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Elemental distribution in the aortic arch using LEXRF: Side effects of angiotensin receptor blockers as antihypertensive treatment

A. Pickler,A. Mantuano,C. Mota,S. FERREIRA-MACHADO,C. C. Lau,C. E. D. Almeida,C. Salata,A. L. Nascimento,T. Tanure,L. Serqueira,G. Sena,G. Fidalgo,M. Colaço,D. Bedolla,A. Gianoncelli,D. Braz,R. Barroso

Published 2019 in Microchemical journal (Print)

ABSTRACT

Abstract Hypertension is one of the major public health problems worldwide due to its strong impact on cardiovascular morbidity and mortality. It can cause damage in target organs such as arteries. Previous studies have shown that the blockade of angiotensin II type 1 receptor (AT1) with an angiotensin II receptor blocker (ARB) may reverse vascular pathology independent of blood pressure lowering. Antihypertensive agents such as ARBs have demonstrated some vascular and cardiac benefits. Studies on the distribution of elemental constituents in tissues have a great importance in the study of diseases since chemical imbalance can alter biological functions. The efficiency of ARBs in protecting organs at an elemental level has not been demonstrated in the literature. The aim of this work was to evaluate, at an elemental level, the effects of two ARBs (losartan and olmesartan) in the aortic arch of hypertensive rats. Low-energy X-ray fluorescence technique was used to analyze elemental and morphological differences in aortic samples. In view of the amount of O, Na, Mg and Zn in the aorta of the rats treated with losartan were comparable to the health rats, it can be conclude that losartan is more efficient in protect, at an elemental level, the aortic arch of hypertensive rats.

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