The anti-apoptotic effect of leukotriene B4 in neutrophils: a role for phosphatidylinositol 3-kinase, extracellular signal-regulated kinase and Mcl-1.

No abstract is available for this paper.

• Publication year

  2006

• Venue

  Cellular Signalling

• Publication date

  2006-04-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/J.CELLSIG.2005.05.021PMID 15970427
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Granulocyte Macrophage Colony-stimulating Factor Signaling and Proteasome Inhibition Delay Neutrophil Apoptosis by Increasing the Stability of Mcl-1*

  2004cited by this paper
• p38-MAPK Signals Survival by Phosphorylation of Caspase-8 and Caspase-3 in Human Neutrophils

  2004cited by this paper
• Increased leukotriene B4 and interleukin-6 in exhaled breath condensate in cystic fibrosis.

  2003cited by this paper
• macrophage survival Serine phosphorylation of STAT 3 is essential for Mcl-1 expression and

  2003cited by this paper
• A Combinatorial G Protein-coupled Receptor Reconstitution System on Budded Baculovirus

  2003cited by this paper
• The role of PI3K in immune cells

  2003cited by this paper
• Map kinase signaling pathways and hematologic malignancies.

  2003cited by this paper
• Janus Kinase 2 Activation by the Platelet-Activating Factor Receptor (PAFR): Roles of Tyk2 and PAFR C Terminus1

  2003cited by this paper
• Exhaled leukotrienes and prostaglandins in asthma.

  2002cited by this paper
• Requirement of Phosphatidylinositol 3-Kinase Activation and Calcium Influx for Leukotriene B4-induced Enzyme Release*

  2002cited by this paper
• Leukotriene B4 Stimulates Rac-ERK Cascade to Generate Reactive Oxygen Species That Mediates Chemotaxis*

  2002cited by this paper
• Modulation of Leukotriene B4 Receptor-1 Expression by Dexamethasone: Potential Mechanism for Enhanced Neutrophil Survival1

  2002cited by this paper
• Mechanisms involved in interleukin‐15‐induced suppression of human neutrophil apoptosis: role of the anti‐apoptotic Mcl‐1 protein and several kinases including Janus kinase‐2, p38 mitogen‐activated protein kinase and extracellular signal‐regulated kinases‐1/2

  2002cited by this paper
• The Phosphatidylinositol 3-Kinase (PI3K)-Akt Pathway Suppresses Bax Translocation to Mitochondria*

  2002cited by this paper
• Role of extracellular signal-regulated kinase and phosphatidylinositol-3 kinase in chemoattractant and LPS delay of constitutive neutrophil apoptosis.

  2001cited by this paper
• Inhibition of STAT3 signaling leads to apoptosis of leukemic large granular lymphocytes and decreased Mcl-1 expression.

  2001cited by this paper
• Cleavage of Mitogen-Activated Protein Kinases in Human Neutrophils Undergoing Apoptosis: Role in Decreased Responsiveness to Inflammatory Cytokines1

  2001cited by this paper
• Bltr Mediates Leukotriene B4–Induced Chemotaxis and Adhesion and Plays a Dominant Role in Eosinophil Accumulation in a Murine Model of Peritonitis

  2000cited by this paper
• Granulocyte-Macrophage Colony-Stimulating Factor Delays Neutrophil Constitutive Apoptosis Through Phosphoinositide 3-Kinase and Extracellular Signal-Regulated Kinase Pathways1

  2000cited by this paper
• Roles of PLC-β2 and -β3 and PI3Kγ in Chemoattractant-Mediated Signal Transduction

  2000cited by this paper
• Roles of PLC-beta2 and -beta3 and PI3Kgamma in chemoattractant-mediated signal transduction.

  2000cited by this paper
• Interleukin-8 and leukotriene-B(4), but not formylmethionyl leucylphenylalanine, stimulate CD18-independent migration of neutrophils across human pulmonary endothelial cells in vitro.

  2000cited by this paper
• Apoptotic signaling through the beta -adrenergic receptor. A new Gs effector pathway.

  2000cited by this paper
• Src tyrosine kinase is a novel direct effector of G proteins.

  2000cited by this paper
• Function of PI3Kgamma in thymocyte development, T cell activation, and neutrophil migration.

  2000cited by this paper
• Central role for G protein-coupled phosphoinositide 3-kinase γ in inflammation

  2000cited by this paper
• A second leukotriene B(4) receptor, BLT2. A new therapeutic target in inflammation and immunological disorders.

  2000cited by this paper
• Central role for G protein-coupled phosphoinositide 3-kinase gamma in inflammation.

  2000cited by this paper
• Apoptotic Signaling through the β-Adrenergic Receptor

  2000cited by this paper
• Differential Regulation of Responsiveness to fMLP and C5a Upon Dendritic Cell Maturation: Correlation with Receptor Expression1 2

  2000cited by this paper
• The loss of Mcl‐1 expression in human polymorphonuclear leukocytes promotes apoptosis

  2000cited by this paper
• Cytokine-mediated Bax deficiency and consequent delayed neutrophil apoptosis: a general mechanism to accumulate effector cells in inflammation.

  1999cited by this paper
• PI 3‐kinase γ and protein kinase C‐ζ mediate RAS‐independent activation of MAP kinase by a Gi protein‐coupled receptor

  1999cited by this paper
• Regulation of MCL1 through a Serum Response Factor/Elk-1-mediated Mechanism Links Expression of a Viability-promoting Member of the BCL2 Family to the Induction of Hematopoietic Cell Differentiation*

  1999cited by this paper
• Cytokine-specific activation of distinct mitogen-activated protein kinase subtype cascades in human neutrophils stimulated by granulocyte colony-stimulating factor, granulocyte-macrophage colony-stimulating factor, and tumor necrosis factor-alpha.

  1999cited by this paper
• Role of p38-mitogen-activated protein kinase in spontaneous apoptosis of human neutrophils.

  1999cited by this paper
• Mcl-1 Expression in Human Neutrophils: Regulation by Cytokines and Correlation With Cell Survival

  1998cited by this paper
• Mcl-1 expression in human neutrophils: regulation by cytokines and correlation with cell survival.

  1998cited by this paper
• Signalling through the leukotriene B4 receptor involves both alphai and alpha16, but not alphaq or alpha11 G-protein subunits.

  1998cited by this paper
• A G-protein-coupled receptor for leukotriene B4 that mediates chemotaxis

  1997cited by this paper
• Leukotrienes in ulcerative colitis: results of a multicenter trial of a leukotriene biosynthesis inhibitor, MK-591.

  1997cited by this paper
• Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery.

  1997cited by this paper
• Linkage of G Protein-Coupled Receptors to the MAPK Signaling Pathway Through PI 3-Kinase γ

  1997cited by this paper
• Role of c-Src Tyrosine Kinase in G Protein-coupled Receptorand Gβγ Subunit-mediated Activation of Mitogen-activated Protein Kinases*

  1996cited by this paper
• Neutrophil oxygen radical generation. Synergistic responses to tumor necrosis factor and mono/polyunsaturated fatty acids.

  1996cited by this paper
• Role of c-Src tyrosine kinase in G protein-coupled receptor- and Gbetagamma subunit-mediated activation of mitogen-activated protein kinases.

  1996cited by this paper
• Sequential morphologic events during apoptosis of human neutrophils. Modulation by lipoxygenase-derived eicosanoids.

  1996cited by this paper
• Ras-dependent activation of MAP kinase pathway mediated by G-protein beta gamma subunits.

  1994cited by this paper
• Direct evidence that Gi-coupled receptor stimulation of mitogen-activated protein kinase is mediated by G beta gamma activation of p21ras.

  1994cited by this paper
• Ras-dependent activation of MAP kinase pathway mediated by G-protein βγ subunits

  1994cited by this paper
• Increased Levels of Leukotriene B4 and Interleukin‐8 in Psoriatic Skin

  1993cited by this paper
• Subcellular localization of Gi alpha in human neutrophils.

  1988cited by this paper
• Molecular cloning and amino acid sequence of human 5-lipoxygenase.

  1988cited by this paper
• Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate

  1988cited by this paper
• Leukotriene B4 generation by human neutrophils following IgG-dependent stimulation.

  1987cited by this paper
• Pertussis toxin inhibition of chemotactic factor-induced calcium mobilization and function in human polymorphonuclear leukocytes

  1985cited by this paper
• Sputum leukotrienes in obstructive airways diseases.

  1984cited by this paper
• Human alveolar macrophages produce leukotriene B4.

  1982cited by this paper
• Leukotriene B4 is a potent and stereospecific stimulator of neutrophil chemotaxis and adherence.

  1981cited by this paper
• Stimulation of human leukocyte degranulation by leukotriene B4 and its omega-oxidized metabolites.

  1981cited by this paper
• Stimulation of human leukocyte degranulation by leukotriene B4 and its ω‐oxidized metabolites

  1981cited by this paper
• Transformation of arachidonic acid by rabbit polymorphonuclear leukocytes. Formation of a novel dihydroxyeicosatetraenoic acid.

  1979cited by this paper
• Macrophage and Neutrophil Specific Chemotactic Factors in Serum

  1969cited by this paper

• Neutrophils secrete exosome-associated DNA to resolve sterile acute inflammation

  2025cites this paper
• Ferroptosis in neutrophils.

  2025cites this paper
• Tumor-microbe transkingdom interactions in cancers at body interfaces: mechanisms of neutrophil lifespan extension and functional reprogramming with therapeutic implications.

  2025cites this paper
• Recent advances in function and structure of two leukotriene B4 receptors: BLT1 and BLT2.

  2022cites this paper
• Microbes and the fate of neutrophils

  2022cites this paper
• Targeting Molecular and Cellular Mechanisms in Steroid-Resistant Asthma

  2021cites this paper
• Neutrophils in the Pathogenesis of Rheumatoid Arthritis and Systemic Lupus Erythematosus: Same Foe Different M.O.

  2021cites this paper
• An ACE inhibitor reduces bactericidal activity of human neutrophils in vitro and impairs mouse neutrophil activity in vivo

  2021cites this paper
• Novel protective role for MAP kinase phosphatase 2 in inflammatory arthritis

  2019cites this paper
• Neutrophils and redox stress in the pathogenesis of autoimmune disease.

  2018cites this paper
• Always Look On the Bright Side: Anti-Tumor Functions of Neutrophils.

  2017cites this paper
• The role of the LTB4-BLT1 axis in chemotactic gradient sensing and directed leukocyte migration.

  2017cites this paper
• The proinflammatory LTB4/BLT1 signal axis confers resistance to TGF-β1-induced growth inhibition by targeting Smad3 linker region

  2015cites this paper
• Activation of TAK1 by Chemotactic and Growth Factors, and Its Impact on Human Neutrophil Signaling and Functional Responses

  2015cites this paper
• Extracellular NAD+ inhibits human neutrophil apoptosis

  2014cites this paper
• IL-32γ Delays Spontaneous Apoptosis of Human Neutrophils through MCL-1, Regulated Primarily by the p38 MAPK Pathway

  2014cites this paper
• Tulathromycin Exerts Proresolving Effects in Bovine Neutrophils by Inhibiting Phospholipases and Altering Leukotriene B4, Prostaglandin E2, and Lipoxin A4 Production

  2014cites this paper
• 5-Lipoxygenase Pathway in Experimental Abdominal Aortic Aneurysms

  2014cites this paper
• Antinociceptive and antitumor activity of novel synthetic mononuclear Ruthenium (II) compounds

  2013cites this paper
• Mechanisms regulating neutrophil survival and cell death

  2013cites this paper
• Recovery of neutrophil apoptosis by ectoine: a new strategy against lung inflammation

  2012influential citation
• Leukotriene B(4) inhibits neutrophil apoptosis via NADPH oxidase activity: redox control of NF-κB pathway and mitochondrial stability.

  2012cites this paper
• Constitutive Neutrophil Apoptosis: Regulation by Cell Concentration via S100 A8/9 and the MEK – ERK Pathway

  2012cites this paper
• Bax/Mcl-1 balance affects neutrophil survival in intermittent hypoxia and obstructive sleep apnea: effects of p38MAPK and ERK1/2 signaling

  2012influential citation
• Neutrophilic airways inflammation in lung cancer: the role of exhaled LTB-4 and IL-8

  2011cites this paper
• Leukotriene receptors.

  2011cites this paper
• International Union of Basic and Clinical Pharmacology. LXXXIV: Leukotriene Receptor Nomenclature, Distribution, and Pathophysiological Functions

  2011cites this paper
• Effects of areca nut extract on the apoptosis pathways in human neutrophils.

  2010cites this paper
• Functional Impacts of Signal Integration: Regulation of Inflammation-Related Transcription Factors by Heterotrimeric G Proteins

  2010cites this paper
• The CD14+/lowCD16+ monocyte subset is more susceptible to spontaneous and oxidant-induced apoptosis than the CD14+CD16− subset

  2010cites this paper
• 4-Hydroxynonenal enhances MMP-9 production in murine macrophages via 5-lipoxygenase-mediated activation of ERK and p38 MAPK.

  2010cites this paper
• Oberflächenrezeptoren auf Neutrophilen Granulozyten bei Patienten mit Chronischer Granulomatose

  2009cites this paper
• Regulation of neutrophil apoptosis by cytokines, pathogens and environmental stressors.

  2009cites this paper
• Calcium pyrophosphate dihydrate crystal-induced inhibition of neutrophil apoptosis: involvement of Bcl-2 family members

  2009cites this paper
• Phosphatidylinositol 3-kinase and p38 mitogen-activated protein kinase regulate induction of Mcl-1 and survival in glucocorticoid-treated human neutrophils.

  2008cites this paper
• Study of molecular and immunological factors that determine the sensitivity to the antitumor effect of Tumor Necrosis Factor

  2008cites this paper
• P2Y2 nucleotide receptors inhibit trauma‐induced death of astrocytic cells

  2007cites this paper
• Non-redundant and critical roles for leukotriene B4 receptors BLT1 and BLT2 in mouse models of inflammatory arthritis.

  2007cites this paper
• IgE Modulates Neutrophil Survival in Asthma: Role of Mitochondrial Pathway1

  2007cites this paper
• Microbe-induced apoptosis in phagocytic cells and its role in innate immunity

  2006cites this paper