Fast lidocaine block of cardiac and skeletal muscle sodium channels: one site with two routes of access.

No abstract is available for this paper.

• Publication year

  1993

• Venue

  Biophysical Journal

• Publication date

  1993-07-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1016/S0006-3495(93)81042-7PMID 8396459PMCID PMC1225702
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• State-dependent block underlies the tissue specificity of lidocaine action on batrachotoxin-activated cardiac sodium channels.

  1993cited by this paper
• Block of the cyclic GMP-gated channel of vertebrate rod and cone photoreceptors by l-cis-diltiazem

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  1991cited by this paper
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  1990cited by this paper
• pH-dependent binding of local anesthetics in single batrachotoxin-activated Na+ channels. Cocaine vs. quaternary compounds.

  1990influential reference
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  1990cited by this paper
• Changes in membrane structure induced by electroporation as revealed by rapid-freezing electron microscopy.

  1990cited by this paper
• Class I antiarrhythmic drug receptor: biochemical evidence for state-dependent interaction with quinidine and lidocaine.

  1989cited by this paper
• Isolation of membranes enriched in "tetrodotoxin-insensitive" saxitoxin-binding sites from mammalian ventricle. Receptor solubilization.

  1989cited by this paper
• Cocaine-induced closures of single batrachotoxin-activated Na+ channels in planar lipid bilayers

  1988influential reference
• Mechanisms of antiarrhytmic drug action: block of sodium channels in voltage clamped cardiac cell membranes

  1987cited by this paper
• A Receptor for Type I Antiarrhythmic Drugs Associated With Rat Cardiac Sodium Channels

  1987cited by this paper
• Kinetic basis for insensitivity to tetrodotoxin and saxitoxin in sodium channels of canine heart and denervated rat skeletal muscle.

  1987cited by this paper
• Blocking mechanisms of batrachotoxin-activated Na channels in artificial bilayers.

  1986cited by this paper
• Isochannels and Blocking Modes of Voltage‐Dependent Sodium Channels a

  1986cited by this paper
• BLOCKING PHARMACOLOGY OF BATRACHOTOXIN-ACTIVATED SODIUM CHANNELS

  1986cited by this paper
• Ionic permeation and blockade in Ca2+-activated K+ channels of bovine chromaffin cells

  1984influential reference
• Voltage-dependent block by saxitoxin of sodium channels incorporated into planar lipid bilayers.

  1984cited by this paper
• Batrachotoxin-activated Na+ channels in planar lipid bilayers. Competition of tetrodotoxin block by Na+

  1984cited by this paper
• Single sodium channels from rat brain incorporated into planar lipid bilayer membranes

  1983cited by this paper
• Interactions between quaternary lidocaine, the sodium channel gates, and tetrodotoxin.

  1979cited by this paper
• Local anesthetics: hydrophilic and hydrophobic pathways for the drug- receptor reaction

  1977cited by this paper
• Time- and voltage-dependent interactions of antiarrhythmic drugs with cardiac sodium channels.

  1977cited by this paper
• The pH-dependent rate of action of local anesthetics on the node of Ranvier

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• Ionic Blockage of Sodium Channels in Nerve

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• The Inhibition of Sodium Currents in Myelinated Nerve by Quaternary Derivatives of Lidocaine

  1973cited by this paper
• The Permeability of the Sodium Channel to Organic Cations in Myelinated Nerve

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• Effects of calcium ions and local anaesthetics on electrical properties of Purkinje fibres

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• Contribution to the Statistics of Pneumonia

  1857cited by this paper

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  2016cites this paper
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  2014cites this paper
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  2014cites this paper
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  2011cites this paper
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  2011cites this paper
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  2011cites this paper
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  2010cites this paper
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  2010cites this paper
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  2010cites this paper
• Novel Molecular Determinants in the Pore Region of Sodium Channels Regulate Local Anesthetic Binding

  2009cites this paper
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  2007cites this paper
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  2006cites this paper
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  2005cites this paper
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• Molecular Modeling of Local Anesthetic Drug Binding by Voltage-Gated Na Channels

  2005cites this paper
• Single sodium channels from human skeletal muscle in planar lipid bilayers: characterization and response to pentobarbital

  2004cites this paper
• Antagonism by Local Anesthetics of Sodium Channel Activators in the Presence of Scorpion Toxins: Two Mechanisms for Competitive Inhibition

  2004cites this paper
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  2003cites this paper
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  2003cites this paper
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  2003cites this paper
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  2003cites this paper
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  2002cites this paper
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  1998cites this paper
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  1998cites this paper
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  1998cites this paper
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  1998cites this paper
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  1996cites this paper
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  1996cites this paper
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  1995cites this paper
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  1995cites this paper
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  1995influential citation
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  1995cites this paper
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• Sodium channel subtypes in the rat display functional differences in the presence of veratridine.

  1994cites this paper
• Transcainide causes two modes of open-channel block with different voltage sensitivities in batrachotoxin-activated sodium channels.

  1994cites this paper
• Inhibition of the Sodium Channel by SK&F 96365, an Inhibitor of the Receptor-Operated Calcium Channel, in Mouse Diaphragm.

  1994cites this paper
• Bimodal gating of the Na+ channel.

  1994cites this paper
• Dissecting lidocaine action: diethylamide and phenol mimic separate modes of lidocaine block of sodium channels from heart and skeletal muscle.

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