microRNA‐Mediated Regulation of Bone Remodeling: A Brief Review

microRNA (miRNA)‐mediated regulation represents a highly efficient posttranscriptional mechanism for controlling intracellular protein expression. In the past decade, many studies have shown that various miRNAs are involved in regulating bone remodeling by affecting different stages of osteoblastogenesis, osteocytic differentiation, and osteoclastogenesis to govern osteoblastic bone formation and osteoclastic bone resorption. Moreover, miRNAs are recently implicated in mediating the cell‐cell communications among bone cells. This review concentrates on the miRNA‐mediated regulatory mechanisms of osteoblasts, osteoclasts, and osteocytes, and their contribution to bone remodeling. © 2019 The Authors. JBMR Plus published by Wiley Periodicals, Inc. on behalf of American Society for Bone and Mineral Research.

• Publication year

  2019

• Venue

  JBMR Plus

• Publication date

  2019-08-07

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1002/jbm4.10213PMID 31667459PMCID 6808222
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• MiRNA-133a is involved in the regulation of postmenopausal osteoporosis through promoting osteoclast differentiation

  2018cited by this paper
• miR‐199a‐3p is involved in estrogen‐mediated autophagy through the IGF‐1/mTOR pathway in osteocyte‐like MLO‐Y4 cells

  2018cited by this paper
• Dicer1 ablation in osterix positive bone forming cells affects cortical bone homeostasis.

  2018cited by this paper
• miR-375-3p negatively regulates osteogenesis by targeting and decreasing the expression levels of LRP5 and β-catenin

  2017cited by this paper
• MicroRNA-433-3p promotes osteoblast differentiation through targeting DKK1 expression

  2017cited by this paper
• Disruption of the Cx43/miR21 pathway leads to osteocyte apoptosis and increased osteoclastogenesis with aging

  2017cited by this paper
• Osteoclastic miR-214 targets TRAF3 to contribute to osteolytic bone metastasis of breast cancer

  2017cited by this paper
• Myostatin inhibits osteoblastic differentiation by suppressing osteocyte-derived exosomal microRNA-218: A novel mechanism in muscle-bone communication

  2017cited by this paper
• Circulating osteocyte-derived exosomes contain miRNAs which are enriched in exosomes from MLO-Y4 cells.

  2017cited by this paper
• Bone-derived exosomes.

  2017cited by this paper
• miR-21 deficiency inhibits osteoclast function and prevents bone loss in mice

  2017cited by this paper
• Omics analysis of human bone to identify genes and molecular networks regulating skeletal remodeling in health and disease.

  2017cited by this paper
• MicroRNA miR-23a cluster promotes osteocyte differentiation by regulating TGF-β signalling in osteoblasts

  2017cited by this paper
• Deficiency of DGCR8 increases bone formation through downregulation of miR-22 expression.

  2017cited by this paper
• MicroRNA-467g inhibits new bone regeneration by targeting Ihh/Runx-2 signaling.

  2017cited by this paper
• miR-628-3p regulates osteoblast differentiation by targeting RUNX2: Possible role in atrophic non-union

  2016cited by this paper
• Exosomes derived from mineralizing osteoblasts promote ST2 cell osteogenic differentiation by alteration of microRNA expression

  2016cited by this paper
• miR-203 and miR-320 Regulate Bone Morphogenetic Protein-2-Induced Osteoblast Differentiation by Targeting Distal-Less Homeobox 5 (Dlx5)

  2016cited by this paper
• Dicer-dependent pathway contribute to the osteogenesis mediated by regulation of Runx2.

  2016cited by this paper
• Osteoclast-derived exosomal miR-214-3p inhibits osteoblastic bone formation

  2016cited by this paper
• RBP-J–Regulated miR-182 Promotes TNF-α–Induced Osteoclastogenesis

  2016cited by this paper
• Dicer ablation in osteoblasts by Runx2 driven cre-loxP recombination affects bone integrity, but not glucocorticoid-induced suppression of bone formation

  2016cited by this paper
• MicroRNA-335-5p inhibits osteoblast apoptosis induced by high glucose.

  2016cited by this paper
• miR-106b-5p and miR-17-5p suppress osteogenic differentiation by targeting Smad5 and inhibit bone formation.

  2016cited by this paper
• Osteoclast-derived microRNA-containing exosomes selectively inhibit osteoblast activity

  2016cited by this paper
• The roles of bone‐derived exosomes and exosomal microRNAs in regulating bone remodelling

  2016cited by this paper
• miR-214 promotes osteoclastogenesis by targeting Pten/PI3k/Akt pathway

  2015cited by this paper
• MiR‐503 Regulates Osteoclastogenesis via Targeting RANK

  2014cited by this paper
• Exosomes as divine messengers: are they the Hermes of modern molecular oncology?

  2014cited by this paper
• Expression of DGCR8‐Dependent MicroRNAs Is Indispensable for Osteoclastic Development and Bone‐Resorbing Activity

  2014cited by this paper
• miR-34a Blocks Osteoporosis and Bone Metastasis by Inhibiting Osteoclastogenesis and Tgif2

  2014cited by this paper
• Identification and Characterization of MicroRNAs Controlled by the Osteoblast-Specific Transcription Factor Osterix

  2013cited by this paper
• MicroRNA-29a protects against glucocorticoid-induced bone loss and fragility in rats by orchestrating bone acquisition and resorption.

  2013cited by this paper
• Tumor-induced osteoclast miRNA changes as regulators and biomarkers of osteolytic bone metastasis.

  2013cited by this paper
• OstemiR: A Novel Panel of MicroRNA Biomarkers in Osteoblastic and Osteocytic Differentiation from Mesencymal Stem Cells

  2013cited by this paper
• miR‐148a regulates osteoclastogenesis by targeting V‐maf musculoaponeurotic fibrosarcoma oncogene homolog B

  2013cited by this paper
• Down‐regulation of miR‐21 biogenesis by estrogen action contributes to osteoclastic apoptosis

  2013cited by this paper
• MicroRNA-214 suppresses osteogenic differentiation of C2C12 myoblast cells by targeting Osterix.

  2013cited by this paper
• miR-29 Promotes Murine Osteoclastogenesis by Regulating Osteoclast Commitment and Migration*

  2013cited by this paper
• miR-214 targets ATF4 to inhibit bone formation

  2012cited by this paper
• The RNase III Enzyme DROSHA Is Essential for MicroRNA Production and Spermatogenesis*

  2012cited by this paper
• MicroRNA control of bone formation and homeostasis

  2012cited by this paper
• The miR-29 family: genomics, cell biology, and relevance to renal and cardiovascular injury.

  2012cited by this paper
• TNF-induced osteoclastogenesis and inflammatory bone resorption are inhibited by transcription factor RBP-J

  2012cited by this paper
• Regulation and function of miRNA-21 in health and disease

  2011cited by this paper
• A microRNA expression signature of osteoclastogenesis.

  2011cited by this paper
• Effects of miR‐335‐5p in modulating osteogenic differentiation by specifically downregulating Wnt antagonist DKK1

  2011cited by this paper
• A program of microRNAs controls osteogenic lineage progression by targeting transcription factor Runx2

  2011cited by this paper
• miR-29 Modulates Wnt Signaling in Human Osteoblasts through a Positive Feedback Loop*

  2010cited by this paper
• The Amazing Osteocyte

  2010cited by this paper
• Dicer inactivation in osteoprogenitor cells compromises fetal survival and bone formation, while excision in differentiated osteoblasts increases bone mass in the adult mouse.

  2010influential reference
• Osteoclast‐specific Dicer gene deficiency suppresses osteoclastic bone resorption

  2009cited by this paper
• Impaired Micro-RNA Pathways Diminish Osteoclast Differentiation and Function*

  2009cited by this paper
• Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight?

  2008cited by this paper
• Activating transcription factor 4 is critical for proliferation and survival in primary bone marrow stromal cells and calvarial osteoblasts

  2008cited by this paper
• MicroRNA-21 (miR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer

  2008cited by this paper
• A microRNA signature for a BMP2-induced osteoblast lineage commitment program

  2008cited by this paper
• Programmed Cell Death 4 (PDCD4) Is an Important Functional Target of the MicroRNA miR-21 in Breast Cancer Cells*

  2008cited by this paper
• Skeletal remodeling in health and disease

  2007cited by this paper
• Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells

  2007cited by this paper
• The RNaseIII enzyme Dicer is required for morphogenesis but not patterning of the vertebrate limb.

  2005cited by this paper
• ATF4 is a substrate of RSK2 and an essential regulator of osteoblast biology; implication for Coffin-Lowry Syndrome.

  2004cited by this paper
• ATF4, the Osteoblast Accumulation of Which Is Determined Post-translationally, Can Induce Osteoblast-specific Gene Expression in Non-osteoblastic Cells*

  2004cited by this paper
• Processing of primary microRNAs by the Microprocessor complex

  2004cited by this paper
• The Microprocessor complex mediates the genesis of microRNAs

  2004cited by this paper
• Intensified Cloning Efforts Have Revealed Numer

  2004cited by this paper
• The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation.

  2002cited by this paper
• Tumor necrosis factor α stimulates osteoclast differentiation by a mechanism independent of the ODF/RANKL-RANK interaction

  2002cited by this paper
• Role for a bidentate ribonuclease in the initiation step of RNA interference

  2001cited by this paper
• Variation in the reversibility of evolution

  2000cited by this paper
• Tumor Necrosis Factor (cid:97) Stimulates Osteoclast Differentiation by a Mechanism Independent of the ODF/RANKL–RANK Interaction

  2000cited by this paper
• A BMP-inducible gene, dlx5, regulates osteoblast differentiation and mesoderm induction.

  1999cited by this paper

• [miR-488-5p promotes osteogenic and neurogenic differentiation of rat bone marrow mesenchymal stem cells and enhances neuralized bone regeneration].

  2026cites this paper
• miR-202-5p mitigates the advancement of osteoporosis through the regulation of PTEN

  2025cites this paper
• Platycodin D inhibits non-small cell lung cancer bone metastasis by inducing ferroptosis through miR-877-3P/PNMA5 regulatory axis.

  2025cites this paper
• Comprehensive profiling of plasma and exosomal microRNAs in medication-related osteonecrosis of the jaw

  2025cites this paper
• MiR-217 participates in the progression of postmenopausal osteoporosis by regulating the OPG/RANKL/RANK pathway

  2025cites this paper
• A comprehensive review of dental bone regeneration

  2025cites this paper
• The Pivotal Role of miR-27 in the Procedure of Stem Cell Differentiation: Focused on Osteogenesis and Chondrogenesis

  2025influential citation
• Osteoclast-derived exosomal miR-30a-3p promotes lead exposure-induced osteoporosis by triggering osteoblastic pyroptosis

  2025cites this paper
• mmu‐miR‐185 regulates osteoclasts differentiation and migration by targeting Btk

  2024cites this paper
• MiR-495 reverses in the mechanical unloading, random rotating and aging induced muscle atrophy via targeting MyoD and inactivating the Myostatin/TGF-β/Smad3 axis.

  2024cites this paper
• Unveiling the intricacies of bone homeostasis: Epigenetic regulation, extracellular vesicles, and angiogenesis integration

  2024cites this paper
• Treatment Promotion of Osteoporotic Fractures by microRNA-320 Nanocapsules Through Stimulating Bone Marrow Mesenchymal Stem Cells

  2024cites this paper
• Accelerated reconstruction of rat calvaria bone defect using 3D-printed scaffolds coated with hydroxyapatite/bioglass

  2023cites this paper
• Oxidative Stress and Inflammation in Osteoporosis: Molecular Mechanisms Involved and the Relationship with microRNAs

  2023cites this paper
• The Bone Microenvironment Soil in Prostate Cancer Metastasis: An miRNA Approach

  2023cites this paper
• MicroRNAs mediated interaction of tumor microenvironment cells with breast cancer cells during bone metastasis

  2023cites this paper
• Exploring the Feasibility of Circulating miRNAs as Diagnostic and Prognostic Biomarkers in Osteoarthritis: Challenges and Opportunities

  2023cites this paper
• From Cells to Environment: Exploring the Interplay between Factors Shaping Bone Health and Disease

  2023cites this paper
• 3D-printed TCP-HA scaffolds delivering MicroRNA-302a-3p improve bone regeneration in a mouse calvarial model

  2023cites this paper
• Highly Multiplexed, Efficient, and Automated Single‐Cell MicroRNA Sequencing with Digital Microfluidics.

  2023cites this paper
• Characterization of Extracellular Vesicles in Osteoporotic Patients Compared to Osteopenic and Healthy Controls

  2022cites this paper
• MicroRNAs: emerging biomarkers and therapeutic targets of bone fragility in chronic kidney disease

  2022cites this paper
• Clinical utility of bone turnover markers in patients with chronic kidney disease

  2022cites this paper
• Applications of Nonviral Biomaterials for microRNA Transfection in Bone Tissue Engineering

  2022cites this paper
• Long Non-coding RNAs and MicroRNAs Interplay in Osteogenic Differentiation of Mesenchymal Stem Cells

  2021cites this paper
• Circulating miRNAs associated with bone mineral density in healthy adult baboons

  2021cites this paper
• The Effect of Inflammation on Bone

  2021cites this paper
• Bone Aging, Cellular Senescence, and Osteoporosis

  2021cites this paper
• MicroRNAs Modulate Signaling Pathways in Osteogenic Differentiation of Mesenchymal Stem Cells

  2021influential citation
• Roles of MicroRNAs in Bone Destruction of Rheumatoid Arthritis

  2020cites this paper
• microRNA‐146a controls age‐related bone loss

  2020cites this paper
• Transcriptome sequencing profiling identifies miRNA-331-3p as an osteoblast-specific miRNA in infected bone nonunion.

  2020cites this paper
• Associations of Serum MicroRNA with Bone Mineral Density in Community-Dwelling Subjects: The Yakumo Study

  2020cites this paper
• MicroRNA-29b Promotes Subchondral Bone Loss in TMJ Osteoarthritis

  2020cites this paper
• MiR-146a controls age related bone loss

  2020cites this paper
• Identification of Serum Exosomal MicroRNA Expression Profiling in Menopausal Females with Osteoporosis by High-throughput Sequencing

  2020cites this paper
• The role of microRNAs in bone development.

  2020cites this paper
• miR‐199a‐3p is involved in estrogen‐mediated autophagy through the IGF‐1/mTOR pathway in osteocyte‐like MLO‐Y4 cells

  2018cites this paper