Coupled enhancer and coding sequence evolution of a homeobox gene shaped leaf diversity

In this study, Vuolo et al. investigate the mechanisms underlying the genetic basis for morphological diversity in leaf shape. They show that evolution of an enhancer element in the homeobox gene REDUCED COMPLEXITY (RCO) altered leaf shape by changing gene expression from the distal leaf blade to its base.

• Publication year

  2016

• Venue

  Genes & Development

• Publication date

  2016-11-01

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1101/gad.290684.116PMID 27852629PMCID 5131777
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Insights into Interspecific Hybridization Events in Allotetraploid Cotton Formation from Characterization of a Gene-Regulating Leaf Shape

  2016cited by this paper
• Evolving New Skeletal Traits by cis-Regulatory Changes in Bone Morphogenetic Proteins.

  2016cited by this paper
• Human-chimpanzee differences in a FZD8 enhancer alter cell-cycle dynamics in the developing neocortex.

  2015cited by this paper
• Enhancer Evolution across 20 Mammalian Species

  2015cited by this paper
• Unraveling the Tangled Skein: The Evolution of Transcriptional Regulatory Networks in Development.

  2015cited by this paper
• Alternate wiring of a KNOXI genetic network underlies differences in leaf development of A. thaliana and C. hirsuta

  2015cited by this paper
• Suboptimization of developmental enhancers

  2015cited by this paper
• Leaf development and morphogenesis

  2014cited by this paper
• Repeated evolutionary changes of leaf morphology caused by mutations to a homeobox gene.

  2014cited by this paper
• Cardamine hirsuta: a versatile genetic system for comparative studies.

  2014cited by this paper
• Leaf Shape Evolution Through Duplication, Regulatory Diversification, and Loss of a Homeobox Gene

  2014influential reference
• Emergence and Diversification of Fly Pigmentation Through Evolution of a Gene Regulatory Module

  2013cited by this paper
• Dynamic growth program regulated by LANCEOLATE enables flexible leaf patterning

  2011cited by this paper
• Model for the regulation of Arabidopsis thaliana leaf margin development

  2011cited by this paper
• Faculty Opinions recommendation of Morphological evolution caused by many subtle-effect substitutions in regulatory DNA.

  2011cited by this paper
• Morphological evolution caused by many subtle-effect substitutions in a transcriptional enhancer

  2011cited by this paper
• Inaugural Article: Evolutionary origin of a novel gene expression pattern through co-option of the latent activities of existing regulatory sequences

  2011cited by this paper
• Epistatic selection between coding and regulatory variation in human evolution and disease.

  2011cited by this paper
• Identification of a functional transposon insertion in the maize domestication gene tb1

  2011cited by this paper
• Report rm Evolved via Loss of KNOX Expression in Leaves in Association with a Selective Sweep

  2010cited by this paper
• Adaptive Evolution of Pelvic Reduction in Sticklebacks by Recurrent Deletion of a Pitx1 Enhancer

  2010cited by this paper
• The Loci of Evolution: How Predictable is Genetic Evolution?

  2008cited by this paper
• Evo‐Devo and an Expanding Evolutionary Synthesis

  2008cited by this paper
• PAML 4: phylogenetic analysis by maximum likelihood.

  2007cited by this paper
• Why Do Toothed Leaves Correlate with Cold Climates? Gas Exchange at Leaf Margins Provides New Insights into a Classic Paleotemperature Proxy

  2006cited by this paper
• The genetic basis for differences in leaf form between Arabidopsis thaliana and its wild relative Cardamine hirsuta

  2006cited by this paper
• Repeated morphological evolution through cis-regulatory changes in a pleiotropic gene

  2006cited by this paper
• Chance caught on the wing: cis-regulatory evolution and the origin of pigment patterns in Drosophila

  2005cited by this paper
• of three protozoan proteins from the isochorismatase superfamily Crystal structures and proposed structural / functional classification

  2005cited by this paper
• Detecting Selection in Noncoding Regions of Nucleotide Sequences

  2004cited by this paper
• Vascular patterning and leaf shape.

  2001cited by this paper
• THE ROLE OF PHYLLOTACTIC PATTERN AS A “DEVELOPMENTAL CONSTRAINT” ON THE INTERCEPTION OF LIGHT BY LEAF SURFACES

  1988cited by this paper
• Canopy photosynthesis and its relationship to plant productivity in near-isogenic cotton lines differing in leaf morphology.

  1986cited by this paper

• Cloning and functional analysis of the lobed-leaf gene BjA10.LL in Brassica juncea L.

  2026cites this paper
• From genes to climate: a perspective on the importance of leaf shape

  2025cites this paper
• Leaf wrinkling in Brassica campestris: involvement of brassinosteroid signaling

  2025cites this paper
• RsRCO and RsLMI1 co-regulate the formation of lobed leaf in radish (Raphanus sativus L.)

  2025cites this paper
• The complex REDUCED COMPLEXITY locus contributes to leaf shape diversification in Brassica rapa.

  2025cites this paper
• Three-year QTL mapping discovers a novel locus and candidate gene BnC09.LMI1 regulating the leaf complexity of Brassica napus

  2025cites this paper
• Evolution of repressive sequences within an enhancer contributed to morphological diversity in crucifer plants

  2025cites this paper
• A Review of Regulation of Leaf Margin Development: Integrating Genetic, Hormonal, and Environmental Controls

  2025cites this paper
• BrRCO promotes leaf lobe formation by repressing BrACP5 expression in Brassica rapa

  2025cites this paper
• Discovery of variation in genes related to agronomic traits by sequencing the genome of Cucurbita pepo varieties

  2025cites this paper
• Shaping leaves through TALE homeodomain transcription factors

  2024cites this paper
• Are complex traits underpinned by polygenic molecular traits? A reflection on the complexity of gene expression

  2024cites this paper
• Identification of CaPCR1, an OFP gene likely involved in pointed versus concave fruit tip regulation in pepper (Capsicum annuum L.) using recombinant inbred lines

  2024cites this paper
• Age-associated growth control modifies leaf proximodistal symmetry and enables leaf shape diversification

  2024cites this paper
• Molecular regulation of oil gland development and biosynthesis of essential oils in Citrus spp.

  2024cites this paper
• Design and deep learning of synthetic B-cell-specific promoters

  2023cites this paper
• Morphogenesis of leaves: from initiation to the production of diverse shapes.

  2023cites this paper
• GRASSY TILLERS1 (GT1) and SIX-ROWED SPIKE1 (VRS1) homologs share conserved roles in growth repression

  2023cites this paper
• Duplicate transcription factors GT1 and VRS1 regulate branching and fertile flower number in maize and Brachypodium distachyon

  2023cites this paper
• The cellular basis for synergy between RCO and KNOX1 homeobox genes in leaf shape diversity.

  2022cites this paper
• Molecular architecture of enhancer-promoter interaction.

  2022cites this paper
• Genome-Wide Identification of Wheat KNOX Gene Family and Functional Characterization of TaKNOX14-D in Plants

  2022cites this paper
• The Lobed-Leaf Phenotype in Brassica juncea Is Associated with the BjLMI1 Locus as Evidenced Using GradedPool-Seq

  2022cites this paper
• The Formation of Shapes: Interplay of Genes during Leaf Development Processes

  2022cites this paper
• Is auxin enough? Cytokinins and margin patterning in simple leaves.

  2022cites this paper
• A single nucleotide polymorphism in WRKY33 promoter is associated with the cold sensitivity in cultivated tomato.

  2022cites this paper
• Phenotyping in Evo-Devo

  2021cites this paper
• From genes to networks: The genetic control of leaf development.

  2021cites this paper
• Leaf Shape Diversity: From Genetic Modules to Computational Models.

  2021cites this paper
• Quantitative trait loci (QTL) analysis of leaf related traits in spinach (Spinacia oleracea L.)

  2021cites this paper
• Promoter Variations Strongly Enhance the Transcription Level of the BoLMI1 Gene, Causing Lobed Leaves in Ornamental Kale (Brassica Oleracea L. Var. Acephala)

  2021cites this paper
• Map-based cloning and promoter variation analysis of the lobed leaf gene BoLMI1a in ornamental kale (Brassica oleracea L. var. acephala)

  2021cites this paper
• Genome Duplications as the Basis of Vertebrates’ Evolutionary Success

  2021cites this paper
• Active suppression of leaflet emergence as a mechanism of simple leaf development

  2021cites this paper
• LATE MERISTEM IDENTITY1 regulates leaf margin development via the auxin transporter gene SMOOTH LEAF MARGIN1.

  2021cites this paper
• GhARF16‐1 modulates leaf development by transcriptionally regulating the GhKNOX2‐1 gene in cotton

  2020cites this paper
• CRISPR/Cas9-Mediated Mutagenesis of RCO in Cardamine hirsuta

  2020cites this paper
• A basic/helix-loop-helix transcription factor controls leaf shape by regulating auxin signaling in apple.

  2020cites this paper
• BnA10.RCO, a homeobox gene, positively regulates leaf lobe formation in Brassica napus L.

  2020cites this paper
• A WOX/Auxin Biosynthesis Module Controls Growth to Shape Leaf Form.

  2020cites this paper
• Autoregulation of RCO by Low-Affinity Binding Modulates Cytokinin Action and Shapes Leaf Diversity.

  2019influential citation
• Photoreceptor Activity Contributes to Contrasting Responses to Shade in Cardamine and Arabidopsis Seedlings

  2019cites this paper
• Interspecies association mapping links reduced CG to TG substitution rates to the loss of gene-body methylation

  2019cites this paper
• A Growth-Based Framework for Leaf Shape Development and Diversity

  2019cites this paper
• Duplication of a domestication locus neutralized a cryptic variant that caused a breeding barrier in tomato

  2019cites this paper
• Chromatin Evolution-Key Innovations Underpinning Morphological Complexity

  2019cites this paper
• Assessing the remarkable morphological diversity and transcriptomic basis of leaf shape in Ipomoea batatas (sweetpotato)

  2019cites this paper
• Regulatory Diversification of INDEHISCENT in the Capsella Genus Directs Variation in Fruit Morphology

  2019cites this paper
• Fine-mapping of a gene for the lobed leaf, BoLl, in ornamental kale (Brassica oleracea L. var. acephala)

  2019cites this paper
• Leaf development and evolution.

  2019cites this paper
• Evolution: How a Homeobox Gene Cuts the Mustard Leaf

  2019cites this paper
• Studying genetics of leaf shape variation in Arabidopsis lyrata

  2019cites this paper
• The remarkable morphological diversity of leaf shape in sweetpotato (Ipomoea batatas): the influence of genetics, environment, and G×E.

  2019cites this paper
• Heterophylly: Phenotypic Plasticity of Leaf Shape in Aquatic and Amphibious Plants

  2019cites this paper
• Shaping of a three-dimensional carnivorous trap through modulation of a planar growth mechanism

  2019cites this paper
• Successive duplication-divergence mechanisms at the RCO locus contributed to leaf shape diversity in the Brassicaceae

  2018cites this paper
• Getting leaves into shape: a molecular, cellular, environmental and evolutionary view

  2018cites this paper
• Gene networks and the evolution of plant morphology.

  2018cites this paper
• Differential spatial distribution of miR165/6 determines variability in plant root anatomy

  2018cites this paper
• Significance of whole-genome duplications on the emergence of evolutionary novelties

  2018cites this paper
• The Analysis of Genes and Phytohormone Metabolic Pathways Associated with Leaf Shape Development in Liriodendron chinense via De Novo Transcriptome Sequencing

  2018cites this paper
• Building the differences: a case for the ground tissue patterning in plants

  2018cites this paper
• LMI1 homeodomain protein regulates organ proportions by spatial modulation of endoreduplication

  2018cites this paper
• Mechanisms Underlying the Environmentally Induced Plasticity of Leaf Morphology

  2018cites this paper
• On genes and form

  2017cites this paper
• University of Dundee Conservation versus divergence in LEAFY and APETALA functions between Arabidopsis thaliana and Cardamine hirsuta Monniaux,

  2017cites this paper
• Using mustard genomes to explore the genetic basis of evolutionary change.

  2017cites this paper
• The shape of things to come: From typology to predictive models for leaf diversity.

  2017cites this paper
• Explosive seed dispersal.

  2017cites this paper
• Enhancer evolution and the origins of morphological novelty.

  2017cites this paper
• Conservation vs divergence in LEAFY and APETALA1 functions between Arabidopsis thaliana and Cardamine hirsuta.

  2017cites this paper