A safety review of topical bovine thrombin-induced generation of antibodies to bovine proteins.

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Clinical Therapeutics

• Publication date

  2009-04-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1016/j.clinthera.2009.04.021PMID 19446142
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Development of a factor V and thrombin inhibitor following partial hepatic resection and the use of topical thrombin concentrate.

  2008cited by this paper
• A comparison of recombinant thrombin to bovine thrombin as a hemostatic ancillary in patients undergoing peripheral arterial bypass and arteriovenous graft procedures.

  2008cited by this paper
• Phase 3, randomized, double-blind study of plasma-derived human thrombin versus bovine thrombin in achieving hemostasis in patients undergoing surgery*

  2008cited by this paper
• Factor VIII genotype and inhibitor development in patients with haemophilia A: highest risk in patients with splice site mutations

  2008cited by this paper
• A phase 3, randomized, double-blind comparative study of the efficacy and safety of topical recombinant human thrombin and bovine thrombin in surgical hemostasis.

  2007cited by this paper
• Inhibitor development in haemophilia A: the role of von Willebrand factor/factor VIII concentrates

  2007cited by this paper
• Factor VIII inhibitors: role of von Willebrand factor on the uptake of factor VIII by dendritic cells

  2007cited by this paper
• Coexistence of autoantibodies and alloantibodies to red blood cells due to blood transfusion

  2007cited by this paper
• The clinical use and immunologic impact of thrombin in surgery.

  2006cited by this paper
• Overview of inhibitors.

  2006cited by this paper
• Antibody-mediated side effects of recombinant proteins.

  2005cited by this paper
• Prospective, Randomized, Controlled Clinical Trial of a Novel Matrix Hemostatic Sealant in Children Undergoing Adenoidectomy

  2004cited by this paper
• Structure-Immunogenicity Relationships of Therapeutic Proteins

  2004cited by this paper
• Autoantibodies induced by blood transfusion

  2004cited by this paper
• A review of the therapeutic uses of thrombin

  2004cited by this paper
• Factor V inhibitors: rare or not so uncommon? A multi-laboratory investigation

  2004cited by this paper
• Severe Coagulopathy following Intraoperative Use of Topical Thrombin

  2004cited by this paper
• Bovine Thrombin Induces an Acquired Coagulopathy in Sensitized Patients Undergoing Revision Spinal Surgery: A Report of Two Cases

  2003cited by this paper
• Anaphylaxis from topical bovine thrombin (Thrombostat®) during haemodialysis and evaluation of sensitization among a dialysis population

  2003cited by this paper
• Factor V inhibitor after injection of human thrombin (tissucol) into a bleeding peptic ulcer.

  2003cited by this paper
• Relative purity of thrombin-based hemostatic agents used in surgery.

  2003cited by this paper
• Strategies for detection, measurement and characterization of unwanted antibodies induced by therapeutic biologicals.

  2003cited by this paper
• Neutralising antibodies to interferon beta during the treatment of multiple sclerosis

  2002cited by this paper
• Antiphospholipid antibodies after surgical exposure to topical bovine thrombin.

  2002cited by this paper
• Pure red-cell aplasia and antierythropoietin antibodies in patients treated with recombinant erythropoietin.

  2002cited by this paper
• Inhibitor development in correlation to factor VIII genotypes

  2002cited by this paper
• Acquired FV inhibitors: a needless iatrogenic complication of bovine thrombin exposure

  2002cited by this paper
• Development of pancytopenia with neutralizing antibodies to thrombopoietin after multicycle chemotherapy supported by megakaryocyte growth and development factor.

  2002cited by this paper
• Left Ventricular Assist System Recipients Exposed to Bovine Thrombin Preparations Have a Higher Frequency of Antiphospholipid Antibodies than Nonexposed Recipients

  2001cited by this paper
• Development of antibodies to topical bovine thrombin after abdominal hysterectomy. A case report.

  2001cited by this paper
• Serological analysis of patients treated with a new surgical hemostat containing bovine proteins and autologous plasma.

  2001cited by this paper
• Antibodies to Prothrombin, Factor V, and &bgr;2-Glycoprotein I and Vascular Access Thrombosis

  2001cited by this paper
• Immunologic Impact and Clinical Outcomes After Surgical Exposure to Bovine Thrombin

  2001cited by this paper
• Antibodies to topical bovine thrombin correlate with access thrombosis.

  2000cited by this paper
• Exposure to Topical Bovine Thrombin During Surgery Elicits a Response Against the Xenogeneic Carbohydrate Galactose α1-3Galactose

  2000cited by this paper
• Severe Hemorrhagic Complication Due to Acquired Factor V Inhibitor After Single Exposure to Bovine Thrombin Product

  2000cited by this paper
• ORIGINAL INVESTIGATIONS Antibodies to Topical Bovine Thrombin Correlate With Access Thrombosis

  2000cited by this paper
• Management of a patient with a mechanical aortic valve and antibodies to both thrombin and factor V after repeat exposure to fibrin sealant

  2000cited by this paper
• The factor VIII Structure and Mutation Resource Site: HAMSTeRS version 4

  1998cited by this paper
• Tissue adhesives in cardiovascular surgery.

  1998cited by this paper
• Risk and clinical significance of developing antibodies induced by topical thrombin preparations.

  1998cited by this paper
• Severe Bleeding due to Factor V Inhibitor after Repeated Operations Using Fibrin Sealant Containing Bovine Thrombin

  1997cited by this paper
• Postoperative bleeding induced by topical bovine thrombin: report of two cases.

  1997cited by this paper
• Simultaneous Occurrence of Human Antibodies Directed against Fibrinogen, Thrombin, and Factor V Following Exposure to Bovine Thrombin: Effects on Blood Coagulation, Protein C Activation and Platelet Function

  1997cited by this paper
• Modulation of an acquired coagulation factor V inhibitor with intravenous immune globulin.

  1997cited by this paper
• Fibrin sealant: current and potential clinical applications.

  1996cited by this paper
• Immunologic Assessment of Patients Treated with Bovine Fibrin as a Hemostatic Agent

  1996cited by this paper
• Haemophilia A: Mutation Type Determines Risk of Inhibitor Formation

  1995cited by this paper
• Brief report: fatal hemorrhage in a patient with an acquired inhibitor of human thrombin.

  1995cited by this paper
• Fibrin sealant: summary of a conference on characteristics and clinical uses

  1995cited by this paper
• Topical thrombin and acquired coagulation factor inhibitors: Clinical spectrum and laboratory diagnosis

  1994cited by this paper
• Development of Antibodies to Bovine and Human Factor V in Two Children After Exposure to Topical Bovine Thrombin

  1994cited by this paper
• Inhibitor to factor V after exposure to fibrin sealant during cardiac surgery in a two‐year‐old child

  1994cited by this paper
• Redo cardiac surgery: late bleeding complications from topical thrombin-induced factor V deficiency.

  1993cited by this paper
• Fibrin glue in surgery: frequent development of inhibitors of bovine thrombin and human factor V

  1993cited by this paper
• Immunization by bovine thrombin used with fibrin glue during cardiovascular operations. Development of thrombin and factor V inhibitors.

  1993cited by this paper
• Bovine thrombin-induced inhibitor of factor V and bleeding risk in postoperative neurosurgical patients. Report of three cases.

  1993cited by this paper
• Anaphylactic reaction to topical bovine thrombin.

  1993cited by this paper
• Clinical significance of antibodies to bovine and human thrombin and factor V after surgical use of bovine thrombin.

  1992cited by this paper
• Warning: fatal reaction to the use of fibrin glue in deep hepatic wounds. Case reports.

  1991cited by this paper
• DEVELOPMENT OF ANTI‐BOVINE THROMBIN ANTIBODIES FOLLOWING NEUROSURGICAL PROCEDURES

  1990cited by this paper
• Development of antibodies to thrombin and factor V with recurrent bleeding in a patient exposed to topical bovine thrombin.

  1990cited by this paper
• Recombinant human interferon (IFN) alpha‐2b in chronic myelogenous leukaemia: dose dependency of response and frequency of neutralizing anti‐interferon antibodies

  1989cited by this paper
• Clinical Significance of Insulin Antibodies in Insulin-Treated Diabetic Patients

  1989cited by this paper
• Iatrogenic immunization with bovine thrombin: a mechanism for prolonged thrombin times after surgery.

  1989cited by this paper
• Clinical significance of insulin antibodies in insulin-treated diabetic patients.

  1989cited by this paper
• Man, apes, and Old World monkeys differ from other mammals in the expression of alpha-galactosyl epitopes on nucleated cells.

  1988cited by this paper
• Resistance to recombinant interferon alfa-2a in hairy-cell leukemia associated with neutralizing anti-interferon antibodies.

  1988cited by this paper
• Overview of inhibitors to factor VIII and IX.

  1984cited by this paper
• The carbohydrate of human thrombin: structural analysis of glycoprotein oligosaccharides by mass spectrometry.

  1983cited by this paper
• Bovine prothrombin does not contain alpha-D-galactopyranosyl groups.

  1980cited by this paper
• Bovine prothrombin does not contain α-d-galactopyranosyl groups

  1980cited by this paper
• The carbohydrate of bovine prothrombin. Occurrence of Gal beta 1 leads to 3GlcNAc grouping in asparagine-linked sugar chains.

  1979cited by this paper
• The carbohydrate of bovine prothrombin. Partial structural determination demonstrating the presence of -galactose residues.

  1972cited by this paper
• Report of Three Cases

  1962cited by this paper

• Antifibrinolytic and Adjunct Hemostatic Agents: The Pediatric Extracorporeal Membrane Oxygenation Anticoagulation CollaborativE Consensus Conference

  2024cites this paper
• Comparative study between platelet-rich plasma (PRP) and mechanically emulsified fat grafts in management of chronic wounds.

  2023cites this paper
• Composition, host responses and clinical applications of bioadhesives.

  2022cites this paper
• Dependence of Electric Pulse Mediated Growth Factor Release on the Platelet Rich Plasma Separation Method

  2022cites this paper
• Isolation of thrombin by ultrafiltration

  2022cites this paper
• A Multi-Donor Ex Vivo Platelet Activation and Growth Factor Release Study Using Electric Pulses With Durations Up to 100 Microseconds

  2021cites this paper
• Advances in the development of hemostatic biomaterials for medical application

  2021cites this paper
• DNA-nanorobot-guided thrombin-inducing tumor infarction: raising new potential clinical concerns.

  2020cites this paper
• Electrical stimulation of whole blood for growth factor release and potential clinical implications.

  2020cites this paper
• Prospective, Randomized, Phase II, non-Inferiority Study to Evaluate the Safety and Efficacy of Topical Thrombin (Human) Grifols as Adjunct to Hemostasis during Vascular, Hepatic, Soft Tissue, and Spinal Open Surgery.

  2019cites this paper
• Synergy in thrombin-graphene sponge for improved hemostatic efficacy and facile utilization.

  2018cites this paper
• Successful Outcome of Severe Intra-cerebral Bleeding Associated with Acquired Factor V Inhibition: Utilization of Multiple Therapeutic Agents

  2017cites this paper
• Modification of Pulsed Electric Field Conditions Results in Distinct Activation Profiles of Platelet-Rich Plasma

  2016cites this paper
• Thromboelastographic Clot Characteristics of Autologous Equine Blood Products After Activation by Autologous Thrombin, Bovine Thrombin, or Calcium Chloride.

  2015cites this paper
• Platelet-rich plasma stimulated by pulse electric fields: Platelet activation, procoagulant markers, growth factor release and cell proliferation

  2015cites this paper
• Nanocomplexation of thrombin with cationic amylose derivative for improved stability and hemostatic efficacy

  2015cites this paper
• Life-threatening large subcutaneous hematoma after minor head trauma: A young female patient who was suspected of having new Ehlers–Danlos syndrome

  2015cites this paper
• Efficacy of a topical bovine-derived thrombin solution as a hemostatic agent in a rodent model of hepatic injury.

  2015cites this paper
• Thromboelastographic Clot Parameters of Autologous Equine Blood Products Activated by Various Clotting Agents

  2014cites this paper
• Acquired thrombin and FV inhibitors upon aortic bioprosthetic valve replacement

  2014cites this paper
• Improved fusion tag cleavage strategies in the downstream processing of self-assembling virus-like particle vaccines

  2014cites this paper
• Obtaining rapid and effective hemostasis: Part I. Update and review of topical hemostatic agents.

  2013cites this paper
• The effect of storage time on the platelet concentration of Choukroun ’ s platelet rich fibrin ( PRF ) Candidate

  2012cites this paper
• Use of topical bovine thrombin in an anti-coagulated rat model of hepatic injury.

  2012cites this paper
• Platelet-rich plasma activation in combination with biphasic osteochondral scaffolds–conditions for maximal growth factor production

  2011cites this paper
• Safety and Efficacy of Thrombin-JMI: A Multidisciplinary Expert Group Consensus

  2011cites this paper
• A Novel Autologous Scaffold for Diced-cartilage Grafts in Dorsal Augmentation Rhinoplasty

  2011cites this paper
• Immune Responses Associated With Perioperative Exposure and Reexposure to Topical Bovine Thrombin Do Not Impair Hemostasis

  2011influential citation
• Hemostasis in burn surgery--a review.

  2011cites this paper
• Adverse drug events associated with disorders of coagulation

  2010cites this paper
• The use of platelet-rich plasma combined with demineralized freeze-dried bone allograft in the treatment of periodontal endosseous defects

  2010cites this paper
• The use of platelet-rich plasma combined with demineralized freeze-dried bone allograft in the treatment of periodontal endosseous defects: a report of two clinical cases.

  2010cites this paper
• The long term immunological response of swine after two exposures to a salmon thrombin and fibrinogen hemostatic bandage.

  2010cites this paper
• False Aneurysm in the Groin Following Coronary Angioplasty

  2010cites this paper
• Topical recombinant human thrombin in surgical hemostasis.

  2010cites this paper
• Cross-Reactivity of Rabbit Anti-Bovine Prothrombin/Thrombin IgGs With Bovine Factor V/Va-Related Antigens

  2010influential citation
• Topical Recombinant Human Thrombin in Surgical Hemostasis

  2010cites this paper
• Platelet-Rich Fibrin ( PRF )-The effect of storage time on platelet concentration acronYmS

  year unknowncites this paper