Antiviral properties and interaction of novel chalcone derivatives containing a purine and benzenesulfonamide moiety.

A new concise and facile method was explored to synthesize a series of novel chalcone derivatives containing a purine and benzenesulfonamide moiety and their antiviral properties were evaluated against TMV and CMV. Biological assays indicated that several of the derivatives exhibited significant anti-TMV and anti-CMV activities in vivo. In particular, compound d2 displayed excellent inactivating activity against TMV, with the EC50 value of 51.65 μg/mL, which was better than that of ribavirin (150.45 μg/mL). Molecular docking showed that there are four hydrogen bonds between compound d2 and TMV coat protein (TMV-CP). Compound d2 demonstrated strong binding capacity to TMV-CP with Ka = 1.58 × 105 L/mol and Kd = 12.16 μM. These findings indicated that chalcone derivatives are worthy of further research and development as templates for new antiviral agents.

• Publication year

  2018

• Venue

  Bioorganic & Medicinal Chemistry Letters

• Publication date

  2018-06-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1016/j.bmcl.2018.04.042PMID 29724588
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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