Suppression of leukemia development caused by PTEN loss

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Proceedings of the National Academy of Sciences of the United States of America

• Publication date

  2011-01-06

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1073/pnas.1006937108PMID 21212363PMCID PMC3029702
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Distinct roles for PTEN in prevention of T cell lymphoma and autoimmunity in mice.

  2010influential reference
• Regulation of PTEN by CK2 and Notch1 in primary T-cell acute lymphoblastic leukemia: rationale for combined use of CK2- and γ-secretase inhibitors

  2010cited by this paper
• The impact of NOTCH1, FBW7 and PTEN mutations on prognosis and downstream signaling in pediatric T- cell acute lymphoblastic leukemia: A report from the Children's Oncology Group

  2009cited by this paper
• Phosphoinositide-dependent kinase 1 controls migration and malignant transformation but not cell growth and proliferation in PTEN-null lymphocytes

  2009cited by this paper
• Hematopoietic stem cells reversibly switch from dormancy to self-renewal during homeostasis and repair.

  2009cited by this paper
• Cancer Stem Cells in Solid Tumors

  2009cited by this paper
• Bidirectional transport of amino acids regulates mTOR and autophagy.

  2009cited by this paper
• IFNα activates dormant haematopoietic stem cells in vivo

  2009cited by this paper
• High frequency of PTEN, PI3K, and AKT abnormalities in T-cell acute lymphoblastic leukemia.

  2009cited by this paper
• Critical roles of the PI3K/Akt signaling pathway in T cell development.

  2008cited by this paper
• Multi-genetic events collaboratively contribute to Pten-null leukaemia stem-cell formation

  2008influential reference
• Identification and detection of murine leukemia blasts by flow cytometry

  2008cited by this paper
• Detection of LacZ expression by FACS-Gal analysis

  2008cited by this paper
• Genomic Analysis of the Clonal Origins of Relapsed Acute Lymphoblastic Leukemia

  2008cited by this paper
• Cancer stem cells in solid tumors.

  2007cited by this paper
• Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers

  2007cited by this paper
• Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemia

  2007influential reference
• Akt1 and Akt2 are required for αβ thymocyte survival and differentiation

  2007cited by this paper
• New therapeutic strategies for the treatment of acute lymphoblastic leukaemia

  2007cited by this paper
• Akt1 and Akt2 are required for alphabeta thymocyte survival and differentiation.

  2007cited by this paper
• Rb regulates interactions between hematopoietic stem cells and their bone marrow microenvironment.

  2007cited by this paper
• Acute myeloid leukemia is propagated by a leukemic stem cell with lymphoid characteristics in a mouse model of CALM/AF10-positive leukemia.

  2006cited by this paper
• PTEN maintains haematopoietic stem cells and acts in lineage choice and leukaemia prevention

  2006cited by this paper
• Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells

  2006influential reference
• Essential role of PI3Kdelta and PI3Kgamma in thymocyte survival.

  2006cited by this paper
• Developmental and molecular characterization of emerging beta- and gammadelta-selected pre-T cells in the adult mouse thymus.

  2006cited by this paper
• VE‐Cadherin‐Cre‐recombinase transgenic mouse: A tool for lineage analysis and gene deletion in endothelial cells

  2006cited by this paper
• Notch promotes survival of pre–T cells at the β-selection checkpoint by regulating cellular metabolism

  2005cited by this paper
• AKT signaling in normal and malignant cells

  2005cited by this paper
• mTOR·RICTOR Is the Ser473 Kinase for Akt/Protein Kinase B in 3T3-L1 Adipocytes*

  2005influential reference
• Perturbations of the AKT signaling pathway in human cancer

  2005cited by this paper
• Phosphorylation and Regulation of Akt/PKB by the Rictor-mTOR Complex

  2005influential reference
• Cutting Edge: T Cell Development Requires the Combined Activities of the p110γ and p110δ Catalytic Isoforms of Phosphatidylinositol 3-Kinase1

  2005cited by this paper
• Enforcing order within a complex locus: current perspectives on the control of V(D)J recombination at the murine T-cell receptor alpha/delta locus.

  2004cited by this paper
• Acceleration of apoptosis in CD4+CD8+ thymocytes by rapamycin accompanied by increased CD4+CD25+ T cells in the periphery1

  2004cited by this paper
• Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy

  2004cited by this paper
• Enforcing order within a complex locus: current perspectives on the control of V(D)J recombination at the murine T‐cell receptor α/δ locus

  2004cited by this paper
• The Loss of PTEN Allows TCR Lineage Thymocytes to Bypass IL-7 and Pre-TCR–mediated Signaling

  2004cited by this paper
• Activating Mutations of NOTCH1 in Human T Cell Acute Lymphoblastic Leukemia

  2004cited by this paper
• Take care of your chromosomes lest cancer take care of you.

  2003cited by this paper
• NOD/SCID/gamma(c)(null) mouse: an excellent recipient mouse model for engraftment of human cells.

  2002cited by this paper
• Regulation of the TCRalpha repertoire by the survival window of CD4(+)CD8(+) thymocytes.

  2002cited by this paper
• Cre/loxP‐mediated inactivation of the murine Pten tumor suppressor gene

  2002cited by this paper
• Clinical Resistance to STI-571 Cancer Therapy Caused by BCR-ABL Gene Mutation or Amplification

  2001cited by this paper
• Generalized lacZ expression with the ROSA26 Cre reporter strain

  1999cited by this paper
• The effect of rapamycin on T cell development in mice

  1994cited by this paper
• Immunophenotyping of acute leukemia by flow cytometric analysis. Use of CD45 and right-angle light scatter to gate on leukemic blasts in three-color analysis.

  1993cited by this paper
• RAG-1-deficient mice have no mature B and T lymphocytes.

  1992influential reference

• Regulatory role of protein tyrosine phosphatases in hematopoiesis and leukemogenesis.

  2026cites this paper
• The mitochondria as an emerging target of self-renewal in T-cell acute lymphoblastic leukemia

  2025cites this paper
• EZH2 inhibition and 5-azacytidine enhance antitumor immunity in PTEN-deficient glioblastoma by activation viral mimicry response

  2025cites this paper
• ATP citrate lyase is an essential player in the metabolic rewiring induced by PTEN loss during T-ALL development

  2024cites this paper
• ATP citrate lyase is an essential player of the metabolic rewiring induced by PTEN loss during T-ALL development

  2023cites this paper
• Signaling Pathways Leading to mTOR Activation Downstream Cytokine Receptors in Lymphocytes in Health and Disease

  2023cites this paper
• PTEN regulates hematopoietic lineage plasticity via PU.1-dependent chromatin accessibility.

  2023cites this paper
• The Effect of miR-520b on Macrophage Polarization and T Cell Immunity by Targeting PTEN in Breast Cancer

  2021cites this paper
• The telomere complex and the origin of the cancer stem cell

  2021cites this paper
• Wnt signaling mediates oncogenic synergy between Akt and Dlx5 in T-cell lymphomagenesis by enhancing cholesterol synthesis

  2020cites this paper
• Miltefosine suppression of Pten null T-ALL leukemia via β-catenin degradation through inhibition of pT308-Akt and TGFβ1/Smad3.

  2020cites this paper
• TRIM21 and PHLDA3 negatively regulate the crosstalk between the PI3K/AKT pathway and PPP metabolism

  2020cites this paper
• Antileukemic activity and mechanism of action of the novel PI3K and histone deacetylase dual inhibitor CUDC-907 in acute myeloid leukemia

  2019cites this paper
• PTEN Tumor-Suppressor: The Dam of Stemness in Cancer

  2019cites this paper
• Signaling Pathways in Leukemic Stem Cells.

  2019cites this paper
• The Key Roles of PTEN in T-Cell Acute Lymphoblastic Leukemia Development, Progression, and Therapeutic Response

  2019influential citation
• Revisiting β‐Catenin Signaling in T‐Cell Development and T‐Cell Acute Lymphoblastic Leukemia

  2019cites this paper
• Cellular Processes Involved in Jurkat Cells Exposed to Nanosecond Pulsed Electric Field

  2019cites this paper
• PTEN in Regulating Hematopoiesis and Leukemogenesis.

  2019cites this paper
• Gene expression profiling by mRNA sequencing reveals dysregulation of core genes in Rictor deficient T-ALL mouse model.

  2019cites this paper
• TRIM21 and PHLDA3 Negatively Regulate the Cross-Talk between the PI3K/AKT Pathway and PPP Metabolism

  2019cites this paper
• 3 The PI 3 K / PKB Signaling Module in Normal and Malignant Hematopoiesis

  2018cites this paper
• Functional cross-talk between PTEN and PDK1 in normal haematopoiesis and leukaemia development

  2018cites this paper
• T-ALL leukemia stem cell 'stemness' is epigenetically controlled by the master regulator SPI1

  2018cites this paper
• Analysis of the expression level and methylation of tumor protein p53, phosphatase and tensin homolog and mutS homolog 2 in N-methyl-N-nitrosourea-induced thymic lymphoma in C57BL/6 mice.

  2017cites this paper
• MN1 and PTEN gene expression in acute myeloid leukemia

  2017cites this paper
• Baboon envelope pseudotyped lentiviral vectors: a highly efficient new tool to genetically manipulate T-cell acute lymphoblastic leukaemia-initiating cells

  2017cites this paper
• Control of amino acid transport coordinates metabolic reprogramming in T-cell malignancy

  2017cites this paper
• Improving leukemic CD34+/CD38− blasts characterization with single-cell transcriptome sequencing

  2017cites this paper
• PTEN regulates PLK1 and controls chromosomal stability during cell division

  2016cites this paper
• PTEN regulates EG5 to control spindle architecture and chromosome congression during mitosis

  2016cites this paper
• Targeting childhood, adolescent and young adult non‐Hodgkin lymphoma: therapeutic horizons

  2016cites this paper
• Oncogenic PTEN functions and models in T-cell malignancies

  2016cites this paper
• Methods for PTEN in Stem Cells and Cancer Stem Cells.

  2016cites this paper
• Why should cancer biologists care about tRNAs? tRNA synthesis, mRNA translation and the control of growth.

  2015cites this paper
• Targeted therapy against cancer stem cells.

  2015cites this paper
• Outlook on PI3K/AKT/mTOR inhibition in acute leukemia

  2015cites this paper
• The effect of age at exposure on the inactivating mechanisms and relative contributions of key tumor suppressor genes in radiation-induced mouse T-cell lymphomas.

  2015cites this paper
• Targeted therapy against cancer stem cells (Review)

  2015cites this paper
• mTOR Links Environmental Signals to T Cell Fate Decisions

  2015cites this paper
• Metabolic regulation in phosphatase and tensin homologue (PTEN) null T cell lymphoma/leukaemia cells

  2015cites this paper
• Short-Term PTEN Inhibition Improves In Vitro Activation of Primordial Follicles, Preserves Follicular Viability, and Restores AMH Levels in Cryopreserved Ovarian Tissue From Cancer Patients

  2015cites this paper
• Rictor/mammalian target of rapamycin 2 regulates the development of Notch1 induced murine T-cell acute lymphoblastic leukemia via forkhead box O3.

  2014cites this paper
• Premalignant PTEN-deficient thymocytes activate microRNAs miR-146a and miR-146b as a cellular defense against malignant transformation.

  2014cites this paper
• mTOR signaling, Tregs and immune modulation.

  2014cites this paper
• Targeting the MYC and PI3K pathways eliminates leukemia-initiating cells in T-cell acute lymphoblastic leukemia.

  2014cites this paper
• Connection between Tumor Suppressor BRCA1 and PTEN in Damaged DNA Repair

  2014cites this paper
• PTEN and leukemia stem cells.

  2014cites this paper
• Winoto and miR-146 b as a cellular defense against malignant transformation Premalignant PTEN-deficient thymocytes activate microRNAs miR-146 a

  2014cites this paper
• MYC fails to efficiently shape malignant transformation in T‐cell acute lymphoblastic leukemia

  2014cites this paper
• Cancer stem cells: constantly evolving and functionally heterogeneous therapeutic targets.

  2014influential citation
• Therapeutic potential of targeting mTOR in T-cell acute lymphoblastic leukemia (review).

  2014cites this paper
• Targeting signaling pathways in T-cell acute lymphoblastic leukemia initiating cells.

  2014cites this paper
• β-Catenin activation synergizes with Pten loss and Myc overexpression in Notch-independent T-ALL.

  2013cites this paper
• AWARD NUMBER: W81XWH-10-1-0596 TITLE: Targeting Class I PI3Ks in the Treatment of T-cell Acute Lymphoblastic Leukemia

  2013cites this paper
• Cell of origin in radiation‐induced premalignant thymocytes with differentiation capability in mice conditionally losing one Bcl11b allele

  2013cites this paper
• LYMPHOID NEOPLASIA b-Catenin activation synergizes with Pten loss and Myc overexpression in Notch-independent TALL

  2013cites this paper
• Rho-associated coiled-coil kinase (ROCK) signaling and disease

  2013cites this paper
• mTOR and metabolic pathways in T cell quiescence and functional activation.

  2012cites this paper
• The PI3K/PKB signaling module as key regulator of hematopoiesis: implications for therapeutic strategies in leukemia.

  2012cites this paper
• Two hits are better than one: targeting both phosphatidylinositol 3-kinase and mammalian target of rapamycin as a therapeutic strategy for acute leukemia treatment

  2012cites this paper
• Identification of key regulatory pathways of myeloid differentiation using an mESC-based karyotypically normal cell model.

  2012cites this paper
• Targeting nonclassical oncogenes for therapy in T-ALL.

  2012cites this paper
• Selective treatment of mixed-lineage leukemia leukemic stem cells through targeting glycogen synthase kinase 3 and the canonical Wnt/&bgr;-catenin pathway

  2012cites this paper
• mTOR complex 1 plays critical roles in hematopoiesis and Pten-loss-evoked leukemogenesis.

  2012cites this paper
• Does the PI3K pathway promote or antagonize regulatory T cell development and function?

  2012influential citation
• Regulation of T Cell Homeostasis and Responses by Pten

  2012cites this paper
• PI3K/AKT/mTORC1 and MEK/ERK signaling in T-cell acute lymphoblastic leukemia: new options for targeted therapy.

  2012cites this paper
• PTEN in DNA damage repair.

  2012cites this paper
• This information is current as Autoimmunity or Lymphoma Helper Function but Does Not Lead to Pten Loss in CD 4 T Cells Enhances Their

  2012cites this paper
• Regulation and function of mTOR signalling in T cell fate decisions

  2012cites this paper
• The PI3K/PKB Signaling Module in Normal and Malignant Hematopoiesis

  2011cites this paper
• Targeting the translational apparatus to improve leukemia therapy: roles of the PI3K/PTEN/Akt/mTOR pathway

  2011cites this paper
• Autoimmunity or Lymphoma Helper Function but Does Not Lead to Pten Loss in Cd4 T Cells Enhances Their Pten Loss in Cd4 T Cells Enhances Their Helper Function but Does Not Lead to Autoimmunity or Lymphoma Materials and Methods

  year unknowncites this paper