ETV6 gene rearrangements in hematopoietic malignant disorders.

No abstract is available for this paper.

• Publication year

  1996

• Venue

  Leukemia and Lymphoma

• Publication date

  1996-10-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.3109/10428199609054831PMID 9031109
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The 12;21 translocation involving TEL and deletion of the other TEL allele: two frequently associated alterations found in childhood acute lymphoblastic leukemia.

  1996cited by this paper
• The ETV6, CDKN1B and D12S178 loci are involved in a segment commonly deleted in various 12p aberration in different hematological malignancies.

  1996cited by this paper
• Deletion of the short arm of chromosome 12 is a secondary event in acute lymphoblastic leukemia with t(12;21).

  1996cited by this paper
• Molecular characterization of 12p abnormalities in hematologic malignancies: deletion of KIP1, rearrangement of TEL, and amplification of CCND2.

  1996cited by this paper
• Catalog of Chromosome Aberrations in Cancer

  1996cited by this paper
• Loss of heterozygosity in the chromosomal region 12p12-13 is very common in childhood acute lymphoblastic leukemia and permits the precise localization of a tumor-suppressor gene distinct from p27KIP1.

  1995cited by this paper
• Identification of cytogenetically undetected 12p13 translocations and associated deletions with fluorescence in situ hybridization

  1995cited by this paper
• Assignment of the human p27Kip1 gene to 12p13 and its analysis in leukemias.

  1995cited by this paper
• TEL/AML1 fusion resulting from a cryptic t(12;21) is the most common genetic lesion in pediatric ALL and defines a subgroup of patients with an excellent prognosis.

  1995cited by this paper
• Breakpoint heterogeneity in t(10;11) translocation in AML-M4/M5 resulting in fusion of AF10 and MLL is resolved by fluorescent in situ hybridization analysis.

  1995cited by this paper
• Fusion of the TEL gene on 12p13 to the AML1 gene on 21q22 in acute lymphoblastic leukemia.

  1995cited by this paper
• The novel activation of ABL by fusion to an ets-related gene, TEL.

  1995cited by this paper
• The t(12;21) of acute lymphoblastic leukemia results in a tel-AML1 gene fusion.

  1995cited by this paper
• Cloning and characterization of MN1, a gene from chromosome 22q11, which is disrupted by a balanced translocation in a meningioma.

  1995cited by this paper
• 5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers

  1995cited by this paper
• The fusion of TEL and ABL in human acute lymphoblastic leukaemia is a rare event

  1995cited by this paper
• Frequent loss of heterozygosity at the TEL gene locus in acute lymphoblastic leukemia of childhood.

  1995cited by this paper
• TEL and KIP1 define the smallest region of deletions on 12p13 in hematopoietic malignancies.

  1995cited by this paper
• TEL gene is involved in myelodysplastic syndromes with either the typical t(5;12)(q33;p13) translocation or its variant t(10;12)(q24;p13).

  1995cited by this paper
• High frequency of t(12;21) in childhood B-lineage acute lymphoblastic leukemia.

  1995cited by this paper
• Translocation (12;22) (p13;q11) in myeloproliferative disorders results in fusion of the ETS-like TEL gene on 12p13 to the MN1 gene on 22q11.

  1995cited by this paper
• AML1 and the 8;21 and 3;21 translocations in acute and chronic myeloid leukemia.

  1995cited by this paper
• Chronic myelomonocytic leukemia: Tel-a-kinase what Ets all about.

  1994cited by this paper
• Transcriptional activation modulated by homopolymeric glutamine and proline stretches.

  1994cited by this paper
• Fluorescence in situ hybridization mapping of translocations and deletions involving the short arm of human chromosome 12 in malignant hematologic diseases.

  1994cited by this paper
• Consistent intergenic splicing and production of multiple transcripts between AML1 at 21q22 and unrelated genes at 3q26 in (3;21)(q26;q22) translocations.

  1994cited by this paper
• Generation of the AML1‐EVI‐1 fusion gene in the t(3;21)(q26;q22) causes blastic crisis in chronic myelocytic leukemia.

  1994cited by this paper
• Chromosomal translocations in human cancer

  1994cited by this paper
• Translocation t(5;12)(q31‐q33;p12‐p13): a non‐random translocation associated with a myeloid disorder with eosinophilia

  1994cited by this paper
• DNA-binding and transcriptional activation properties of the EWS-FLI-1 fusion protein resulting from the t(11;22) translocation in Ewing sarcoma

  1994cited by this paper
• Fusion of PDGF receptor beta to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation.

  1994cited by this paper
• t( 12;21): A new recurrent translocation in acute lymphoblastic leukemia

  1994cited by this paper
• Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals.

  1994cited by this paper
• p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21.

  1994cited by this paper
• The 3;21 translocation in myelodysplasia results in a fusion transcript between the AML1 gene and the gene for EAP, a highly conserved protein associated with the Epstein-Barr virus small RNA EBER 1.

  1993cited by this paper
• Current status of cytogenetic research in childhood acute lymphoblastic leukemia.

  1993cited by this paper
• A coiled-coil oligomerization domain of Bcr is essential for the transforming function of Bcr-Abl oncoproteins

  1993cited by this paper
• t(5;12)(q31;p12). A clinical entity with features of both myeloid leukemia and chronic myelomonocytic leukemia.

  1993cited by this paper
• Current Status of Cytogenetic Research in Childhood Acute Lymphoblastic Leukemia

  1993cited by this paper
• Cytogenetic deletion maps of hematologic neoplasms: Circumstantial evidence for tumor suppressor Loci

  1993cited by this paper
• Transcriptionally active chimeric gene derived from the fusion of the AML1 gene and a novel gene on chromosome 8 in t(8;21) leukemic cells.

  1992cited by this paper
• Clinical significance of the BCR-ABL fusion gene in adult acute lymphoblastic leukemia: a Cancer and Leukemia Group B Study (8762).

  1992cited by this paper
• Identification of breakpoints in t(8;21) acute myelogenous leukemia and isolation of a fusion transcript, AML1/ETO, with similarity to Drosophila segmentation gene, runt.

  1992cited by this paper
• t(8;21) breakpoints on chromosome 21 in acute myeloid leukemia are clustered within a limited region of a single gene, AML1.

  1991cited by this paper
• Dimerization of B-type platelet-derived growth factor receptors occurs after ligand binding and is closely associated with receptor kinase activation.

  1989cited by this paper
• Nonrandom involvement of the 12p12 breakpoint in chromosome abnormalities of childhood acute lymphoblastic leukemia

  1986cited by this paper
• Nonrandom involvement of the 12p12 breakpoint in chromosome abnormalities of childhood acute lymphoblastic leukemia.

  1986cited by this paper

• Efficacy and Safety of Homoharringtonine for the Treatment of Acute Myeloid Leukemia: A Meta-analysis.

  2021cites this paper
• Identification of a novel ETV6 truncated fusion gene in myeloproliferative neoplasm, unclassifiable with t(4;12)(q12;p13)

  2020cites this paper
• Identification of candidates for driver oncogenes in scirrhous‐type gastric cancer cell lines

  2019cites this paper
• Secretory carcinoma - impact of translocation and gene fusions on salivary gland tumor.

  2017cites this paper
• Pathological features of mammary analogue secretory carcinoma of the salivary gland.

  2017cites this paper
• Chronic eosinophilic leukemia, NOS with t(5;12)(q31;p13)/ETV6-ACSL6 gene fusion: a novel variant of myeloid proliferative neoplasm with eosinophilia.

  2016cites this paper
• Expression of ETV6/TEL is associated with prognosis in non-small cell lung cancer.

  2015cites this paper
• Expression of ETV 6 / TEL is associated with prognosis in non-small cell lung cancer

  2015cites this paper
• A Case of Newly Diagnosed Chronic Myelomonocytic Leukemia with Rheumatoid Arthritis Presentation

  2014cites this paper
• Zinc finger protein 382 is downregulated by promoter hypermethylation in pediatric acute myeloid leukemia patients

  2014cites this paper
• Cytogenetic abnormalities in lymphoid disorders

  2014cites this paper
• prolymphocytic leukemia Haploinsufficiency of CDKN1B contributes to leukemogenesis in T-cell

  2013cites this paper
• ETV6 fusion genes in hematological malignancies: a review.

  2012cites this paper
• Clinicopathological characterization of mammary analogue secretory carcinoma of salivary glands

  2012cites this paper
• ABL1 fusion genes in hematological malignancies: a review

  2011cites this paper
• Acute Leukaemia: Integration of Morphological, Immunophenotypic and Genetic Information and the WHO Classification

  2010cites this paper
• Genomische Aberrationen bei primären Lymphomen des Zentralnervensystems

  2009cites this paper
• Adult B lymphoblastic leukaemia/lymphoma with hypodiploidy (-9) and a novel chromosomal translocation t(7;12)(q22;p13) presenting with severe eosinophilia – case report and review of literature

  2009cites this paper
• SNPs and Haplotypes of Ets variant 6 (ETV6) Gene Is Associated with Overweight/Obese in Korean Population

  2009cites this paper
• Chromosomal imbalances and partial uniparental disomies in primary central nervous system lymphoma

  2009cites this paper
• Haploinsufficiency of CDKN1B contributes to leukemogenesis in T-cell prolymphocytic leukemia.

  2008cites this paper
• Transformation of cytogenetically normal chronic myelomonocytic leukaemia to an acute myeloid leukaemia and the emergence of a novel +13,+15 double trisomy resulting in an adverse outcome

  2007cites this paper
• Tumor Progression and Serial Analysis of Gene Expression Analysis of Breast Combined cDNA Array Comparative Genomic Hybridization

  2006cites this paper
• Combined cDNA array comparative genomic hybridization and serial analysis of gene expression analysis of breast tumor progression.

  2006cites this paper
• ETV6 gene rearrangements in invasive breast carcinoma

  2005cites this paper
• FISH-Diagnostik bei hämatologischen Neoplasien FISH diagnostics in hematological malignancies

  2005cites this paper
• Somatic heterozygous mutations in ETV6 (TEL) and frequent absence of ETV6 protein in acute myeloid leukemia

  2005cites this paper
• Distinct molecular phenotype of malignant CD34+ hematopoietic stem and progenitor cells in chronic myelogenous leukemia

  2005cites this paper
• A new complex rearrangement involving the ETV6, LOC115548, and MN1 genes in a case of acute myeloid leukemia

  2004cites this paper
• [Biologic and clinical relevance of cytogenetic analysis in primary myelodysplastic syndromes].

  2003cites this paper
• Pituitary tumour transforming gene in endocrine cancer

  2003cites this paper
• Place de la cytogénétique dans la prise en charge des syndromes myélodysplasiques primaires

  2003cites this paper
• Translocation (8;12)(q13;p13) during disease progression in acute myelomonocytic leukemia with t(11;19)(q23;p13.1).

  2002cites this paper
• TEL Induces Aggregation in Transformed Cells and Induces Tube Formation in NIH3T3-UCLA Cells.

  2002cites this paper
• Genetic targets for the treatment of pituitary adenomas: focus on the pituitary tumor transforming gene.

  2001cites this paper
• A new family of small, palmitoylated, membrane‐associated proteins, characterized by the presence of a cysteine‐rich hydrophobic motif

  2001cites this paper
• t(7;12)(q36;p13), a new recurrent translocation involving ETV6 in infant leukemia

  2000cites this paper
• Analysis of ETV6/AML1 abnormalities in acute lymphoblastic leukaemia: incidence, alternative spliced forms and minimal residual disease value

  2000cites this paper
• Interstitial deletion of the short arm of chromosome 12 during clonal evolution in myelodysplastic syndrome with t(5;12)(q13;p13) involving the ETV6 gene.

  2000influential citation
• The ETS family member Tel antagonizes the Fli-1 phenotype in hematopoietic cells.

  2000cites this paper
• Molecular characterization of pediatric spindle cell tumors

  2000cites this paper
• Molecular cytogenetics localizes two new breakpoints on 11q23.3 and 21q11.2 in myelodysplastic syndrome with t(11;21) translocation

  1999cites this paper
• Multiplex PCR – a rapid screening method for detection of gene rearrangements in childhood acute lymphoblastic leukemia

  1999cites this paper
• Myeloid‐ and lymphoid‐specific breakpoint cluster regions in chromosome band 13q14 in acute leukemia

  1999cites this paper
• Augmentation of immune response by altered peptide ligands of the antigenic peptide in a human CD4+ T-cell clone reacting to TEL/AML1 fusion protein.

  1999cites this paper
• PTTG--a new pituitary tumour transforming gene.

  1999cites this paper
• Molecular features of primary MDS with cytogenetic changes.

  1998cites this paper
• Classification of acute leukaemia: the need to incorporate cytogenetic and molecular genetic information.

  1998cites this paper
• A new subtype of pre-B acute lymphoblastic leukemia with t(5;12)(q31q33;p12), molecularly and cytogenetically distinct from t(5;12) in chronic myelomonocytic leukemia.

  1997cites this paper
• THE MORPHOLOGICAL , IMMUNOPHENOTYPIC , CYTOGENETIC , MOLECULAR GENETIC ( MIC-M ) CLASSIFICATION OF ACUTE LEUKAEMIA

  year unknowncites this paper