Caffeoylquinic Acids in Centella asiatica Protect against Amyloid-β Toxicity

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Journal of Alzheimer's Disease

• Publication date

  2014-03-31

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.3233/JAD-131913PMID 24448790PMCID PMC3973491
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Curcumin attenuates amyloid-β-induced tau hyperphosphorylation in human neuroblastoma SH-SY5Y cells involving PTEN/Akt/GSK-3β signaling pathway

  2014cited by this paper
• Dose-dependent folic acid and memantine treatments promote synergistic or additive protection against Aβ(25-35) peptide-induced apoptosis in SH-SY5Y cells mediated by mitochondria stress-associated death signals.

  2013cited by this paper
• Mitochondrial Ferritin Attenuates β-Amyloid-Induced Neurotoxicity: Reduction in Oxidative Damage Through the Erk/P38 Mitogen-Activated Protein Kinase Pathways

  2013cited by this paper
• Centella asiatica attenuates the neurobehavioral, neurochemical and histological changes in transient focal middle cerebral artery occlusion rats

  2013cited by this paper
• Caffeoylquinic acid-rich purple sweet potato extract, with or without anthocyanin, imparts neuroprotection and contributes to the improvement of spatial learning and memory of SAMP8 mouse.

  2013cited by this paper
• Attenuation of β-Amyloid-Induced Oxidative Cell Death by Sulforaphane via Activation of NF-E2-Related Factor 2

  2013cited by this paper
• Neuritogenic effect of standardized extract of Centella asiatica ECa233 on human neuroblastoma cells

  2013cited by this paper
• Intraneuronal tau aggregation precedes diffuse plaque deposition, but amyloid-β changes occur before increases of tau in cerebrospinal fluid

  2013cited by this paper
• Tau protein kinases: involvement in Alzheimer's disease.

  2013cited by this paper
• Wild‐type, Flemish, and Dutch amyloid‐β exhibit different cytotoxicities depending on Aβ40 to Aβ42 interaction time and concentration ratio

  2013cited by this paper
• Tanshinones inhibit amyloid aggregation by amyloid-β peptide, disaggregate amyloid fibrils, and protect cultured cells.

  2013cited by this paper
• Caffeinated coffee, decaffeinated coffee, and the phenolic phytochemical chlorogenic acid up-regulate NQO1 expression and prevent H₂O₂-induced apoptosis in primary cortical neurons.

  2012cited by this paper
• Neuroprotection of Ilex latifolia and caffeoylquinic acid derivatives against excitotoxic and hypoxic damage of cultured rat cortical neurons

  2012cited by this paper
• Centella asiatica Extract Improves Behavioral Deficits in a Mouse Model of Alzheimer's Disease: Investigation of a Possible Mechanism of Action

  2012cited by this paper
• EVALUATION OF PHYTOCHEMICALS, ANTIOXIDANT ACTIVITY AND NUTRIENT CONTENT OF CENTELLA ASIATICA (L.) URBAN LEAVES FROM DIFFERENT LOCALITIES OF ASSAM

  2012cited by this paper
• Notes on the occurrence and significance of triterpenoids (asiaticoside and related compounds) and caffeoylquinic acids in Centella species

  2012cited by this paper
• Caffeic acid ester fraction from Erigeron breviscapus inhibits microglial activation and provides neuroprotection

  2012cited by this paper
• Asiatic acid protects primary neurons against C2-ceramide-induced apoptosis.

  2012cited by this paper
• Hyperphosphorylation of Tau Induced by Naturally Secreted Amyloid-β at Nanomolar Concentrations Is Modulated by Insulin-dependent Akt-GSK3β Signaling Pathway*

  2012cited by this paper
• Asiatic acid, a pentacyclic triterpene in Centella asiatica, attenuates glutamate-induced cognitive deficits in mice and apoptosis in SH-SY5Y cells

  2012cited by this paper
• Protective effects of caffeoylquinic acids on the aggregation and neurotoxicity of the 42-residue amyloid β-protein.

  2012cited by this paper
• Asp664 cleavage of amyloid precursor protein induces tau phosphorylation by decreasing protein phosphatase 2A activity

  2012cited by this paper
• Proteomic study of amyloid beta (25–35) peptide exposure to neuronal cells: Impact on APE1/Ref‐1's protein–protein interaction

  2012cited by this paper
• Accuracy, precision, and reliability of chemical measurements in natural products research.

  2011cited by this paper
• Pre-aggregated Aβ1–42 peptide increases tau aggregation and hyperphosphorylation after short-term application

  2011cited by this paper
• Inhibition of glycogen synthase kinase‐3β by Angelica sinensis extract decreases β‐amyloid‐induced neurotoxicity and tau phosphorylation in cultured cortical neurons

  2011cited by this paper
• 3,4,5-tri-O-caffeoylquinic acid inhibits amyloid β-mediated cellular toxicity on SH-SY5Y cells through the upregulation of PGAM1 and G3PDH

  2011cited by this paper
• 1,5-dicaffeoylquinic acid protects primary neurons from amyloid β 1-42-induced apoptosis via PI3K/Akt signaling pathway.

  2011cited by this paper
• The antiepileptic effect of Centella asiatica on the activities of Na+/K+, Mg2+ and Ca2+-ATPases in rat brain during pentylenetetrazol–induced epilepsy

  2010cited by this paper
• Neuroprotective effect of 3,5-di-O-caffeoylquinic acid on SH-SY5Y cells and senescence-accelerated-prone mice 8 through the up-regulation of phosphoglycerate kinase-1.

  2010cited by this paper
• Neuroprotective effect of Centella asiatica extract (CAE) on experimentally induced parkinsonism in aged Sprague-Dawley rats.

  2010cited by this paper
• Indirubin-3'-monoxime inhibits beta-amyloid-induced neurotoxicity in neuroblastoma SH-SY5Y cells.

  2009cited by this paper
• Pentacyclic Triterpenoids from the Medicinal Herb, Centella asiatica (L.) Urban

  2009cited by this paper
• Centella asiatica extract selectively decreases amyloid β levels in hippocampus of Alzheimer's disease animal model

  2009cited by this paper
• Tau phosphorylation: the therapeutic challenge for neurodegenerative disease.

  2009cited by this paper
• Effect of Centella asiatica leaf powder on oxidative markers in brain regions of prepubertal mice in vivo and its in vitro efficacy to ameliorate 3-NPA-induced oxidative stress in mitochondria.

  2008cited by this paper
• EFFECT OF CENTELLA ASIATICA ON MILD COGNITIVE IMPAIRMENT (MCI) AND OTHER COMMON AGE-RELATED CLINICAL PROBLEMS

  2008cited by this paper
• Positive modulation of cognition and mood in the healthy elderly volunteer following the administration of Centella asiatica.

  2008cited by this paper
• Quality Assurance of Herbal Raw Materials in Supply Chain: Challenges and Opportunities

  2008cited by this paper
• Forecasting the global burden of Alzheimer's disease

  2007cited by this paper
• Effects of chemical chaperones on oxidative stress and detergent-insoluble species formation following conditional expression of amyloid precursor protein carboxy-terminal fragment.

  2007cited by this paper
• Kinases and phosphatases and tau sites involved in Alzheimer neurofibrillary degeneration

  2007cited by this paper
• Enhancement of Amygdaloid Neuronal Dendritic Arborization by Fresh Leaf Juice of Centella asiatica (Linn) During Growth Spurt Period in Rats

  2007cited by this paper
• Effect of Centella asiatica on arsenic induced oxidative stress and metal distribution in rats

  2006cited by this paper
• Centella asiatica accelerates nerve regeneration upon oral administration and contains multiple active fractions increasing neurite elongation in‐vitro

  2005cited by this paper
• In vitro model of neurotoxicity of Aβ 1–42 and neuroprotection by a pentapeptide: irreversible events during the first hour

  2004cited by this paper
• Advanced glycation endproduct precursor alters intracellular amyloid- β/AβPP carboxy-terminal fragment aggregation and cytotoxicity

  2004cited by this paper
• Inhibitory Effects of Centella asiatica Water Extract and Asiaticoside on Inducible Nitric Oxide Synthase During Gastric Ulcer Healing in Rats

  2004cited by this paper
• Neuroprotective effect of genistein against beta amyloid-induced neurotoxicity.

  2004cited by this paper
• Effect of Centella asiatica on cognition and oxidative stress in an intracerebroventricular streptozotocin model of Alzheimer's disease in rats

  2003cited by this paper
• Antioxidative activity and total phenolic compounds of leaf, root and petiole of four accessions of Centella asiatica (L.) Urban

  2003cited by this paper
• Effect of Centella asiatica on pentylenetetrazole-induced kindling, cognition and oxidative stress in rats.

  2003cited by this paper
• Signaling Events in Amyloid β-Peptide-induced Neuronal Death and Insulin-like Growth Factor I Protection*

  2002cited by this paper
• Abeta 17-42 in Alzheimer's disease activates JNK and caspase-8 leading to neuronal apoptosis.

  2002cited by this paper
• Use of alternative therapies in older outpatients in the United States and Japan: prevalence, reporting patterns, and perceived effectiveness.

  2001cited by this paper
• PP2A mRNA expression is quantitatively decreased in Alzheimer's disease hippocampus.

  2001cited by this paper
• The molecular bases of Alzheimer's disease and other neurodegenerative disorders.

  2001cited by this paper
• Chemical, pharmacological and clinical profile of the East Asian medical plant Centella asiatica.

  2000cited by this paper
• Oligomerization and toxicity of beta-amyloid-42 implicated in Alzheimer's disease.

  2000cited by this paper
• Complementary and alternative medicine use among elderly persons: one-year analysis of a Blue Shield Medicare supplement.

  2000cited by this paper
• Oligomerization and Toxicity of β-Amyloid-42 Implicated in Alzheimer's Disease

  2000cited by this paper
• Transgenic mice expressing Alzheimer amyloid precursor proteins.

  1998cited by this paper
• Neurodegenerative mechanisms in Alzheimer disease. A role for oxidative damage in amyloid beta protein precursor-mediated cell death.

  1996influential reference
• Restoration of biological activity of Alzheimer abnormally phosphorylated tau by dephosphorylation with protein phosphatase-2A, -2B and -1.

  1996cited by this paper
• Plant drug analysis : a thin layer chromatography atlas

  1996cited by this paper
• Dephosphorylation of Alzheimer Paired Helical Filaments by Protein Phosphatase-2A and −2B (*)

  1995cited by this paper
• Phosphatase Activity Toward Abnormally Phosphorylated τ: Decrease in Alzheimer Disease Brain

  1995cited by this paper
• Cytotoxicity mediated by conditional expression of a carboxyl-terminal derivative of the beta-amyloid precursor protein.

  1994cited by this paper
• Phosphoprotein Phosphatase Activities in Alzheimer Disease Brain

  1993cited by this paper
• Neurotrophic and neurotoxic effects of amyloid beta protein: reversal by tachykinin neuropeptides.

  1990cited by this paper

• Diversity, characterization of medicinal potential, and analysis of understory plant species on the lowland tropical forest floor in Mount Ciremai National Park, Indonesia.

  2026cites this paper
• Phytochemical Profiling and Antioxidant Activity of True Leaves and Cotyledons of Adenocaulon himalaicum

  2025cites this paper
• Oral Asiatic Acid Improves Cognitive Function and Modulates Antioxidant and Mitochondrial Pathways in Female 5xFAD Mice

  2025cites this paper
• Development of a Proton Spin Network Fingerprint Library to Support Mass Spectrometry-Based Identification of Pharmacophore-Bearing Constituents in the Botanical Supplement Centella asiatica.

  2025cites this paper
• Interlinking Diabetes and Alzheimer's Disease: A Pathway Through Medicinal Plant-Based Treatments.

  2025cites this paper
• Reevaluating Alzheimer's disease treatment: Can phytochemicals bridge the therapeutic Gap?

  2025cites this paper
• Comparative Analysis of Root Phenolic Profiles and Antioxidant Activity of Five Native and Invasive Solidago L. Species

  2024cites this paper
• Centella asiatica and its caffeoylquinic acid and triterpene constituents increase dendritic arborization of mouse primary hippocampal neurons and improve age-related locomotion deficits in Drosophila

  2024cites this paper
• Decoding eggplant fruit: Multi-omics profiling of caffeoyl-CoA-3-OMT expression

  2024cites this paper
• Neuroprotective effect against amyloidogenic transthyretin aggregates - Induced cytotoxicity on human neuroblastoma cell by phenolic-rich Centella asiatica extract

  2024cites this paper
• Centella asiatica improves cognitive function and alters the hippocampal metabolome of aged Tg2576 and wild-type mice

  2024cites this paper
• Influence of Bilberry Extract on Neuronal Cell Toxicity

  2024cites this paper
• Caffeoylquinic Acid Mitigates Neuronal Loss and Cognitive Decline in 5XFAD Mice Without Reducing the Amyloid-β Plaque Burden

  2024cites this paper
• Quinic and caffeic acids derivatives: Affecting antioxidant capacities and phenolics contents of certain therapeutic and specialty crops employing water and ethanolic extracts

  2024cites this paper
• Effects of Cooking Methods on Caffeoylquinic Acids and Radical Scavenging Activity of Sweet Potato

  2024cites this paper
• Asiatic acid improves mitochondrial function, activates antioxidant response in the mouse brain and improves cognitive function in beta-amyloid overexpressing mice

  2024cites this paper
• Integrating High-Resolution Mass Spectral Data, Bioassays and Computational Models to Annotate Bioactives in Botanical Extracts: Case Study Analysis of C. asiatica Extract Associates Dicaffeoylquinic Acids with Protection against Amyloid-β Toxicity

  2024influential citation
• Perspective: Council for Responsible Nutrition (CRN) Science in Session. Optimizing Health with Nutrition - Opportunities, Gaps, and the Future.

  2023cites this paper
• Chlorogenic Acids, Acting via Calcineurin, Are the Main Compounds in Centella asiatica Extracts That Mediate Resilience to Chronic Stress in Drosophila melanogaster

  2023cites this paper
• Characteristics of Phenolic Compounds in Peucedanum japonicum According to Various Stem and Seed Colors

  2023cites this paper
• Bioanalytical method validation and application to a phase 1, double-blind, randomized pharmacokinetic trial of a standardized Centella asiatica (L.) Urban water extract product in healthy older adults

  2023influential citation
• Quantification of Caffeoylquinic Acids and Triterpenes as Targeted Bioactive Compounds of Centella asiatica in Extracts and Formulations by Liquid Chromatography Mass Spectrometry.

  2023cites this paper
• Safety Assessment of Centella asiatica-Derived Ingredients as Used in Cosmetics

  2023cites this paper
• Identification and evaluation of a novel tribenzamide derivative as an inhibitor targeting the entry of the respiratory syncytial virus.

  2023cites this paper
• Developing a Rational, Optimized Product of Centella asiatica for Examination in Clinical Trials: Real World Challenges

  2022cites this paper
• A Comprehensive Review of C. capsularis and C. olitorius: A Source of Nutrition, Essential Phytoconstituents and Pharmacological Activities

  2022cites this paper
• The Regulatory effect of chlorogenic acid on gut-brain function and its mechanism: A systematic review.

  2022cites this paper
• Pharmacokinetics and Pharmacodynamics of Key Components of a Standardized Centella asiatica Product in Cognitively Impaired Older Adults: A Phase 1, Double-Blind, Randomized Clinical Trial

  2022cites this paper
• Phytochemical Analysis of Polyphenols in Leaf Extract from Vernonia amygdalina Delile Plant Growing in Uganda

  2022cites this paper
• Centella asiatica

  2021cites this paper
• Caffeoylquinic acids: Chemistry, biosynthesis, occurrence, analytical challenges, and bioactivity.

  2021cites this paper
• Neuromodulation and neuroprotective effects of chlorogenic acids in excitatory synapses of mouse hippocampal slices

  2021cites this paper
• Prolonged Treatment with Centella asiatica Improves Memory, Reduces Amyloid-β Pathology, and Activates NRF2-Regulated Antioxidant Response Pathway in 5xFAD Mice

  2021cites this paper
• A review of antioxidant and anti-acetylcholinesterase activities of Centella asiatica (L.) Urb. for the treatment of Alzheimer’s disease

  2021cites this paper
• Chemical Structure and Biological Activities of Secondary Metabolites from Salicornia europaea L.

  2021cites this paper
• Variability, association and path analysis of centellosides and agro-morphological characteristics in Iranian Centella asiatica (L.) Urban ecotypes

  2021cites this paper
• Centella asiatica (Gotu kola) leaves

  2021cites this paper
• Free radical biology in neurological manifestations: mechanisms to therapeutics interventions

  2021cites this paper
• Identification of TrkB Binders from Complex Matrices Using a Magnetic Drug Screening Nanoplatform.

  2021cites this paper
• 3,5-Dicaffeoylquinic Acid Lowers 3T3-L1 Mitotic Clonal Expansion and Adipocyte Differentiation by Enhancing Heme Oxygenase-1 Expression

  2021cites this paper
• Polymeric colloidal nanocarriers entrapped with Centella asiatica extract

  2020cites this paper
• NRF2 as a Therapeutic Target in Neurodegenerative Diseases

  2020cites this paper
• Caffeoylquinic acids with potential biological activity from plant in vitro cultures as alternative sources of valuable natural products.

  2020cites this paper
• Integration of mass spectral fingerprinting analysis with precursor ion (MS1) quantification for the characterisation of botanical extracts: application to extracts of Centella asiatica (L.) Urban

  2020cites this paper
• Special Section on Natural Products: Experimental Approaches to Elucidate Disposition Mechanisms and Predict Pharmacokinetic Drug Interactions Centella asiatica Water Extract Shows Low Potential for Cytochrome P450–Mediated Drug Interactions

  2020cites this paper
• Current advances in naturally occurring caffeoylquinic acids: structure, bioactivity and synthesis.

  2020cites this paper
• Intracellular amyloid toxicity induces oxytosis/ferroptosis regulated cell death

  2020cites this paper
• A GDSL lipase-like from Ipomoea batatas catalyzes efficient production of 3,5-diCQA when expressed in Pichia pastoris

  2020cites this paper
• Caffeoylquinic Acids in Centella asiatica Reverse Cognitive Deficits in Male 5XFAD Alzheimer’s Disease Model Mice

  2020cites this paper
• Attenuation of methylglyoxal-induced glycation and cellular dysfunction in wound healing by Centella cordifolia.

  2020cites this paper
• Loss of NRF2 accelerates cognitive decline, exacerbates mitochondrial dysfunction, and is required for the cognitive enhancing effects of Centella asiatica during aging.

  2020cites this paper
• Caffeoylquinic Acids

  2020cites this paper
• A GDSL lipase-like from Ipomoea batatas catalyzes efficient production of 3,5-diCQA when expressed in Pichia pastoris

  2020cites this paper
• Centella Asiatica Improves Memory and Promotes Antioxidative Signaling in 5XFAD Mice

  2019cites this paper
• LCMS/MS metabolite profiling and analysis of acute toxicity effect of the ethanolic extract of Centella asiatica on zebrafish model

  2019cites this paper
• Preparative isolation of caffeoylquinic acid isomers from Kuding tea by salt‐containing aqueous two‐phase extraction and purification by high‐speed countercurrent chromatography

  2019cites this paper
• Potential Treatment Strategies of Dementia With Ayurvedic Medicines

  2019cites this paper
• Neuromodulatory Activity of Dietary Phenolics Derived from Corchorus olitorius L.

  2019cites this paper
• Centella asiatica Protects d-Galactose/AlCl3 Mediated Alzheimer’s Disease-Like Rats via PP2A/GSK-3β Signaling Pathway in Their Hippocampus

  2019cites this paper
• Structural Stabilization of Human Transthyretin by Centella asiatica (L.) Urban Extract: Implications for TTR Amyloidosis

  2019cites this paper
• Organic anion transporter 3 (OAT3)‐mediated transport of dicaffeoylquinic acids and prediction of potential drug‐drug interaction

  2019cites this paper
• Protective effect of Centella asiatica against D-galactose and aluminium chloride induced rats: Behavioral and ultrastructural approaches.

  2019cites this paper
• Effect of high-frequency low-intensity pulsed electric field on protecting SH-SY5Y cells against hydrogen peroxide and β-amyloid-induced cell injury via ERK pathway

  2019cites this paper
• Centella asiatica attenuates hippocampal mitochondrial dysfunction and improves memory and executive function in &bgr;‐amyloid overexpressing mice

  2018cites this paper
• An updated review on Anti-Alzheimer’s herbal drugs

  2018cites this paper
• Lost in Translation? Finding Our Way To Effective Alzheimer’s Disease Therapies

  2018cites this paper
• Centella asiatica increases hippocampal synaptic density and improves memory and executive function in aged mice

  2018cites this paper
• The Anti-Amyloid-β and Neuroprotective Properties of a Novel Tricyclic Pyrone Molecule

  2017cites this paper
• Metabolite profiling of the undifferentiated cultured cells and differentiated leaf tissues of Centella asiatica

  2017cites this paper
• Chlorogenic Acid and Mental Diseases: From Chemistry to Medicine

  2017cites this paper
• Isochlorogenic acid A promotes melanin synthesis in B16 cell through the &bgr;-catenin signal pathway

  2017cites this paper
• Differentiation of Three Centella Species in Australia as Inferred from Morphological Characteristics, ISSR Molecular Fingerprinting and Phytochemical Composition

  2017cites this paper
• Centella asiatica Attenuates Mitochondrial Dysfunction and Oxidative Stress in Aβ-Exposed Hippocampal Neurons

  2017cites this paper
• Centella asiatica attenuates Aβ-induced neurodegenerative spine loss and dendritic simplification.

  2017cites this paper
• Toxicological evaluation of ethanolic extract from Stevia rebaudiana Bertoni leaves: Genotoxicity and subchronic oral toxicity

  2017cites this paper
• Stimulatory Effects of Acibenzolar-S-Methyl on Chlorogenic Acids Biosynthesis in Centella asiatica Cells

  2016cites this paper
• Herbal CNS stimulants

  2016cites this paper
• STX, a Novel Membrane Estrogen Receptor Ligand, Protects Against Amyloid-β Toxicity

  2016cites this paper
• Centella asiatica modulates antioxidant and mitochondrial pathways and improves cognitive function in mice.

  2016cites this paper
• Chlorogenic Acids Biosynthesis in Centella asiatica Cells Is not Stimulated by Salicylic Acid Manipulation

  2016cites this paper
• Recent Updates in Neuroprotective and Neuroregenerative Potential of Centella asiatica.

  2016cites this paper
• C-Glycosylflavones Alleviate Tau Phosphorylation and Amyloid Neurotoxicity through GSK3β Inhibition.

  2016cites this paper
• Molecular mechanism of the binding of 3,4,5-tri-O-caffeoylquinic acid to human serum albumin: Saturation transfer difference NMR, multi-spectroscopy, and docking studies.

  2016cites this paper
• Identification of Phlogacantholide C as a Novel ADAM10 Enhancer from Traditional Chinese Medicinal Plants

  2016cites this paper
• Metabolomics-derived insights into the manipulation of terpenoid synthesis in Centella asiatica cells by methyl jasmonate

  2015cites this paper
• Extract of Caragana sinica as a potential therapeutic option for increasing alpha-secretase gene expression.

  2015cites this paper
• Carqueja (Baccharis trimera) Protects against Oxidative Stress and β-Amyloid-Induced Toxicity in Caenorhabditis elegans

  2015cites this paper
• Baccharis trimera protege contra o estresse oxidativo e toxicidade induzida pelo peptídeo β-amilóide no Caenorhabditis elegans.

  2015cites this paper
• Rhodiola Rosea L.- An Evaluation of Safety and Efficacy in the Context of a Neurological Disorder, Alzheimer Disease

  2015cites this paper
• Centella asiatica Attenuates Amyloid-β-Induced Oxidative Stress and Mitochondrial Dysfunction

  2015cites this paper
• Cognitive Enhancers (Nootropics). Part 3: Drugs Interacting with Targets other than Receptors or Enzymes. Disease-Modifying Drugs. Update 2014

  2014cites this paper
• Perspective Perspective: Council for Responsible Nutrition Science in Session. Optimizing Health with Nutrition — Opportunities, Gaps, and the Future

  year unknowncites this paper