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Sol-gel composites based on alumina and ferria for cardiovascular diseases treatment

A. Drozdov,A. Fakhardo,V. Vinogradov

Published 2019 in Biocompatible Hybrid Oxide Nanoparticles for Human Health

ABSTRACT

Abstract Atherothrombosis is the reason for more than 28% of deaths in the world. Its frequency is increasing, as testified by a sharp increase in the incidence of heart attack and stroke. The paradox lies in the fact that despite its extraordinary social importance, the non-surgical methodology of treatment of these diseases has so far been very poorly developed. While traditional thrombolytic therapy is relying on enzymes which are rapidly losing their activity when introduced into the human body, the other common cardiovascular disease - atherosclerosis, remains a major challenge and still can only be prevented rather than threated. In order to change the situation, drug delivery systems are studied intensively to ensure both targeted delivery of therapeutics and their protection from degradation. Alumina and ferria as sol-gel derived materials are promising matrices for enzyme formulation. In this chapter the aspects of synthesis, properties, and bioactivity of enzyme-grafted alumina and ferria-based systems are described, focusing on their prospects for treatment of cardiovascular diseases.

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