The MAPK/ERK and PI(3)K Pathways Additively Coordinate the Transcription of Recombination-Activating Genes in B Lineage Cells

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Journal of Immunology

• Publication date

  2010-09-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.4049/jimmunol.1001430PMID 20709952
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2010cited by this paper
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• Distinct roles for Foxo1 at multiple stages of B cell differentiation

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• SLP-65 regulates immunoglobulin light chain gene recombination through the PI(3)K-PKB-Foxo pathway

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• The BCL-2 protein family: opposing activities that mediate cell death

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• Effective Use of PI3K and MEK Inhibitors to Treat Mutant K-Ras G12D and PIK3CA H1047R Murine Lung Cancers

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• Accelerated Notch-Dependent Degradation of E47 Proteins in Aged B Cell Precursors Is Associated with Increased ERK MAPK Activation1

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• Basal B Cell Receptor-Directed Phosphatidylinositol 3-Kinase Signaling Turns Off RAGs and Promotes B Cell-Positive Selection1

  2007cited by this paper
• Cutting Edge: The PI3K p110δ Is Required for Down-Regulation of RAG Expression in Immature B Cells1

  2007cited by this paper
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  2007cited by this paper
• Subversion of B lymphocyte tolerance by hydralazine, a potential mechanism for drug-induced lupus

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• Foxp1 is an essential transcriptional regulator of B cell development

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• RalA interacts with ZONAB in a cell density‐dependent manner and regulates its transcriptional activity

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• E47 is required for V(D)J recombinase activity in common lymphoid progenitors

  2005cited by this paper
• A role for nuclear factor kappa B/rel transcription factors in the regulation of the recombinase activator genes.

  2005cited by this paper
• CD19 regulates positive selection and maturation in B lymphopoiesis: lack of CD19 imposes developmental arrest of immature B cells and consequential stimulation of receptor editing.

  2005cited by this paper
• Survival of Resting Mature B Lymphocytes Depends on BCR Signaling via the Igα/β Heterodimer

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• Modification of Ligand-independent B Cell Receptor Tonic Signals Activates Receptor Editing in Immature B Lymphocytes*

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• Receptor Editing and Marginal Zone B Cell Development Are Regulated by the Helix-Loop-Helix Protein, E2A

  2004cited by this paper
• Important Roles for E Protein Binding Sites within the Immunoglobulin κ Chain Intronic Enhancer in Activating Vκ Jκ Rearrangement

  2004cited by this paper
• Receptor Editing in Positive and Negative Selection of B Lymphopoiesis1

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• Signaling to NF-kappaB.

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• The nonimmunoglobulin portion of λ5 mediates cell-autonomous pre-B cell receptor signaling

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• Notch‐induced E2A ubiquitination and degradation are controlled by MAP kinase activities

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  2003cited by this paper
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• Impaired Light Chain Allelic Exclusion and Lack of Positive Selection in Immature B Cells Expressing Incompetent Receptor Deficient of CD191

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  2002cited by this paper
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• Inhibition of the MEK/ERK Signaling Pathway Blocks a Subset of B Cell Responses to Antigen1

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• Regulation of the helix-loop-helix proteins, E2A and Id3, by the Ras-ERK MAPK cascade

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• Secondary V(D)J Rearrangements and B Cell Receptor-Mediated Down-Regulation of Recombination Activating Gene-2 Expression in a Murine B Cell Line1

  2000cited by this paper
• E2A and EBF act in synergy with the V(D)J recombinase to generate a diverse immunoglobulin repertoire in nonlymphoid cells.

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• Host control of HIV-1 parasitism in T cells by the nuclear factor of activated T cells.

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• V(D)J recombinase induction in splenic B lymphocytes is inhibited by antigen-receptor signalling

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• Bcl-2 family proteins

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• In vivo ablation of surface immunoglobulin on mature B cells by inducible gene targeting results in rapid cell death.

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• Kidins220 regulates the development of B cells bearing the λ light chain

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• Activation of the MEK-ERK Pathway Is Necessary but Not Sufficient for Breaking Central B Cell Tolerance

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• The c-Myc/miR17-92/PTEN Axis Tunes PI3K Activity to Control Expression of Recombination Activating Genes in Early B Cell Development

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