Perfluorooctane sulfonate effects on the reproductive axis in adult male rats.

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Environmental Research

• Publication date

  2014-10-01

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1016/j.envres.2014.07.006PMID 25171141
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• PFOS (perfluorooctanesulfonate) in serum is negatively associated with testosterone levels, but not with semen quality, in healthy men.

  2014cited by this paper
• The kisspeptin-GnRH pathway in human reproductive health and disease

  2014cited by this paper
• Regulation of spermatogenesis: an evolutionary biologist's perspective.

  2014cited by this paper
• Regulation of corticosterone secretion is modified by PFOS exposure at different levels of the hypothalamic-pituitary-adrenal axis in adult male rats.

  2014cited by this paper
• Exposure to Perfluorooctane Sulfonate In Utero Reduces Testosterone Production in Rat Fetal Leydig Cells

  2014cited by this paper
• Perfluorooctanesulfonate (PFOS) perturbs male rat Sertoli cell blood-testis barrier function by affecting F-actin organization via p-FAK-Tyr(407): an in vitro study.

  2014cited by this paper
• Cooking fish is not effective in reducing exposure to perfluoroalkyl and polyfluoroalkyl substances.

  2014cited by this paper
• Physiological roles of gonadotropin-inhibitory hormone signaling in the control of mammalian reproductive axis: studies in the NPFF1 receptor null mouse.

  2014cited by this paper
• Sorption of perfluorooctane sulfonate to carbon nanotubes in aquatic sediments.

  2013cited by this paper
• Sertoli cell is a potential target for perfluorooctane sulfonate-induced reproductive dysfunction in male mice.

  2013cited by this paper
• A single neonatal exposure to perfluorohexane sulfonate (PFHxS) affects the levels of important neuroproteins in the developing mouse brain.

  2013cited by this paper
• Neurotoxicity of Perfluorooctane Sulfonate to Hippocampal Cells in Adult Mice

  2013cited by this paper
• The hypothalamic-pituitary-gonadal axis is target of cadmium toxicity. An update of recent studies and potential therapeutic approaches.

  2013cited by this paper
• Occurrence of perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) in N.E. Spanish surface waters and their removal in a drinking water treatment plant that combines conventional and advanced treatments in parallel lines.

  2013cited by this paper
• Regulation of gonadotropins by corticotropin-releasing factor and urocortin

  2013cited by this paper
• Effects of an Early Experience Involving Training in a T-Maze Under either Denial or Receipt of Expected Reward through Maternal Contact

  2013cited by this paper
• PFOS (perfluorooctanesulfonate) in serum is negatively associated with testosterone levels, but not with semen quality, in healthy men.

  2013cited by this paper
• Bioaccumulation of perfluoroalkyl acids in dairy cows in a naturally contaminated environment

  2013cited by this paper
• Perfluorooctane sulfonate (PFOS) affects hormone receptor activity, steroidogenesis, and expression of endocrine‐related genes in vitro and in vivo

  2013cited by this paper
• PFOS elicits transcriptional responses of the ER, AHR and PPAR pathways in Oryzias melastigma in a stage-specific manner.

  2012cited by this paper
• Perfluorooctane sulfonate induces apoptosis of cerebellar granule cells via a ROS-dependent protein kinase C signaling pathway.

  2012cited by this paper
• Neurotoxic effects of perfluoroalkylated compounds: mechanisms of action and environmental relevance

  2012cited by this paper
• Human dietary exposure to perfluoroalkyl substances in Catalonia, Spain. Temporal trend.

  2012cited by this paper
• Perfluorinated compounds in surficial sediments of the Ganges River and adjacent Sundarban mangrove wetland, India.

  2012cited by this paper
• Perfluorooctane sulfonate triggers tight junction "opening" in brain endothelial cells via phosphatidylinositol 3-kinase.

  2011cited by this paper
• Modulatory Effects of Melatonin on Cadmium-Induced Changes in Biogenic Amines in Rat Hypothalamus

  2011cited by this paper
• The inhibition of human and rat 11β-hydroxysteroid dehydrogenase 2 by perfluoroalkylated substances.

  2011cited by this paper
• Occurrence of perfluorinated compounds in water, sediment and mussels from the Cantabrian Sea (North Spain).

  2011cited by this paper
• Induction of apoptosis and CYP4A1 expression in Sprague-Dawley rats exposed to low doses of perfluorooctane sulfonate.

  2011cited by this paper
• Type 1 and Type 2 cytokines imbalance in adult male C57BL/6 mice following a 7-day oral exposure to perfluorooctanesulfonate (PFOS)

  2011cited by this paper
• Testicular Signaling Is the Potential Target of Perfluorooctanesulfonate-Mediated Subfertility in Male Mice1

  2011cited by this paper
• Combined effects of perfluorooctane sulfonate (PFOS) and maternal restraint stress on hypothalamus adrenal axis (HPA) function in the offspring of mice.

  2010cited by this paper
• Gestational and lactational exposure to potassium perfluorooctanesulfonate (K+PFOS) in rats: toxicokinetics, thyroid hormone status, and related gene expression.

  2009cited by this paper
• Neurotoxicity of perfluorooctane sulfonate (PFOS) in rats and mice after single oral exposure.

  2009cited by this paper
• Studies on the Toxicological Effects of PFOA and PFOS on Rats Using Histological Observation and Chemical Analysis

  2009cited by this paper
• The effect of perfluorododecanonic acid on endocrine status, sex hormones and expression of steroidogenic genes in pubertal female rats.

  2009cited by this paper
• Perfluorooctane sulfonate (PFOS), perfluorooctanoic acid (PFOA) and their salts Scientific Opinion of the Panel on Contaminants in the Food chain.

  2008cited by this paper
• Human exposure to perfluorinated chemicals through the diet: intake of perfluorinated compounds in foods from the Catalan (Spain) market.

  2008cited by this paper
• Norepinephrine suppresses gonadotropin-releasing hormone neuron excitability in the adult mouse.

  2008cited by this paper
• Neonatal exposure to perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) causes neurobehavioural defects in adult mice.

  2008cited by this paper
• Brain Norepinephrine: Regulation of gene transcription in the central nervous system by norepinephrine

  2007cited by this paper
• Occurrence of perfluorinated substances in an adult German population in southern Bavaria

  2007cited by this paper
• Behavioral effects in adult mice exposed to perfluorooctane sulfonate (PFOS).

  2007cited by this paper
• Dietary exposure of Canadians to perfluorinated carboxylates and perfluorooctane sulfonate via consumption of meat, fish, fast foods, and food items prepared in their packaging.

  2007cited by this paper
• Perfluorinated chemicals in blood of residents in Catalonia (Spain) in relation to age and gender: a pilot study.

  2007cited by this paper
• Biomagnification of perfluoroalkyl compounds in the bottlenose dolphin (Tursiops truncatus) food web.

  2006cited by this paper
• Ecotoxicological evaluation of perfluorooctanesulfonate (PFOS).

  2006cited by this paper
• Is fish a major source of fluorinated surfactants and repellents in humans living on the Baltic Coast?

  2006cited by this paper
• Regulation of endocrine-disrupting chemicals: critical overview and deficiencies in toxicology and risk assessment for human health.

  2006cited by this paper
• Role of noradrenergic projections to the bed nucleus of the stria terminalis in the regulation of the hypothalamic-pituitary-adrenal axis.

  2004cited by this paper
• Perfluorooctanesulfonate and related fluorochemicals in human blood from several countries.

  2004cited by this paper
• Gonadotropin-releasing hormone (GnRH) neurons and pathways in the rat brain

  2004cited by this paper
• Sub-chronic dietary toxicity of potassium perfluorooctanesulfonate in rats.

  2003cited by this paper
• Neuroendocrine effects of perfluorooctane sulfonate in rats.

  2003cited by this paper
• Exposure to perfluorooctane sulfonate during pregnancy in rat and mouse. II: postnatal evaluation.

  2003cited by this paper
• Importance of the paraventricular nucleus of the hypothalamus as a component of a neural pathway between the brain and the testes that modulates testosterone secretion independently of the pituitary.

  2003cited by this paper
• Quantification of MYCN, DDX1, and NAG Gene Copy Number in Neuroblastoma Using a Real-Time Quantitative PCR Assay

  2002cited by this paper
• Neuroendocrine vs. paracrine control of follicle-stimulating hormone.

  2001cited by this paper
• The Intracerebroventricular Injection of Interleukin-1β Blunts the Testosterone Response to Human Chorionic Gonadotropin: Role of Prostaglandin- and Adrenergic-Dependent Pathways.

  1998cited by this paper
• The intracerebroventricular injection of interleukin-1beta blunts the testosterone response to human chorionic gonadotropin: role of prostaglandin- and adrenergic-dependent pathways.

  1998cited by this paper
• Noradrenergic regulation of cyclic GnRH secretion.

  1997cited by this paper
• Brain gonadotropin releasing hormone receptors: localization and regulation.

  1997cited by this paper
• Differential secretion of follicle-stimulating hormone and luteinizing hormone from ovine pituitary cells following activation of protein kinase A, protein kinase C, or increased intracellular calcium.

  1994cited by this paper
• Ultrastructure of hypothalamic paraventricular neurons.

  1993cited by this paper
• Biological characterization of the naturally occurring analogues of intrapituitary human follicle-stimulating hormone.

  1992cited by this paper
• A norepinephrine-dependent mechanism in the preoptic/anterior hypothalamic area but not in the mediobasal hypothalamus is involved in the regulation of the gonadotropin-releasing hormone pulse generator in ovariectomized rats.

  1990cited by this paper
• Endocrinology of the hypothalamic-pituitary-testicular axis with particular reference to the hormonal control of spermatogenesis.

  1987cited by this paper
• Further evidence that luteinizing hormone-releasing hormone also is follicle-stimulating hormone-releasing hormone.

  1979cited by this paper
• Pituitary gland: site of short-loop feedback for luteinizing hormone in the rabbit.

  1979cited by this paper
• A quantitative study on feedback control of LH by testosterone in young adult and old male rats.

  1978cited by this paper
• Gonadotropin-Releasing Hormone: One Polypeptide Regulates Secretion of Luteinizing and Follicle-Stimulating Hormones

  1971cited by this paper

• Association between prenatal exposure to per- and polyfluoroalkyl substances and pubertal development in boys and girls in the Spanish INMA cohort.

  2026cites this paper
• Systematic review and Integrated Approaches to Testing and Assessment (IATA) of PFOA and PFOS for endocrine disrupting effects based on the AOP framework

  2025cites this paper
• 1α,25(OH)2D3 alleviates perfluorooctane sulfonic acid-induced oxidative injury through the Nrf2-ARE pathway via VDR in Sertoli cells

  2025cites this paper
• Exposure of mice to environmentally relevant per- and polyfluoroalkyl substances (PFAS) alters the sperm epigenome

  2025cites this paper
• Potential human health effects of per- and polyfluoroalkyl substances (PFAS) prevalent in aquatic environment: a review

  2025cites this paper
• Advancing the understanding of PFAS-induced reproductive toxicity in key model species.

  2025cites this paper
• Reproductive toxicity of PFOA, PFOS and their substitutes: A review based on epidemiological and toxicological evidence.

  2024cites this paper
• Role of Rab proteins in PFOA-induced changes in boar sperm motility and capacitation.

  2024cites this paper
• Advances in immunology of male reproductive toxicity induced by common environmental pollutants.

  2024cites this paper
• How Per- and Poly-Fluoroalkyl Substances Affect Gamete Viability and Fertilization Capability: Insights from the Literature

  2024cites this paper
• PFAS: exploration of neurotoxicity and environmental impact

  2024cites this paper
• Toxic effects of per- and polyfluoroalkyl substances on sperm: Epidemiological and experimental evidence

  2023cites this paper
• Perfluorooctanoic acid suppresses sperm functions via abnormal Protein Kinase B activation during capacitation.

  2023cites this paper
• PFOS and F-53B disrupted inner cell mass development in mouse preimplantation embryo.

  2023cites this paper
• Protective effect of curcumin against perfluorooctane sulfonate induced oxidative stress

  2023cites this paper
• PFAS and Phthalate/DINCH Exposure in Association with Age at Menarche in Teenagers of the HBM4EU Aligned Studies

  2023cites this paper
• A Nested Case–Control Study of Serum Per- and Polyfluoroalkyl Substances and Testicular Germ Cell Tumors among U.S. Air Force Servicemen

  2023cites this paper
• Perfluoroundecanoic acid induces DNA damage, reproductive and pathophysiological dysfunctions via oxidative stress in male Swiss mice.

  2023cites this paper
• Effect of prenatal perfluoroheptanoic acid exposure on spermatogenesis in offspring mice.

  2023cites this paper
• PFAS association with kisspeptin and sex hormones in teenagers of the HBM4EU aligned studies.

  2023cites this paper
• Putative adverse outcome pathways of the male reproductive toxicity derived from toxicological studies of perfluoroalkyl acids.

  2023cites this paper
• Endocrine-Disrupting Chemicals and Their Effects in Pet Dogs and Cats: An Overview

  2023cites this paper
• Toward a Mechanistic Understanding of Poly- and Perfluoroalkylated Substances and Cancer

  2022cites this paper
• 1α,25‐dihydroxyvitamin D3 supplementation alleviates perfluorooctanesulfonate acid‐induced reproductive injury in male mice: Modulation of Nrf2 mediated oxidative stress response

  2022cites this paper
• Neurotransmission Targets of Per- and Polyfluoroalkyl Substance Neurotoxicity: Mechanisms and Potential Implications for Adverse Neurological Outcomes.

  2022cites this paper
• Perfluorooctanesulfonic acid exposure altered hypothalamic metabolism and disturbed male fecundity.

  2022cites this paper
• Effects of an environmentally relevant PFAS mixture on dopamine and steroid hormone levels in exposed mice.

  2021cites this paper
• Perfluoroalkyl Chemicals and Male Reproductive Health: Do PFOA and PFOS Increase Risk for Male Infertility?

  2021cites this paper
• Male reproductive health at risk due to exposure to perfluoroalkyl substances: Recent research highlights

  2021cites this paper
• Overview of the Mechanisms of Action of Selected Bisphenols and Perfluoroalkyl Chemicals on the Male Reproductive Axes

  2021cites this paper
• Impact of Endocrine Disruptors on Male Sexual Development

  2021cites this paper
• Impact of endocrine disruptors on neurons expressing GnRH or kisspeptin and pituitary gonadotropin.

  2021cites this paper
• Signaling Proteins That Regulate Spermatogenesis Are the Emerging Target of Toxicant-Induced Male Reproductive Dysfunction

  2021cites this paper
• Endocrine disruption by PFAS: A major concern associated with legacy and replacement substances

  2021cites this paper
• Perfluorooctane Sulfonate (PFOS) Disrupts Testosterone Biosynthesis via CREB/CRTC2/StAR Signaling Pathway in Leydig Cells.

  2020cites this paper
• Exposure to per- and polyfluoroalkyl substances (PFASs) in serum versus semen and their association with male reproductive hormones.

  2020cites this paper
• F-53B and PFOS treatments skew human embryonic stem cell in vitro cardiac differentiation towards epicardial cells by partly disrupting the WNT signaling pathway.

  2020cites this paper
• Perfluoroalkyl chemicals in neurological health and disease: Human concerns and animal models.

  2020cites this paper
• Linking emerging contaminants exposure to adverse health effects: Crosstalk between epigenome and environment

  2020cites this paper
• Alteration of neuro-dopamine and steroid hormone homeostasis in wild Bank voles in relation to tissue concentrations of PFAS at a Nordic skiing area.

  2020cites this paper
• Perfluorooctane sulfonate exposure alters sexual behaviors and transcriptions of genes in hypothalamic-pituitary-gonadal-liver axis of male zebrafish (Danio rerio).

  2020cites this paper
• Endocrine disruptors of inhibiting testicular 3β-hydroxysteroid dehydrogenase.

  2019cites this paper
• Assessing the human health risks of perfluorooctane sulfonate by in vivo and in vitro studies.

  2019cites this paper
• Human health risks due to exposure to inorganic and organic chemicals from textiles: A review

  2019cites this paper
• Water and soil pollution as determinant of water and food quality/contamination and its impact on male fertility

  2019cites this paper
• Impact of perfluorochemicals on human health and reproduction: a male’s perspective

  2018cites this paper
• Perfluorooctane sulfonate impairs rat Leydig cell development during puberty.

  2018cites this paper
• Perfluoroalkyl Substances in the Environment

  2018cites this paper
• Endocrine Disruption of Androgenic Activity by Perfluoroalkyl Substances: Clinical and Experimental Evidence

  2018cites this paper
• Subchronic reproductive effects of 6:2 chlorinated polyfluorinated ether sulfonate (6:2 Cl-PFAES), an alternative to PFOS, on adult male mice.

  2018cites this paper
• Impact of Perfluorooctane Sulfonate on Reproductive Ability of Female Mice through Suppression of Estrogen Receptor &agr;-Activated Kisspeptin Neurons

  2018cites this paper
• Perfluorooctane sulfonate (PFOS) can alter the hypothalamic-pituitary-adrenal (HPA) axis activity by modifying CRF1 and glucocorticoid receptors.

  2018cites this paper
• Acute toxicity effects of perfluorooctane sulfonate on sperm vitality, kinematics and fertilization success in zebrafish

  2017cites this paper
• Testosterone and Endocrine Disruptors: Influence of Endocrine Disruptors on Male Reproductive Tract

  2017cites this paper
• Estrogen receptor beta mediates hepatotoxicity induced by perfluorooctane sulfonate in mouse

  2017cites this paper
• The expression of several reproductive hormone receptors can be modified by perfluorooctane sulfonate (PFOS) in adult male rats.

  2016cites this paper
• Perfluorooctane sulfonate (PFOS) exposure could modify the dopaminergic system in several limbic brain regions.

  2016cites this paper
• Health Effects Support Document for Perfluorooctane Sulfonate (PFOS)

  2016cites this paper
• Perfluorooctane sulfonate-induced testicular toxicity and differential testicular expression of estrogen receptor in male mice.

  2016cites this paper
• Perfluoroalkyl and polyfluoroalkyl substances and measures of human fertility: a systematic review

  2016influential citation
• The Association of Prenatal Exposure to Perfluorinated Chemicals with Glucocorticoid and Androgenic Hormones in Cord Blood Samples: The Hokkaido Study

  2016cites this paper
• Possible role of serotonin and neuropeptide Y on the disruption of the reproductive axis activity by perfluorooctane sulfonate.

  2015cites this paper
• Perfluorooctane Sulfonate Concentrations in Amniotic Fluid, Biomarkers of Fetal Leydig Cell Function, and Cryptorchidism and Hypospadias in Danish Boys (1980–1996)

  2015cites this paper
• Initial study on the possible mechanisms involved in the effects of high doses of perfluorooctane sulfonate (PFOS) on prolactin secretion.

  2015cites this paper
• PERFLUOROOCTANOIC ACID (PFOA) AND PERFLUOROOCTANESULFONIC

  year unknowncites this paper