Polychlorinated Biphenyls and Nonalcoholic Fatty Liver Disease.

Polychlorinated biphenyls (PCBs) have been associated with abnormal liver enzymes and suspected nonalcoholic fatty liver disease (NAFLD) in cohort studies. NAFLD affects greater than 25% of the global population and may result in liver-related mortality. Both dioxin-like and non-dioxin-like PCBs have been associated with NAFLD, but their effects and mechanisms differ. Dioxin-like PCBs altered the gut:liver axis and microbiome and caused hepatic steatosis by disrupting hepatic lipid metabolism. In contrast, NDL PCBs reduced the liver's protective responses to promote diet-induced NAFLD. Mechanisms included the disruption of phosphoprotein signaling resulting in altered nuclear receptor function.

• Publication year

  2019

• Venue

  Current Opinion in Toxicology

• Publication date

  2019-04-01

• Fields of study

  Medicine, Environmental Science

• Identifiers
  DOI 10.1016/J.COTOX.2019.06.001PMID 34485777PMCID PMC8412140
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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