Brain derived neurotrophic factor mediated learning, fear acquisition and extinction as targets for developing novel treatments for anxiety

Os transtornos da ansiedade e o transtorno obsessivo-compulsivo (TOC) e transtornos relacionados sao altamente prevalentes e incapacitantes. Apesar disso, ainda existem lacunas a serem exploradas em relacao ao tratamento desses transtornos. O medo e um sintoma central desses transtornos e sua aprendizagem e altamente dependente da atividade do fator neurotrofico derivado do cerebro (BDNF). Porem, sera que a aprendizagem de medo mediada pelo BDNF deve ser considerada um alvo para o desenvolvimento de novos tratamentos para transtornos da ansiedade, TOC e transtornos relacionados? Revisamos as evidencias que sugerem que a expressao de BDNF e necessaria para a aquisicao do medo condicionado, bem como para a evocacao de sua extincao. Descrevemos os resultados relacionados a aprendizagem de medo, manipulacao genetica e epigenetica da expressao de Bdnf em animais e variantes alelicas de BDNF em seres humanos. Posteriormente, discutimos como a manipulacao dos niveis de BDNF representa um alvo em potencial para o tratamento, o que pode aumentar os beneficios das terapias que extinguem o medo previamente condicionado.

• Publication year

  2016

• Venue

  Jornal Brasileiro De Psiquiatria

• Publication date

  2016-09-01

• Fields of study

  Not labeled

• Identifiers
  DOI 10.1590/0047-2085000000132
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

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