Nitroxyl, redox switches, cardiac myofilaments, and heart failure: a prequel to novel therapeutics?

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Circulation Research

• Publication date

  2012-09-28

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1161/CIRCRESAHA.112.278416PMID 23023505PMCID PMC3494458
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Nitroxyl-Mediated Disulfide Bond Formation Between Cardiac Myofilament Cysteines Enhances Contractile Function

  2012cited by this paper
• Purification and high-resolution top-down mass spectrometric characterization of human salivary α-amylase.

  2012cited by this paper
• Playing with Cardiac “Redox Switches”: The “HNO Way” to Modulate Cardiac Function

  2011cited by this paper
• Comprehensive Analysis of Protein Modifications by Top-Down Mass Spectrometry

  2011cited by this paper
• Cardiac inotropes: current agents and future directions.

  2011influential reference
• Disulfides as Redox Switches: From Molecular Mechanisms to Functional Significance

  2010cited by this paper
• The emergence of nitroxyl (HNO) as a pharmacological agent.

  2009influential reference
• Top-down high-resolution mass spectrometry of cardiac myosin binding protein C revealed that truncation alters protein phosphorylation state

  2009cited by this paper
• Nitroxyl (HNO): the Cinderella of the nitric oxide story.

  2008cited by this paper
• Cardiac myofilaments: from proteome to pathophysiology

  2008cited by this paper
• Myofilament proteins: From cardiac disorders to proteomic changes

  2008cited by this paper
• Tackling heart failure in the twenty-first century

  2008cited by this paper
• Nitroxyl Improves Cellular Heart Function by Directly Enhancing Cardiac Sarcoplasmic Reticulum Ca2+ Cycling

  2007cited by this paper
• The pharmacology of nitroxyl (HNO) and its therapeutic potential: not just the Janus face of NO.

  2007influential reference
• Nitroxyl increases force development in rat cardiac muscle

  2007cited by this paper
• Hydrolysis of acyloxy nitroso compounds yields nitroxyl (HNO).

  2006cited by this paper
• The chemistry of nitroxyl (HNO) and implications in biology

  2005cited by this paper
• Myosin Crossbridge Activation of Cardiac Thin Filaments: Implications for Myocardial Function in Health and Disease

  2004cited by this paper
• Positive inotropic and lusitropic effects of HNO/NO− in failing hearts: Independence from β-adrenergic signaling

  2003cited by this paper
• Protein disulfide bond determination by mass spectrometry.

  2002cited by this paper
• On the acidity and reactivity of HNO in aqueous solution and biological systems

  2001cited by this paper
• Nitroxyl anion exerts redox-sensitive positive cardiac inotropy in vivo by calcitonin gene-related peptide signaling

  2001cited by this paper

• Gasotransmitter-Mediated Cysteinome Oxidative Posttranslational Modifications: Formation, Biological Effects, and Detection

  2023cites this paper
• Para-Substituted O-Benzyl Sulfohydroxamic Acid Derivatives as Redox-Triggered Nitroxyl (HNO) Sources

  2022cites this paper
• Cardiac myosin motor deficits are associated with left ventricular dysfunction in human ischemic heart failure.

  2022cites this paper
• Redox signaling in heart failure and therapeutic implications.

  2021cites this paper
• Interaction among Hydrogen Sulfide and Other Gasotransmitters in Mammalian Physiology and Pathophysiology.

  2021cites this paper
• In vivo effects of nitrosyl hydrogen on cardiac function and sarcoplasmic reticulum calcium pump (SERCA2a) in rats with heart failure after myocardial infarction.

  2020cites this paper
• Nitroxyl as a Potential Theranostic in the Cancer Arena

  2020cites this paper
• Role of nitroxyl (HNO) in cardiovascular system: From biochemistry to pharmacology.

  2020cites this paper
• Advances in research on treatment of heart failure with nitrosyl hydrogen

  2019cites this paper
• Gaseous Signaling Molecules in Cardiovascular Function: From Mechanisms to Clinical Translation.

  2018cites this paper
• The chemical biology of HNO signaling.

  2017cites this paper
• Interaction of Hydrogen Sulfide with Nitric Oxide in the Cardiovascular System

  2015cites this paper
• Nitroxyl (HNO) for Treatment of Acute Heart Failure

  2014cites this paper
• Functional decorations: post-translational modifications and heart disease delineated by targeted proteomics

  2013cites this paper
• Noninvasive imaging of myocardial extracellular matrix for assessment of fibrosis

  2013cites this paper
• Nitroxyl accelerates the oxidation of oxyhemoglobin by nitrite.

  2011cites this paper