Inhaled NO reduces leukocyte-endothelial cell interactions and myocardial dysfunction in endotoxemic rats.

No abstract is available for this paper.

• Publication year

  2000

• Venue

  American Journal of Physiology. Heart and Circulatory Physiology

• Publication date

  2000-06-01

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1152/AJPHEART.2000.278.6.H1783PMID 10843873
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Effects of endotoxin on human myocardial contractility involvement of nitric oxide and peroxynitrite.

  1999cited by this paper
• Inhaled NO preadministration modulates local and remote ischemia-reperfusion organ injury in a rat model.

  1999cited by this paper
• Inhaled nitric oxide inhibits human platelet aggregation, P-selectin expression, and fibrinogen binding in vitro and in vivo.

  1998cited by this paper
• Inhaled NO as a viable antiadhesive therapy for ischemia/reperfusion injury of distal microvascular beds.

  1998influential reference
• L-2-Oxothiazolidine-4-carboxylic acid prevents endotoxin-induced cardiac dysfunction.

  1998cited by this paper
• Cardiopulmonary effects of inhaled nitric oxide in normal dogs and during E. coli pneumonia and sepsis.

  1998cited by this paper
• Improved Monte Carlo method for ion transport in ion-molecule asymmetric systems at high electric fields

  1998cited by this paper
• Endothelial nitric oxide synthase is downregulated during hyperdynamic sepsis.

  1997cited by this paper
• Leukocytes and decreased left-ventricular contractility during endotoxemia in rabbits.

  1997cited by this paper
• Constitutive expression of ICAM-1 in rat microvascular systems analyzed by laser confocal microscopy.

  1997cited by this paper
• Inhaled Nitric Oxide Inhibits Platelet Aggregation after Pulmonary Embolism in Pigs

  1997cited by this paper
• Blood flow regulation by S-nitrosohemoglobin in the physiological oxygen gradient.

  1997cited by this paper
• Nitric oxide, the biological mediator of the decade: fact or fiction?

  1997cited by this paper
• Myocardial morphometric changes related to decreased contractility after endotoxin.

  1996cited by this paper
• Combined inhibition of P-selectin and ICAM-1 reduces myocardial injury following ischemia and reperfusion.

  1996cited by this paper
• Nitric oxide and septic shock.

  1996influential reference
• Nitric oxide decreases cytokine-induced endothelial activation. Nitric oxide selectively reduces endothelial expression of adhesion molecules and proinflammatory cytokines.

  1995cited by this paper
• Endothelium-dependent relaxation is depressed at the macro- and microcirculatory levels during sepsis.

  1995cited by this paper
• Nitric oxide. To block or enhance its production during sepsis?

  1994cited by this paper
• The microcirculation and inflammation: modulation of leukocyte‐endothelial cell adhesion

  1994cited by this paper
• Microvascular perfusion is impaired in a rat model of normotensive sepsis.

  1994cited by this paper
• Myocardial relaxant effect of exogenous nitric oxide in isolated ejecting hearts.

  1994cited by this paper
• Development of ischemia/reperfusion tolerance in the rat small intestine. An epithelium-independent event.

  1994cited by this paper
• NO donors prevent integrin-induced leukocyte adhesion but not P-selectin-dependent rolling in postischemic venules.

  1994cited by this paper
• Diminished basal nitric oxide release after myocardial ischemia and reperfusion promotes neutrophil adherence to coronary endothelium.

  1993cited by this paper
• Nitric oxide prevents leukocyte adherence: role of superoxide.

  1993cited by this paper
• NO forms an adduct with serum albumin that has endothelium-derived relaxing factor-like properties.

  1993cited by this paper
• Inhaled nitric oxide for the adult respiratory distress syndrome.

  1993cited by this paper
• S-nitrosylation of proteins with nitric oxide: synthesis and characterization of biologically active compounds.

  1992cited by this paper
• Nitric oxide, an endothelial cell relaxation factor, inhibits neutrophil superoxide anion production via a direct action on the NADPH oxidase.

  1992cited by this paper
• Nitric oxide modulates microvascular permeability.

  1992cited by this paper
• Neutrophil induced oxidative injury of cardiac myocytes. A compartmented system requiring CD11b/CD18-ICAM-1 adherence.

  1992cited by this paper
• Nitric oxide: an endogenous modulator of leukocyte adhesion.

  1991cited by this paper
• Role of CD11/CD18 in shear rate-dependent leukocyte-endothelial cell interactions in cat mesenteric venules.

  1991cited by this paper
• Control of coronary vascular tone by nitric oxide.

  1990cited by this paper
• Role of endotoxemia in cardiovascular dysfunction and mortality. Escherichia coli and Staphylococcus aureus challenges in a canine model of human septic shock.

  1989cited by this paper
• Endotoxin pretreatment increases endogenous myocardial catalase activity and decreases ischemia-reperfusion injury of isolated rat hearts.

  1989cited by this paper
• The cardiovascular response of normal humans to the administration of endotoxin.

  1989cited by this paper
• Coronary hemodynamics and myocardial metabolism of lactate, free fatty acids, glucose, and ketones in patients with septic shock.

  1987cited by this paper
• Gram-negative bacteremia produces both severe systolic and diastolic cardiac dysfunction in a canine model that simulates human septic shock.

  1986cited by this paper
• Modification by oxygen free radical scavengers of the metabolic and cardiovascular effects of endotoxin infusion in conscious rats.

  1986cited by this paper
• Substrate utilization and high energy phosphate levels of hearts from hyperdynamic septic rats.

  1986cited by this paper
• Profound but reversible myocardial depression in patients with septic shock.

  1984cited by this paper

• Issue Highlights.

  2017cites this paper
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  2016cites this paper
• Randomized Controlled Trial of Inhaled Nitric Oxide for the Treatment of Microcirculatory Dysfunction in Patients With Sepsis*

  2014cites this paper
• Objectives: Sepsis treatment guidelines recommend macrocircu- latory hemodynamic optimization; however, microcirculatory dys- function is integral to sepsis pathogenesis. We aimed to test the hypothesis that following macrocirculatory optimization, inhaled nitric oxide would improve microcirculation

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  2013cites this paper
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  2013cites this paper
• Inhaled NO therapy increases blood nitrite, nitrate and S- nitrosohemoglobin concentrations in infants with pulmonary hypertension

  2012cites this paper
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  2012cites this paper
• Extrapulmonary Effects of Inhaled Nitric Oxide

  2012cites this paper
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  2012cites this paper
• Is nitroglycerine ready for prime time in septic shock management?

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  2011cites this paper
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  2011cites this paper
• Nitric Oxide and Inhaled Pulmonary Vasodilators

  2010cites this paper
• S-nitroso human serum albumin given after LPS challenge reduces acute lung injury and prolongs survival in a rat model of endotoxemia

  2009cites this paper
• Steroids and nitric oxide in sepsis.

  2008cites this paper
• Plasma detection of NO by a catheter

  2008cites this paper
• Resuscitating the microcirculation in sepsis: the central role of nitric oxide, emerging concepts for novel therapies, and challenges for clinical trials.

  2008cites this paper
• Steroids and nitric oxide in sepsis 1700 1700 release of adrenocorticotropic hormone ( ACTH ) from the anterior pituitary into the blood

  2007cites this paper
• Sepsis and the heart.

  2007cites this paper
• Inhaled nitric oxide treatment inhibits neuronal injury after meconium aspiration in piglets.

  2007cites this paper
• Nitric oxide inhalation improves microvascular flow and decreases infarction size after myocardial ischemia and reperfusion.

  2007cites this paper
• Cardiac ICAM-1 mediates leukocyte-dependent decreased ventricular contractility in endotoxemic mice.

  2006influential citation
• Inhaled nitric oxide decreases infarction size and improves left ventricular function in a murine model of myocardial ischemia-reperfusion injury.

  2006cites this paper
• Extrapulmonary effects of inhaled nitric oxide: role of reversible S-nitrosylation of erythrocytic hemoglobin.

  2006cites this paper
• EVALUATING MYOCARDIAL DEPRESSION IN SEPSIS

  2004cites this paper
• Peroxynitrite decomposition catalysts prevent myocardial dysfunction and inflammation in endotoxemic rats.

  2004cites this paper
• Inhaled nitric oxide in 2003: a review of its mechanisms of action

  2003cites this paper
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  2002cites this paper
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  2002cites this paper
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  2001cites this paper