Comparative efficacy of IV phenytoin, IV valproate and IV levetiracetam in childhood seizures

Background: Seizures are the most common pediatric neurologic disorder, with 4% to 10% of children suffering at least one seizure in the first 16 years of life objectives to compare efficacy of IV phenytoin, IV valproate, and IV levetiracetam in childhood seizures between 2months to 16 years of age.Methods: This prospective, randomized, study was done on pediatric patients in the age group of 2 months to 16 years who present actively convulsing to the emergency department of pediatrics.Results: At 24 hours seizures were controlled in 44 (88%) patients out of 50 patients in phenytoin group, 39 (78%) out of 50 patients in levetiracetam group and 46 (92%) out of 50 patients in valproate group (p-value 0.115). The relative risk of seizure recurrence for levetiracetam and phenytoin groups when compared to valproate was 2.75 and 1.5, respectively.Conclusions: Present study demonstrates that IV levetiracetam and IV valproate were comparable to IV phenytoin in terms of seizure control in acute setting. All the three are safe and efficacious. Time to regain consciousness was less in valproate group and long-term seizure control too was also better.

• Publication year

  2019

• Venue

  International Journal of Contemporary Pediatrics

• Publication date

  2019-06-27

• Fields of study

  Medicine

• Identifiers
  DOI 10.18203/2349-3291.IJCP20192761
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Status Epilepticus.

  2016cited by this paper
• Pediatric seizures.

  2013cited by this paper
• Generalized convulsive status epilepticus in adults and children: treatment guidelines and protocols.

  2011cited by this paper
• Comparative efficacy and safety of intravenous valproate and phenytoin in children.

  2011influential reference
• The role of intravenous valproate in convulsive status epilepticus in the future.

  2010cited by this paper
• Intravenous levetiracetam in critically ill children with status epilepticus or acute repetitive seizures

  2009cited by this paper
• Intravenous levetiracetam in children with epilepsy.

  2008cited by this paper
• Sodium valproate vs phenytoin in status epilepticus: A pilot study

  2007cited by this paper
• The synaptic vesicle protein SV2A is the binding site for the antiepileptic drug levetiracetam.

  2004cited by this paper
• Safety and Efficacy of Intravenous Valproate in Pediatric Status Epilepticus and Acute Repetitive Seizures

  2003cited by this paper
• Status epilepticus: emergency management.

  2003cited by this paper
• Selective Blockade of N‐Type Calcium Channels by Levetiracetam

  2002cited by this paper
• The anti‐epileptic drug levetiracetam reverses the inhibition by negative allosteric modulators of neuronal GABA‐ and glycine‐gated currents

  2002cited by this paper
• A practical approach to uncomplicated seizures in children.

  2000cited by this paper
• Treatment of Status Epilepticus

  1993cited by this paper

• No citing papers are available for this paper.