Screening for Oral Premalignancy and Cancer: What Platform and Which Biomarkers?

This perspective on the report by Pattani et al. in this issue of the journal (beginning on page 1093) examines the utility of detecting hypermethylation of the candidate tumor suppressor genes endothelin receptor type B (EDNRB) and kinesin family member 1A (KIF1A) as a means of oral cancer or premalignancy screening. The data discussed here raise the possibility that saliva-based hypermethylation studies may hold promise as a cancer screening platform. This perspective also discusses some of the challenges and current limitations of developing biomarkers to screen not only for oral premalignancy and early cancer but for human papillomavirus–related oropharyngeal neoplasia as well. Cancer Prev Res; 3(9); 1056–9. ©2010 AACR.

• Publication year

  2010

• Venue

  Cancer Prevention Research

• Publication date

  2010-08-24

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1158/1940-6207.CAPR-10-0173PMID 20798207
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Endothelin Receptor Type B Gene Promoter Hypermethylation in Salivary Rinses Is Independently Associated with Risk of Oral Cavity Cancer and Premalignancy

  2010cited by this paper
• Nano-Bio-Chip Sensor Platform for Examination of Oral Exfoliative Cytology

  2010cited by this paper
• Evidence-based clinical recommendations regarding screening for oral squamous cell carcinomas

  2010cited by this paper
• Salivary microRNA: Discovery, Characterization, and Clinical Utility for Oral Cancer Detection

  2009cited by this paper
• Objective Detection and Delineation of Oral Neoplasia Using Autofluorescence Imaging

  2009cited by this paper
• Noninvasive evaluation of oral lesions using depth‐sensitive optical spectroscopy

  2009cited by this paper
• Anatomy-Based Algorithms for Detecting Oral Cancer Using Reflectance and Fluorescence Spectroscopy

  2009cited by this paper
• Cancer Statistics, 2009

  2009cited by this paper
• Incidence trends for human papillomavirus-related and -unrelated oral squamous cell carcinomas in the United States.

  2008cited by this paper
• Critical evaluation of diagnostic aids for the detection of oral cancer.

  2008cited by this paper
• Improved survival of patients with human papillomavirus-positive head and neck squamous cell carcinoma in a prospective clinical trial.

  2008cited by this paper
• Adjunctive techniques for oral cancer examination and lesion diagnosis: a systematic review of the literature.

  2008cited by this paper
• Salivary Proteomics for Oral Cancer Biomarker Discovery

  2008cited by this paper
• Distinct risk factor profiles for human papillomavirus type 16-positive and human papillomavirus type 16-negative head and neck cancers.

  2008cited by this paper
• Evaluation of Promoter Hypermethylation Detection in Body Fluids as a Screening/Diagnosis Tool for Head and Neck Squamous Cell Carcinoma

  2008cited by this paper
• Impact of Second Primary Tumors on Survival in Head and Neck Cancer: An Analysis of 2,063 Cases

  2008cited by this paper
• Fundamental differences in cell cycle deregulation in human papillomavirus-positive and human papillomavirus-negative head/neck and cervical cancers.

  2007cited by this paper
• Gene expression profiles in HPV‐infected head and neck cancer

  2007cited by this paper
• Case-control study of human papillomavirus and oropharyngeal cancer.

  2007cited by this paper
• Non-invasive measurement of the morphology and physiology of oral mucosa by use of optical spectroscopy.

  2007cited by this paper
• Prognostic value of human papillomavirus in the survival of head and neck cancer patients: an overview of the evidence.

  2005cited by this paper
• Field change and oral cancer: new evidence for widespread carcinogenesis?

  2002cited by this paper
• Evidence-Based Surgery Chirurgie factuelle Users ’ guides to the surgical literature : how to use an article about a diagnostic test

  2001cited by this paper
• Evidence for a causal association between human papillomavirus and a subset of head and neck cancers.

  2000cited by this paper
• The rational clinical examination. Does this patient have a mole or a melanoma?

  1998cited by this paper
• False-negative findings in skin cancer and melanoma screening.

  1995cited by this paper
• Users' guides to the medical literature. III. How to use an article about a diagnostic test. B. What are the results and will they help me in caring for my patients? The Evidence-Based Medicine Working Group.

  1994cited by this paper
• Users' Guides to the Medical Literature: III. How to Use an Article About a Diagnostic Test: B. What Are the Results and Will They Help Me In Caring for My Patients?

  1994cited by this paper
• NATIONAL CANCER INSTITUTE

  1993cited by this paper
• Users' guides to the medical literature.

  1993cited by this paper
• The rational clinical examination.

  1992cited by this paper
• Second malignant tumors in head and neck squamous cell carcinoma: the overshadowing threat for patients with early-stage disease.

  1989cited by this paper
• Cancer statistics

  1989cited by this paper
• Smoking and drinking in relation to oral and pharyngeal cancer.

  1988cited by this paper

• Methylation of HPV16 and EPB41L3 in oral gargles and the detection of early and late oropharyngeal cancer

  2022cites this paper
• Cellular Concentration of Survivin and Caspase 3 in Habitual Tobacco Chewers with and without Oral Squamous Cell Carcinoma in South Indian Rural Population—A Case Control Study

  2022cites this paper
• BIOMARKERS IN ORAL CANCER-A REVIEW

  2022cites this paper
• m6A Regulator-Mediated Methylation Modification Patterns and Tumor Microenvironment Cell-Infiltration Characterization in Head and Neck Cancer

  2022cites this paper
• Epidermal growth factor as a potential prognostic and predictive biomarker of response to platinum-based chemotherapy

  2021cites this paper
• Usefulness of salivary sialic acid as a tumor marker in tobacco chewers with oral cancer

  2020cites this paper
• Methylation of HPV 16 and EPB41L3 in oral gargles: Associations with oropharyngeal cancer detection and tumor characteristics

  2020cites this paper
• Diagnostic Value of FTIR Spectroscopy, Metabolomic Screening and Molecular Genetics in Saliva for Early Detection of Oral Squamous Cell Carcinoma (OSCC)

  2020cites this paper
• A Literature Review of the Potential Diagnostic Biomarkers of Head and Neck Neoplasms

  2020cites this paper
• Non-Invasive Methods for Early Diagnosis of Oral Cancer

  2019cites this paper
• Salivary proteins from dysplastic leukoplakia and oral squamous cell carcinoma and their potential for early detection.

  2019cites this paper
• Volatilomic insight of head and neck cancer via the effects observed on saliva metabolites

  2018cites this paper
• Molecular markers associated with development and progression of potentially premalignant oral epithelial lesions: Current knowledge and future implications.

  2018cites this paper
• Loss of heterozygosity as a marker to predict progression of oral epithelial dysplasia to oral squamous cell carcinoma

  2018cites this paper
• Individualized five-year risk assessment for oral premalignant lesion progression to cancer.

  2017cites this paper
• Evaluation of type-specific antibodies to high risk-human papillomavirus (HPV) proteins in patients with oropharyngeal cancer.

  2017cites this paper
• Early Detection of Malignancies and Potential Malignancies in the Oral Cavity - a systematic review

  2017cites this paper
• Human Papilloma Virus and Oropharyngeal Carcinoma - Lessons from History.

  2016cites this paper
• Identification of salivary metabolomic biomarkers for oral cancer screening

  2016cites this paper
• DETECTION OF HUMAN PAPILLOMA VIRUS IN HEAD AND NECK SQUAMOUS CELL CARCINOMAS: A LITERATURE REVIEW.

  2015cites this paper
• Quantitative proteomic analysis of microdissected oral epithelium for cancer biomarker discovery.

  2015cites this paper
• Complement activation product C4d in oral and oropharyngeal squamous cell carcinoma.

  2015cites this paper
• Patient experiences with high-risk oral lesions from detection to diagnosis

  2014cites this paper
• Proliferative verrucous leukoplakia: Recognition and differentiation from conventional leukoplakia and mimics

  2014cites this paper
• The endothelin axis in head and neck cancer: a promising therapeutic opportunity?

  2014cites this paper
• Challenges in predicting which oral mucosal potentially malignant disease will progress to neoplasia.

  2014cites this paper
• Salivary Biomarkers in Early Diagnosis and Monitoring of Cancer

  2014cites this paper
• Dilemmas of oral cancer screening: an update.

  2013cites this paper
• Urban legends series: oral leukoplakia.

  2013cites this paper
• A Light Based Screening Method Based on Tissue Autofluorescence for Oral Precancerous Lesions: A Review

  2013influential citation
• Oral prekanseröz lezyonlarda doku otofloresansı esaslı ışıkla değerlendirme yöntemi: Derleme

  2013cites this paper
• Proliferative Verrucous Leukoplakia (PVL): A Review of an Elusive Pathologic Entity!

  2013cites this paper
• Comparison of Promoter Hypermethylation Pattern in Salivary Rinses Collected with and without an Exfoliating Brush from Patients with HNSCC

  2012cites this paper
• Brush-based Cytology Screening in the Tonsils and Cervix: There Is a Difference!

  2011cites this paper