Investigation of the role of lipoxygenase in bioactivation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in human lung.

No abstract is available for this paper.

• Publication year

  2002

• Venue

  Chemical Research in Toxicology

• Publication date

  2002-09-13

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1021/TX025524MPMID 12387624
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The assay of catalases and peroxidases.

  2006cited by this paper
• Formation of spiroiminodihydantoin nucleoside by reaction of 8-oxo-7,8-dihydro-2'-deoxyguanosine with hypochlorous acid or a myeloperoxidase-H(2)O(2)-Cl(-) system.

  2001cited by this paper
• Aromatic substrate specificity of horseradish peroxidase C studied by a combined fluorescence line narrowing/energy minimization approach: the effect of localized side-chain reorganization.

  2001cited by this paper
• Quantitative studies on the peroxidation of human low-density lipoprotein initiated by superoxide and by charged and neutral alkylperoxyl radicals.

  2001cited by this paper
• Strand cleavage of supercoiled DNA by water-soluble peroxyl radicals. The overlooked importance of peroxyl radical charge.

  2000cited by this paper
• Reactivity of horseradish peroxidase compound II toward substrates: kinetic evidence for a two-step mechanism.

  2000cited by this paper
• Lipoxygenase-mediated hydrogen peroxide-dependent N-demethylation of N,N-dimethylaniline and related compounds.

  2000cited by this paper
• Human term placental lipoxygenase-mediated N-demethylation of phenothiazines and insecticides in the presence of linoleic acid.

  2000cited by this paper
• DNA adduct formation from tobacco-specific N-nitrosamines.

  1999cited by this paper
• Co-oxidation of acrylonitrile by soybean lipoxygenase and partially purified human lung lipoxygenase.

  1999cited by this paper
• Biotransformation of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in freshly isolated human lung cells.

  1999cited by this paper
• 12-Lipoxygenase: classification, possible therapeutic benefits from inhibition, and inhibitors.

  1999cited by this paper
• Biochemistry, biology, and carcinogenicity of tobacco-specific N-nitrosamines.

  1998cited by this paper
• Inhibitors of lipoxygenase: a new class of cancer chemopreventive agents.

  1998cited by this paper
• An investigation of the metabolism of N-nitrosodimethylamine and N-nitrosomethylaniline by horseradish peroxidase in vitro.

  1997cited by this paper
• The changing cigarette, 1950-1995.

  1997cited by this paper
• Peroxidase-dependent bioactivation and oxidation of DNA and protein in benzo[a]pyrene-initiated micronucleus formation.

  1997cited by this paper
• Co-oxidative metabolism of 4-aminobiphenyl by lipoxygenase from soybean and human term placenta.

  1997cited by this paper
• Immunochemical, 32P-postlabeling, and GC/MS detection of 4-aminobiphenyl-DNA adducts in human peripheral lung in relation to metabolic activation pathways involving pulmonary N-oxidation, conjugation, and peroxidation.

  1997cited by this paper
• Cigarette smoking and changes in the histopathology of lung cancer.

  1997cited by this paper
• Nitrosamines and human cancer: introduction and overview

  1996cited by this paper
• Biotransformation of aflatoxin B1 in human lung.

  1996cited by this paper
• Recent studies on mechanisms of bioactivation and detoxification of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), a tobacco-specific lung carcinogen.

  1996cited by this paper
• The biological significance of tobacco-specific N-nitrosamines: smoking and adenocarcinoma of the lung.

  1996cited by this paper
• Co-oxidation of all-trans retinol acetate by human term placental lipoxygenase and soybean lipoxygenase.

  1996cited by this paper
• Activation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in human lung microsomes by cytochromes P450, lipoxygenase, and hydroperoxides.

  1995cited by this paper
• Formation of hydroxyl radicals on reaction of hypochlorous acid with ferrocyanide, a model iron(II) complex.

  1994cited by this paper
• Superoxide generation by lipoxygenase in the presence of NADH and NADPH.

  1994cited by this paper
• Free hydroxyl radicals are formed on reaction between the neutrophil‐derived species Superoxide anion and hypochlorous acid

  1993cited by this paper
• Two types of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone hemoglobin adducts, from metabolites which migrate into or are formed in red blood cells.

  1993cited by this paper
• Purification and partial characterization of lipoxygenase with dual catalytic activities from human term placenta.

  1993cited by this paper
• Metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in human lung and liver microsomes and cytochromes P-450 expressed in hepatoma cells.

  1992cited by this paper
• Comparison of cytochrome P-450- and peroxidase-mediated activations of carcinogenic azo dyes and N-nitrosamines.

  1992cited by this paper
• Xenobiotic metabolism by prostaglandin H synthase.

  1992cited by this paper
• Rat pulmonary lipoxygenase: dioxygenase activity and role in xenobiotic metabolism.

  1992cited by this paper
• Cooxidation of cyclophosphamide as an alternative pathway for its bioactivation and lung toxicity.

  1991cited by this paper
• Biotransformation of aflatoxin B1 in rabbit lung and liver microsomes.

  1990cited by this paper
• Prostaglandin synthase-mediated metabolism of carcinogens and a potential role for peroxyl radicals as reactive intermediates.

  1990cited by this paper
• Dioxygenase and peroxidase activities of soybean lipoxygenase: synergistic interaction between linoleic acid and hydrogen peroxide.

  1989cited by this paper
• Co-oxidation of xenobiotics: lipid peroxyl derivatives as mediators of metabolism.

  1987cited by this paper
• Deuterium isotope effect on denitrosation and demethylation of N-nitrosodimethylamine by rat liver microsomes.

  1987cited by this paper
• Reductive inactivation of soybean lipoxygenase 1 by catechols: a possible mechanism for regulation of lipoxygenase activity.

  1987cited by this paper
• The importance of hydroperoxide activation for the detection and assay of mammalian 5‐lipoxygenase

  1986cited by this paper
• Conversion of linoleic acid hydroperoxide to hydroxy, keto, epoxyhydroxy, and trihydroxy fatty acids by hematin.

  1985cited by this paper
• Hematin-catalyzed epoxidation of 7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene by polyunsaturated fatty acid hydroperoxides.

  1985cited by this paper
• Prostaglandin H synthase-dependent epoxidation of aflatoxin B1.

  1985cited by this paper
• Comparative carcinogenicity in A/J mice and metabolism by cultured mouse peripheral lung of N'-nitrosonornicotine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, and their analogues.

  1983cited by this paper
• Quasi-lipoxygenase activity of haemoglobin. A model for lipoxygenases.

  1981cited by this paper
• The lipoxygenase of reticulocytes. Purification, characterization and biological dynamics of the lipoxygenase; its identity with the respiratory inhibitors of the reticulocyte.

  1979cited by this paper
• Human pulmonary alveolar macrophages metabolise benzo(a)pyrene to proximate and ultimate mutagens

  1978cited by this paper
• Singlet oxygen formation during peroxidase catalyzed degradation of carcinogenic N-nitrosamine.

  1978cited by this paper
• Protein measurement with the Folin phenol reagent.

  1951cited by this paper

• Effects of tobacco compound 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) on the expression of epigenetically regulated genes in lung carcinogenesis

  2021cites this paper
• 1-Aminobenzotriazole: A Mechanism-Based Cytochrome P450 Inhibitor and Probe of Cytochrome P450 Biology

  2018cites this paper
• A high-effective method to separate nicotine from the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) mixtures using electrodialysis

  2017cites this paper
• Overexpression of phosphorylated MARCKS in the nicotine-derived nitrosamine ketone-induced lung cancer mice

  2017cites this paper
• Targeting histone deacetylase in lung cancer for early diagnosis: (18)F-FAHA PET/CT imaging of NNK-treated A/J mice model.

  2014cites this paper
• Cigarette Smoke and Cancer

  2011cites this paper
• NNK-Induced Lung Tumors: A Review of Animal Model

  2011cites this paper
• Vergleichende Untersuchung zum Metabolismus von nano- und mikromolaren Konzentrationen des tabakspezifischen Nitrosamins NNK in humanen Leber- und Lungenmikrosomen

  2010cites this paper
• Co-oxidation-mediated xenobiotic activation and cytotoxicity by 12-lipoxygenase in intact platelets.

  2008cites this paper
• Bioactivation of Xenobiotics in Lung: Role of CYPs and FMOs

  2008cites this paper
• Biotransformation and DNA Repair in 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone-Induced Pulmonary Carcinogenesis

  2008influential citation
• Analysis of CYP2A Contributions to Metabolism of 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone in Human Peripheral Lung Microsomes

  2007cites this paper
• CYP2A13: Variable Expression and Role in Human Lung Microsomal Metabolic Activation of the Tobacco-Specific Carcinogen 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone

  2007cites this paper
• INVESTIGATION OF THE BIOTRANSFORMATION OF 4-(METHYLNITROSAMINO)-1-(3-PYRIDYL)-1-BUTANONE BY PROSTAGLANDIN H SYNTHASE AND CYTOCHROME P450 2F

  2007cites this paper
• Cytochrome P450 enzymes as catalysts of metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, a tobacco specific carcinogen.

  2005cites this paper
• Biotransformation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in peripheral human lung microsomes.

  2003cites this paper
• IARC Monographs on the Evaluation of Carcinogenic Risks to Humans

  2003cites this paper
• IARC MONOGRAPHS ON THE EVALUATION OF CARCINOGENIC RISKS TO HUMANS

  2000cites this paper