease?

  1998cited by this paper
• Chromosomal assignment of human endogenous retrovirus K (HERV-K) env open reading frames.

  1997cited by this paper
• Multiple human endogenous retrovirus (HERV-K) loci with gag open reading frames in the human genome.

  1997cited by this paper
• Our retroviral heritage.

  1997cited by this paper
• Human endogenous retroviruses: nature, occurrence, and clinical implications in human disease

  1996cited by this paper
• The viruses in all of us: characteristics and biological significance of human endogenous retrovirus sequences.

  1996cited by this paper
• Endogenous D-type (HERV-K) related sequences are packaged into retroviral particles in the placenta and possess open reading frames for reverse transcriptase.

  1996cited by this paper
• HERV-H endogenous retroviruses: presence in the New World branch but amplification in the Old World primate lineage.

  1995influential reference
• Gene conversion as a secondary mechanism of short interspersed element (SINE) evolution

  1995cited by this paper
• Sex identification of archaeological human remains based on amplification of the X and Y amelogenin alleles.

  1995cited by this paper
• Spliced HERV-H endogenous retroviral sequences in human genomic DNA: evidence for amplification via retrotransposition.

  1995influential reference
• Ancestry of SINE-R.C2 a human-specific retroposon

  1994cited by this paper
• Structure and genetics of the partially duplicated gene RP located immediately upstream of the complement C4A and the C4B genes in the HLA class III region. Molecular cloning, exon-intron structure, composite retroposon, and breakpoint of gene duplication.

  1994cited by this paper
• Characterization of novel reverse transcriptase encoding human endogenous retroviral sequences similar to type A and type B retroviruses: differential transcription in normal human tissues

  1993cited by this paper
• Evolutionary implications of primate endogenous retroviruses.

  1991cited by this paper
• Homologous recombination between the LTRs of a human retrovirus-like element causes a 5-kb deletion in two siblings.

  1989cited by this paper
• Nucleotide sequence of human endogenous retrovirus genome related to the mouse mammary tumor virus genome

  1986cited by this paper

• Compilation of all known HERV-K HML-2 proviral integrations

  2025cites this paper
• Human Endogenous Retrovirus-K (HML-2)-Related Genetic Variation: Human Genome Diversity and Disease

  2023cites this paper
• Marsupial satellite DNA as faithful reflections of long terminal repeat (LTR) retroelement structure.

  2022cites this paper
• Z-DNA–Containing Long Terminal Repeats of Human Endogenous Retrovirus Families Provide Alternative Promoters for Human Functional Genes

  2022cites this paper
• p53 Binding Sites in Long Terminal Repeat 5Hs (LTR5Hs) of Human Endogenous Retrovirus K Family (HML-2 Subgroup) Play Important Roles in the Regulation of LTR5Hs Transcriptional Activity

  2022influential citation
• Influenza A Virus Infection Reactivates Human Endogenous Retroviruses Associated with Modulation of Antiviral Immunity

  2022cites this paper
• Endogenous retrovirus HERV-K6 and HERV-K11 polymorphisms’ analyses in head and neck squamous cell carcinoma patients

  2021cites this paper
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  2020cites this paper
• Differences between human and chimpanzee genomes and their implications in gene expression, protein functions and biochemical properties of the two species

  2020cites this paper
• Human Endogenous Retrovirus K (HML-2) in Health and Disease

  2020cites this paper
• Human Endogenous Retrovirus K in Cancer: A Potential Biomarker and Immunotherapeutic Target

  2020cites this paper
• Human Endogenous Retrovirus K Rec Forms a Regulatory Loop with MITF that Opposes the Progression of Melanoma to an Invasive Stage

  2020cites this paper
• Is the HERV-K HML-2 Xq21.33, an endogenous retrovirus mutated by gene conversion of chromosome X in a subset of African populations, associated with human breast cancer?

  2020cites this paper
• Retrovirus insertion site analysis of LGL leukemia patient genomes

  2019cites this paper
• A model of human endogenous retrovirus (HERV) activation in mental health and illness.

  2019cites this paper
• ERVcaller: identifying polymorphic endogenous retrovirus and other transposable element insertions using whole-genome sequencing data

  2019cites this paper
• Structural variation of centromeric endogenous retroviruses in human populations and their impact on cutaneous T-cell lymphoma, Sézary syndrome, and HIV infection

  2019cites this paper
• Nomenclature for endogenous retrovirus (ERV) loci

  2018cites this paper
• To ERV Is Human: A Phenotype-Wide Scan Linking Polymorphic Human Endogenous Retrovirus-K Insertions to Complex Phenotypes

  2018cites this paper
• Human endogenous retrovirus-K (HML-2): a comprehensive review

  2018cites this paper
• ERVcaller: Identify polymorphic endogenous retrovirus (ERV) and other transposable element (TE) insertions using whole-genome sequencing data

  2018cites this paper
• Variation in proviral content among human genomes mediated by LTR recombination

  2018influential citation
• Diverse endogenous retroviruses generate structural variation between human genomes via LTR recombination

  2018cites this paper
• ERVcaller: Identifying and genotyping non-reference unfixed endogenous retroviruses (ERVs) and other transposable elements (TEs) using next-generation sequencing data

  2018cites this paper
• Biological determinants of health disparities in multiple myeloma

  2018cites this paper
• The role of genetic and environmental immune dysregulation in the etiology of childhood acute lymphoblastic leukemia and other complex diseases

  2017cites this paper
• [DNA sequences from mobile genetic elements, a hidden half of the human genome].

  2017cites this paper
• Characteristics and Relevance of the Interaction between Staufen-1 and Rev-related retroviral Proteins

  2016cites this paper
• A contaminant-free assessment of Endogenous Retroviral RNA in human plasma

  2016cites this paper
• HERV‐K(HML‐2), a seemingly silent subtenant – but still waters run deep

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• Human endogenous retrovirus K (HERV-K) in prostate cancer

  2016cites this paper
• Genome-wide amplification of proviral sequences reveals new polymorphic HERV-K(HML-2) proviruses in humans and chimpanzees that are absent from genome assemblies

  2015influential citation
• Gene activity in primary T cells infected with HIV89.6: intron retention and induction of genomic repeats

  2015cites this paper
• An Evolutionarily Young Polar Bear (Ursus maritimus) Endogenous Retrovirus Identified from Next Generation Sequence Data

  2015cites this paper
• Latency, expression and splicing during infection with HIV

  2015cites this paper
• Molecular functions of human endogenous retroviruses in health and disease

  2015cites this paper
• The Influence of LINE-1 and SINE Retrotransposons on Mammalian Genomes

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• from Human Primary Lymphocytes Retrovirus K ( HML-2 ) Envelopes Derived HIV-1 Interacts with Human Endogenous

  2014cites this paper
• HIV-1 Interacts with Human Endogenous Retrovirus K (HML-2) Envelopes Derived from Human Primary Lymphocytes

  2014cites this paper
• Human endogenous retroviruses and the nervous system.

  2014cites this paper
• Elevated HERV-K mRNA expression in PBMC is associated with a prostate cancer diagnosis particularly in older men and smokers.

  2014cites this paper
• Repetitive elements and epigenetic marks in behavior and psychiatric disease.

  2014cites this paper
• Evolutionary History of the Proviruses HERV‐K 113 and HERV‐K 115

  2014cites this paper
• HERV-K(HML-2), the Best Preserved Family of HERVs: Endogenization, Expression, and Implications in Health and Disease

  2013cites this paper
• Frequency of Human Endogenous Retroviral Sequences (HERV) K113 and K115 in the Polish Population, and Their Effect on HIV Infection

  2013cites this paper
• Human-Specific HERV-K Insertion Causes Genomic Variations in the Human Genome

  2013cites this paper
• Transcriptional Profiling of Human Endogenous Retrovirus Group HERV-K(HML-2) Loci in Melanoma

  2013influential citation
• Genomic flexibility of human endogenous retrovirus type K

  2013cites this paper
• Genomic analysis of ERVWE2 locus in patients with multiple sclerosis: absence of genetic association but potential role of human endogenous retrovirus type W elements in molecular mimicry with myelin antigen

  2013cites this paper
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  2013cites this paper
• Human endogenous retrovirus K gene expression in cutaneous melanoma

  2012cites this paper
• Genomic impact, chromosomal distribution and transcriptional regulation of HERV elements

  2012cites this paper
• LINE-1 elements in structural variation and disease.

  2011cites this paper
• Identification, characterization, and comparative genomic distribution of the HERV-K (HML-2) group of human endogenous retroviruses

  2011influential citation
• Polymorphic Integrations of an Endogenous Gammaretrovirus in the Mule Deer Genome

  2011cites this paper
• Human Endogenous Retrovirus K106 (HERV-K106) Was Infectious after the Emergence of Anatomically Modern Humans

  2011influential citation
• Dynamic control of endogenous retroviruses during development.

  2011cites this paper
• A novel Y chromosome microdeletion with the loss of an endogenous retrovirus related, testis specific transcript in AZFb region.

  2011cites this paper
• Characterization of Human Endogenous Retroviral Elements in the Blood of HIV-1-Infected Individuals

  2011cites this paper
• A functional analysis of retroviral endogenous inserts in view of human genome evolution

  2010cites this paper
• [Functional analysis of retroviral endogenous inserts in the human genome evolution].

  2010cites this paper
• Evolutionary dynamics of endogenous feline leukemia virus proliferation among species of the domestic cat lineage.

  2010cites this paper
• Beneficial and detrimental effects of human endogenous retroviruses

  2010cites this paper
• FUNKTIONELLE CHARAKTERISIERUNG DER HERV-K PROTEINE ENV UND REC

  2010cites this paper
• Reconstitution and Characterization of Human Endogenous Retrovirus-K

  2010cites this paper
• Classification and nomenclature of endogenous retroviral sequences (ERVs): problems and recommendations.

  2009cites this paper
• Reconstitution of the Ancestral Glycoprotein of Human Endogenous Retrovirus K and Modulation of Its Functional Activity by Truncation of the Cytoplasmic Domain

  2009cites this paper
• Molecular mechanisms mediated by human endogenous retroviruses (HERVs) in autoimmunity

  2009cites this paper
• Cross-Sectional Dating of Novel of and Indicate These Proviruses Originated in Africa before Homo sapiens

  2009cites this paper
• Cross-Sectional Dating of Novel Haplotypes of HERV-K 113 and HERV-K 115 Indicate These Proviruses Originated in Africa before Homo sapiens

  2009cites this paper
• human genome Mobile elements create structural variation : Analysis of a complete Material Supplemental

  2009cites this paper
• Loss of epigenetic silencing in tumors preferentially affects primate-specific retroelements.

  2009influential citation
• The role of human endogenous retroviruses in melanoma

  2009cites this paper
• Mobile elements create structural variation: analysis of a complete human genome.

  2009cites this paper
• Human Endogenous Retrovirus (HERV-K) Reverse Transcriptase as a Breast Cancer

  2008cites this paper
• Endogenous retroviruses

  2008cites this paper
• Molecular cloning and functional characterization of the human endogenous retrovirus K113.

  2008cites this paper
• Human endogenous retrovirus (HERV-K) reverse transcriptase as a breast cancer prognostic marker.

  2008cites this paper
• An investigation into the distribution of human molecular genetic variation in Sub-Saharan Africa

  2008cites this paper
• Expression patterns of transcribed human endogenous retrovirus HERV-K(HML-2) loci in human tissues and the need for a HERV Transcriptome Project

  2008cites this paper
• Human RNA “Rumor” Viruses: the Search for Novel Human Retroviruses in Chronic Disease

  2008cites this paper
• Effects of retroviruses on host genome function.

  2008cites this paper
• Human Endogenous Retrovirus (HERV-K) Reverse Transcriptase as a Breast Cancer Prognostic Marker 1,2,3

  2008cites this paper
• Human-Specific Endogenous Retroviruses

  2007cites this paper
• Expression pattern analysis of transcribed HERV sequences is complicated by ex vivo recombination

  2007cites this paper
• Directly accessing de novo L1 retrotransposition in the human germline

  2007cites this paper
• The 193-Base Pair Gsg2 (Haspin) Promoter Region Regulates Germ Cell-Specific Expression Bidirectionally and Synchronously

  2007cites this paper
• Insertional polymorphisms: a new lease of life for endogenous retroviruses in human disease.

  2007cites this paper
• Infectious agents and gene–environmental interactions in the etiopathogenesis of schizophrenia

  2006cites this paper
• [Retroviruses-derived sequences in the human genome. Human endogenous retroviruses (HERVs)].

  2006cites this paper
• Insertional polymorphism of endogenous retrovirus HERV-K115 in schizophrenia.

  2006cites this paper
• At Least 50% of Human-Specific HERV-K (HML-2) Long Terminal Repeats Serve In Vivo as Active Promoters for Host Nonrepetitive DNA Transcription

  2006cites this paper
• Functional human endogenous retroviral LTR transcription start sites are located between the R and U5 regions.

  2006cites this paper
• Ancient retroviral insertions among human populations

  2006cites this paper
• The evolutionary dynamics of human endogenous retroviral families.

  2006cites this paper
• Haplotype Analysis of the Human Endogenous Retrovirus Locus HERV-K(HML-2.HOM) and Its Evolutionary Implications

  2005influential citation
• The distribution of the endogenous retroviruses HERV-K113 and HERV-K115 in health and disease.

  2005cites this paper
• The evolutionary dynamics of endogenous retroviruses.

  2005cites this paper
• Human natural killer cells: a comprehensive review.

  2005cites this paper
• List of papers

  1995cites this paper