PTEN/PI3K/Akt/VEGF signaling and the cross talk to KRIT1, CCM2, and PDCD10 proteins in cerebral cavernous malformations

No abstract is available for this paper.

• Publication year

  2015

• Venue

  Neurosurgical review

• Publication date

  2015-04-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1007/s10143-014-0597-8PMID 25403688
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Bleeding propensity of cavernous malformations: impact of tight junction alterations on the occurrence of overt hematoma.

  2014cited by this paper
• Cerebral cavernous malformation proteins at a glance

  2014cited by this paper
• STRIPAK complexes: structure, biological function, and involvement in human diseases.

  2014cited by this paper
• The association between cerebral developmental venous anomaly and concomitant cavernous malformation: an observational study using magnetic resonance imaging

  2014cited by this paper
• Signaling pathways and the cerebral cavernous malformations proteins: lessons from structural biology

  2014cited by this paper
• ccm2-like is required for cardiovascular development as a novel component of the Heg-CCM pathway.

  2013cited by this paper
• The Structure of the Ternary Complex of Krev Interaction Trapped 1 (KRIT1) Bound to Both the Rap1 GTPase and the Heart of Glass (HEG1) Cytoplasmic Tail*

  2013cited by this paper
• Loss of CCM3 impairs DLL4-Notch signalling: implication in endothelial angiogenesis and in inherited cerebral cavernous malformations

  2013cited by this paper
• SOcK, MiSTs, MASK and STicKs: the GCKIII (germinal centre kinase III) kinases and their heterologous protein-protein interactions.

  2013cited by this paper
• PD-1 Increases PTEN Phosphatase Activity While Decreasing PTEN Protein Stability by Inhibiting Casein Kinase 2

  2013cited by this paper
• Mechanism for KRIT1 release of ICAP1-mediated suppression of integrin activation.

  2013cited by this paper
• Loss of Pten promotes angiogenesis and enhanced vegfaa expression in zebrafish

  2013cited by this paper
• Structural studies of cerebral cavernous malformations 2 (CCM2) reveal a folded helical domain at its C‐terminus

  2013cited by this paper
• Cerebral cavernous malformations: from CCM genes to endothelial cell homeostasis.

  2013cited by this paper
• Thrombin-triggered angiogenesis in rat brains following experimental intracerebral hemorrhage.

  2012cited by this paper
• Structural basis of the junctional anchorage of the cerebral cavernous malformations complex

  2012cited by this paper
• Dynamic regulation of the cerebral cavernous malformation pathway controls vascular stability and growth.

  2012cited by this paper
• PI3K-PKB/Akt pathway.

  2012cited by this paper
• Cerebral cavernous malformations: Spectrum of neuroradiological findings

  2012cited by this paper
• The functions and regulation of the PTEN tumour suppressor

  2012cited by this paper
• Cerebral cavernous malformations: spectrum of neuroradiological findings.

  2012cited by this paper
• In Vitro Characterization of the Angiogenic Phenotype and Genotype of the Endothelia Derived From Sporadic Cerebral Cavernous Malformations

  2011cited by this paper
• Mutations in 2 distinct genetic pathways result in cerebral cavernous malformations in mice.

  2011cited by this paper
• Loss of Mel-18 induces tumor angiogenesis through enhancing the activity and expression of HIF-1α mediated by the PTEN/PI3K/Akt pathway

  2011cited by this paper
• Cerebral cavernous malformations: from molecular pathogenesis to genetic counselling and clinical management

  2011cited by this paper
• A mechanism of Rap1-induced stabilization of endothelial cell–cell junctions

  2011cited by this paper
• Impairment of Tight Junctions and Glucose Transport in Endothelial Cells of Human Cerebral Cavernous Malformations

  2011cited by this paper
• Stabilization of VEGFR2 Signaling by Cerebral Cavernous Malformation 3 Is Critical for Vascular Development

  2010cited by this paper
• Recent insights into cerebral cavernous malformations: the molecular genetics of CCM

  2010cited by this paper
• PTEN regulates angiogenesis and VEGF expression through phosphatase-dependent and -independent mechanisms in HepG2 cells.

  2010cited by this paper
• PDCD10/CCM3 Acts Downstream of γ-Protocadherins to Regulate Neuronal Survival*

  2010cited by this paper
• Crystal Structure of CCM3, a Cerebral Cavernous Malformation Protein Critical for Vascular Integrity*

  2010cited by this paper
• CCM3/PDCD10 stabilizes GCKIII proteins to promote Golgi assembly and cell orientation

  2010cited by this paper
• A New Role for PTEN in Regulating Transient Receptor Potential Canonical Channel 6-mediated Ca2+ Entry, Endothelial Permeability, and Angiogenesis*

  2010cited by this paper
• Differential angiogenesis function of CCM2 and CCM3 in cerebral cavernous malformations.

  2010cited by this paper
• The emerging mechanisms of isoform-specific PI3K signalling

  2010cited by this paper
• Defining the Functional Domain of Programmed Cell Death 10 through Its Interactions with Phosphatidylinositol-3,4,5-Trisphosphate

  2010cited by this paper
• Regulation of cardiovascular development and integrity by the Heart of Glass-Cerebral Cavernous Malformation pathway

  2009cited by this paper
• Cavernous malformations: natural history, diagnosis and treatment

  2009cited by this paper
• Involvement of PTEN Promoter Methylation in Cerebral Cavernous Malformations

  2009cited by this paper
• CCM2 mediates death signaling by the TrkA receptor tyrosine kinase.

  2009cited by this paper
• The Cerebral Cavernous Malformation signaling pathway promotes vascular integrity via Rho GTPases

  2009cited by this paper
• Functional analyses of human and zebrafish 18–amino acid in‐frame deletion pave the way for domain mapping of the cerebral cavernous malformation 3 protein

  2009cited by this paper
• PI3K/PTEN signaling in angiogenesis and tumorigenesis.

  2009cited by this paper
• Biallelic somatic and germline mutations in cerebral cavernous malformations (CCMs): evidence for a two-hit mechanism of CCM pathogenesis.

  2009cited by this paper
• Biology of Vascular Malformations of the Brain

  2009cited by this paper
• Novel CCM1, CCM2, and CCM3 mutations in patients with cerebral cavernous malformations: in‐frame deletion in CCM2 prevents formation of a CCM1/CCM2/CCM3 protein complex

  2008cited by this paper
• Morphological Observation and In Vitro Angiogenesis Assay of Endothelial Cells Isolated From Human Cerebral Cavernous Malformations

  2007cited by this paper
• KRIT-1/CCM1 is a Rap1 effector that regulates endothelial cell–cell junctions

  2007cited by this paper
• Genetics of cavernous angiomas.

  2007cited by this paper
• CCM3 interacts with CCM2 indicating common pathogenesis for cerebral cavernous malformations

  2007cited by this paper
• INTERACTION BETWEEN KRIT1 AND MALCAVERNIN: IMPLICATIONS FOR THE PATHOGENESIS OF CEREBRAL CAVERNOUS MALFORMATIONS

  2007cited by this paper
• The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism

  2006cited by this paper
• Regulation of Ang2 release by PTEN/PI3‐kinase/Akt in lung microvascular endothelial cells

  2006cited by this paper
• Neuronal expression of the Ccm2 gene in a new mouse model of cerebral cavernous malformations

  2006cited by this paper
• Low frequency of PDCD10 mutations in a panel of CCM3 probands: potential for a fourth CCM locus

  2006cited by this paper
• The PTEN/PI3K pathway governs normal vascular development and tumor angiogenesis.

  2005cited by this paper
• Mutations within the programmed cell death 10 gene cause cerebral cavernous malformations.

  2005influential reference
• Hypoxia inducible factor-1alpha and expression of vascular endothelial growth factor and its receptors in cerebral arteriovenous malformations.

  2005cited by this paper
• Biallelic Somatic and Germ Line CCM1 Truncating Mutations in a Cerebral Cavernous Malformation Lesion

  2005cited by this paper
• Hypoxia inducible factor-1α and expression of vascular endothelial growth factor and its receptors in cerebral arteriovenous malformations

  2005cited by this paper
• Ccm1 is required for arterial morphogenesis: implications for the etiology of human cavernous malformations

  2004cited by this paper
• Hypoxia-inducible Factor and Vascular Endothelial Growth Factor Are Expressed More Frequently in Embolized than in Nonembolized Cerebral Arteriovenous Malformations

  2004cited by this paper
• Mutations within the MGC4607 gene cause cerebral cavernous malformations.

  2004influential reference
• Mutations in a gene encoding a novel protein containing a phosphotyrosine-binding domain cause type 2 cerebral cavernous malformations.

  2003cited by this paper
• Deep and brainstem cavernomas: a consecutive 8-year series.

  2003cited by this paper
• Targeting HIF-1 for cancer therapy

  2003cited by this paper
• The phosphoinositide 3-kinase pathway.

  2002cited by this paper
• PTEN Modulates Vascular Endothelial Growth Factor-Mediated Signaling and Angiogenic Effects*

  2002cited by this paper
• Cerebral cavernomas in the adult. Review of the literature and analysis of 72 surgically treated patients

  2002cited by this paper
• KRIT1, a gene mutated in cerebral cavernous malformation, encodes a microtubule-associated protein

  2002cited by this paper
• Computational and experimental analyses reveal previously undetected coding exons of the KRIT1 (CCM1) gene.

  2001cited by this paper
• Surgical management of brainstem cavernomas.

  2001cited by this paper
• PKB/AKT: functional insights from genetic models

  2001cited by this paper
• PTEN controls tumor-induced angiogenesis

  2001cited by this paper
• Endothelial proliferation, neoangiogenesis, and potential de novo generation of cerebrovascular malformations.

  2001cited by this paper
• Ten years of protein kinase B signalling: a hard Akt to follow.

  2001cited by this paper
• Structure of the ERM protein moesin reveals the FERM domain fold masked by an extended actin binding tail domain.

  2000cited by this paper
• Germline and germline mosaic PTEN mutations associated with a Proteus-like syndrome of hemihypertrophy, lower limb asymmetry, arteriovenous malformations and lipomatosis.

  2000cited by this paper
• Loss of PTEN facilitates HIF-1-mediated gene expression.

  2000cited by this paper
• Mutations in KRIT1 in familial cerebral cavernous malformations.

  2000cited by this paper
• Identification of Tek/Tie2 Binding Partners

  1999cited by this paper
• Mutations in the gene encoding KRIT1, a Krev-1/rap1a binding protein, cause cerebral cavernous malformations (CCM1).

  1999cited by this paper
• PTEN suppresses breast cancer cell growth by phosphatase activity-dependent G1 arrest followed by cell death.

  1999cited by this paper
• Truncating mutations in CCM1, encoding KRIT1, cause hereditary cavernous angiomas

  1999cited by this paper
• The tumor-suppressor activity of PTEN is regulated by its carboxyl-terminal region.

  1999cited by this paper
• Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association.

  1999cited by this paper
• The Tumor Suppressor, PTEN/MMAC1, Dephosphorylates the Lipid Second Messenger, Phosphatidylinositol 3,4,5-Trisphosphate*

  1998cited by this paper
• PTEN, a Putative Protein Tyrosine Phosphatase Gene Mutated in Human Brain, Breast, and Prostate Cancer

  1997cited by this paper
• Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers

  1997cited by this paper
• Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis.

  1997cited by this paper
• Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome

  1997cited by this paper
• Germline mutations in PTEN are present in Bannayan-Zonana syndrome

  1997cited by this paper
• Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning.

  1996cited by this paper
• Mapping a gene causing cerebral cavernous malformation to 7q11.2-q21.

  1995cited by this paper
• Refined localization of the cerebral cavernous malformation gene (CCM1) to a 4-cM interval of chromosome 7q contained in a well-defined YAC contig.

  1995cited by this paper
• A gene responsible for cavernous malformations of the brain maps to chromosome 7q.

  1995cited by this paper
• Indications for surgery and prognosis in patients with cerebral cavernous angiomas.

  1992cited by this paper

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  2025cites this paper
• Molecular roles of microRNA-21 and exosomal miR-21 in gastrointestinal cancers: diagnostic, therapeutic, and drug resistance insights

  2025cites this paper
• Comprehensive analysis of bioinformatics and system biology reveals the association between Girdin and hepatocellular carcinoma

  2024cites this paper
• Research progress in the pathogenesis of hormone-induced femoral head necrosis based on microvessels: a systematic review

  2024cites this paper
• Case report: Association between PTEN-gene variant and an aggressive case of multiple dAVFs

  2024cites this paper
• Tumor hypoxia evidences the differential regulation of Mdm2-p53 axis by PTEN in tumor derived vs. normal endothelial cells

  2024cites this paper
• Multidrug-Loaded Lipid Nanoemulsions for the Combinatorial Treatment of Cerebral Cavernous Malformation Disease

  2023cites this paper
• Review of spinal dural arteriovenous fistulas: Challenges, diagnostics, management, and pathophysiology

  2023cites this paper
• Circulating Plasma miRNA Homologs in Mice and Humans Reflect Familial Cerebral Cavernous Malformation Disease

  2022cites this paper
• Molecular Genetic Features of Cerebral Cavernous Malformations (CCM) Patients: An Overall View from Genes to Endothelial Cells

  2021cites this paper
• Contribution of protein–protein interactions to the endothelial-barrier-stabilizing function of KRIT1

  2021cites this paper
• Genetic testing in vascular and lymphatic malformations

  2021cites this paper
• Inhibition of the HEG1–KRIT1 interaction increases KLF4 and KLF2 expression in endothelial cells

  2021cites this paper
• From Genes and Mechanisms to Molecular-Targeted Therapies: The Long Climb to the Cure of Cerebral Cavernous Malformation (CCM) Disease.

  2020cites this paper
• Correlation between quantitative perfusion histogram parameters of DCE-MRI and PTEN, P-Akt and m-TOR in different pathological types of lung cancer

  2020cites this paper
• An efficient hybrid feature selection method to identify potential biomarkers in common chronic lung inflammatory diseases.

  2020cites this paper
• Arctiin attenuates high glucose‐induced human retinal capillary endothelial cell proliferation by regulating ROCK1/PTEN/PI3K/Akt/VEGF pathway in vitro

  2020cites this paper
• Vascular anomalies: molecular bases, genetic testing and therapeutic approaches.

  2019cites this paper
• Cavernomas

  2019cites this paper
• lncRNA MEG3 Suppresses the Tumorigenesis of Hemangioma by Sponging miR-494 and Regulating PTEN/ PI3K/AKT Pathway

  2018cites this paper
• Vis-à-vis: a focus on genetic features of cerebral cavernous malformations and brain arteriovenous malformations pathogenesis

  2018cites this paper
• Intranasal administration of nerve growth factor promotes angiogenesis via activation of PI3K/Akt signaling following cerebral infarction in rats.

  2018cites this paper
• miR-25 inhibits sepsis-induced cardiomyocyte apoptosis by targetting PTEN

  2018cites this paper
• MiRNA-451 Inhibits Glioma Cell Proliferation and Invasion Through the mTOR/HIF-1α/VEGF Signaling Pathway by Targeting CAB39

  2018cites this paper
• PTEN inhibition enhances angiogenesis in an in vitro model of ischemic injury by promoting Akt phosphorylation and subsequent hypoxia inducible factor-1α upregulation

  2018cites this paper
• miR‑214 mediates vascular inflammation and apoptosis via PTEN expression.

  2018cites this paper
• Knockdown of HMGB1 inhibits cell proliferation and induces apoptosis in hemangioma via downregulation of AKT pathway.

  2017cites this paper
• Cerebral Cavernous Malformation: When the Key to Diagnosis Is on the Skin.

  2017cites this paper
• Klippel-Trenauney syndrome with axillary hyperhidrosis.

  2017cites this paper
• Cerebral Cavernous Malformation: When the Key to Diagnosis Is on the Skin.

  2017cites this paper
• Genome-Wide Sequencing Reveals MicroRNAs Downregulated in Cerebral Cavernous Malformations

  2017cites this paper
• [Gene mutations in patients with hereditary cavernous malformations].

  2017cites this paper
• Nogo-B receptor deficiency causes cerebral vasculature defects during embryonic development in mice.

  2016cites this paper
• Role of Delta-Notch signaling in cerebral cavernous malformations

  2016cites this paper
• PHACE syndrome is associated with intracranial cavernous malformations

  2016cites this paper
• MicroRNA-21 promotes cell proliferation, migration, and resistance to apoptosis through PTEN/PI3K/AKT signaling pathway in esophageal cancer

  2016cites this paper
• A novel CCM2 variant in a family with non‐progressive cognitive complaints and cerebral microbleeds

  2016cites this paper
• Intracerebral Hemorrhage and Ischemic Stroke of Different Etiologies Have Distinct Alternatively Spliced mRNA Profiles in the Blood: a Pilot RNA-seq Study

  2015cites this paper
• Neuroimaging of cerebral cavernous malformations.

  2015cites this paper