Curcumin Clubbed Preventive for Renal Damage

Curcumin (CUR) is considered of the main biological macromolecules, which is used in many foods and has an important role in the prevention of many diseases. A retrospective cohort study was performed, Sulfa drug (Sd) can cause perilous renal damages and there is no enough critical healing for Sd -induced renal damage. The work is aimed to induce nephrotoxicity through regulate the protective effects of curcumin (CUR) with Sulfa drug. Wistar Albino male rats have been administrated Sd to induce their Nephrotoxicity. "Malondialdehyde (MDA), glutathione (GSH) level and antioxidant enzyme activity" were measured in the renal tissue. Wherever, "urea, creatinine levels" were determined in the blood. Sulfa drug administration caused elevation of antioxidant enzyme activity, and levels of renal Malondialdehyde. CUR evidently was reduced the advancement of MDA levels, height antioxidant enzyme efficacy and maintained transformed renal morphology normally in administrated Sulfa drug animals.

• Publication year

  2019

• Venue

  International journal of drug development and research

• Publication date

  Unknown publication date

• Fields of study

  Medicine

• Identifiers
  DOI 10.36648/0975-9344.11.2.137
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

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