Comprehensive management of HPV‐related squamous cell carcinoma of the head and neck of unknown primary

Human papillomavirus (HPV)‐related squamous cell carcinoma of unknown primary (SCCUP) is currently rising in incidence but lacks a validated management approach.

• Publication year

  2019

• Venue

  Head and Neck

• Publication date

  2019-07-13

• Fields of study

  Medicine

• Identifiers
  DOI 10.1002/hed.25858PMID 31301162
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• AHNS Series: Do you know your guidelines? Guideline recommendations for head and neck cancer of unknown primary site

  2018cited by this paper
• Transoral endoscopic base of tongue mucosectomy for investigation of unknown primary cancers of head and neck

  2018cited by this paper
• Antibodies against human papillomaviruses as diagnostic and prognostic biomarker in patients with neck squamous cell carcinoma from unknown primary tumor

  2018influential reference
• Outcomes of patients diagnosed with carcinoma metastatic to the neck from an unknown primary source and treated with intensity‐modulated radiation therapy

  2018cited by this paper
• Unknown primary squamous cell carcinoma of the head and neck: retrospective analysis of 80 cases

  2018cited by this paper
• Unilateral radiotherapy treatment for p16/human papillomavirus–positive squamous cell carcinoma of unknown primary in the head and neck

  2018influential reference
• Squamous cell carcinoma of unknown primary of the head and neck: Favorable prognostic factors comparable to those in oropharyngeal cancer

  2018cited by this paper
• A matched comparison of human papillomavirus–induced squamous cancer of unknown primary with early oropharynx cancer

  2018influential reference
• Patterns of care analysis for head & neck cancer of unknown primary site: a survey inside the German society of radiation oncology (DEGRO)

  2018cited by this paper
• Prevalence, prognosis, and treatment implications of retropharyngeal nodes in unknown primary head and neck carcinoma.

  2018cited by this paper
• Oropharynx‐directed ipsilateral irradiation for p16‐positive squamous cell carcinoma involving the cervical lymph nodes of unknown primary origin

  2018cited by this paper
• Transoral robotic surgery for management of cervical unknown primary squamous cell carcinoma: Updates on efficacy, surgical technique and margin status.

  2017cited by this paper
• Prognostic factors for head and neck cancer of unknown primary including the impact of human papilloma virus infection

  2017influential reference
• Neck lymph node metastases from unknown primary.

  2017cited by this paper
• Neck dissection for unknown cancer of the head and neck in the era of chemoradiation.

  2017cited by this paper
• Unknown primary head and neck squamous cell carcinoma in the era of fluorodeoxyglucose‐positron emission tomography/CT and intensity‐modulated radiotherapy

  2017cited by this paper
• 18F‐FDG PET/CT vs. human papillomavirus, p16 and Epstein–Barr virus detection in cervical metastatic lymph nodes for identifying primary tumors

  2017cited by this paper
• p16 Immunohistochemistry Is a Useful Diagnostic Adjunct in Cases of Metastatic Cervical Carcinoma of Unknown Origin.

  2017cited by this paper
• Validation of Human Papillomavirus as a Favourable Prognostic Marker and Analysis of CD8+ Tumour-infiltrating Lymphocytes and Other Biomarkers in Cancer of Unknown Primary in the Head and Neck Region.

  2017cited by this paper
• Human papillomavirus as prognostic marker with rising prevalence in neck squamous cell carcinoma of unknown primary: A retrospective multicentre study.

  2017influential reference
• Head and neck cancers—major changes in the American Joint Committee on cancer eighth edition cancer staging manual

  2017cited by this paper
• Detection of clinically occult primary tumours in patients with cervical metastases of unknown primary tumours: comparison of three-dimensional THRIVE MRI, two-dimensional spin-echo MRI, and contrast-enhanced CT.

  2017cited by this paper
• Current and future techniques for human papilloma virus (HPV) testing in oropharyngeal squamous cell carcinoma

  2017cited by this paper
• F-fluorodeoxyglucose positron emission tomography-computed tomography as a screening tool for second primary cancers in cancer patients

  2017cited by this paper
• Targeted sequencing of tonsillar and base of tongue cancer and human papillomavirus positive unknown primary of the head and neck reveals prognostic effects of mutated FGFR3

  2017influential reference
• p16‐positive lymph node metastases from cutaneous head and neck squamous cell carcinoma: No association with high‐risk human papillomavirus or prognosis and implications for the workup of the unknown primary

  2016cited by this paper
• Optimization of radiotherapy for neck carcinoma metastasis from unknown primary sites: a meta-analysis

  2016cited by this paper
• Impact of p16 expression, nodal status, and smoking on oncologic outcomes of patients with head and neck unknown primary squamous cell carcinoma

  2016influential reference
• Impact of cisplatin dose intensity on human papillomavirus-related and -unrelated locally advanced head and neck squamous cell carcinoma.

  2016cited by this paper
• Investigation and management of the unknown primary with metastatic neck disease: United Kingdom National Multidisciplinary Guidelines

  2016cited by this paper
• The role of transoral robotic surgery, transoral laser microsurgery, and lingual tonsillectomy in the identification of head and neck squamous cell carcinoma of unknown primary origin: a systematic review

  2016cited by this paper
• A Nordic survey on the management of head and neck CUP

  2016influential reference
• Narrow band imaging for the diagnosis of head and neck squamous cell carcinoma: A systematic review

  2016cited by this paper
• Radiotherapy Characteristics and Outcomes for Head and Neck Carcinoma of Unknown Primary vs T1 Base-of-Tongue Carcinoma.

  2016influential reference
• Challenging the need for random directed biopsies of the nasopharynx, pyriform sinus, and contralateral tonsil in the workup of unknown primary squamous cell carcinoma of the head and neck

  2016cited by this paper
• Changes in Unknown Primary Squamous Cell Carcinoma of the Head and Neck at Initial Presentation in the Era of Human Papillomavirus.

  2016cited by this paper
• Detection of occult primary tumors in patients with cervical metastases of unknown primary tumors: comparison of (18)F FDG PET/CT with contrast-enhanced CT or CT/MR imaging-prospective study.

  2015cited by this paper
• Management of human papillomavirus–related unknown primaries of the head and neck with a transoral surgical approach

  2015influential reference
• Head and neck squamous cell carcinoma of unknown primary: Neck dissection and radiotherapy or definitive radiotherapy

  2014cited by this paper
• NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines

  2014cited by this paper
• Transoral robotic approach to carcinoma of unknown primary

  2014cited by this paper
• p16 status, pathologic and clinical characteristics, biomolecular signature, and long‐term outcomes in head and neck squamous cell carcinomas of unknown primary

  2014influential reference
• A mini review on cancer of unknown primary site: A clinical puzzle for the oncologists

  2014cited by this paper
• Human papillomavirus and p53 expression in cancer of unknown primary in the head and neck region in relation to clinical outcome

  2014cited by this paper
• Human Papillomavirus in Head and Neck Squamous Cell Carcinoma of Unknown Primary Is a Common Event and a Strong Predictor of Survival

  2014cited by this paper
• Clinical Features of Human Papilloma Virus-Related Head and Neck Squamous Cell Carcinoma of an Unknown Primary Site

  2014influential reference
• p16 Expression in cutaneous squamous carcinomas with neck metastases: A potential pitfall in identifying unknown primaries of the head and neck

  2013cited by this paper
• Robotic surgery for primary head and neck squamous cell carcinoma of unknown site.

  2013cited by this paper
• p16 Expression in carcinoma of unknown primary: Diagnostic indicator and prognostic marker

  2013cited by this paper
• Role of Cytology in the Diagnosis and Management of HPV-Associated Head and Neck Carcinoma

  2013cited by this paper
• Contemporary management of lymph node metastases from an unknown primary to the neck: II. A review of therapeutic options

  2013cited by this paper
• Impact of FDG-PET/CT for the Detection of Unknown Primary Tumours in Patients with Cervical Lymph Node Metastases

  2012cited by this paper
• Human papillomavirus related head and neck cancer survival: a systematic review and meta-analysis.

  2012cited by this paper
• Radiotherapeutic management of cervical lymph node metastases from an unknown primary site.

  2012influential reference
• HPV status in patients with head and neck of carcinoma of unknown primary site: HPV, tobacco smoking, and outcome.

  2012influential reference
• Detection of Transcriptionally Active High-risk HPV in Patients With Head and Neck Squamous Cell Carcinoma as Visualized by a Novel E6/E7 mRNA In Situ Hybridization Method

  2012cited by this paper
• Squamous cell carcinoma metastatic to neck from an unknown primary: The potential impact of modern pathologic evaluation on perceived incidence of human papillomavirus–positive oropharyngeal carcinoma prior to 1970

  2012cited by this paper
• Human papilloma virus associated head and neck cancer: A PCR based study

  2012cited by this paper
• Cancer of unknown primary originating from oropharyngeal carcinomas are strongly correlated to HPV positivity

  2012cited by this paper
• A new paradigm for the diagnosis and management of unknown primary tumors of the head and neck: A role for transoral robotic surgery

  2012cited by this paper
• Human Papillomavirus in Metastatic Lymph Nodes from Unknown Primary Head and Neck Squamous Cell Carcinoma

  2011cited by this paper
• Evaluation of Human Papilloma Virus Diagnostic Testing in Oropharyngeal Squamous Cell Carcinoma: Sensitivity, Specificity, and Prognostic Discrimination

  2011cited by this paper
• Carcinoma of unknown primary in the head and neck: Comparison between positron emission tomography (PET) and PET/CT

  2011cited by this paper
• National Comprehensive Cancer Network (NCCN) Head and Neck Cancers NCCN Clinical Practice Guidelines in Oncology . 2010.

  2011cited by this paper
• Head and neck squamous cell carcinoma from an unknown primary site.

  2011influential reference
• Transoral laser microsurgery: A new approach for unknown primaries of the head and neck

  2011cited by this paper
• HEAD AND NECK SQUAMOUS CELL CANCER AND THE HUMAN PAPILLOMAVIRUS : SUMMARY OF A NATIONAL CANCER INSTITUTE STATE OF THE SCIENCE MEETING , NOVEMBER

  2009cited by this paper
• Frequency and Evolution of Azole Resistance in Aspergillus fumigatus Associated with Treatment Failure

  2009cited by this paper
• Impact of target volumes and radiation technique on loco-regional control and survival for patients with unilateral cervical lymph node metastases from an unknown primary.

  2009influential reference
• Cervical lymph node metastases of squamous cell carcinoma from an unknown primary site: a favourable prognosis subset of patients with CUP

  2009cited by this paper
• Human papillomavirus in metastatic squamous carcinoma from unknown primaries in the head and neck: a retrospective 7 year study.

  2009cited by this paper
• Head and neck squamous cell cancer and the human papillomavirus: Summary of a National Cancer Institute State of the Science Meeting, November 9–10, 2008, Washington, D.C.

  2009cited by this paper
• Diagnostic evaluation of squamous cell carcinoma metastatic to cervical lymph nodes from an unknown head and neck primary site

  2009cited by this paper
• HEAD AND NECK SQUAMOUS CELL CANCER AND THE HUMAN PAPILLOMAVIRUS: SUMMARY OF A NATIONAL CANCER INSTITUTE STATE OF THE SCIENCE MEETING,

  2009cited by this paper
• Prospective study of 18FDG‐PET in the detection and management of patients with lymph node metastases to the neck from an unknown primary tumor. Results from the DAHANCA‐13 study

  2008cited by this paper
• Cystic lymph node metastasis in patients with head and neck cancer: An HPV‐associated phenomenon

  2008cited by this paper
• Transmission of Human Papillomavirus in Heterosexual Couples

  2008cited by this paper
• P16 is overexpressed in cutaneous carcinomas located on sun-exposed areas.

  2006cited by this paper
• Diagnostic work-up and outcome of cervical metastases from an unknown primary

  2006cited by this paper
• Larynx-Sparing Radiotherapy for Squamous Cell Carcinoma From an Unknown Head and Neck Primary Site

  2005cited by this paper
• The role of fluorodeoxyglucose positron emission tomography in cervical lymph node metastases from an unknown primary tumor

  2004cited by this paper
• The unknown biology of the unknown primary tumour: a literature review.

  2003cited by this paper
• The usefulness of fluorine 18–labelled deoxyglucose positron emission tomography in the investigation of patients with cervical lymphadenopathy from an unknown primary tumor

  2003cited by this paper
• Detection of human papillomavirus in cervical lymph nodes: a highly effective strategy for localizing site of tumor origin.

  2003cited by this paper
• The p16 (CDKN2a/INK4a) Tumor-Suppressor Gene in Head and Neck Squamous Cell Carcinoma: A Promoter Methylation and Protein Expression Study in 100 Cases

  2003cited by this paper
• Detection of unknown primary tumours and distant metastases in patients with cervical metastases: value of FDG-PET versus conventional modalities

  2002cited by this paper
• Implication of 18F‐Fluoro‐2‐Deoxy‐D‐Glucose Positron Emission Tomography on Management of Carcinoma of Unknown Primary in the Head and Neck: A Danish Cohort Study

  2002cited by this paper
• Metastatic squamous cell carcinoma of the neck from an unknown primary: Management options and patterns of relapse

  2002cited by this paper
• Oncologic Rationale for Bilateral Tonsillectomy in Head and Neck Squamous Cell Carcinoma of Unknown Primary Source

  2001cited by this paper
• Cervical lymph node metastases from occult squamous cell carcinoma: cut down a tree to get an apple?

  2001cited by this paper
• 2[18F]-Fluoro-2-Deoxy-D-Glucose Positron Emission Tomography is a Sensitive Tool for the Detection of Occult Primary Cancer (Carcinoma of Unknown Primary Syndrome) with Head and Neck Lymph Node Manifestation

  2000cited by this paper
• Uses and limitations of fdg positron emission tomography in patients with head and neck cancer

  1999cited by this paper
• SQUAMOUS CELL CARCINOMA METASTATIC TO CERVICAL LYMPH NODES FROM AN UNKNOWN HEAD AND NECK PRIMARY SITE

  1998cited by this paper
• Human Papillomavirus E6 and E7: Proteins which deregulate the cell cycle

  1995cited by this paper
• The spontaneous regression of cancer. A review of cases from 1900 to 1987.

  1990cited by this paper

• Accuracy of frozen section for HPV-Associated squamous cell carcinoma of unknown primary.

  2026cites this paper
• Evaluating Clinical Factors Including HPV Clearance on Survival Outcomes in HPV+ Oropharyngeal Carcinoma

  2025cites this paper
• Efficacy of Multimodal Work-Up of Head and Neck Squamous Cell Carcinoma Lymph Node Metastasis of Unknown Primary.

  2025cites this paper
• Evaluation of Efficacy of Neoadjuvant Immunochemotherapy for Cervical Metastatic Squamous Cell Carcinoma of Unknown Primary

  2025cites this paper
• Patterns of Failure in Head and Neck Carcinoma of Unknown Primary: Insights from a Tobacco-Associated Cancer Cohort

  2025cites this paper
• HPV-Driven Head and Neck Cancer: The European Perspective

  2025cites this paper
• Cancer in Patients With Incidental Asymmetric Oropharynx Positron Emission Tomography Uptake.

  2024cites this paper
• Diagnostik, Therapie und onkologisches Outcome bei zervikalen CUP-Syndromen je nach p16-Status

  2024influential citation
• Comparative analysis of the expression of р16, PD-L1 in squamous cell carcinoma of the oropharynx and CUP syndrome

  2024cites this paper
• Challenges and Considerations in Diagnosing and Managing p16+-Related Oropharyngeal Squamous Cell Carcinoma (OPSCC) with Neck Metastasis: Implications of p16 Positivity, Tobacco Exposure, and De-Escalation Strategies

  2024cites this paper
• Postoperative Complications in Lingual Versus Palatine Tonsillectomies

  2024cites this paper
• Transoral robotic surgery in the diagnosis and treatment of primary unknown head and neck squamous cell carcinoma: A preliminary single centre experience

  2024cites this paper
• Recurrence of Cervical Lymph Node Metastasis From an Unknown Primary Site: A Report of a Case Treated Using a Multidisciplinary Approach

  2024cites this paper
• HPV-related metastatic retroperitoneal pelvic squamous cell carcinoma of unknown primary origin in a patient previously treated for endometrial cancer

  2024cites this paper
• The prognostic effect of radiological extranodal extension in HPV-positive oropharyngeal squamous cell carcinomas: a retrospective cohort analysis

  2024cites this paper
• Diagnostik, Therapie und onkologisches Outcome bei zervikalen CUP-Syndromen je nach p16-Status

  2024cites this paper
• The diagnosis and treatment for a patient with cancer of unknown primary: A case report

  2023cites this paper
• Molecular and biological factors in the prognosis of head and neck squamous cell cancer

  2023cites this paper
• Neck Node Squamous Cell Metastasis from Unknown Primary and Mutagen Sensitivity: A Case Series

  2023cites this paper
• Predictors for Survival of Patients with Squamous Cell Carcinoma of Unknown Primary in the Head and Neck Region

  2023cites this paper
• Exploring NK‐Cell molecules that impact the immune response and microenvironment in head and neck squamous cell carcinoma

  2023cites this paper
• Extracellular Vesicles as Biomarkers in Head and Neck Squamous Cell Carcinoma: From Diagnosis to Disease-Free Survival

  2023cites this paper
• Imaging Recommendations for Diagnosis, Staging, and Management of Carcinoma of Unknown Origin (Lymph Node, Pulmonary, Liver, Skeletal, and Brain) with Emphasis on the Current Position of PET-CT in Carcinoma of Unknown Origin (CUP)

  2023cites this paper
• Comprehensive analysis of cancer of unknown primary and recommendation of a histological and immunohistochemical diagnostic strategy from China

  2023cites this paper
• Systematic review of the CUP trials characteristics and perspectives for next-generation studies.

  2022cites this paper
• Prognostic Analysis of HPV Status in Sinonasal Squamous Cell Carcinoma

  2022influential citation
• Establishment and Analysis of Hypoxia-Related Model in Oral Squamous Cell Carcinoma

  2022cites this paper
• Intraoperative delineation of p16+ oropharyngeal carcinoma of unknown primary origin with fluorescence lifetime imaging: Preliminary report

  2022cites this paper
• PET-CT in Clinical Adult Oncology—V. Head and Neck and Neuro Oncology

  2022cites this paper
• Advancement in the Oropharyngeal Primary Unknown Cancer Diagnostic and Current Treatments Pathway: A Narrative Review

  2022cites this paper
• Influence of Case Management Model Combined with Continuous Nursing Care on Compliance Behavior and Adverse Emotions in Elderly Patients with Lung Cancer: A Prospective Single-Center Case-Control Study

  2022cites this paper
• Immune Cells in Head-and-Neck Tumor Microenvironments

  2022cites this paper
• Cervical squamous cell carcinoma of unknown primary: Oncological outcomes and prognostic factors

  2022influential citation
• Comparison of PD-L1 expression in squamous cell cancer of unknown primary and oropharyngeal squamous cell carcinoma

  2022cites this paper
• Survival Outcome in True Carcinoma of Unknown Primary (tCUP) with p16 + Cervical Metastasis

  2021cites this paper
• Local ablative treatment with surgery and/or radiotherapy in single-site and oligometastatic carcinoma of unknown primary.

  2021cites this paper
• Immune Infiltrates of m6A RNA Methylation-Related lncRNAs and Identification of PD-L1 in Patients With Primary Head and Neck Squamous Cell Carcinoma

  2021cites this paper
• Performance of 18F-FDG-PET/CT as a next step in the search of occult primary tumors for patients with head and neck squamous cell carcinoma of unknown primary: a systematic review and meta-analysis

  2021cites this paper
• Genomic correlates of response and resistance to immune checkpoint inhibitors in carcinomas of unknown primary

  2021cites this paper
• Human papillomavirus-related head and neck adenosquamous carcinoma: A systematic review and individual patient data meta-analysis.

  2021cites this paper
• Cancer of Unknown Primary: Challenges and Progress in Clinical Management

  2021cites this paper
• Diagnostic performance of 18F-FDG PET/CT for the detection of occult primary tumors in squamous cell carcinoma of unknown primary in the head and neck: a single-center retrospective study.

  2021cites this paper
• Technical feasibility of radiomics signature analyses for improving detection of occult tonsillar cancer

  2021cites this paper
• Carcinoma of Unknown Primary and the 8th Edition TNM Classification for Head and Neck Cancer

  2021cites this paper
• Progress in refining the clinical management of cancer of unknown primary in the molecular era

  2020cites this paper
• New rising entities in cancer of unknown primary: Is there a real therapeutic benefit?

  2020cites this paper
• The management of patients with cancer of unknown primary in middle-income countries: an ESO-AROME survey.

  2020cites this paper
• Squamous cell carcinoma of the oral cavity, larynx, oropharynx and hypopharynx: EHNS-ESMO-ESTRO Clinical Practice Guidelines for diagnosis, treatment and follow-up.

  2020cites this paper
• Exploring the biological hallmarks of cancer of unknown primary: where do we stand today?

  2020cites this paper
• The diagnostic challenges of patients with carcinoma of unknown primary

  2020cites this paper
• Squamous cell carcinoma of the oral cavity, larynx, oropharynx and hypopharynx: EHNS e ESMO e ESTRO Clinical Practice Guidelines for diagnosis, treatment and follow-up y sore tongue or non-healing

  2020cites this paper
• Clinico-pathological peculiarities of human papilloma virus driven head and neck squamous cell carcinoma: A comprehensive update.

  2020cites this paper
• Reprint of "Squamous cell carcinoma of the oral cavity, larynx, oropharynx and hypopharynx: EHNS-ESMO-ESTRO Clinical Practice Guidelines for diagnosis, treatment and follow-up".

  2020cites this paper
• HPV-related head and neck cancer

  2019cites this paper
• Tratamento de urgência em tumor primário oculto de cabeça e pescoço com sangramento refratário

  2019cites this paper
• Diagnostik, Therapie und onkologisches Outcome bei zervikalen CUP-Syndromen je nach p16-Status Diagnosis, treatment and oncological outcome of cervical CUP-syndrome depending on p16 status

  year unknowncites this paper