In Vitro Anti-Helicobacter pylori Activity of Berberine and Barberry Extracts: A Preliminary Report

The berberine accumulation in Berberis vulgaris and antibacterial activity of plant extracts against Helicobacter pylori were examined. The antibacterial activities of berberine, the main alkaloid of B. vulgaris, and standard antimicrobials metronidazole and tetracycline were also determined. Berberine content was investigated using high-performance liquid chromatography. The antibacterial activity of plant extracts, berberine and reference antibiotics was tested by the broth microdilution method. The highest amount of berberine was found in the root bark (3.99 g/kg, dry wt). The plant extracts tested exhibited in vitro antibacterial activity against H. pylori, but the activities were lower than those of berberine.

• Publication year

  2019

• Venue

  Natural Product Communications

• Publication date

  2019-06-01

• Fields of study

  Medicine, Chemistry, Environmental Science

• Identifiers
  DOI 10.1177/1934578X19857905
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

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