Role of vav1 in the Lipopolysaccharide-Mediated Upregulation of Inducible Nitric Oxide Synthase Production and Nuclear Factor for Interleukin-6 Expression Activity in Murine Macrophages

No abstract is available for this paper.

• Publication year

  2004

• Venue

  Clinical Diagnostic Laboratory Immunology

• Publication date

  2004-05-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1128/CDLI.11.3.525-531.2004PMID 15138177PMCID PMC404562
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Role of vav1- and src-related Tyrosine Kinases in Macrophage Activation by CpG DNA*

  2004cited by this paper
• Vav1 Transduces T Cell Receptor Signals to the Activation of Phospholipase C-γ1 via Phosphoinositide 3-Kinase-dependent and -independent Pathways

  2002cited by this paper
• Differential effects of p38- and extracellular signal-regulated kinase mitogen-activated protein kinase inhibitors on inducible nitric oxide synthase and tumor necrosis factor production in murine macrophages stimulated with Streptococcus pneumoniae.

  2002cited by this paper
• Vav1 Is a Component of Transcriptionally Active Complexes

  2002influential reference
• Toll receptors, CD14, and macrophage activation and deactivation by LPS.

  2002cited by this paper
• Vav-Rac1-Mediated Activation of the c-Jun N-Terminal Kinase/c-Jun/AP-1 Pathway Plays a Major Role in Stimulation of the Distal NFAT Site in the Interleukin-2 Gene Promoter

  2001influential reference
• Structural basis for relief of autoinhibition of the Dbl homology domain of proto-oncogene Vav by tyrosine phosphorylation.

  2000cited by this paper
• Toll-like receptors in the induction of the innate immune response

  2000cited by this paper
• Regulatory and Signaling Properties of the Vav Family

  2000influential reference
• Physical contact between lipopolysaccharide and toll-like receptor 4 revealed by genetic complementation.

  2000cited by this paper
• Vav2 Is an Activator of Cdc42, Rac1, and RhoA*

  2000influential reference
• A Guanine Nucleotide Exchange Factor-independent Function of Vav1 in Transcriptional Activation*

  2000influential reference
• The src family-selective tyrosine kinase inhibitor PP1 blocks LPS and IFN-gamma-mediated TNF and iNOS production in murine macrophages.

  1999cited by this paper
• The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens

  1999influential reference
• The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens

  1999cited by this paper
• Central role of transcription factor NF-IL6 for cytokine and iron-mediated regulation of murine inducible nitric oxide synthase expression.

  1999cited by this paper
• Toll-like receptor-2 mediates mycobacteria-induced proinflammatory signaling in macrophages.

  1999cited by this paper
• The role of p38 mitogen-activated protein kinase in IL-1 beta transcription.

  1999cited by this paper
• Specific inhibitors of p38 and extracellular signal-regulated kinase mitogen-activated protein kinase pathways block inducible nitric oxide synthase and tumor necrosis factor accumulation in murine macrophages stimulated with lipopolysaccharide and interferon-gamma.

  1999cited by this paper
• Role of substrates and products of PI 3-kinase in regulating activation of Rac-related guanosine triphosphatases by Vav.

  1998influential reference
• Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene.

  1998cited by this paper
• MacMARCKS Is Not Essential for Phagocytosis in Macrophages*

  1998cited by this paper
• The Vav–Rac1 Pathway in Cytotoxic Lymphocytes Regulates the Generation of Cell-mediated Killing

  1998cited by this paper
• Delay in resumption of the activity of tetracycline-regulatable promoter following removal of tetracycline analogues

  1997cited by this paper
• Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product

  1997cited by this paper
• Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) is required for lipopolysaccharide stimulation of tumor necrosis factor alpha (TNF-alpha) translation: glucocorticoids inhibit TNF-alpha translation by blocking JNK/SAPK

  1997cited by this paper
• Tyrosine Phosphorylation of the vav Proto-oncogene Product Links FcεRI to the Rac1-JNK Pathway*

  1997cited by this paper
• Bacterial LPS and IFN‐γ trigger the tyrosine phosphorylation of vav in macrophages: evidence for involvement of the hck tyrosine kinase

  1997cited by this paper
• Differential effects of tyrosine kinase inhibitors on tumor necrosis factor and nitric oxide production by murine macrophages.

  1996cited by this paper
• Role of CSBP/p38/RK stress response kinase in LPS and cytokine signaling mechanisms

  1996cited by this paper
• In vivo footprinting of the mouse inducible nitric oxide synthase gene: inducible protein occupation of numerous sites including Oct and NF-IL6.

  1996cited by this paper
• Diverse strategies for tetracycline-regulated inducible gene expression.

  1996influential reference
• Defective T-cell receptor signalling and positive selection of Vav-deficient CD4+CDS+thymocytes

  1995cited by this paper
• Defective antigen receptor-mediated proliferation of B and T cells in the absence of Vav

  1995influential reference
• A functional T-cell receptor signaling pathway is required for p95vav activity

  1995influential reference
• Defective signalling through the T- and B-cell antigen receptors in lymphoid cells lacking the vav proto-oncogene

  1995cited by this paper
• Transcriptional activation by tetracyclines in mammalian cells.

  1995cited by this paper
• A modified tetracycline-regulated system provides autoregulatory, inducible gene expression in cultured cells and transgenic mice.

  1995cited by this paper
• Upstream NFIL-6-like site located within a DNase I hypersensitivity region mediates LPS-induced transcription of the murine interleukin-1 beta gene.

  1994cited by this paper
• Monocyte deactivation by interleukin 10 via inhibition of tyrosine kinase activity and the Ras signaling pathway.

  1994cited by this paper
• Vav cooperates with Ras to transform rodent fibroblasts but is not a Ras GDP/GTP exchange factor.

  1994influential reference
• An NFIL-6 Sequence Near the Transcriptional Initiation Site Is Necessary for the Lipopolysaccharide Induction of Murine Interleukin-lβ

  1994cited by this paper
• An NFIL-6 sequence near the transcriptional initiation site is necessary for the lipopolysaccharide induction of murine interleukin-1 beta.

  1994cited by this paper
• Interferon alpha induces rapid tyrosine phosphorylation of the vav proto-oncogene product in hematopoietic cells.

  1994cited by this paper
• Mitogenic signalling and substrate specificity of the Flk2/Flt3 receptor tyrosine kinase in fibroblasts and interleukin 3-dependent hematopoietic cells

  1993cited by this paper
• The PH domain: a common piece in the structural patchwork of signalling proteins.

  1993cited by this paper
• Interleukin-2 induces tyrosine phosphorylation of the vav proto-oncogene product in human T cells: lack of requirement for the tyrosine kinase lck.

  1993cited by this paper
• Tyrosine kinase-stimulated guanine nucleotide exchange activity of Vav in T cell activation.

  1993influential reference
• Tight control of gene expression in mammalian cells by tetracycline-responsive promoters.

  1992cited by this paper
• IL‐6 and NF‐IL6 in Acute‐Phase Response and Viral Infection

  1992cited by this paper
• Proto-vav and gene expression

  1992cited by this paper
• Tyrosine Phosphorylation of the vav Proto-Oncogene Product in Activated B Cells

  1992cited by this paper
• Bacterial lipopolysaccharide induces tyrosine phosphorylation and activation of mitogen-activated protein kinases in macrophages.

  1992cited by this paper
• Product of vav proto-oncogene defines a new class of tyrosine protein kinase substrates

  1992cited by this paper
• The hematopoietically expressed vav proto-oncogene shares homology with the dbl GDP-GTP exchange factor, the bcr gene and a yeast gene (CDC24) involved in cytoskeletal organization.

  1992cited by this paper
• Tyrosine phosphorylation of vav proto-oncogene product containing SH2 domain and transcription factor motifs

  1992cited by this paper
• Bacterial lipopolysaccharide stimulates protein tyrosine phosphorylation in macrophages.

  1991cited by this paper
• Mechanism of activation of the vav protooncogene.

  1991cited by this paper
• A nuclear factor for IL‐6 expression (NF‐IL6) is a member of a C/EBP family.

  1990cited by this paper
• vav, a novel human oncogene derived from a locus ubiquitously expressed in hematopoietic cells.

  1989cited by this paper

• Proteomic profiling of macrophages: effects of inflammatory activation and anti-inflammatory treatment with IBD therapeutics.

  2025cites this paper
• Mitochondrial dynamics in diabetic peripheral neuropathy: Pathogenesis, progression, and therapeutic approaches

  2025cites this paper
• Unraveling the Oncogenic Potential of VAV1 in Human Cancer: Lessons from Mouse Models

  2023cites this paper
• Vav proteins do not influence dengue virus replication but are associated with induction of phospho-ERK, IL-6, and viperin mRNA following DENV infection in vitro

  2023cites this paper
• Proteomic analysis of the effects of Nur77 on lipopolysaccharide-induced microglial activation.

  2017cites this paper
• The Salmonella Typhimurium effector SteC inhibits Cdc42-mediated signaling through binding to the exchange factor Cdc24 in Saccharomyces cerevisiae

  2012cites this paper
• In Vitro Differentiation and Expansion of Intrathymic T Cell Progenitors from Human Umbilical Cord Blood-Derived CD34(+) Cells.

  2009cites this paper
• Cytokine-induced arginase activity in pulmonary endothelial cells is dependent on Src family tyrosine kinase activity.

  2008cites this paper
• The role of Vav proteins in macrophage morphology and migration.

  2007cites this paper
• Deficiency of Cbl-b Gene Enhances Infiltration and Activation of Macrophages in Adipose Tissue and Causes Peripheral Insulin Resistance in Mice

  2007cites this paper
• Anti-inflammatory effects of 8-hydroxy-2'-deoxyguanosine on lipopolysaccharide-induced inflammation via Rac suppression in Balb/c mice.

  2007cites this paper
• SHP-1 inhibits LPS-mediated TNF and iNOS production in murine macrophages.

  2006cites this paper
• Vav1 and Vav2 play different roles in macrophage migration and cytoskeletal organization.

  2005cites this paper