Ursolic acid improves domoic acid-induced cognitive deficits in mice.

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Toxicology and Applied Pharmacology

• Publication date

  2013-09-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/j.taap.2013.04.038PMID 23707761
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Ursolic acid promotes the neuroprotection by activating Nrf2 pathway after cerebral ischemia in mice.

  2013cited by this paper
• Small interfering RNA-mediated knockdown of protein kinase C zeta attenuates domoic acid-induced cognitive deficits in mice.

  2012cited by this paper
• Cyanidin 3-glucoside attenuates obesity-associated insulin resistance and hepatic steatosis in high-fat diet-fed and db/db mice via the transcription factor FoxO1.

  2012cited by this paper
• Purple sweet potato color attenuates domoic acid-induced cognitive deficits by promoting estrogen receptor-α-mediated mitochondrial biogenesis signaling in mice.

  2012influential reference
• Ursolic acid attenuates lipopolysaccharide-induced cognitive deficits in mouse brain through suppressing p38/NF-κB mediated inflammatory pathways.

  2011influential reference
• Troxerutin protects against high cholesterol-induced cognitive deficits in mice.

  2011influential reference
• A High Content Drug Screen Identifies Ursolic Acid as an Inhibitor of Amyloid β Protein Interactions with Its Receptor CD36*

  2011cited by this paper
• mRNA Expression Signatures of Human Skeletal Muscle Atrophy Identify a Natural Compound that Increases Muscle Mass

  2011influential reference
• Ursolic acid improves high fat diet-induced cognitive impairments by blocking endoplasmic reticulum stress and IκB kinase β/nuclear factor-κB-mediated inflammatory pathways in mice.

  2011influential reference
• Analytical approaches for an important shellfish poisoning agent: domoic Acid.

  2010cited by this paper
• Domoic acid as a developmental neurotoxin.

  2010influential reference
• NGF‐Dependent Activation of TrkA Pathway: A Mechanism for the Neuroprotective Effect of Troxerutin in D‐Galactose‐Treated Mice

  2010influential reference
• Ursolic acid attenuates D-galactose-induced inflammatory response in mouse prefrontal cortex through inhibiting AGEs/RAGE/NF-κB pathway activation.

  2010influential reference
• Inhibition of PI3K/AKT and MAPK/ERK pathways causes activation of FOXO transcription factor, leading to cell cycle arrest and apoptosis in pancreatic cancer

  2010cited by this paper
• Domoic acid and human exposure risks: a review.

  2010cited by this paper
• Purple Sweet Potato Color Alleviates D‐galactose‐induced Brain Aging in Old Mice by Promoting Survival of Neurons via PI3K Pathway and Inhibiting Cytochrome C‐mediated Apoptosis

  2010influential reference
• Quercetin activates AMP‐activated protein kinase by reducing PP2C expression protecting old mouse brain against high cholesterol‐induced neurotoxicity

  2010cited by this paper
• Chronic administration of troxerutin protects mouse brain against D-galactose-induced impairment of cholinergic system.

  2010influential reference
• Spectral analysis of electrocorticographic activity during pharmacological preconditioning and seizure induction by intrahippocampal domoic acid

  2009cited by this paper
• Trace amounts of copper exacerbate beta amyloid-induced neurotoxicity in the cholesterol-fed mice through TNF-mediated inflammatory pathway.

  2009influential reference
• Foxo1 integrates insulin signaling with mitochondrial function in the liver

  2009influential reference
• FoxO1 and hepatic lipid metabolism

  2009cited by this paper
• Domoic acid impairment of cardiac energetics.

  2008cited by this paper
• FoxO1 mediates insulin-dependent regulation of hepatic VLDL production in mice.

  2008cited by this paper
• Dynamic FoxO transcription factors

  2007cited by this paper
• Ursolic acid ameliorates cognition deficits and attenuates oxidative damage in the brain of senescent mice induced by D-galactose.

  2007cited by this paper
• Stressing the role of FoxO proteins in lifespan and disease

  2007cited by this paper
• Amelioration of obesity and glucose intolerance in high-fat-fed C57BL/6 mice by anthocyanins and ursolic acid in Cornelian cherry (Cornus mas).

  2006cited by this paper
• RNAi-mediated silencing of estrogen receptor α in the ventromedial nucleus of hypothalamus abolishes female sexual behaviors

  2006influential reference
• Ursolic acid protects hippocampal neurons against kainate-induced excitotoxicity in rats.

  2004cited by this paper
• Multiple elements regulate nuclear/cytoplasmic shuttling of FOXO1: characterization of phosphorylation- and 14-3-3-dependent and -independent mechanisms.

  2004cited by this paper
• The mouse brain in stereotaxic coordinates

  2003influential reference
• Cellular response to oxidative stress: Signaling for suicide and survival *

  2002cited by this paper
• Working memory deficits induced by single but not repeated exposures to domoic acid.

  1999cited by this paper
• Brain Fos induction is a sensitive biomarker for the lowest observed neuroexcitatory effects of domoic acid.

  1996cited by this paper
• Neurologic sequelae of domoic acid intoxication due to the ingestion of contaminated mussels.

  1990cited by this paper
• Protein measurement with the Folin phenol reagent.

  1951cited by this paper

• Molecular and Cellular Mechanisms Underlying Domoic Acid-Induced Neurotoxicity and Therapeutic Drugs: A Comprehensive Review

  2026cites this paper
• The Toxic Effects of Environmental Domoic Acid Exposure on Humans and Marine Wildlife

  2025cites this paper
• Ursolic acid enhances social behavior and modulates Th1, Th17, and T regulatory cell-related transcription factor signaling in the BTBR T+ Itpr3tf/J mouse model of autism.

  2025cites this paper
• Combined Exercise and Ursolic Acid Improve Hippocampal Neuronal Markers and Exploratory-Locomotor Behavior in Aged Diabetic Rats

  2025cites this paper
• Network toxicology and molecular docking reveal key mechanisms of domoic acid neurotoxicity with bio-layer interferometry validation.

  2025cites this paper
• Multifunctional Roles and Phytopharmacological Potential of Ursolic Acid: an Invaluable Natural Nutraceutical Agent

  2025cites this paper
• Chemistry and bioactivity of marine algal toxins and their geographic distribution in China.

  2024cites this paper
• Neuroprotective properties of Betulin, Betulinic acid, and Ursolic acid as triterpenoids derivatives: a comprehensive review of mechanistic studies

  2023cites this paper
• Echinacoside alleviates sevoflurane‐induced cognitive dysfunction by activating FOXO1‐mediated autophagy

  2022cites this paper
• Ursolic Acid Enhances Myelin Repair in Adult Mice Brains and Stimulates Exhausted Oligodendrocyte Progenitors to Remyelinate

  2022cites this paper
• Oleanolic acid and ursolic acid: therapeutic potential in neurodegenerative diseases, neuropsychiatric diseases and other brain disorders

  2022influential citation
• Public health risks associated with chronic, low-level domoic acid exposure: A review of the evidence.

  2021cites this paper
• Therapeutic Potential of Ursolic Acid in Cancer and Diabetic Neuropathy Diseases

  2021cites this paper
• Potential Role of Natural Products to Combat Radiotherapy and Their Future Perspectives

  2021cites this paper
• MECHANISTIC EVALUATION OF URSOLIC ACID AGAINST ROTENONE INDUCED PARKINSON'S DISEASE- EMPHASIZING THE ROLE OF MITOCHONDRIAL BIOGENESIS.

  2020cites this paper
• Myelin Protection by Ursolic Acid in Cuprizone-Induced Demyelination in Mice

  2019cites this paper
• Antioxidant and Anti-inflammatory Mechanisms of Neuroprotection by Ursolic Acid: Addressing Brain Injury, Cerebral Ischemia, Cognition Deficit, Anxiety, and Depression

  2019cites this paper
• Recent Trends in Drug Discovery against Alzheimer's Disease: Use of Natural Products and Nutraceuticals from Botanicals

  2018cites this paper
• Quercetin attenuates domoic acid-induced cognitive deficits in mice

  2018cites this paper
• Therapeutic benefits of Ursolic acid in Parkinson’s, Alzheimer’s and Psychiatric diseases

  2018cites this paper
• Adeno-associated virus vector-mediated expression of DJ-1 attenuates learning and memory deficits in 2, 2´, 4, 4´-tetrabromodiphenyl ether (BDE-47)-treated mice.

  2018cites this paper
• Ursolic acid in health and disease

  2018cites this paper
• The human natural killer-1 (HNK-1) glycan mimetic ursolic acid promotes functional recovery after spinal cord injury in mouse.

  2018cites this paper
• Assessment of the Anticonvulsant Potency of Ursolic Acid in Seizure Threshold Tests in Mice

  2018cites this paper
• Functional single-walled carbon nanotubes 'CAR' for targeting dopamine delivery into the brain of parkinsonian mice.

  2017cites this paper
• Immunomodulation of Parkinson's disease using Mucuna pruriens (Mp).

  2017cites this paper
• Radioprotective effect of ursolic acid in radiation-induced impairment of neurogenesis, learning and memory in adolescent BALB/c mouse.

  2017cites this paper
• Therapeutic Potential of Ursolic Acid to Manage Neurodegenerative and Psychiatric Diseases

  2017cites this paper
• Bisphenol A and alternatives in thermal paper receipts - a German market analysis from 2015 to 2017.

  2017cites this paper
• Natural products against Alzheimer's disease: Pharmaco-therapeutics and biotechnological interventions.

  2017cites this paper
• Ursolic acid attenuates oxidative stress in nigrostriatal tissue and improves neurobehavioral activity in MPTP-induced Parkinsonian mouse model.

  2016cites this paper
• Potential hepatoprotective effects of fullerenol nanoparticles on alcohol-induced oxidative stress by ROS

  2016cites this paper
• Ursolic Acid—A Pentacyclic Triterpenoid with a Wide Spectrum of Pharmacological Activities

  2015cites this paper
• Synthesis, characterization and thermal analysis of ursolic acid solid forms

  2015cites this paper
• Mitochondrial reactive oxygen species production mediates ursolic acid-induced mitochondrial uncoupling and glutathione redox cycling, with protection against oxidant injury in H9c2 cells.

  2015cites this paper
• Neurobehavioral changes induced by di(2-ethylhexyl) phthalate and the protective effects of vitamin E in Kunming mice

  2015cites this paper
• AOP Title Binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities Short name: Binding of antagonist to NMDARs impairs cognition

  2015cites this paper
• Anxiolytic-like effects of ursolic acid in mice.

  2015cites this paper
• Cognitive deficits and anxiety induced by diisononyl phthalate in mice and the neuroprotective effects of melatonin

  2015cites this paper
• Amnesic Shellfish Poisoning: Emergency Medical Management

  2015cites this paper
• Composition nutritionnelle contenant un composant neurologique d'acide ursolique

  2014cites this paper
• 8. Domoic Acid

  2014cites this paper
• Cognitive deficits and decreased locomotor activity induced by single-walled carbon nanotubes and neuroprotective effects of ascorbic acid

  2014influential citation